gossypol has been researched along with Breast Cancer in 27 studies
Gossypol: A dimeric sesquiterpene found in cottonseed (GOSSYPIUM). The (-) isomer is active as a male contraceptive (CONTRACEPTIVE AGENTS, MALE) whereas toxic symptoms are associated with the (+) isomer.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We observed that gossypol inhibited expression of both MDM2 and VEGF in human breast cancer cells with either wild-type or mutant p53." | 7.85 | Gossypol has anti-cancer effects by dual-targeting MDM2 and VEGF in human breast cancer. ( Li, J; Su, T; Wang, J; Xiong, J; Yang, Q; Zhou, S, 2017) |
| "We have demonstrated that (-)-gossypol-enriched cottonseed oil [(-)-GPCSO] can down-regulate Bcl-2 expression in MCF-7 and primary cultured human breast cancer epithelial cells (PCHBCECs)." | 7.77 | Liposomes containing (-)-gossypol-enriched cottonseed oil suppress Bcl-2 and Bcl-xL expression in breast cancer cells. ( Cho, Y; Kulp, SK; Lee, LJ; Lee, RJ; Li, H; Lin, SH; Lin, YC; Mao, Y; Piao, L; Xu, P; Ye, W; Zhong, S, 2011) |
| "It is suggested that obese individuals may be at greater risk of developing zeranol-induced breast cancer." | 7.75 | Mitogenic activity of zeranol in human breast cancer cells is enhanced by leptin and suppressed by gossypol. ( Jen, R; Kuo, CT; Lin, SH; Lin, YC; Xu, P; Ye, W, 2009) |
| "The antiproliferative effects of gossypol on human MCF-7 mammary cancer cells and cyclin D1-transfected HT-1060 human fibrosarcoma cells were investigated by cell cycle analysis and effects on the cell cycle regulatory proteins Rb and cyclin D1." | 7.69 | Gossypol inhibition of mitosis, cyclin D1 and Rb protein in human mammary cancer cells and cyclin-D1 transfected human fibrosarcoma cells. ( Hochhauser, D; Jeoung, D; Ligueros, M; Reidenberg, MM; Sonenberg, M; Tang, B, 1997) |
| "Gossypol plasma levels were measured (n = 8) and the modulation of the retinoblastoma (Rb) gene protein and Cyclin D1 was assessed by serial biopsies (n = 4)." | 6.70 | Oral gossypol in the treatment of patients with refractory metastatic breast cancer: a phase I/II clinical trial. ( Bacotti, D; Bloch, R; Borgen, P; Gollub, M; Hudis, C; Ligueros, M; Moasser, MM; Norton, L; Reidenberg, MM; Seidman, AD; Sklarin, N; Sonenberg, M; Van Poznak, C; Van Zee, K; Yao, TJ, 2001) |
| "Gossypol is a polyphenolic aldehyde occurring naturally in cottonseed that produces antisteroidogenic activity in vivo, has been extensively investigated as a male contraceptive agent, and has demonstrated anticancer activity." | 5.29 | Antiproliferative activity of gossypol and gossypolone on human breast cancer cells. ( Brueggemeier, RW; Chang, CJ; Gilbert, NE; Lin, YC; O'Reilly, JE, 1995) |
| "We observed that gossypol inhibited expression of both MDM2 and VEGF in human breast cancer cells with either wild-type or mutant p53." | 3.85 | Gossypol has anti-cancer effects by dual-targeting MDM2 and VEGF in human breast cancer. ( Li, J; Su, T; Wang, J; Xiong, J; Yang, Q; Zhou, S, 2017) |
