gossypol has been researched along with Body Weight in 58 studies
Gossypol: A dimeric sesquiterpene found in cottonseed (GOSSYPIUM). The (-) isomer is active as a male contraceptive (CONTRACEPTIVE AGENTS, MALE) whereas toxic symptoms are associated with the (+) isomer.
Body Weight: The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "When (+/-) gossypol acetic acid was administered to male Sprague-Dawley rats for 26 weeks, the most significant toxicological finding was marked suppression of body weight gain in rats receiving 25 mg/kg per day." | 3.67 | The toxicity of gossypol to the male rat. ( Gopinath, C; Heywood, R; Lloyd, GK; Majeed, SK, 1986) |
| "The effects of gossypol acetic on pregnancy, embryofoetal development and on some selected parameters of immunological response in mice were studied." | 3.67 | The embryotoxic and immunodepressive effects of gossypol. ( Sein, GM, 1986) |
| "Gossypol is an important allelochemical produced by the subepidermal glands of some cotton varieties and important for their ability to respond to changing biotic stress by exhibiting antibiosis against some cotton pests." | 1.43 | Rhizobacteria activates (+)-δ-cadinene synthase genes and induces systemic resistance in cotton against beet armyworm (Spodoptera exigua). ( Fadamiro, H; Kloepper, JW; Song, Y; Zebelo, S, 2016) |
| " Our results indicated that both gossypol enantiomers were toxic to broilers but that (-)-gossypol was more harmful to efficient broiler production than (+)-gossypol." | 1.33 | Relative toxicity of gossypol enantiomers in broilers. ( Calhoun, MC; Dale, NM; Davis, AJ; Dowd, MK; Lordelo, MM, 2005) |
| "In gossypol treated rats, sperm morphology was compromised severely, but the epithelium in testis and epididymis appeared morphologically normal." | 1.33 | Epididymis-specific pathologic disorders in rats exposed to gossypol from weaning through puberty. ( de Andrade, SF; De Grava Kempinas, W; Klinefelter, GR; Oliva, SU, 2006) |
| " Results demonstrated that the combined dosage regimen could damage epididymal sperm motility and density, and induce infertility within 8 weeks in rats; the infertility could be consistently sustained by giving single GA (12." | 1.32 | Combined administration of low-dose gossypol acetic acid with desogestrel/mini-dose ethinylestradiol/testosterone undecanoate as an oral contraceptive for men. ( Cui, GH; Guo, Y; Xue, SP; Yang, ZJ; Ye, WS, 2004) |
| " Treatment of mice with gossypol produced significant adverse effects on the dam and offspring including decreased pregnancy weight gain of the dam and growth retardation of the offspring." | 1.28 | Evidence for embryotoxicity of gossypol in mice and chicks with no evidence of mutagenic activity in the Ames test. ( Booth, GM; Li, YF; Seegmiller, RE, 1989) |
