gossypol has been researched along with Adrenocortical Carcinoma in 1 studies
Gossypol: A dimeric sesquiterpene found in cottonseed (GOSSYPIUM). The (-) isomer is active as a male contraceptive (CONTRACEPTIVE AGENTS, MALE) whereas toxic symptoms are associated with the (+) isomer.
Adrenocortical Carcinoma: A malignant neoplasm of the ADRENAL CORTEX. Adrenocortical carcinomas are unencapsulated anaplastic (ANAPLASIA) masses sometimes exceeding 20 cm or 200 g. They are more likely to be functional than nonfunctional, and produce ADRENAL CORTEX HORMONES that may result in hypercortisolism (CUSHING SYNDROME); HYPERALDOSTERONISM; and/or VIRILISM.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Background Adrenal cortical carcinoma (ACC) is a rare cancer with treatment options of limited efficacy, and poor prognosis if metastatic." | 2.90 | A phase II study of the orally administered negative enantiomer of gossypol (AT-101), a BH3 mimetic, in patients with advanced adrenal cortical carcinoma. ( Adjei, AA; Bible, KC; Erlichman, C; Gandara, DR; Kane, MA; Menefee, ME; Quinn, DI; Reidy-Lagunes, D; Shah, MH; Xie, H; Yin, J, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Xie, H | 1 |
| Yin, J | 1 |
| Shah, MH | 1 |
| Menefee, ME | 1 |
| Bible, KC | 1 |
| Reidy-Lagunes, D | 1 |
| Kane, MA | 1 |
| Quinn, DI | 1 |
| Gandara, DR | 1 |
| Erlichman, C | 1 |
| Adjei, AA | 1 |
1 trial available for gossypol and Adrenocortical Carcinoma
| Article | Year |
|---|---|
A phase II study of the orally administered negative enantiomer of gossypol (AT-101), a BH3 mimetic, in patients with advanced adrenal cortical carcinoma.
Topics: Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Adult; Aged; Antineoplastic Agents, Phytogenic; | 2019 |