| " Here, we examined the combination of TRA-8 with doxorubicin or bortezomib in breast cancer cells." | 3.77 | Mechanisms of drug sensitization to TRA-8, an agonistic death receptor 5 antibody, involve modulation of the intrinsic apoptotic pathway in human breast cancer cells. ( Amm, HM; Buchsbaum, DJ; Kuo, H; Li, Y; Steg, AD; Zhou, T, 2011) |
| "We have demonstrated that (-)-gossypol-enriched cottonseed oil [(-)-GPCSO] can down-regulate Bcl-2 expression in MCF-7 and primary cultured human breast cancer epithelial cells (PCHBCECs)." | 3.77 | Liposomes containing (-)-gossypol-enriched cottonseed oil suppress Bcl-2 and Bcl-xL expression in breast cancer cells. ( Cho, Y; Kulp, SK; Lee, LJ; Lee, RJ; Li, H; Lin, SH; Lin, YC; Mao, Y; Piao, L; Xu, P; Ye, W; Zhong, S, 2011) |
| "Sera from chickens that consumed a known level of (-)-gossypol (-)-GP) exhibited bioactivity against human breast cancer cells in vitro." | 3.76 | (-)-Gossypol containing hen sera and a myosin (-)-gossypol conjugate reduces the proliferation of MCF-7 cells. ( Lin, YC; Reddish, JM; Wick, M; Ye, W, 2010) |
| "It is suggested that obese individuals may be at greater risk of developing zeranol-induced breast cancer." | 3.75 | Mitogenic activity of zeranol in human breast cancer cells is enhanced by leptin and suppressed by gossypol. ( Jen, R; Kuo, CT; Lin, SH; Lin, YC; Xu, P; Ye, W, 2009) |
| "The antiproliferative effects of gossypol on human MCF-7 mammary cancer cells and cyclin D1-transfected HT-1060 human fibrosarcoma cells were investigated by cell cycle analysis and effects on the cell cycle regulatory proteins Rb and cyclin D1." | 3.69 | Gossypol inhibition of mitosis, cyclin D1 and Rb protein in human mammary cancer cells and cyclin-D1 transfected human fibrosarcoma cells. ( Hochhauser, D; Jeoung, D; Ligueros, M; Reidenberg, MM; Sonenberg, M; Tang, B, 1997) |
| "Gossypol plasma levels were measured (n = 8) and the modulation of the retinoblastoma (Rb) gene protein and Cyclin D1 was assessed by serial biopsies (n = 4)." | 2.70 | Oral gossypol in the treatment of patients with refractory metastatic breast cancer: a phase I/II clinical trial. ( Bacotti, D; Bloch, R; Borgen, P; Gollub, M; Hudis, C; Ligueros, M; Moasser, MM; Norton, L; Reidenberg, MM; Seidman, AD; Sklarin, N; Sonenberg, M; Van Poznak, C; Van Zee, K; Yao, TJ, 2001) |
| "Human breast cancer (MCF-7 and MDA-MB-231) and normal breast cells (MCF-10A) were treated with drugs alone/in combination/sequentially." | 1.38 | Pretreatment with AT-101 enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis of breast cancer cells by inducing death receptors 4 and 5 protein levels. ( Atmaca, H; Cakar, B; Karabulut, B; Karaca, B; Kisim, A; Sezgin, C; Uslu, R; Uzunoglu, S, 2012) |
| "Gossypol was shown to inhibit TNF-α-induced ICAM-1 expression and U937 cell adhesion to MDA-MB-231 and MCF-7 cells." | 1.37 | Gossypol decreases tumor necrosis factor-α-induced intercellular adhesion molecule-1 expression via suppression of NF-κB activity. ( Choi, YH; Kim, GY; Kim, WJ; Moon, DO; Moon, SK, 2011) |