| "No gossypol was found in plasma taken before, during, or after Trial 1 or from body organs or plasma taken during or after Trial 2." | 1.28 | Effect of feeding gossypol in cottonseed meal on growth, semen quality, and spermatogenesis of yearling Holstein bulls. ( Adkinson, RW; Baham, A; Chandler, JE; Jimenez, DA; Nipper, WA; Saxton, AM, 1989) |
| "Body weights were also reduced in rats treated with 40 mg or 60 mg/kg per day for 30 days when compared to controls." | 1.27 | A histopathologic study of the effects of gossypol on the female rat. ( Bender, HS; Misra, HP; Saunders, GK, 1988) |
| "Gossypol treatment of males had no effect on the outcome of pregnancy." | 1.27 | A developmental toxicity evaluation of gossypol. ( Beaudoin, AR, 1988) |
| " Splenectomized rats dosed with GAA exhibited a significant decrease in hemoglobin concentration, hematocrit and erythrocyte count." | 1.27 | Radioiron utilization and gossypol acetic acid in male rats. ( Jensen, DR; Tone, JN, 1985) |
| " Infertility was exhibited at the end of the 4-week dosing period." | 1.26 | Deposition pattern of the antifertility agent, gossypol, in selected organs of male rats. ( Bozek, SA; Jensen, DR; Sorensen, RH; Tone, JN, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 41 (70.69) | 18.7374 |
| 1990's | 6 (10.34) | 18.2507 |
| 2000's | 7 (12.07) | 29.6817 |
| 2010's | 3 (5.17) | 24.3611 |
| 2020's | 1 (1.72) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, C | 1 |
| Li, Y | 1 |
| MaiTiSaiYiDi, T | 1 |
| Yang, H | 1 |
| Yang, K | 1 |
| Zebelo, S | 1 |
| Song, Y | 1 |
| Kloepper, JW | 1 |
| Fadamiro, H | 1 |
| Villaseñor, M | 1 |
| Coscioni, AC | 1 |
| Galvão, KN | 1 |
| Chebel, RC | 1 |
| Santos, JE | 1 |
| Blevins, S | 1 |
| Siegel, PB | 1 |
| Blodgett, DJ | 1 |
| Ehrich, M | 1 |
| Saunders, GK | 2 |
| Lewis, RM | 1 |
| Wu, G | 1 |
| Guo, JY | 1 |
| Wan, FH | 1 |
| Xiao, NW | 1 |
| Fombad, RB | 2 |
| Bryant, MJ | 2 |
| Yang, ZJ | 1 |
| Ye, WS | 1 |
| Cui, GH | 1 |
| Guo, Y | 1 |
| Xue, SP | 1 |
| Lordelo, MM | 1 |
| Davis, AJ | 1 |
| Calhoun, MC | 1 |
| Dowd, MK | 1 |
| Dale, NM | 1 |
| de Andrade, SF | 1 |
| Oliva, SU | 1 |
| Klinefelter, GR | 1 |
| De Grava Kempinas, W | 1 |
| Braham, JE | 5 |
| Jarquín, R | 2 |
| Elías, LG | 2 |
| González, M | 1 |
| Bressani, R | 5 |
| González, JM | 1 |
| Chang, CC | 1 |
| Gu, Z | 1 |
| Tsong, YY | 1 |
| Yannai, S | 1 |
| Bensal, D | 1 |
| Tso, WW | 1 |
| Tang, F | 1 |
| Wong, PY | 1 |
| Wang, JM | 1 |
| Gu, CH | 1 |
| Qian, ZM | 1 |
| Jing, GW | 1 |
| Oko, R | 1 |
| Hrudka, F | 1 |
| Wu, YM | 1 |
| Chappel, SC | 1 |
| Flickinger, GL | 1 |
| Sotelo, A | 1 |
| Montalvo, I | 1 |
| de la Luz Crail, M | 1 |
| González-Garza, MT | 1 |
| Hoffer, AP | 1 |
| Jensen, DR | 3 |
| Tone, JN | 5 |
| Sorensen, RH | 1 |
| Bozek, SA | 1 |
| Akingbemi, BT | 2 |
| Aire, TA | 2 |
| Cusack, PM | 1 |
| Perry, V | 1 |
| Oke, BO | 1 |
| Noftsger, SM | 1 |
| Hopkins, BA | 1 |
| Diaz, DE | 1 |
| Brownie, C | 1 |
| Whitlow, LW | 1 |
| El-DIN, S | 1 |
| Aboul-Ela, S | 1 |
| Clawson, AJ | 2 |
| Maner, JH | 1 |
| Gomez, G | 1 |
| Mejia, O | 1 |
| Flores, Z | 1 |
