Page last updated: 2024-10-28

glyphosate and Neoplasms

glyphosate has been researched along with Neoplasms in 31 studies

glyphosate: active cpd in herbicidal formulation Roundup; inhibits EC 2.5.1.19, 5-enolpyruvylshikimate-3-phosphate synthase; structure
glyphosate : A phosphonic acid resulting from the formal oxidative coupling of the methyl group of methylphosphonic acid with the amino group of glycine. It is one of the most commonly used herbicides worldwide, and the only one to target the enzyme 5-enolpyruvyl-3-shikimate phosphate synthase (EPSPS).

Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.

Research Excerpts

ExcerptRelevanceReference
" The hyperhomocysteinemia, suppressed immunity, and altered oxidative metabolism observed in atherosclerosis and dementia are attributed to deficiency of adenosyl methionine which results from increased polyamine biosynthesis by pathogenic microbes that are demonstrated in atherosclerotic plaques and cerebral plaques."9.05Environmental Pollution, Oxidative Stress and Thioretinaco Ozonide: Effects of Glyphosate, Fluoride and Electromagnetic Fields on Mitochondrial Dysfunction in Carcinogenesis, Atherogenesis and Aging. ( McCully, KS, 2020)
"Glyphosate has been detected in urine, blood and maternal milk and has been found to induce the generation of reactive oxygen species (ROS) and several cytotoxic and genotoxic effects in vitro and in animal models directly or indirectly through its metabolite, aminomethylphosphonic acid (AMPA)."6.72Pleiotropic Outcomes of Glyphosate Exposure: From Organ Damage to Effects on Inflammation, Cancer, Reproduction and Development. ( Marino, M; Meccariello, R; Mele, E; Nori, SL; Santoro, A; Viggiano, A, 2021)
" The hyperhomocysteinemia, suppressed immunity, and altered oxidative metabolism observed in atherosclerosis and dementia are attributed to deficiency of adenosyl methionine which results from increased polyamine biosynthesis by pathogenic microbes that are demonstrated in atherosclerotic plaques and cerebral plaques."5.05Environmental Pollution, Oxidative Stress and Thioretinaco Ozonide: Effects of Glyphosate, Fluoride and Electromagnetic Fields on Mitochondrial Dysfunction in Carcinogenesis, Atherogenesis and Aging. ( McCully, KS, 2020)
"This systematic review and meta-analysis rigorously examines the relationship between glyphosate exposure and risk of lymphohematopoietic cancer (LHC) including NHL, Hodgkin lymphoma (HL), multiple myeloma (MM), and leukemia."4.93Systematic review and meta-analysis of glyphosate exposure and risk of lymphohematopoietic cancers. ( Chang, ET; Delzell, E, 2016)
"Glyphosate is a broad-spectrum and one of the most widely used herbicides in the world, which has led to its high environmental dissemination."3.01Occurrence and exposure assessment of glyphosate in the environment and its impact on human beings. ( Calaf, GM; Carrillo-Beltrán, D; Muñoz, JP; Silva-Pavez, E, 2023)
