gossypol has been researched along with Adrenal Cortex Neoplasms in 4 studies
Gossypol: A dimeric sesquiterpene found in cottonseed (GOSSYPIUM). The (-) isomer is active as a male contraceptive (CONTRACEPTIVE AGENTS, MALE) whereas toxic symptoms are associated with the (+) isomer.
Adrenal Cortex Neoplasms: Tumors or cancers of the ADRENAL CORTEX.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The efficacy of mitotane in providing objective tumour responses in patients with adrenocortical carcinoma (ACC), has been recently questioned." | 6.17 | Cytotoxic chemotherapy for adrenocortical carcinoma. ( Alì, A; Angeli, A; Berruti, A; Dogliotti, L; Paccotti, P; Pia, A, 1995) |
| "Background Adrenal cortical carcinoma (ACC) is a rare cancer with treatment options of limited efficacy, and poor prognosis if metastatic." | 2.90 | A phase II study of the orally administered negative enantiomer of gossypol (AT-101), a BH3 mimetic, in patients with advanced adrenal cortical carcinoma. ( Adjei, AA; Bible, KC; Erlichman, C; Gandara, DR; Kane, MA; Menefee, ME; Quinn, DI; Reidy-Lagunes, D; Shah, MH; Xie, H; Yin, J, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (25.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Xie, H | 1 |
| Yin, J | 1 |
| Shah, MH | 1 |
| Menefee, ME | 1 |
| Bible, KC | 1 |
| Reidy-Lagunes, D | 1 |
| Kane, MA | 1 |
| Quinn, DI | 1 |
| Gandara, DR | 1 |
| Erlichman, C | 1 |
| Adjei, AA | 1 |
| Schteingart, DE | 1 |
| Benitez, R | 1 |
| Bradford, C | 1 |
| Narayan, A | 1 |
| Wang, S | 1 |
| Dogliotti, L | 1 |
| Berruti, A | 1 |
| Pia, A | 1 |
| Paccotti, P | 1 |
| Alì, A | 1 |
| Angeli, A | 1 |
| Wu, YW | 1 |
| Chik, CL | 1 |
| Knazek, RA | 1 |
1 review available for gossypol and Adrenal Cortex Neoplasms
| Article | Year |
|---|---|
Cytotoxic chemotherapy for adrenocortical carcinoma.
Topics: Adolescent; Adrenal Cortex Neoplasms; Adult; Animals; Antineoplastic Combined Chemotherapy Protocols | 1995 |
2 trials available for gossypol and Adrenal Cortex Neoplasms
| Article | Year |
|---|---|
A phase II study of the orally administered negative enantiomer of gossypol (AT-101), a BH3 mimetic, in patients with advanced adrenal cortical carcinoma.
Topics: Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Adult; Aged; Antineoplastic Agents, Phytogenic; | 2019 |
Cytotoxic chemotherapy for adrenocortical carcinoma.
Topics: Adolescent; Adrenal Cortex Neoplasms; Adult; Animals; Antineoplastic Combined Chemotherapy Protocols | 1995 |
2 other studies available for gossypol and Adrenal Cortex Neoplasms
| Article | Year |
|---|---|
Expression of anti-apoptosis genes determines the response of adrenal cancer to apoptosis-inducing chemotherapy.
Topics: Adrenal Cortex Neoplasms; Animals; Apoptosis; bcl-X Protein; Cell Line, Tumor; Docetaxel; Genes, bcl | 2010 |
An in vitro and in vivo study of antitumor effects of gossypol on human SW-13 adrenocortical carcinoma.
Topics: Adrenal Cortex Neoplasms; Animals; Antineoplastic Agents; Cell Division; Cell Line; Cell Membrane; G | 1989 |