gossypol and Acute Promyelocytic Leukemia studies

gossypol and Acute Promyelocytic Leukemia

Gossypol: A dimeric sesquiterpene found in cottonseed (GOSSYPIUM). The (-) isomer is active as a male contraceptive (CONTRACEPTIVE AGENTS, MALE) whereas toxic symptoms are associated with the (+) isomer.

Research Excerpts

Excerpt	Relevance	Reference
"Gossypol was found to be cytotoxic in HL-60 cells with the IC(50) dose of 4."	1.36	Gossypol exerts its cytotoxic effect on HL-60 leukemic cell line via decreasing activity of protein phosphatase 2A and interacting with human telomerase reverse transcriptase activity. ( Avci, CB; Gunduz, C; Sahin, F; Saydam, G; Sezgin, C; Simsir, IY, 2010)
"Gossypol acetic acid was added to HL 60 cells at 50, 100, 150 and 200 microM concentrations for six hours."	1.30	Gossypol induced apoptosis in the human promyelocytic leukemia cell line HL 60. ( Balci, A; Ekmekci, A; Sahin, FI, 1999)

Research

Studies (3)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	2 (66.67)	18.2507
2000's	0 (0.00)	29.6817
2010's	1 (33.33)	24.3611
2020's	0 (0.00)	2.80

Timeframe

Studies, this research(%)

All Research%

pre-1990

0 (0.00)

18.7374

1990's

2 (66.67)

18.2507

2000's

0 (0.00)

29.6817

2010's

1 (33.33)

24.3611

2020's

0 (0.00)

2.80

Authors

Authors	Studies
Sahin, F	1
Avci, CB	1
Gunduz, C	1
Sezgin, C	1
Simsir, IY	1
Saydam, G	1
Jarvis, WD	1
Turner, AJ	1
Povirk, LF	1
Traylor, RS	1
Grant, S	1
Balci, A	1
Sahin, FI	1
Ekmekci, A	1

Studies

Sahin, F

Avci, CB

Gunduz, C

Sezgin, C

Simsir, IY

Saydam, G

Jarvis, WD

Turner, AJ

Povirk, LF

Traylor, RS

Grant, S

Balci, A

Sahin, FI

Ekmekci, A

Other Studies

3 other studies available for gossypol and Acute Promyelocytic Leukemia

Article	Year
Gossypol exerts its cytotoxic effect on HL-60 leukemic cell line via decreasing activity of protein phosphatase 2A and interacting with human telomerase reverse transcriptase activity. Hematology (Amsterdam, Netherlands), 2010, Volume: 15, Issue:3 Topics: Apoptosis; Cell Line, Tumor; Cell Survival; Gossypol; HL-60 Cells; Humans; Leukemia, Promyelocytic,	2010
Induction of apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells by pharmacological inhibitors of protein kinase C. Cancer research, 1994, Apr-01, Volume: 54, Issue:7 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Anthracenes; Antineoplastic Agents; Apopto	1994
Gossypol induced apoptosis in the human promyelocytic leukemia cell line HL 60. The Tohoku journal of experimental medicine, 1999, Volume: 189, Issue:1 Topics: Apoptosis; DNA Fragmentation; Electrophoresis, Agar Gel; Enzyme Inhibitors; Gossypol; HL-60 Cells; H	1999

Article

Year

Gossypol exerts its cytotoxic effect on HL-60 leukemic cell line via decreasing activity of protein phosphatase 2A and interacting with human telomerase reverse transcriptase activity.

Hematology (Amsterdam, Netherlands), 2010, Volume: 15, Issue:3

Topics: Apoptosis; Cell Line, Tumor; Cell Survival; Gossypol; HL-60 Cells; Humans; Leukemia, Promyelocytic,

2010

Induction of apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells by pharmacological inhibitors of protein kinase C.

Cancer research, 1994, Apr-01, Volume: 54, Issue:7

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Anthracenes; Antineoplastic Agents; Apopto

1994

Gossypol induced apoptosis in the human promyelocytic leukemia cell line HL 60.

The Tohoku journal of experimental medicine, 1999, Volume: 189, Issue:1

Topics: Apoptosis; DNA Fragmentation; Electrophoresis, Agar Gel; Enzyme Inhibitors; Gossypol; HL-60 Cells; H

1999