"Glyphosate was classified as a probable human carcinogen (Group 2A) by the International Agency for Research on Cancer (IARC) partially due to strong mechanistic evidence in 2015."3.01Mapping the key characteristics of carcinogens for glyphosate and its formulations: A systematic review. ( Lee, J; Louie, A; Nguyen, PK; Rana, I; Rigutto, G; Smith, MT; Zhang, L, 2023)
"Glyphosate has been detected in urine, blood and maternal milk and has been found to induce the generation of reactive oxygen species (ROS) and several cytotoxic and genotoxic effects in vitro and in animal models directly or indirectly through its metabolite, aminomethylphosphonic acid (AMPA)."2.72Pleiotropic Outcomes of Glyphosate Exposure: From Organ Damage to Effects on Inflammation, Cancer, Reproduction and Development. ( Marino, M; Meccariello, R; Mele, E; Nori, SL; Santoro, A; Viggiano, A, 2021)
" Presenting adverse effects of glyphosate and its formulations we focused on the role of glyphosate formulations in hormonal disorders by impeding the expression of steroidogenic acute regulatory protein and the inhibition of aromatase activity."2.49[Glyphosate and its formulations--toxicity, occupational and environmental exposure]. ( Bukowska, B; Kwiatkowska, M; Paweł, J, 2013)
"To examine potential cancer risks in humans, we reviewed the epidemiologic literature to evaluate whether exposure to glyphosate is associated causally with cancer risk in humans."2.48Epidemiologic studies of glyphosate and cancer: a review. ( Lundin, JI; Mandel, JS; Mink, PJ; Sceurman, BK, 2012)
"I then present two exposure-cancer cases, namely talcum powder-ovarian cancer and glyphosate-non-Hodgkin lymphoma, that led to civil lawsuits decided, in the United States, in favor of the claimants."1.56Difficulties in establishing a causal link between chemical exposures and cancer cannot be overcome by court assessments. ( Dragani, TA, 2020)
"Scientists worldwide endorse IARC cancer evaluations and process."1.48Commentary: IARC Monographs Program and public health under siege by corporate interests. ( Huff, J; Infante, PF; Melnick, R; Vainio, H, 2018)
"Rational and effective cancer prevention activities depend on scientifically sound and unbiased assessments of the carcinogenic potential of suspected agents."1.48On the International Agency for Research on Cancer classification of glyphosate as a probable human carcinogen. ( Tarone, RE, 2018)
"Glycine is a nonessential amino acid that is reversibly converted from serine intracellularly by serine hydroxymethyltransferase."1.39Glyphosate and AMPA inhibit cancer cell growth through inhibiting intracellular glycine synthesis. ( Ge, D; Lambrechts, MJ; Li, Q; Liu, S; Xi, M; Yin, R; You, Z; Zhang, Q, 2013)
"Glyphosate is a broad-spectrum herbicide that is one of the most frequently applied pesticides in the world."1.33Cancer incidence among glyphosate-exposed pesticide applicators in the Agricultural Health Study. ( Alavanja, MC; Blair, A; De Roos, AJ; Dosemeci, M; Hoppin, JA; Rusiecki, JA; Sandler, DP; Svec, M, 2005)

