gossypol has been researched along with Astrocytoma, Grade IV in 12 studies
Gossypol: A dimeric sesquiterpene found in cottonseed (GOSSYPIUM). The (-) isomer is active as a male contraceptive (CONTRACEPTIVE AGENTS, MALE) whereas toxic symptoms are associated with the (+) isomer.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Temozolomide is the current first-line treatment for glioblastoma patients but, because many patients are resistant to it, there is an urgent need to develop antitumor agents to treat temozolomide-resistant glioblastoma." | 7.91 | Gossypol Suppresses Growth of Temozolomide-Resistant Glioblastoma Tumor Spheres. ( Jang, H; Jeon, JH; Kang, SG; Kang, SW; Kim, DK; Kim, HY; Kim, SY; Lee, BI; Shim, JK, 2019) |
| "Malignant gliomas (glioblastoma multiforme) are the most aggressive of the primary brain tumors." | 5.40 | Gossypol enhances radiation induced autophagy in glioblastoma multiforme. ( Goliaei, B; Keshmiri-Neghab, H; Nikoofar, A, 2014) |
| " The present study evaluates the effects of AT101, alone or in combination with temozolomide (TMZ), in a microenvironmental glioma stem cell niche model of two GBM cell lines (U251MG and U87MG)." | 4.02 | Effects of the Anti-Tumorigenic Agent AT101 on Human Glioblastoma Cells in the Microenvironmental Glioma Stem Cell Niche. ( Caylioglu, D; Held-Feindt, J; Hellmold, D; Kubelt, C; Meyer, RJ; Synowitz, M, 2021) |
| "AT101, the R-(-)-enantiomer of the cottonseed-derived polyphenol gossypol, is a promising drug in glioblastoma multiforme (GBM) therapy due to its ability to trigger autophagic cell death but also to facilitate apoptosis in tumor cells." | 3.96 | AT101-Loaded Cubosomes as an Alternative for Improved Glioblastoma Therapy. ( Adamski, V; Flak, DK; Held-Feindt, J; Jurga, S; Nowaczyk, G; Synowitz, M; Szutkowski, K, 2020) |
| "Temozolomide is the current first-line treatment for glioblastoma patients but, because many patients are resistant to it, there is an urgent need to develop antitumor agents to treat temozolomide-resistant glioblastoma." | 3.91 | Gossypol Suppresses Growth of Temozolomide-Resistant Glioblastoma Tumor Spheres. ( Jang, H; Jeon, JH; Kang, SG; Kang, SW; Kim, DK; Kim, HY; Kim, SY; Lee, BI; Shim, JK, 2019) |
| "Gossypol acts as a Bcl-2 inhibitor that induces apoptosis in apoptosis-competent cells." | 1.48 | A novel role of the mitochondrial permeability transition pore in (-)-gossypol-induced mitochondrial dysfunction. ( Hamann, A; Kögel, D; Meyer, N; Osiewacz, HD; Warnsmann, V, 2018) |
| "Targeted approaches for treating glioblastoma (GBM) attempted to date have consistently failed, highlighting the imperative for treatment strategies that operate on different mechanistic principles." | 1.48 | Regulation of bioenergetics through dual inhibition of aldehyde dehydrogenase and mitochondrial complex I suppresses glioblastoma tumorspheres. ( Chang, JH; Choi, J; Kang, JH; Kang, SG; Kim, SY; Park, J; Shim, JK, 2018) |
| "Malignant gliomas (glioblastoma multiforme) are the most aggressive of the primary brain tumors." | 1.40 | Gossypol enhances radiation induced autophagy in glioblastoma multiforme. ( Goliaei, B; Keshmiri-Neghab, H; Nikoofar, A, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 6 (50.00) | 24.3611 |
| 2020's | 6 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hellmold, D | 3 |
| Arnaldi, P | 1 |
| Synowitz, M | 7 |
| Held-Feindt, J | 7 |
| Akbari, M | 1 |
| Kubelt, C | 3 |
| Daunke, T | 1 |
| Beckinger, S | 1 |
| Janssen, O | 1 |
| Hauck, M | 1 |
| Schütt, F | 1 |
| Adelung, R | 3 |
| Lucius, R | 3 |
| Haag, J | 1 |
| Sebens, S | 1 |
| Kim, HY | 1 |
| Lee, BI | 1 |
| Jeon, JH | 1 |