| Buitrago, J | 1 |
| Aburto, A | 1 |
| Gómez-Brenes, R | 1 |
| Bertrand, V | 1 |
| Belleville, J | 1 |
| Johansen, RL | 1 |
| Misra, HP | 2 |
| Lohiya, NK | 1 |
| Sharma, K | 1 |
| Kumar, M | 1 |
| Sharma, S | 1 |
| Li, YF | 1 |
| Booth, GM | 1 |
| Seegmiller, RE | 1 |
| Chadha, S | 2 |
| Sanyal, SN | 2 |
| Kanwar, U | 2 |
| Jimenez, DA | 1 |
| Chandler, JE | 1 |
| Adkinson, RW | 1 |
| Nipper, WA | 1 |
| Baham, A | 1 |
| Saxton, AM | 1 |
| Panigrahi, S | 1 |
| Plumb, VE | 1 |
| Machin, DH | 1 |
| Bender, HS | 1 |
| Rajpurohit, R | 1 |
| Giridharan, N | 1 |
| Liu, GZ | 1 |
| Lyle, KC | 1 |
| Cao, J | 1 |
| Heywood, R | 2 |
| Beaudoin, AR | 1 |
| Reynolds, JM | 1 |
| MacNab, RK | 1 |
| Nollen, PM | 1 |
| Lloyd, GK | 1 |
| Majeed, SK | 1 |
| Gopinath, C | 1 |
| Sein, GM | 1 |
| Rikihisa, Y | 1 |
| Lin, YC | 1 |
| Lagerlöf, RK | 1 |
| Kornegay, ET | 1 |
| Kelly, RF | 1 |
| Campbell, TC | 1 |
| Libke, KG | 1 |
| Sandrock, FW | 1 |
| Blair, JE | 1 |
| Skutches, CL | 2 |
| Herman, DL | 2 |
| Smith, FH | 3 |
| Ogot, JO | 1 |
| Cañas, AG | 1 |
| Albrecht, JE | 1 |
| Alsmeyer, WL | 1 |
| Graham, GG | 1 |
| Morales, E | 1 |
| Acevedo, G | 1 |
| Baertl, JM | 1 |
| Cordano, A | 1 |
2 trials available for gossypol and Body Weight
| Article | Year |
|---|---|
Effects of silymarin on gossypol toxicosis in divergent lines of chickens.
Topics: Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Body Weight; Chickens; Diet; Eatin | 2010 |
Clinical trial of gossypol as a male contraceptive drug. Part I. Efficacy study.
Topics: Appetite; Blood Pressure; Body Weight; Clinical Trials as Topic; Contraceptive Agents, Male; Double- | 1987 |
56 other studies available for gossypol and Body Weight
| Article | Year |
|---|---|
Effect of dietary gossypol supplement on fermentation characteristics and bacterial diversity in the rumen of sheep.
Topics: Animal Feed; Animals; Bacteria; Body Weight; Diet; Dietary Supplements; Female; Fermentation; Gastro | 2020 |
Rhizobacteria activates (+)-δ-cadinene synthase genes and induces systemic resistance in cotton against beet armyworm (Spodoptera exigua).
Topics: Animals; Body Weight; Cyclopentanes; Disease Resistance; Gene Expression Regulation, Plant; Genes, P | 2016 |
Gossypol disrupts embryo development in heifers.
Topics: Animals; Body Weight; Cattle; Diet; Eating; Embryo Culture Techniques; Embryo, Mammalian; Embryonic | 2008 |
Responses of three successive generations of beet armyworm, Spodoptera exigua, fed exclusively on different levels of gossypol in cotton leaves.
Topics: Analysis of Variance; Animals; Body Weight; China; Diet; Fertility; Gossypol; Insect Control; Larva; | 2010 |
An evaluation of the use of cottonseed cake in the diet of growing pigs.
Topics: Animal Feed; Animals; Body Composition; Body Weight; Cameroon; Cost-Benefit Analysis; Cottonseed Oil | 2004 |
Effects of cottonseed cake-based diets supplemented with blood meal, alone or with lysine, on the growth of pigs.
