gossypol has been researched along with Alveolitis, Fibrosing in 4 studies
Gossypol: A dimeric sesquiterpene found in cottonseed (GOSSYPIUM). The (-) isomer is active as a male contraceptive (CONTRACEPTIVE AGENTS, MALE) whereas toxic symptoms are associated with the (+) isomer.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pulmonary fibrosis is a chronic and irreversible scarring disease in the lung with poor prognosis." | 5.48 | Prevention and treatment of bleomycin-induced pulmonary fibrosis with the lactate dehydrogenase inhibitor gossypol. ( Judge, JL; Kottmann, RM; Nagel, DJ; Owens, KM; Phipps, RP; Rackow, A; Sime, PJ, 2018) |
| "Pulmonary fibrosis is a chronic and irreversible scarring disease in the lung with poor prognosis." | 1.48 | Prevention and treatment of bleomycin-induced pulmonary fibrosis with the lactate dehydrogenase inhibitor gossypol. ( Judge, JL; Kottmann, RM; Nagel, DJ; Owens, KM; Phipps, RP; Rackow, A; Sime, PJ, 2018) |
| "Pulmonary fibrosis is a common and dose-limiting side-effect of ionizing radiation used to treat cancers of the thoracic region." | 1.42 | Ionizing radiation induces myofibroblast differentiation via lactate dehydrogenase. ( Judge, JL; Kottmann, RM; Owens, KM; Phipps, RP; Pollock, SJ; Sime, PJ; Thatcher, TH; Williams, JP; Woeller, CF, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Judge, JL | 4 |
| Lacy, SH | 1 |
| Ku, WY | 1 |
| Owens, KM | 4 |
| Hernady, E | 1 |
| Thatcher, TH | 3 |
| Williams, JP | 2 |
| Phipps, RP | 4 |
| Sime, PJ | 4 |
| Kottmann, RM | 4 |
| Nagel, DJ | 1 |
| Rackow, A | 1 |
| Pollock, SJ | 1 |
| Woeller, CF | 1 |
| Trawick, E | 1 |
| Wahl, LA | 1 |
| Epa, AP | 1 |
4 other studies available for gossypol and Alveolitis, Fibrosing
| Article | Year |
|---|---|
The Lactate Dehydrogenase Inhibitor Gossypol Inhibits Radiation-Induced Pulmonary Fibrosis.
Topics: Animals; Cytokines; Dose-Response Relationship, Drug; Gossypol; L-Lactate Dehydrogenase; Male; Mice; | 2017 |
Prevention and treatment of bleomycin-induced pulmonary fibrosis with the lactate dehydrogenase inhibitor gossypol.
Topics: Animals; Antibiotics, Antineoplastic; Bleomycin; Cell Differentiation; Cells, Cultured; Contraceptiv | 2018 |
Ionizing radiation induces myofibroblast differentiation via lactate dehydrogenase.
Topics: Animals; Cell Differentiation; Cells, Cultured; Enzyme Inhibitors; Gossypol; Humans; Isoenzymes; L-L | 2015 |
Pharmacologic inhibition of lactate production prevents myofibroblast differentiation.
Topics: Animals; Cell Differentiation; Cell Line; Enzyme Inhibitors; Extracellular Matrix; Gene Knockdown Te | 2015 |