Compounds > gossypol
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gossypol and Acute Liver Injury, Drug-Induced

gossypol has been researched along with Acute Liver Injury, Drug-Induced in 5 studies

Gossypol: A dimeric sesquiterpene found in cottonseed (GOSSYPIUM). The (-) isomer is active as a male contraceptive (CONTRACEPTIVE AGENTS, MALE) whereas toxic symptoms are associated with the (+) isomer.

Research Excerpts

ExcerptRelevanceReference
"Gossypol is a highly reactive compound present in cotton (Gossypium spp."1.39Effectiveness of albumin-conjugated gossypol as an immunogen to prevent gossypol-associated acute hepatotoxicity in rats. ( Fonseca, NB; Gadelha, IC; Oloris, SC; Soto-Blanco, B, 2013)
"Gossypol displays anticancer behavior and anti-fertility in males."1.35Mutual anti-oxidative effect of gossypol acetic acid and gossypol-iron complex on hepatic lipid peroxidation in male rats. ( Bader El-Dein, MM; El-Shahawy, IN; El-Sharaky, AS; Fawzy, RA; Wahby, MM, 2009)
"Gossypol acetic acid (GAA) at the dosage of 30 mg/kg daily for 2 weeks could prolong the sleeping time of pentobarbital, increase the SGPT level, decrease the liver concentration of cytochrome P-450 and GSH content, inhibit the activity of cytochrome C reductase and aminopyrine-N-demethylase, but was without effect on cytochrome b5 and aniline hydroxylase."1.27Hepatotoxicity of gossypol in rats. ( Lei, HP; Wang, Y, 1987)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19901 (20.00)18.7374
1990's0 (0.00)18.2507
2000's1 (20.00)29.6817
2010's3 (60.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Fourches, D1
Barnes, JC1
Day, NC1
Bradley, P1
Reed, JZ1
Tropsha, A1
Fonseca, NB1
Gadelha, IC1
Oloris, SC1
Soto-Blanco, B1
El-Sharaky, AS2
Wahby, MM1
Bader El-Dein, MM1
Fawzy, RA1
El-Shahawy, IN1
Newairy, AA1
Elguindy, NM1
Elwafa, AA1
Wang, Y1
Lei, HP1

Other Studies

5 other studies available for gossypol and Acute Liver Injury, Drug-Induced

ArticleYear
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLI

2010
Effectiveness of albumin-conjugated gossypol as an immunogen to prevent gossypol-associated acute hepatotoxicity in rats.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2013, Volume: 56

    Topics: Acute Disease; Animals; Antibodies; Chemical and Drug Induced Liver Injury; Female; Freund's Adjuvan

2013
Mutual anti-oxidative effect of gossypol acetic acid and gossypol-iron complex on hepatic lipid peroxidation in male rats.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2009, Volume: 47, Issue:11

    Topics: Animals; Antineoplastic Agents; Antioxidants; Chemical and Drug Induced Liver Injury; Gossypol; Iron

2009
Spermatotoxicity, biochemical changes and histological alteration induced by gossypol in testicular and hepatic tissues of male rats.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2010, Volume: 48, Issue:12

    Topics: Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Follicle Stimulating Hormone; Gossypo

2010
Hepatotoxicity of gossypol in rats.
    Journal of ethnopharmacology, 1987, Volume: 20, Issue:1

    Topics: Animals; Calcium; Cell Membrane Permeability; Chemical and Drug Induced Liver Injury; Gossypol; Lipi

1987