gossypol-acetic-acid and Uterine-Neoplasms

Effects of the gossypol on endometriosis in 12 cases of control were observed. The results showed that the gossypol administered orally was effective in endometriosis patients. The basal body temperature changed from biophase to monophase. Dysmenorrhea disappeared in 11/12 patients. Amenorrhea occurred in 10/12 patients and the ovarian endometrial cyst was shrinkable. Serum progesterone and estradiol were decreased after gossypol administration, but follicle-stimulating hormone and luteinizing hormone were increased evidently. Histochemical and cytochemical observations revealed that the activity of acid phosphate (ACP), nonspecific esterase (NSE) and alkaline phosphate (AKP) in both aberrant uterine endometrium and uterine endometrium in situ were decreased evidently. The above results suggest that the satisfactory therapeutic effect of gossypol on endometriosis may be due to not only the indirect but also the direct action on uterine endometrium.

Topics: Adult; Antineoplastic Agents, Phytogenic; Drugs, Chinese Herbal; Endometriosis; Female; Gossypol; Humans; Middle Aged; Ovarian Neoplasms; Uterine Neoplasms

Topics: Adult; Female; Gossypol; Humans; Leiomyoma; Middle Aged; Mitochondria, Muscle; Muscle, Smooth; Myometrium; Uterine Neoplasms

Gossypol treatment of endometriosis and uterine myomas in 15 cases was started with a daily dose of 20 mg of gossypol-acetic acid twice a day for 20 days as a loading dose, followed by 40 mg (20 mg twice weekly). A maintenance dose of 20 mg was given weekly. The total course of treatment lasted about 6 months. Light and electron microscopic examination of the endometrium was carried out before treatment and 2, 3, 4, and 6 months after gossypol treatment. After gossypol treatment three different characteristics of the endometrium were noted: (1) irregular secretory activity, (2) proliferative activity, and (3) atrophy. On electron microscopic examination it was shown that there were important changes of the organelles, indicating suppressed secretory activity. Based on the above results, the nature and significance of the ultrastructural changes of the endometrium induced by gossypol were analyzed and the possibility of developing a new field of research in female contraception with gossypol was considered.

Topics: Endocrine Glands; Endometriosis; Endometrium; Female; Gossypol; Humans; Leiomyoma; Menstruation; Time Factors; Uterine Neoplasms