Topics: Animal Feed; Animals; Blood Proteins; Body Weight; Cottonseed Oil; Diet; Eating; Female; Gossypol; K | 2004 |
Combined administration of low-dose gossypol acetic acid with desogestrel/mini-dose ethinylestradiol/testosterone undecanoate as an oral contraceptive for men.
Topics: Animals; Body Weight; Contraceptive Agents, Male; Contraceptives, Oral, Synthetic; Desogestrel; Ethi | 2004 |
Relative toxicity of gossypol enantiomers in broilers.
Topics: Animals; Body Weight; Chickens; Cottonseed Oil; Diet; Gossypol; Liver; Male; Organ Size; Stereoisome | 2005 |
Epididymis-specific pathologic disorders in rats exposed to gossypol from weaning through puberty.
Topics: Aging; Animals; Body Weight; Epididymis; Fructose; Gossypol; Male; Microscopy, Electron; Orchiectomy | 2006 |
Effect of calcium and gossypol on the performance of swine and on certain enzymes and other blood constituents.
Topics: Aminopeptidases; Animals; Aspartate Aminotransferases; Blood Proteins; Blood Urea Nitrogen; Body Wei | 1967 |
Effect of gossypol on the iron-binding capacity of serum in swine.
Topics: Animals; Aspartate Aminotransferases; Blood Chemical Analysis; Body Weight; Calcium; Female; Gossypo | 1967 |
Studies on gossypol. I. Toxicity, antifertility, and endocrine analyses in male rats.
Topics: Animals; Body Weight; Dose-Response Relationship, Drug; Fertility; Follicle Stimulating Hormone; Gen | 1982 |
Gossypol in cottonseed products: toxicology and inactivation.
Topics: Animals; Body Weight; Cottonseed Oil; Diet; Female; Gossypol; Lysine; Male; Plant Proteins; Rats | 1983 |
Gossypol inhibits Ehrlich ascites tumor cell proliferation.
Topics: Animals; Body Weight; Carcinoma, Ehrlich Tumor; Cell Division; Dose-Response Relationship, Drug; Gos | 1984 |
Serum potassium and aldosterone levels in gossypol-treated rats.
Topics: Aldosterone; Animals; Body Weight; Gossypol; Male; Potassium; Rats; Rats, Inbred Strains; Testostero | 1984 |
Effect of gossypol on testicular blood flow and testosterone production in rats.
Topics: Animals; Body Weight; Chorionic Gonadotropin; Fertility; Gossypol; Male; Organ Size; Rats; Rats, Inb | 1984 |
Comparison of the effects of gossypol, estradiol-17 beta and testosterone compensation on male rat reproductive organs.
Topics: Animals; Body Weight; Estradiol; Genitalia, Male; Gossypol; Male; Organ Size; Rats; Rats, Inbred Str | 1984 |
Effects of gossypol on pituitary-ovarian endocrine function, ovulation and fertility in female hamsters.
Topics: Animals; Body Weight; Cricetinae; Estrogens; Estrus; Female; Fertility; Follicle Stimulating Hormone | 1981 |
Infertility in male rats induced by diets containing whole cottonseed flour.
Topics: Animals; Body Weight; Cottonseed Oil; Dose-Response Relationship, Drug; Gossypol; Infertility, Male; | 1982 |
Ultrastructural studies of spermatozoa and the epithelial lining of the epididymis and vas deferens in rats treated with gossypol.
Topics: Animals; Body Weight; Epididymis; Epithelium; Gossypol; Male; Microscopy, Electron; Rats; Spermatozo | 1982 |
Deposition pattern of the antifertility agent, gossypol, in selected organs of male rats.
Topics: Animals; Body Weight; Fertility; Gossypol; Male; Organ Size; Rats; Time Factors; Tissue Distribution | 1982 |
Haematological and serum biochemical changes in the rat due to protein malnutrition and gossypol-ethanol interactions.
Topics: Animals; Blood Cell Count; Blood Chemical Analysis; Blood Proteins; Body Weight; Dietary Proteins; E | 1994 |
The effect of feeding whole cottonseed on the fertility of bulls.
