gossypol has been researched along with B-Cell Lymphoma in 3 studies
Gossypol: A dimeric sesquiterpene found in cottonseed (GOSSYPIUM). The (-) isomer is active as a male contraceptive (CONTRACEPTIVE AGENTS, MALE) whereas toxic symptoms are associated with the (+) isomer.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Hepatotoxicity and gastrointestinal toxicity represented the major adverse activities of gossypol, with apogossypol far less toxic." | 1.35 | Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048). ( Jia, L; Kitada, S; Krajewska, M; Kress, CL; Pellecchia, M; Reed, JC, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Han, Z | 1 |
| Liang, J | 1 |
| Li, Y | 1 |
| He, J | 1 |
| Kitada, S | 1 |
| Kress, CL | 1 |
| Krajewska, M | 1 |
| Jia, L | 1 |
| Pellecchia, M | 1 |
| Reed, JC | 1 |
| Paoluzzi, L | 1 |
| Gonen, M | 1 |
| Gardner, JR | 1 |
| Mastrella, J | 1 |
| Yang, D | 1 |
| Holmlund, J | 1 |
| Sorensen, M | 1 |
| Leopold, L | 1 |
| Manova, K | 1 |
| Marcucci, G | 1 |
| Heaney, ML | 1 |
| O'Connor, OA | 1 |
1 review available for gossypol and B-Cell Lymphoma
| Article | Year |
|---|---|
Drugs and Clinical Approaches Targeting the Antiapoptotic Protein: A Review.
Topics: Aniline Compounds; Antineoplastic Agents; Apoptosis; Biphenyl Compounds; Cell Line, Tumor; Gossypol; | 2019 |
2 other studies available for gossypol and B-Cell Lymphoma
| Article | Year |
|---|---|
Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).
Topics: Animals; B-Lymphocytes; Cell Survival; Cells, Cultured; Female; Gossypol; Humans; Leukemia; Lymphoma | 2008 |
Targeting Bcl-2 family members with the BH3 mimetic AT-101 markedly enhances the therapeutic effects of chemotherapeutic agents in in vitro and in vivo models of B-cell lymphoma.
Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Agents, Phyt | 2008 |