glyx-13-peptide and Brain-Ischemia

glyx-13-peptide has been researched along with Brain-Ischemia* in 1 studies

Other Studies

1 other study(ies) available for glyx-13-peptide and Brain-Ischemia

Article	Year
Neuroprotection by a novel NMDAR functional glycine site partial agonist, GLYX-13. Neuroreport, 2009, Aug-26, Volume: 20, Issue:13 GLYX-13 (threonine-proline-proline-threonine-amide) is an amidated di-pyrrolidine that acts as a functional partial agonist at the glycine site on N-methyl-D-aspartate glutamate receptors (NMDARs). GLYX-13 can both increase NMDAR conductance at NR2B-containing receptors, and reduce conductance of non-NR2B-containing receptors. Here, we report that GLYX-13 potently reduces delayed (24 h) death of CA1 pyramidal neurons produced by bilateral carotid occlusion in Mongolian gerbils, when administered up to 5 h post-ischemia. GLYX-13 also reduced delayed (24 h) neuronal death of CA1, CA3, and dentate gyrus principal neurons elicited by oxygen/glucose deprivation in in-vitro hippocampal organotypic slice cultures, when applied up to 2 h post-oxygen/glucose deprivation. The glycine site full agonist D-serine completely occluded neuroprotection, indicating that GLYX-13 acts by modulating activation of this site. Topics: Animals; Brain Ischemia; Carotid Artery Diseases; Cell Death; Cell Hypoxia; Female; Gerbillinae; Glucose; Hippocampus; In Vitro Techniques; Male; Neurons; Neuroprotective Agents; Oligopeptides; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Serine; Stroke; Time Factors	2009

Article

Year

Neuroprotection by a novel NMDAR functional glycine site partial agonist, GLYX-13.

Neuroreport, 2009, Aug-26, Volume: 20, Issue:13

GLYX-13 (threonine-proline-proline-threonine-amide) is an amidated di-pyrrolidine that acts as a functional partial agonist at the glycine site on N-methyl-D-aspartate glutamate receptors (NMDARs). GLYX-13 can both increase NMDAR conductance at NR2B-containing receptors, and reduce conductance of non-NR2B-containing receptors. Here, we report that GLYX-13 potently reduces delayed (24 h) death of CA1 pyramidal neurons produced by bilateral carotid occlusion in Mongolian gerbils, when administered up to 5 h post-ischemia. GLYX-13 also reduced delayed (24 h) neuronal death of CA1, CA3, and dentate gyrus principal neurons elicited by oxygen/glucose deprivation in in-vitro hippocampal organotypic slice cultures, when applied up to 2 h post-oxygen/glucose deprivation. The glycine site full agonist D-serine completely occluded neuroprotection, indicating that GLYX-13 acts by modulating activation of this site.

Topics: Animals; Brain Ischemia; Carotid Artery Diseases; Cell Death; Cell Hypoxia; Female; Gerbillinae; Glucose; Hippocampus; In Vitro Techniques; Male; Neurons; Neuroprotective Agents; Oligopeptides; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Serine; Stroke; Time Factors

2009