Topics: Animals; Body Weight; Cattle; Cottonseed Oil; Fertility; Food, Fortified; Gossypol; Male; Organ Size | 1995 |
Infection with Trypanosoma brucei potentiates the antifertility effect of gossypol, especially in the protein-malnourished male rat.
Topics: Animals; Body Weight; Genitalia, Male; Gossypol; Infertility, Male; Male; Microscopy, Electron; Orga | 1996 |
Effect of whole and expanded-expelled cottonseed on milk yield and blood gossypol.
Topics: Animal Feed; Animals; Body Weight; Cattle; Cottonseed Oil; Dairying; Energy Intake; Female; Food, Fo | 2000 |
Fish meal supplementation of chick starting rations containing cottonseed cake.
Topics: Animal Feed; Animals; Body Weight; Chickens; Cottonseed Oil; Dietary Proteins; Fish Products; Food A | 1976 |
Effect of different levels of gossypol on transaminase activity, on nonessential to essential amino acid ratio, and on iron and nitrogen retention in rats.
Topics: Alanine Transaminase; Amino Acids; Amino Acids, Essential; Animal Nutritional Physiological Phenomen | 1975 |
Unextracted cottonseed in diets for monogastric animals. I. The effect of ferrous sulfate and calcium hydroxide in reducing gossypol toxicity.
Topics: Animal Feed; Animals; Body Weight; Calcium Hydroxide; Cooking; Cottonseed Oil; Diet; Dietary Protein | 1975 |
[Effect of free gossypol of different cottonseed flours on the growth of rats and levels of free lysin and free gossypol in animal organs, muscle and serum].
Topics: Animals; Body Weight; Cottonseed Oil; Female; Flour; Gossypol; Growth; Intestinal Mucosa; Liver; Lys | 1975 |
Effect of refeeding diets containing cottonseed flour with traces of gossypol on rat liver and testis.
Topics: Animal Feed; Animals; Body Weight; Cottonseed Oil; Gossypol; Liver; Male; Nutrition Disorders; Rats; | 1991 |
Effects of gossypol on the hepatic drug metabolizing system in rats.
Topics: Aniline Hydroxylase; Animals; Body Weight; Cytochrome P-450 Enzyme System; Cytochromes b5; Dose-Resp | 1990 |
Limitations in developing gossypol acetic acid as a male contraceptive.
Topics: Administration, Oral; Animals; Body Weight; Cercopithecidae; Contraceptive Agents, Male; Drug Therap | 1990 |
Evidence for embryotoxicity of gossypol in mice and chicks with no evidence of mutagenic activity in the Ames test.
Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Chick Embryo; Embryo, Mammalian; Female; Fetal Re | 1989 |
Reversibility of the effects of gossypol acetic acid, an antispermatogenic/antifertility agent on the intestinal structure and functions of male albino rats.
Topics: Amino Acids; Animals; Biological Transport; Body Weight; Glucose; Gossypol; Intestinal Absorption; I | 1989 |
Effect of feeding gossypol in cottonseed meal on growth, semen quality, and spermatogenesis of yearling Holstein bulls.
Topics: Animal Feed; Animals; Body Weight; Cattle; Cottonseed Oil; Gossypol; Male; Semen; Sperm Count; Sperm | 1989 |
Effects of dietary cottonseed meal, with and without iron treatment, on laying hens.
Topics: Animal Feed; Animals; Body Weight; Chickens; Cottonseed Oil; Eating; Egg White; Egg Yolk; Eggs; Fatt | 1989 |
A histopathologic study of the effects of gossypol on the female rat.
Topics: Adrenal Glands; Animals; Body Weight; Estrus; Female; Genitalia, Female; Gossypol; Organ Size; Rats; | 1988 |
Failure of oral gossypol to inhibit hepatic microsomal and cytosolic drug-metabolising enzymes.