Research

Studies (31)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (3.23)29.6817
2010's20 (64.52)24.3611
2020's10 (32.26)2.80

Authors

AuthorsStudies
Lin, R1
Elf, S1
Shan, C1
Kang, HB1
Ji, Q1
Zhou, L1
Hitosugi, T1
Zhang, L2
Zhang, S1
Seo, JH1
Xie, J1
Tucker, M1
Gu, TL1
Sudderth, J1
Jiang, L1
Mitsche, M1
DeBerardinis, RJ1
Wu, S1
Li, Y1
Mao, H1
Chen, PR1
Wang, D1
Chen, GZ1
Hurwitz, SJ1
Lonial, S1
Arellano, ML1
Khoury, HJ1
Khuri, FR1
Lee, BH1
Lei, Q1
Brat, DJ1
Ye, K1
Boggon, TJ1
He, C1
Kang, S1
Fan, J1
Chen, J1
Polite, BN1
Ratain, MJ1
Lichter, AS1
Morales, JS1
Castillo-García, A1
Valenzuela, PL1
Saco-Ledo, G1
Mañas, A1
Santos-Lozano, A1
Lucia, A1
Marino, M1
Mele, E1
Viggiano, A1
Nori, SL1
Meccariello, R1
Santoro, A1
Christensen, K1
Muñoz, JP1
Silva-Pavez, E1
Carrillo-Beltrán, D1
Calaf, GM2
Rana, I1
Nguyen, PK1
Rigutto, G1
Louie, A1
Lee, J1
Smith, MT2
Dragani, TA1
Berry, C1
Rusyn, I2
Chiu, WA1
Wright, FA1
McCully, KS1
Andreotti, G2
Koutros, S2
Hofmann, JN2
Sandler, DP3
Lubin, JH2
Lynch, CF2
Lerro, CC2
De Roos, AJ3
Parks, CG2
Alavanja, MC2
Silverman, DT2
Beane Freeman, LE2
Ward, EM1
Infante, PF1
Melnick, R1
Vainio, H2
Huff, J2
Davoren, MJ1
Schiestl, RH1
Sheppard, L1
Shaffer, RM1
Samet, JM1
Morabia, A1
Arjó, G1
Portero, M1
Piñol, C1
Viñas, J1
Matias-Guiu, X1
Capell, T1
Bartholomaeus, A1
Parrott, W1
Christou, P1
Li, Q1
Lambrechts, MJ1
Zhang, Q1
Liu, S1
Ge, D1
Yin, R1
Xi, M1
You, Z1
Kwiatkowska, M1
Paweł, J1
Bukowska, B1
Guyton, KZ1
Loomis, D1
Grosse, Y1
El Ghissassi, F1
Benbrahim-Tallaa, L1
Guha, N1
Scoccianti, C1
Mattock, H1
Straif, K1
Portier, CJ1
Armstrong, BK1
Baguley, BC1
Baur, X1
Belyaev, I1
Bellé, R1
Belpoggi, F1
Biggeri, A1
Bosland, MC1
Bruzzi, P1
Budnik, LT1
Bugge, MD1
Burns, K1
Carpenter, DO1
Carpenter, HM1
López-Carrillo, L1
Clapp, R1
Cocco, P1
Consonni, D1
Comba, P1
Craft, E1
Dalvie, MA1
Davis, D1
Demers, PA1
DeWitt, J1
Forastiere, F1
Freedman, JH1
Fritschi, L1
Gaus, C1
Gohlke, JM1
Goldberg, M1
Greiser, E1
Hansen, J1
Hardell, L1
Hauptmann, M1
Huang, W1
James, MO1
Jameson, CW1
Kortenkamp, A1
Kopp-Schneider, A1
Kromhout, H1
Larramendy, ML1
Landrigan, PJ1
Lash, LH1
Leszczynski, D1
Magnani, C1
Mandrioli, D1
Martin, FL1
Merler, E1
Michelozzi, P1
Miligi, L1
Miller, AB1
Mirabelli, D1
Mirer, FE1
Naidoo, S1
Perry, MJ1
Petronio, MG1
Pirastu, R1
Portier, RJ1
Ramos, KS1
Robertson, LW1
Rodriguez, T1
Röösli, M1
Ross, MK1
Roy, D1
Saldiva, P1
Sass, J1
Savolainen, K1
Scheepers, PT1
Sergi, C1
Silbergeld, EK1
Stewart, BW1
Sutton, P1
Tateo, F1
Terracini, B1
Thielmann, HW1
Thomas, DB1
Vena, JE1
Vineis, P1
Weiderpass, E1
Weisenburger, DD1
Woodruff, TJ1
Yorifuji, T1
Yu, IJ1
Zambon, P1
Zeeb, H1
Zhou, SF1
Chang, ET1
Delzell, E1
Schulte-Wissermann, H1
Tarone, RE1
Bus, JS1
Mink, PJ1
Mandel, JS1
Sceurman, BK1
Lundin, JI1
Blair, A1
Rusiecki, JA1
Hoppin, JA1
Svec, M1
Dosemeci, M1

Reviews

10 reviews available for glyphosate and Neoplasms

ArticleYear
6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling.
    Nature cell biology, 2015, Volume: 17, Issue:11

    Topics: AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Humans; Lipogenesis; Neoplasms;

2015
Mortality from mental disorders and suicide in male professional American football and soccer players: A meta-analysis.
    Scandinavian journal of medicine & science in sports, 2021, Volume: 31, Issue:12

