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go 6976 and Muscle Contraction

go 6976 has been researched along with Muscle Contraction in 9 studies

Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.

Research Excerpts

ExcerptRelevanceReference
" Key Results  In rat ileal smooth muscle, phosphorylation level of CPI-17 at Thr(38) and MYPT1 at Thr(853) , but not MYPT1 at Thr(696) , were increased with carbachol (1μmolL(-1) ) accompanied with muscle contraction."3.77Synchronous phosphorylation of CPI-17 and MYPT1 is essential for inducing Ca(2+) sensitization in intestinal smooth muscle. ( Hori, M; Kishi, H; Kobayashi, S; Mori, D; Murata, T; Ohama, T; Ozaki, H, 2011)
" Dexmedetomidine dose-response curves were generated in the presence or absence of the following inhibitors: the pan-PKC inhibitor, chelerythrine; the PKC-α and -β inhibitor, Go6976; the PKC-α inhibitor, safingol; the PKC-β inhibitor, ruboxistaurin; the PKC-δ inhibitor, rottlerin; the c-Jun NH2-terminal kinase (JNK) inhibitor, SP600125; and the myosin light chain kinase inhibitor, ML-7 hydrochloride."1.42Dexmedetomidine-Induced Contraction in the Isolated Endothelium-Denuded Rat Aorta Involves PKC-δ-mediated JNK Phosphorylation. ( Cho, H; Choi, MJ; Chung, YK; Kim, WH; Kwon, SC; Lee, HK; Ok, SH; Park, J; Shin, IW; Sohn, JT; Yu, J, 2015)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (22.22)18.2507
2000's4 (44.44)29.6817
2010's3 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kunduri, SS1
Mustafa, SJ1
Ponnoth, DS1
Dick, GM1
Nayeem, MA1
Yu, J1
Ok, SH1
Kim, WH1
Cho, H1
Park, J1
Shin, IW1
Lee, HK1
Chung, YK1
Choi, MJ1
Kwon, SC1
Sohn, JT1
Jensen, TE1
Maarbjerg, SJ1
Rose, AJ1
Leitges, M1
Richter, EA1
Mori, D1
Hori, M2
Murata, T1
Ohama, T1
Kishi, H1
Kobayashi, S1
Ozaki, H2
Yasuda, K1
Kim, YS1
Egawa, M1
Kanzaki, H1
Nakazawa, H1
Seto, M1
Karaki, H1
Sakai, H1
Yamamoto, M1
Chiba, Y1
Misawa, M1
Satoh, M1
Hayasaka, M1
Horiuchi, K1
Takayanagi, I1
Yang, ZW1
Altura, BT1
Altura, BM1
Eto, M1
Kitazawa, T1
Yazawa, M1
Mukai, H1
Ono, Y1
Brautigan, DL1

Other Studies

9 other studies available for go 6976 and Muscle Contraction

ArticleYear
Adenosine A1 receptors link to smooth muscle contraction via CYP4a, protein kinase C-α, and ERK1/2.
    Journal of cardiovascular pharmacology, 2013, Volume: 62, Issue:1

    Topics: Adenosine; Adenosine A1 Receptor Agonists; Animals; Blotting, Western; Carbazoles; Cytochrome P-450

2013
Dexmedetomidine-Induced Contraction in the Isolated Endothelium-Denuded Rat Aorta Involves PKC-δ-mediated JNK Phosphorylation.
    International journal of medical sciences, 2015, Volume: 12, Issue:9

    Topics: Animals; Aorta; Azepines; Benzophenanthridines; Carbazoles; Dexmedetomidine; Endothelium, Vascular;

2015
Knockout of the predominant conventional PKC isoform, PKCalpha, in mouse skeletal muscle does not affect contraction-stimulated glucose uptake.
    American journal of physiology. Endocrinology and metabolism, 2009, Volume: 297, Issue:2

    Topics: Animals; Biological Transport; Carbazoles; Enzyme Inhibitors; Glucose; Indoles; Isoenzymes; Male; Ma

2009
Synchronous phosphorylation of CPI-17 and MYPT1 is essential for inducing Ca(2+) sensitization in intestinal smooth muscle.
    Neurogastroenterology and motility, 2011, Volume: 23, Issue:12

    Topics: Amides; Animals; Calcium; Carbachol; Carbazoles; Cholinergic Agonists; Guanosine Triphosphate; Intes

2011
Possible role of the protein kinase C/CPI-17 pathway in the augmented contraction of human myometrium after gestation.
    British journal of pharmacology, 2003, Volume: 140, Issue:7

    Topics: Adult; Blotting, Western; Calcium; Carbazoles; Enzyme Activators; Enzyme Inhibitors; Female; Humans;

2003
Probable involvement of epsilon-isoform of protein kinase C in rat bronchial smooth muscle contraction induced by acetylcholine.
    Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi, 2008, Volume: 44, Issue:1

    Topics: Acetophenones; Acetylcholine; Animals; Benzopyrans; Bronchi; Carbazoles; Dose-Response Relationship,

2008
Protein kinase C mediates increase of Ca2+ sensitivity for contraction by cholinoceptor partial agonist in ileal longitudinal muscle of guinea pig.
    General pharmacology, 1998, Volume: 30, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Carbachol; Carbazoles; Cholinergic

1998
Low extracellular Mg2+ contraction of arterial muscle: role of protein kinase C and protein tyrosine phosphorylation.
    European journal of pharmacology, 1999, Aug-13, Volume: 378, Issue:3

    Topics: Animals; Aorta, Thoracic; Arteries; Calcium; Carbazoles; Dose-Response Relationship, Drug; Endotheli

1999
Histamine-induced vasoconstriction involves phosphorylation of a specific inhibitor protein for myosin phosphatase by protein kinase C alpha and delta isoforms.
    The Journal of biological chemistry, 2001, Aug-03, Volume: 276, Issue:31

    Topics: Amides; Amino Acid Sequence; Animals; Aorta; Carbazoles; Chromatography; Chromatography, Affinity; C

2001