gossypol has been researched along with B-Cell Chronic Lymphocytic Leukemia in 13 studies
Gossypol: A dimeric sesquiterpene found in cottonseed (GOSSYPIUM). The (-) isomer is active as a male contraceptive (CONTRACEPTIVE AGENTS, MALE) whereas toxic symptoms are associated with the (+) isomer.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Together, our data suggest the potential for proteasome inhibitor based therapy in CLL and the rationale design of drug combination strategies based on CLL biology." | 1.40 | The investigational agent MLN2238 induces apoptosis and is cytotoxic to CLL cells in vitro, as a single agent and in combination with other drugs. ( Advani, P; Akhtar, D; Chanan-Khan, A; Chitta, K; Colon-Otero, G; Foran, J; Khan, AN; Masood, A; Miller, KC; Paulus, A; Rivera, C; Roy, V, 2014) |
| "Co-treatment with gossypol acetate and dexamethasone notably amplified the pro-apoptosis activity of the latter in Raji cells." | 1.38 | [Effects of gossypol acetate on apoptosis in primary cultured cells from patients with lymphoid leukemia and its synergy with dexamethasone]. ( Cheng, W; Li, YM; Yang, DJ; Zhao, YQ, 2012) |
| "Since chronic lymphocytic leukemia (CLL) cells express high levels of antiapoptotic proteins that act as a survival mechanism for these replicationally quiescent lymphocytes, we investigated whether gossypol induces apoptosis in these cells and what mechanism underlies gossypol-mediated cytotoxicity." | 1.35 | Gossypol, a BH3 mimetic, induces apoptosis in chronic lymphocytic leukemia cells. ( Balakrishnan, K; Gandhi, V; Keating, MJ; Wierda, WG, 2008) |
| "Free gossypol (Fig." | 1.35 | Long-term clinical remission of a patient with chronic lymphocytic leukemia using alternative treatment option: cottonseed oil (gossypol). ( Politzer, WM, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (23.08) | 29.6817 |
| 2010's | 10 (76.92) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wei, J | 1 |
| Kitada, S | 1 |
| Stebbins, JL | 1 |
| Placzek, W | 1 |
| Zhai, D | 1 |
| Wu, B | 1 |
| Rega, MF | 1 |
| Zhang, Z | 1 |
| Cellitti, J | 1 |
| Yang, L | 1 |
| Dahl, R | 1 |
| Reed, JC | 1 |
| Pellecchia, M | 1 |
| Soderquist, R | 1 |
| Bates, DJ | 1 |
| Danilov, AV | 1 |
| Eastman, A | 1 |
| Paulus, A | 2 |
| Masood, A | 2 |
| Miller, KC | 2 |
| Khan, AN | 2 |
| Akhtar, D | 1 |
| Advani, P | 1 |
| Foran, J | 1 |
| Rivera, C | 1 |
| Roy, V | 1 |
| Colon-Otero, G | 1 |
| Chitta, K | 2 |
| Chanan-Khan, A | 2 |
| Anderson, MA | 2 |
| Huang, D | 1 |
| Roberts, A | 1 |
| Lampson, BL | 1 |
| Davids, MS | 1 |
| Balakrishnan, K | 3 |
| Wierda, WG | 2 |
| Keating, MJ | 1 |
| Gandhi, V | 3 |
| Politzer, WM | 1 |
| Burger, JA | 1 |
| Sher, T | 1 |
| Ersing, N | 1 |
| Manfredi, D | 1 |
| Ailawadhi, S | 1 |
| Borrelo, I | 1 |
| Lee, KP | 1 |
| Billard, C | 1 |
| Cheng, W | 1 |
| Zhao, YQ | 1 |
| Li, YM | 1 |
| Yang, DJ | 1 |
| Aggarwal, S | 1 |
| Wierda, W | 1 |
| Huang, DC | 1 |
| Roberts, AW | 1 |
2 reviews available for gossypol and B-Cell Chronic Lymphocytic Leukemia
| Article | Year |
|---|---|
Targeting BCL2 for the treatment of lymphoid malignancies.
Topics: Aniline Compounds; Antineoplastic Agents; Bridged Bicyclo Compounds, Heterocyclic; Gossypol; Hematol | 2014 |
The Development and Current Use of BCL-2 Inhibitors for the Treatment of Chronic Lymphocytic Leukemia.
Topics: Aniline Compounds; Antineoplastic Agents; Bridged Bicyclo Compounds, Heterocyclic; Gossypol; Humans; | 2017 |
1 trial available for gossypol and B-Cell Chronic Lymphocytic Leukemia
| Article | Year |
|---|---|
Downregulation of BCL2 by AT-101 enhances the antileukaemic effect of lenalidomide both by an immune dependant and independent manner.
Topics: Antibodies, Monoclonal, Murine-Derived; Antineoplastic Agents, Phytogenic; Antineoplastic Combined C | 2012 |
10 other studies available for gossypol and B-Cell Chronic Lymphocytic Leukemia
| Article | Year |
|---|---|
Synthesis and biological evaluation of Apogossypolone derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Membrane Permeability; Cell Prolif | 2010 |
Gossypol overcomes stroma-mediated resistance to the BCL2 inhibitor ABT-737 in chronic lymphocytic leukemia cells ex vivo.
Topics: Biphenyl Compounds; Contraceptive Agents, Male; Drug Resistance, Neoplasm; Gossypol; Humans; Leukemi | 2013 |
The investigational agent MLN2238 induces apoptosis and is cytotoxic to CLL cells in vitro, as a single agent and in combination with other drugs.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocol | 2014 |
Gossypol, a BH3 mimetic, induces apoptosis in chronic lymphocytic leukemia cells.
Topics: Acetylcysteine; Adenosine Triphosphate; Amino Acid Chloromethyl Ketones; Antioxidants; Apoptosis; Ap | 2008 |
Long-term clinical remission of a patient with chronic lymphocytic leukemia using alternative treatment option: cottonseed oil (gossypol).
Topics: Animal Feed; Animals; Antineoplastic Agents; Cattle; Cottonseed Oil; Drug Administration Schedule; G | 2008 |
AT-101 induces apoptosis in CLL B cells and overcomes stromal cell-mediated Mcl-1 induction and drug resistance.
Topics: Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Apoptosis; B-Lymphocytes; Cell Communicati | 2009 |
Development of Noxa-like BH3 mimetics for apoptosis-based therapeutic strategy in chronic lymphocytic leukemia.
Topics: Aniline Compounds; Apoptosis; Biomimetic Materials; Gossypol; Humans; Indoles; Leukemia, Lymphocytic | 2012 |
[Effects of gossypol acetate on apoptosis in primary cultured cells from patients with lymphoid leukemia and its synergy with dexamethasone].
Topics: Apoptosis; Cell Line; Dexamethasone; Gossypol; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Precu | 2012 |
Bax and Bak are required for apogossypolone, a BH3-mimetic, induced apoptosis in chronic lymphocytic leukemia cells.
Topics: Animals; Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; Gene Exp | 2013 |
BH3 mimetic therapy: an emerging and promising approach to treating chronic lymphocytic leukemia.
Topics: Animals; Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; Gossypol | 2013 |