| "Gossypolone was also observed to be more toxic than gossypol against both cell lines." | 1.32 | Cytotoxicity of enantiomers of gossypol Schiff's bases and optical stability of gossypolone. ( Dao, VT; Dowd, MK; Gaspard, C; Martin, MT; Mayer, M; Michelot, RJ, 2004) |
| "Gossypol is a polyphenolic aldehyde occurring naturally in cottonseed that produces antisteroidogenic activity in vivo, has been extensively investigated as a male contraceptive agent, and has demonstrated anticancer activity." | 1.29 | Antiproliferative activity of gossypol and gossypolone on human breast cancer cells. ( Brueggemeier, RW; Chang, CJ; Gilbert, NE; Lin, YC; O'Reilly, JE, 1995) |
| "Two human breast carcinoma cell lines (MCF-7, MCF-7 Adr) and a rat esophageal cancer cell line (RE-B2T) were used to evaluate the antiproliferative potential of gossypol (GP)-containing milk (GP-Milk), which was collected from Brown Swiss dairy cows treated daily with federally allowable 450 ppm of GP for 6 days." | 1.29 | Presence of antitumor activities in the milk collected from gossypol-treated dairy cows. ( Brueggemeier, RW; Chang, CJ; Hu, YF; Lin, YC, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (7.41) | 18.7374 |
| 1990's | 8 (29.63) | 18.2507 |
| 2000's | 4 (14.81) | 29.6817 |
| 2010's | 13 (48.15) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hu, Y | 1 |
| Yagüe, E | 1 |
| Zhao, J | 1 |
| Wang, L | 1 |
| Bai, J | 1 |
| Yang, Q | 2 |
| Pan, T | 1 |
| Zhao, H | 1 |
| Liu, J | 1 |
| Zhang, J | 1 |
| Cao, H | 1 |
| Sethumadhavan, K | 1 |
| Bland, JM | 1 |
| Antonietti, P | 1 |
| Gessler, F | 1 |
| Düssmann, H | 1 |
| Reimertz, C | 1 |
| Mittelbronn, M | 1 |
| Prehn, JH | 1 |
| Kögel, D | 1 |
| Heleg-Shabtai, V | 1 |
| Aizen, R | 1 |
| Sharon, E | 1 |
| Sohn, YS | 1 |
| Trifonov, A | 1 |
| Enkin, N | 1 |
| Freage, L | 1 |
| Nechushtai, R | 1 |
| Willner, I | 1 |
| Xiong, J | 1 |
| Li, J | 1 |
| Wang, J | 1 |
| Su, T | 1 |
| Zhou, S | 1 |
| Xu, P | 2 |
| Ye, W | 4 |
| Jen, R | 1 |
| Lin, SH | 3 |
| Kuo, CT | 1 |
| Lin, YC | 8 |
| Reddish, JM | 1 |
| Wick, M | 1 |
| Chang, HL | 1 |
| Wang, LS | 1 |
| Huang, YW | 1 |
| Shu, S | 1 |
| Sugimoto, Y | 1 |
| Dowd, MK | 2 |
| Wan, PJ | 1 |
| Zhong, S | 2 |
| Ye, WP | 1 |
| Xu, PP | 1 |
| Feng, E | 1 |
| Li, H | 2 |
| Liu, JY | 1 |
| Ma, C | 1 |
| Moon, DO | 1 |
| Choi, YH | 1 |
| Moon, SK | 1 |
| Kim, WJ | 1 |
| Kim, GY | 1 |
| Amm, HM | 1 |
| Zhou, T | 1 |
| Steg, AD | 1 |
| Kuo, H | 1 |
| Li, Y | 1 |
| Buchsbaum, DJ | 1 |
| Piao, L | 1 |
| Kulp, SK | 1 |
| Mao, Y | 1 |
| Cho, Y | 1 |
| Lee, LJ | 1 |
| Lee, RJ | 1 |
| Kisim, A | 1 |
| Atmaca, H | 1 |
| Cakar, B | 1 |
| Karabulut, B | 1 |
| Sezgin, C | 1 |
| Uzunoglu, S | 1 |
| Uslu, R | 1 |
| Karaca, B | 1 |
| Niu, X | 1 |
| Li, S | 1 |
| Wei, F | 1 |
| Huang, J | 1 |
| Wu, G | 1 |
| Xu, L | 1 |
| Xu, D | 1 |
| Wang, S | 1 |
| Dao, VT | 1 |
| Martin, MT | 1 |
| Gaspard, C | 1 |
| Mayer, M | 1 |
| Michelot, RJ | 1 |
| Brozic, P | 1 |
| Lanisnik Risner, T | 1 |
| Gobec, S | 1 |
| Tuszynski, GP | 1 |
| Cossu, G | 1 |
| Gilbert, NE | 1 |
| O'Reilly, JE | 1 |
| Chang, CJ | 3 |
| Brueggemeier, RW | 3 |
| Hu, YF | 2 |
| Liang, XS | 1 |
| Rogers, AJ | 1 |
| Webber, CL | 1 |
| Ormsby, TJ | 1 |
| Tiritan, ME | 1 |
