gossypol has been researched along with Brain Neoplasms in 7 studies
Gossypol: A dimeric sesquiterpene found in cottonseed (GOSSYPIUM). The (-) isomer is active as a male contraceptive (CONTRACEPTIVE AGENTS, MALE) whereas toxic symptoms are associated with the (+) isomer.
Brain Neoplasms: Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The present study evaluates the effects of AT101, alone or in combination with temozolomide (TMZ), in a microenvironmental glioma stem cell niche model of two GBM cell lines (U251MG and U87MG)." | 4.02 | Effects of the Anti-Tumorigenic Agent AT101 on Human Glioblastoma Cells in the Microenvironmental Glioma Stem Cell Niche. ( Caylioglu, D; Held-Feindt, J; Hellmold, D; Kubelt, C; Meyer, RJ; Synowitz, M, 2021) |
| "AT101, the R-(-)-enantiomer of the cottonseed-derived polyphenol gossypol, is a promising drug in glioblastoma multiforme (GBM) therapy due to its ability to trigger autophagic cell death but also to facilitate apoptosis in tumor cells." | 3.96 | AT101-Loaded Cubosomes as an Alternative for Improved Glioblastoma Therapy. ( Adamski, V; Flak, DK; Held-Feindt, J; Jurga, S; Nowaczyk, G; Synowitz, M; Szutkowski, K, 2020) |
| "Targeted approaches for treating glioblastoma (GBM) attempted to date have consistently failed, highlighting the imperative for treatment strategies that operate on different mechanistic principles." | 1.48 | Regulation of bioenergetics through dual inhibition of aldehyde dehydrogenase and mitochondrial complex I suppresses glioblastoma tumorspheres. ( Chang, JH; Choi, J; Kang, JH; Kang, SG; Kim, SY; Park, J; Shim, JK, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (14.29) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 4 (57.14) | 2.80 |
| Authors | Studies |
|---|---|
| Hellmold, D | 2 |
| Kubelt, C | 3 |
| Daunke, T | 1 |
| Beckinger, S | 1 |
| Janssen, O | 1 |
| Hauck, M | 1 |
| Schütt, F | 1 |
| Adelung, R | 1 |
| Lucius, R | 1 |
| Haag, J | 1 |
| Sebens, S | 1 |
| Synowitz, M | 4 |
| Held-Feindt, J | 4 |
| Mehner, M | 1 |
| Adamski, V | 2 |
| Schmitt, C | 1 |
| Flak, DK | 1 |
| Nowaczyk, G | 1 |
| Szutkowski, K | 1 |
| Jurga, S | 1 |
| Caylioglu, D | 1 |
| Meyer, RJ | 1 |
| Park, J | 1 |
| Shim, JK | 1 |
| Kang, JH | 1 |
| Choi, J | 1 |
| Chang, JH | 1 |
| Kim, SY | 1 |
| Kang, SG | 1 |
| Jarzabek, MA | 1 |
| Amberger-Murphy, V | 1 |
| Callanan, JJ | 1 |
| Gao, C | 1 |
| Zagozdzon, AM | 1 |
| Shiels, L | 1 |
| Wang, J | 1 |
| Ligon, KL | 1 |
| Rich, BE | 1 |
| Dicker, P | 1 |
| Gallagher, WM | 1 |
| Prehn, JH | 1 |
| Byrne, AT | 1 |
| Bushunow, P | 1 |
| Reidenberg, MM | 1 |
| Wasenko, J | 1 |
| Winfield, J | 1 |
| Lorenzo, B | 1 |
| Lemke, S | 1 |
| Himpler, B | 1 |
| Corona, R | 1 |
| Coyle, T | 1 |
7 other studies available for gossypol and Brain Neoplasms
| Article | Year |
|---|---|
Sequential Treatment with Temozolomide Plus Naturally Derived AT101 as an Alternative Therapeutic Strategy: Insights into Chemoresistance Mechanisms of Surviving Glioblastoma Cells.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Line, Tumor; Drug Resistance, Neoplasm; Gli | 2023 |
Combined treatment of AT101 and demethoxycurcumin yields an enhanced anti-proliferative effect in human primary glioblastoma cells.
Topics: Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; | 2020 |
AT101-Loaded Cubosomes as an Alternative for Improved Glioblastoma Therapy.
Topics: Antineoplastic Agents, Phytogenic; Biological Availability; Brain Neoplasms; Cell Line, Tumor; Collo | 2020 |
Effects of the Anti-Tumorigenic Agent AT101 on Human Glioblastoma Cells in the Microenvironmental Glioma Stem Cell Niche.
Topics: Antineoplastic Combined Chemotherapy Protocols; Brain; Brain Neoplasms; Carcinogenesis; Cell Line, T | 2021 |
Regulation of bioenergetics through dual inhibition of aldehyde dehydrogenase and mitochondrial complex I suppresses glioblastoma tumorspheres.
Topics: Adenosine Triphosphate; Aldehyde Dehydrogenase; Animals; Biomarkers, Tumor; Brain Neoplasms; Cell Pr | 2018 |
Interrogation of gossypol therapy in glioblastoma implementing cell line and patient-derived tumour models.
Topics: Animals; Brain Neoplasms; Cell Line, Tumor; Female; Glioblastoma; Gossypol; Humans; Mice; Mice, Inbr | 2014 |
Gossypol treatment of recurrent adult malignant gliomas.
Topics: Adult; Aged; Brain Neoplasms; Disease-Free Survival; Female; Glioma; Gossypol; Humans; Male; Middle | 1999 |