| Kim, DK | 1 |
| Kang, SG | 2 |
| Shim, JK | 2 |
| Kim, SY | 2 |
| Kang, SW | 1 |
| Jang, H | 1 |
| Schmitt, C | 3 |
| Adamski, V | 4 |
| Rasch, F | 1 |
| Hattermann, K | 2 |
| Mehner, M | 1 |
| Flak, DK | 1 |
| Nowaczyk, G | 1 |
| Szutkowski, K | 1 |
| Jurga, S | 1 |
| Caylioglu, D | 1 |
| Meyer, RJ | 1 |
| Warnsmann, V | 1 |
| Meyer, N | 1 |
| Hamann, A | 1 |
| Kögel, D | 1 |
| Osiewacz, HD | 1 |
| Park, J | 1 |
| Kang, JH | 1 |
| Choi, J | 1 |
| Chang, JH | 1 |
| Ceynowa, F | 1 |
| Keshmiri-Neghab, H | 1 |
| Goliaei, B | 1 |
| Nikoofar, A | 1 |
| Jarzabek, MA | 1 |
| Amberger-Murphy, V | 1 |
| Callanan, JJ | 1 |
| Gao, C | 1 |
| Zagozdzon, AM | 1 |
| Shiels, L | 1 |
| Wang, J | 1 |
| Ligon, KL | 1 |
| Rich, BE | 1 |
| Dicker, P | 1 |
| Gallagher, WM | 1 |
| Prehn, JH | 1 |
| Byrne, AT | 1 |
12 other studies available for gossypol and Astrocytoma, Grade IV
| Article | Year |
|---|---|
A biopolymeric mesh enriched with PLGA microparticles loaded with AT101 for localized glioblastoma treatment.
Topics: Antineoplastic Agents; Drug Delivery Systems; Glioblastoma; Gossypol; Humans; Microspheres; Surgical | 2023 |
Sequential Treatment with Temozolomide Plus Naturally Derived AT101 as an Alternative Therapeutic Strategy: Insights into Chemoresistance Mechanisms of Surviving Glioblastoma Cells.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Line, Tumor; Drug Resistance, Neoplasm; Gli | 2023 |
Gossypol Suppresses Growth of Temozolomide-Resistant Glioblastoma Tumor Spheres.
Topics: Antineoplastic Agents, Alkylating; Apoptosis; Cell Proliferation; Cell Survival; Combined Modality T | 2019 |
Establishment of a glioblastoma in vitro (in)complete resection dual co-culture model suitable for drug testing.
Topics: Analysis of Variance; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Phytogenic; Astrocyt | 2020 |
Combined treatment of AT101 and demethoxycurcumin yields an enhanced anti-proliferative effect in human primary glioblastoma cells.
Topics: Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; | 2020 |
AT101-Loaded Cubosomes as an Alternative for Improved Glioblastoma Therapy.
Topics: Antineoplastic Agents, Phytogenic; Biological Availability; Brain Neoplasms; Cell Line, Tumor; Collo | 2020 |
Effects of the Anti-Tumorigenic Agent AT101 on Human Glioblastoma Cells in the Microenvironmental Glioma Stem Cell Niche.
Topics: Antineoplastic Combined Chemotherapy Protocols; Brain; Brain Neoplasms; Carcinogenesis; Cell Line, T | 2021 |
A novel role of the mitochondrial permeability transition pore in (-)-gossypol-induced mitochondrial dysfunction.
Topics: Animals; Autophagy; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; Cell Lin | 2018 |
Regulation of bioenergetics through dual inhibition of aldehyde dehydrogenase and mitochondrial complex I suppresses glioblastoma tumorspheres.
Topics: Adenosine Triphosphate; Aldehyde Dehydrogenase; Animals; Biomarkers, Tumor; Brain Neoplasms; Cell Pr | 2018 |
Effects of sequentially applied single and combined temozolomide, hydroxychloroquine and AT101 treatment in a long-term stimulation glioblastoma in vitro model.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cell Growth Processes; Cell Line, Tumor; Dacarbazine | 2018 |
Gossypol enhances radiation induced autophagy in glioblastoma multiforme.
Topics: Autophagy; Cell Line, Tumor; Cell Proliferation; Cell Survival; Combined Modality Therapy; Glioblast | 2014 |
Interrogation of gossypol therapy in glioblastoma implementing cell line and patient-derived tumour models.
Topics: Animals; Brain Neoplasms; Cell Line, Tumor; Female; Glioblastoma; Gossypol; Humans; Mice; Mice, Inbr | 2014 |