gnaphalin and Disease-Models--Animal

gnaphalin has been researched along with Disease-Models--Animal* in 1 studies

Other Studies

1 other study(ies) available for gnaphalin and Disease-Models--Animal

Article	Year
Solving the confusion of gnaphaliin structure: gnaphaliin A and gnaphaliin B identified as active principles of Gnaphalium liebmannii with tracheal smooth muscle relaxant properties. Journal of natural products, 2009, Volume: 72, Issue:6 Inflorescences of Gnaphalium liebmannii, commonly known as "Gordolobo", is the most important remedy in Mexican traditional medicine to treat respiratory diseases, including asthma. By a bioguided fractionation of the n-hexane extract of this plant, following the relaxant effect on guinea pig tracheal smooth muscle, the flavones 5,7-dihydroxy-3,8-dimethoxyflavone (1) and 3,5-dihydroxy-7,8-dimethoxyflavone (2) were identified as the active relaxant compounds. Compounds 1 and 2 showed more potent relaxant properties than aminophylline in this model. Both 1 and 2 have been described as gnaphaliin in the past; here EIMS data, NMR experiments for both compounds, and X-ray diffraction analysis for 1 provided structural information to suggest that 1 and 2 should be named gnaphaliins A and B, respectively. Topics: Aminophylline; Animals; Disease Models, Animal; Flavonoids; Gnaphalium; Guinea Pigs; Molecular Structure; Muscle Relaxation; Muscle, Smooth; Parasympatholytics; Plants, Medicinal; Trachea	2009

Article

Year

Solving the confusion of gnaphaliin structure: gnaphaliin A and gnaphaliin B identified as active principles of Gnaphalium liebmannii with tracheal smooth muscle relaxant properties.

Journal of natural products, 2009, Volume: 72, Issue:6

Inflorescences of Gnaphalium liebmannii, commonly known as "Gordolobo", is the most important remedy in Mexican traditional medicine to treat respiratory diseases, including asthma. By a bioguided fractionation of the n-hexane extract of this plant, following the relaxant effect on guinea pig tracheal smooth muscle, the flavones 5,7-dihydroxy-3,8-dimethoxyflavone (1) and 3,5-dihydroxy-7,8-dimethoxyflavone (2) were identified as the active relaxant compounds. Compounds 1 and 2 showed more potent relaxant properties than aminophylline in this model. Both 1 and 2 have been described as gnaphaliin in the past; here EIMS data, NMR experiments for both compounds, and X-ray diffraction analysis for 1 provided structural information to suggest that 1 and 2 should be named gnaphaliins A and B, respectively.

Topics: Aminophylline; Animals; Disease Models, Animal; Flavonoids; Gnaphalium; Guinea Pigs; Molecular Structure; Muscle Relaxation; Muscle, Smooth; Parasympatholytics; Plants, Medicinal; Trachea

2009