go 6976 has been researched along with Melanoma in 5 studies
Melanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Gö6976 but not Gö6983 reversed the E- to N-cadherin switch and as a consequence induced intercellular interactions, profound morphological changes from elongated mesenchymal-like to cuboidal epithelial-like shape, β-catenin translocation from the nucleus to the plasma membrane inhibiting its oncogenic function, and reverting the metastatic potential of the aggressive melanoma cells." | 7.85 | Protein kinase C inhibitor Gö6976 but not Gö6983 induces the reversion of E- to N-cadherin switch and metastatic phenotype in melanoma: identification of the role of protein kinase D1. ( Auclair, C; Eymard, M; Hugonin, C; Karam, M; Merzoug-Larabi, M; Spasojevic, C, 2017) |
| "Gö6976 but not Gö6983 reversed the E- to N-cadherin switch and as a consequence induced intercellular interactions, profound morphological changes from elongated mesenchymal-like to cuboidal epithelial-like shape, β-catenin translocation from the nucleus to the plasma membrane inhibiting its oncogenic function, and reverting the metastatic potential of the aggressive melanoma cells." | 3.85 | Protein kinase C inhibitor Gö6976 but not Gö6983 induces the reversion of E- to N-cadherin switch and metastatic phenotype in melanoma: identification of the role of protein kinase D1. ( Auclair, C; Eymard, M; Hugonin, C; Karam, M; Merzoug-Larabi, M; Spasojevic, C, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 3 (60.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Uhlenbrock, F | 1 |
| Hagemann-Jensen, M | 1 |
| Kehlet, S | 1 |
| Andresen, L | 1 |
| Pastorekova, S | 1 |
| Skov, S | 1 |
| Merzoug-Larabi, M | 1 |
| Spasojevic, C | 1 |
| Eymard, M | 1 |
| Hugonin, C | 1 |
| Auclair, C | 1 |
| Karam, M | 1 |
| Byers, HR | 1 |
| Boissel, SJ | 1 |
| Tu, C | 1 |
| Park, HY | 1 |
| Szekeres, CK | 1 |
| Trikha, M | 1 |
| Honn, KV | 1 |
| Jørgensen, K | 1 |
| Skrede, M | 1 |
| Cruciani, V | 1 |
| Mikalsen, SO | 1 |
| Slipicevic, A | 1 |
| Flørenes, VA | 1 |
5 other studies available for go 6976 and Melanoma
| Article | Year |
|---|---|
The NKG2D ligand ULBP2 is specifically regulated through an invariant chain-dependent endosomal pathway.
Topics: Antigens, Differentiation, B-Lymphocyte; Antigens, Surface; Biological Transport; Carbazoles; CD4-Po | 2014 |
Protein kinase C inhibitor Gö6976 but not Gö6983 induces the reversion of E- to N-cadherin switch and metastatic phenotype in melanoma: identification of the role of protein kinase D1.
Topics: Aged; Antigens, CD; Blotting, Western; Cadherins; Carbazoles; Cell Line, Tumor; Enzyme-Linked Immuno | 2017 |
RNAi-mediated knockdown of protein kinase C-alpha inhibits cell migration in MM-RU human metastatic melanoma cell line.
Topics: Apoptosis; Carbazoles; cdc42 GTP-Binding Protein; Cell Line, Tumor; Cell Movement; Extracellular Mat | 2010 |
12(S)-HETE, pleiotropic functions, multiple signaling pathways.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Carbazoles; Enzyme Inhibitors; Humans; Indoles; Melanoma | 2002 |
Phorbol ester phorbol-12-myristate-13-acetate promotes anchorage-independent growth and survival of melanomas through MEK-independent activation of ERK1/2.
Topics: Anoikis; Apoptosis; Butadienes; Carbazoles; Cell Adhesion; Cell Culture Techniques; Cell Cycle; Cell | 2005 |