goserelin and Orbital-Neoplasms

To describe the successful hormone treatment of noncircumscribed orbital leiomyoma.. Case report.. A 66-year-old woman with histologically proven orbital leiomyoma.. Because surgical excision of the tumor was impossible, therapy with the gonadotropin-releasing hormone (GnRH) analog goserelin was performed.. Hormone treatment was well tolerated and no side effects were noted. The tumor regressed significantly during treatment. No recurrence occurred during a 5-year follow-up period.. This report describes for the first time successful hormone treatment of a noncircumscribed orbital leiomyoma. Goserelin may have an antiproliferative effect on leiomyoma cells via membrane receptors for GnRH.

Topics: Aged; Antineoplastic Agents, Hormonal; Biomarkers, Tumor; Female; Goserelin; Humans; Leiomyoma; Magnetic Resonance Imaging; Orbital Neoplasms

In the light of a case of left orbital metastasis, constituting the presenting sign of prostatic cancer in a 60-year-old man, the authors emphasize the rarity of this site, despite the high frequency of bone metastases in this disease. They discuss the diagnostic methods and stress the need for urgent treatment to save ocular function.

Topics: Adenocarcinoma; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Diethylstilbestrol; Emergencies; Goserelin; Humans; Injections, Intravenous; Male; Methylprednisolone Hemisuccinate; Middle Aged; Orbital Neoplasms; Prostatic Neoplasms; Vision, Ocular