    Topics: Basketball; Boxing; Brain Concussion; Cardiovascular Diseases; Cause of Death; Competitive Behavior;

2021
Pleiotropic Outcomes of Glyphosate Exposure: From Organ Damage to Effects on Inflammation, Cancer, Reproduction and Development.
    International journal of molecular sciences, 2021, Nov-22, Volume: 22, Issue:22

    Topics: DNA Damage; Europe; Gene Expression Regulation; Glycine; Glyphosate; Herbicides; Humans; Inflammatio

2021
Occurrence and exposure assessment of glyphosate in the environment and its impact on human beings.
    Environmental research, 2023, 08-15, Volume: 231, Issue:Pt 3

    Topics: Carcinogens; Environmental Exposure; Glyphosate; Herbicides; Humans; Neoplasms; Occupational Exposur

2023
Mapping the key characteristics of carcinogens for glyphosate and its formulations: A systematic review.
    Chemosphere, 2023, Volume: 339

    Topics: Animals; Carcinogens; Glyphosate; Herbicides; Humans; Lymphoma, Non-Hodgkin; Mammals; Neoplasms

2023
Environmental Pollution, Oxidative Stress and Thioretinaco Ozonide: Effects of Glyphosate, Fluoride and Electromagnetic Fields on Mitochondrial Dysfunction in Carcinogenesis, Atherogenesis and Aging.
    Annals of clinical and laboratory science, 2020, Volume: 50, Issue:3

    Topics: Aging; Animals; Atherosclerosis; Carcinogenesis; Electromagnetic Fields; Environmental Pollution; Fl

2020
Glyphosate-based herbicides and cancer risk: a post-IARC decision review of potential mechanisms, policy and avenues of research.
    Carcinogenesis, 2018, 10-08, Volume: 39, Issue:10

    Topics: Animals; Carcinogens; Environmental Exposure; Glycine; Glyphosate; Herbicides; Humans; Microbiota; M

2018
[Glyphosate and its formulations--toxicity, occupational and environmental exposure].
    Medycyna pracy, 2013, Volume: 64, Issue:5

    Topics: Agriculture; Animals; Cholinesterase Inhibitors; Environmental Exposure; Glycine; Glyphosate; Herbic

2013
Systematic review and meta-analysis of glyphosate exposure and risk of lymphohematopoietic cancers.
    Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes, 2016, Volume: 51, Issue:6

    Topics: Glycine; Glyphosate; Herbicides; Hodgkin Disease; Humans; Leukemia; Multiple Myeloma; Neoplasms; Ris

2016
Epidemiologic studies of glyphosate and cancer: a review.
    Regulatory toxicology and pharmacology : RTP, 2012, Volume: 63, Issue:3

    Topics: Case-Control Studies; Cohort Studies; Glycine; Glyphosate; Herbicides; Humans; Neoplasms

2012

Other Studies

21 other studies available for glyphosate and Neoplasms

ArticleYear
Oncology's "Hockey Stick" Moment for the Cost of Cancer Drugs-The Climate Is About to Change.
    JAMA oncology, 2021, 01-01, Volume: 7, Issue:1

    Topics: Antineoplastic Agents; Hockey; Humans; Neoplasms

2021
Looking beyond Cancer: Glyphosate and Liver, Metabolic Diseases in Youth.
    Environmental health perspectives, 2023, Volume: 131, Issue:5

    Topics: Adolescent; Glyphosate; Herbicides; Humans; Liver; Metabolic Diseases; Neoplasms

2023
Difficulties in establishing a causal link between chemical exposures and cancer cannot be overcome by court assessments.
    Human & experimental toxicology, 2020, Volume: 39, Issue:8

    Topics: Environmental Exposure; Environmental Pollutants; Glycine; Glyphosate; Humans; Jurisprudence; Neopla