Topics: Administration, Oral; Animals; Body Weight; Cytosol; Gossypol; Liver; Male; Microsomes, Liver; Organ | 1988 |
Effects of gossypol acetic acid on the absorptive and digestive functions of rat intestine.
Topics: Administration, Oral; Animals; Body Weight; Digestion; Gossypol; Intestinal Mucosa; Intestines; Kine | 1988 |
The toxicology of gossypol acetic acid and (-)-gossypol.
Topics: Animals; Body Weight; Contraceptive Agents, Male; Gossypol; Macaca fascicularis; Male; Rats; Rats, I | 1988 |
A developmental toxicity evaluation of gossypol.
Topics: Animals; Body Weight; Contraceptive Agents, Male; Embryonic and Fetal Development; Female; Fetal Res | 1988 |
Subchronic oral administration of gossypol-acetic acid (GAA) alters the distribution and utilization of radioiron in male rats.
Topics: Administration, Oral; Animals; Body Weight; Bone Marrow; Erythrocytes; Gossypol; Iron; Iron Radioiso | 1988 |
The effects of gossypol on spermatogenesis and development of the eyefluke, Philophthalmus gralli, and its chicken host.
Topics: Animal Feed; Animals; Body Weight; Chickens; Ferric Compounds; Gossypol; Male; Organ Size; Poultry D | 1987 |
The toxicity of gossypol to the male rat.
Topics: Animals; Body Weight; Gossypol; Male; Rats; Rats, Inbred Strains; Testis | 1986 |
The embryotoxic and immunodepressive effects of gossypol.
Topics: Animals; Antibody Formation; Body Weight; Embryo Implantation; Embryo, Mammalian; Embryonic and Feta | 1986 |
Taenia taeniaeformis: inhibition of metacestode development in the rat by gossypol.
Topics: Animals; Body Weight; Gossypol; Liver; Male; Rats; Rats, Inbred Strains; Taenia; Taeniasis; Time Fac | 1986 |
Radioiron utilization and gossypol acetic acid in male rats.
Topics: Animals; Body Weight; Erythrocytes; Erythropoiesis; Gossypol; Iron; Iron Radioisotopes; Male; Rats; | 1985 |
The effect of gossypol acetic acid on female reproduction.
Topics: Animals; Body Weight; Estrus; Female; Gossypol; Rats; Reproduction | 1985 |
Fungal-treated cottonseed meal for swine.
Topics: Amino Acids; Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Body Weight; Cottonse | 1972 |
Effect of intravenous gossypol injection on iron ultilization in swine.
Topics: Animal Nutritional Physiological Phenomena; Animals; Bile; Blood Proteins; Body Weight; Gossypol; He | 1973 |
The performance of pigs in Kenya fed cottonseed meal in mixtures of concentrate supplements.
Topics: Animal Feed; Animals; Body Weight; Cottonseed Oil; Diet; Dietary Proteins; Gossypol; Kenya; Swine | 1973 |
Effect of dietary free gossypol on blood components and tissue iron in swine and rats.
Topics: Administration, Oral; Animals; Blood Proteins; Body Weight; Female; Gossypol; Hematocrit; Hemoglobin | 1974 |
[Gossypol absorption in rats and in pigs].
Topics: Administration, Oral; Animals; Body Weight; Cottonseed Oil; Dietary Proteins; Feces; Female; Flour; | 1971 |
Effect of ingested gossypol on the growth performance of rats.
Topics: Animals; Body Weight; Depression, Chemical; Diet; Dietary Proteins; Gossypol; Growth; Male; Rats | 1970 |
Effect of initial weight and days on feed on the accumulation of gossypol in pig livers.
Topics: Animal Feed; Animals; Body Weight; Gossypol; Liver; Swine; Time Factors | 1971 |
Dietary protein quality in infants and children. II. Metabolic studies with cottonseed flour.
Topics: Animals; Body Weight; Caseins; Child Nutritional Physiological Phenomena; Child, Preschool; Deficien | 1969 |