goserelin and Abdominal-Neoplasms

Aggressive angiomyxoma (AA) is a distinctive soft tissue tumor with a high risk of local recurrence. Clinicians must be aware of this rare tumor pre-operatively. Excision is the preferred method of AA treatment. The case report presents a case of a 36-year-old woman who was difficulty in walking due to a non-painful tumor in the abdomen and perineum. She was misdiagnosed as abdomen neurofibroma for more than 10 years, and an operation was performed in 1997. However, the tumor was incompletely resected because its huge volume accompanies with extensive infiltration and bleeding. The tumors in her abdomen and perineum were growing gradually, and the latter became a large lump which impeded her daily life. In 2008, the perineal tumor was incompletely resected, which weighed 10725 g. The severe hemorrhage had been ceased by Gonadotropin-Releasing Hormone treatment. She is alive till now. Details of the history and operative procedures are presented. An AA diagnosis was made by microscopy immunohistochemically. Long-time misdiagnosis and improper treatment are the important reasons for making it impossible to be radically resected. Pathological and immunohistochemical examination are important for avoiding misdiagnosis. For this case, there is a remaining tumor in her abdomen. A special project including further follow-up and treatment will be taken out.

Topics: Abdominal Neoplasms; Adult; Antineoplastic Agents, Hormonal; Combined Modality Therapy; Cystotomy; Diagnostic Errors; Disease Progression; Female; Goserelin; Hemorrhage; Humans; Laparotomy; Magnetic Resonance Imaging; Mobility Limitation; Myxoma; Neoplasm Invasiveness; Neurofibroma; Pelvic Neoplasms; Perineum; Tumor Burden; Ureterostomy

In an open phase II, multicentre study with 118 pre- or perimenopausal women with histologically proven advanced breast cancer, Zoladex depot (3.6 mg) has been shown to produce an effective castration and response rates, which are comparable to those from oophorectomy.

Topics: Abdominal Neoplasms; Bone Neoplasms; Breast Neoplasms; Buserelin; Delayed-Action Preparations; Female; Goserelin; Humans; Multicenter Studies as Topic

Topics: Abdominal Neoplasms; Adenomatous Polyposis Coli; Adult; Aminopyridines; Antineoplastic Combined Chemotherapy Protocols; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase 6; Female; Fibromatosis, Aggressive; Goserelin; Humans; Letrozole; Protein Kinase Inhibitors; Purines; Young Adult

Topics: Abdominal Neoplasms; Adolescent; Adult; Antineoplastic Agents, Hormonal; Buserelin; Child; Child, Preschool; Female; Fibroma, Desmoplastic; Fibromatosis, Aggressive; Follow-Up Studies; Goserelin; Humans; Infant; Male; Middle Aged; Tamoxifen; Treatment Outcome

Four patients are described with familial adenomatous polyposis and an intra-abdominal desmoid tumour located in the mesentery of the small bowel; the fifth patient had a tumour in the abdominal wall. In all patients a colectomy had been performed several years prior to the development of the tumours. Radical resection of the desmoid tumours was not possible because of the location in the mesentery; repeated resection or partial excision was performed in all four patients. NSAIDs, tamoxifen, norethisterone and interferon alpha appeared to have only a temporary effect on the growth of the desmoid tumour. The effect of goserelin, a gonadorelin analogue, on the behaviour of the desmoid tumour appears promising, as two patients treated with it showed no tumour growth after 4 and 16 months respectively.

Topics: Abdominal Neoplasms; Adenomatous Polyposis Coli; Adult; Combined Modality Therapy; Female; Fibroma; Gardner Syndrome; Goserelin; Humans; Male; Recurrence