| Matlin, SA | 2 |
| Benz, CC | 3 |
| Rekha, GK | 1 |
| Sladek, NE | 1 |
| Ligueros, M | 2 |
| Jeoung, D | 1 |
| Tang, B | 1 |
| Hochhauser, D | 1 |
| Reidenberg, MM | 2 |
| Sonenberg, M | 2 |
| Van Poznak, C | 1 |
| Seidman, AD | 1 |
| Moasser, MM | 1 |
| Sklarin, N | 1 |
| Van Zee, K | 1 |
| Borgen, P | 1 |
| Gollub, M | 1 |
| Bacotti, D | 1 |
| Yao, TJ | 1 |
| Bloch, R | 1 |
| Norton, L | 1 |
| Hudis, C | 1 |
| Ford, JM | 1 |
| Hait, WN | 1 |
| Jaroszewski, JW | 1 |
| Kaplan, O | 1 |
| Cohen, JS | 1 |
| Keniry, MA | 1 |
| Hollander, C | 1 |
1 review available for gossypol and Breast Cancer
| Article | Year |
|---|---|
Inhibitors of 17beta-hydroxysteroid dehydrogenase type 1.
Topics: 17-Hydroxysteroid Dehydrogenases; Breast Neoplasms; Enzyme Inhibitors; Estradiol; Estrogens; Estrone | 2008 |
1 trial available for gossypol and Breast Cancer
| Article | Year |
|---|---|
Oral gossypol in the treatment of patients with refractory metastatic breast cancer: a phase I/II clinical trial.
Topics: Administration, Oral; Adult; Aged; Breast Neoplasms; Cell Cycle; Cyclin D1; Dose-Response Relationsh | 2001 |
25 other studies available for gossypol and Breast Cancer
| Article | Year |
|---|---|
Sabutoclax, pan-active BCL-2 protein family antagonist, overcomes drug resistance and eliminates cancer stem cells in breast cancer.
Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Doxorubicin; Drug Re | 2018 |
Isolation of Cottonseed Extracts That Affect Human Cancer Cell Growth.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Survival; Cottonseed Oil; Gossypol; Humans; Mitochondr | 2018 |
AT-101 simultaneously triggers apoptosis and a cytoprotective type of autophagy irrespective of expression levels and the subcellular localization of Bcl-xL and Bcl-2 in MCF7 cells.
Topics: Apoptosis; Autophagy; bcl-X Protein; Breast Neoplasms; Cytoprotection; Female; Gene Expression Regul | 2016 |
Gossypol-Capped Mitoxantrone-Loaded Mesoporous SiO2 NPs for the Cooperative Controlled Release of Two Anti-Cancer Drugs.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Delayed-Action Preparations; Drug Carrier | 2016 |
Gossypol has anti-cancer effects by dual-targeting MDM2 and VEGF in human breast cancer.
Topics: 3' Untranslated Regions; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Breast Neoplasms; Ce | 2017 |
Mitogenic activity of zeranol in human breast cancer cells is enhanced by leptin and suppressed by gossypol.
Topics: Anticarcinogenic Agents; Breast Neoplasms; Cell Growth Processes; Cell Line, Tumor; Cell Transformat | 2009 |
(-)-Gossypol containing hen sera and a myosin (-)-gossypol conjugate reduces the proliferation of MCF-7 cells.
Topics: Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Breast Neoplasms; Cell Proliferati | 2010 |
Induction of apoptosis by (-)-gossypol-enriched cottonseed oil in human breast cancer cells.
Topics: Apoptosis; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cells, Culture | 2010 |
Aromatase expression in leptin-pretreated human breast pre-adipocytes is enhanced by zeranol and suppressed by (-)-gossypol.
Topics: Adipocytes; Aromatase; Breast; Breast Neoplasms; Cell Growth Processes; Estrogens, Non-Steroidal; Go | 2010 |
Gossypol decreases tumor necrosis factor-α-induced intercellular adhesion molecule-1 expression via suppression of NF-κB activity.
Topics: Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Chromatin Immunoprecipitation; Electrophoreti | 2011 |
Mechanisms of drug sensitization to TRA-8, an agonistic death receptor 5 antibody, involve modulation of the intrinsic apoptotic pathway in human breast cancer cells.
Topics: Animals; Antibodies, Monoclonal; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Azocines | 2011 |
Liposomes containing (-)-gossypol-enriched cottonseed oil suppress Bcl-2 and Bcl-xL expression in breast cancer cells.
Topics: Animals; Antineoplastic Agents, Phytogenic; bcl-X Protein; Breast; Breast Neoplasms; Cell Line, Tumo | 2011 |
Pretreatment with AT-101 enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis of breast cancer cells by inducing death receptors 4 and 5 protein levels.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Female; Gossypol; | 2012 |
Apogossypolone induces autophagy and apoptosis in breast cancer MCF-7 cells in vitro and in vivo.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; bcl | 2014 |
Cytotoxicity of enantiomers of gossypol Schiff's bases and optical stability of gossypolone.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Survival; Chromatography, High Pressure Liquid; Doxoru | 2004 |
Differential cytotoxic effect of gossypol on human melanoma, colon carcinoma, and other tissue culture cell lines.
Topics: Breast Neoplasms; Cell Division; Cell Line; Colonic Neoplasms; Fibroblasts; Gossypol; Humans; Leukem | 1984 |
Antiproliferative activity of gossypol and gossypolone on human breast cancer cells.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Division; Drug Resistance, Multiple; Drug Screening As | 1995 |
Presence of antitumor activities in the milk collected from gossypol-treated dairy cows.
Topics: Animals; Breast Neoplasms; Cattle; Cell Division; Dose-Response Relationship, Drug; Esophageal Neopl | 1994 |
Gossypol inhibits basal and estrogen-stimulated DNA synthesis in human breast carcinoma cells.
Topics: Breast Neoplasms; Cell Division; Cell Line; DNA, Neoplasm; Dose-Response Relationship, Drug; Drug Re | 1993 |
Developing gossypol derivatives with enhanced antitumor activity.
Topics: Antineoplastic Agents, Phytogenic; Breast Neoplasms; Dose-Response Relationship, Drug; Drug Screenin | 1995 |
Inhibition of human class 3 aldehyde dehydrogenase, and sensitization of tumor cells that express significant amounts of this enzyme to oxazaphosphorines, by the naturally occurring compound gossypol.
Topics: Adenocarcinoma; Aldehyde Dehydrogenase; Antineoplastic Agents, Alkylating; Breast Neoplasms; Catecho | 1997 |
Gossypol inhibition of mitosis, cyclin D1 and Rb protein in human mammary cancer cells and cyclin-D1 transfected human fibrosarcoma cells.
Topics: Breast Neoplasms; Cell Cycle; Cyclin D1; Cyclins; Fibrosarcoma; Gossypol; Humans; Mitosis; Oncogene | 1997 |
Modulation of resistance to alkylating agents in cancer cell by gossypol enantiomers.
Topics: Alkylating Agents; Animals; Breast Neoplasms; Buthionine Sulfoximine; Carcinoma 256, Walker; Carmust | 1991 |
Action of gossypol and rhodamine 123 on wild type and multidrug-resistant MCF-7 human breast cancer cells: 31P nuclear magnetic resonance and toxicity studies.
Topics: Animals; Breast Neoplasms; Cell Division; Cricetinae; Cricetulus; Drug Resistance; Female; Glucose; | 1990 |
The effect of gossypol and 6-aminonicotinamide on tumor cell metabolism: a 31P-magnetic resonance spectroscopic study.
Topics: 6-Aminonicotinamide; Breast Neoplasms; Cell Line; Female; Gossypol; Humans; Magnetic Resonance Spect | 1989 |