2020
Glyphosate and cancer: the importance of the whole picture.
    Pest management science, 2020, Volume: 76, Issue:9

    Topics: Agrochemicals; Glycine; Glyphosate; Humans; Neoplasms; Pest Control

2020
Questioning Existing Cancer Hazard Evaluation Standards in the Name of Statistics.
    Toxicological sciences : an official journal of the Society of Toxicology, 2020, 10-01, Volume: 177, Issue:2

    Topics: Biological Assay; Glycine; Glyphosate; Humans; Neoplasms; Reference Standards

2020
Glyphosate Use and Cancer Incidence in the Agricultural Health Study.
    Journal of the National Cancer Institute, 2018, 05-01, Volume: 110, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Agricultural Workers' Diseases; Agriculture; Cohort Studies; Farmers

2018
Glyphosate Use and Cancer Incidence in the Agricultural Health Study: An Epidemiologic Perspective.
    Journal of the National Cancer Institute, 2018, 05-01, Volume: 110, Issue:5

    Topics: Agriculture; Glycine; Glyphosate; Humans; Incidence; Neoplasms

2018
Commentary: IARC Monographs Program and public health under siege by corporate interests.
    American journal of industrial medicine, 2018, Volume: 61, Issue:4

    Topics: Carcinogens; Conflict of Interest; Glycine; Glyphosate; Herbicides; Humans; International Agencies;

2018
Ready reckoning.
    Nature plants, 2018, Volume: 4, Issue:9

    Topics: California; Chemical Industry; Glycine; Glyphosate; Herbicides; Humans; Liability, Legal; Neoplasms

2018
Re: Glyphosate Use and Cancer Incidence in the Agricultural Health Study.
    Journal of the National Cancer Institute, 2019, 02-01, Volume: 111, Issue:2

    Topics: Agriculture; Glycine; Glyphosate; Humans; Incidence; Neoplasms

2019
Response to Sheppard and Shaffer.
    Journal of the National Cancer Institute, 2019, 02-01, Volume: 111, Issue:2

    Topics: Glycine; Glyphosate; Humans; Incidence; Neoplasms

2019
Expert Review Under Attack: Glyphosate, Talc, and Cancer.
    American journal of public health, 2019, Volume: 109, Issue:7

    Topics: Asbestos; Glycine; Glyphosate; Humans; Neoplasms; Politics; Talc

2019
Fighting Independent Risk Assessment of Talc and Glyphosate: Whose Benefit Is It Anyway?
    American journal of public health, 2019, Volume: 109, Issue:7

    Topics: Glycine; Glyphosate; Humans; Neoplasms; Risk Assessment; Talc

2019
Plurality of opinion, scientific discourse and pseudoscience: an in depth analysis of the Séralini et al. study claiming that Roundup™ Ready corn or the herbicide Roundup™ cause cancer in rats.
    Transgenic research, 2013, Volume: 22, Issue:2

    Topics: Animals; Cultural Diversity; Drug Tolerance; Food, Genetically Modified; Glycine; Glyphosate; Herbic

2013
Glyphosate and AMPA inhibit cancer cell growth through inhibiting intracellular glycine synthesis.
    Drug design, development and therapy, 2013, Volume: 7

    Topics: Apoptosis; Cell Cycle; Cell Line; Cell Line, Tumor; Cell Proliferation; Down-Regulation; Epithelial

2013
Carcinogenicity of tetrachlorvinphos, parathion, malathion, diazinon, and glyphosate.
    The Lancet. Oncology, 2015, Volume: 16, Issue:5

    Topics: Carcinogenesis; Diazinon; Glycine; Glyphosate; Humans; Malathion; Neoplasms; Parathion; Pesticides;

2015
Differences in the carcinogenic evaluation of glyphosate between the International Agency for Research on Cancer (IARC) and the European Food Safety Authority (EFSA).
    Journal of epidemiology and community health, 2016, Volume: 70, Issue:8

    Topics: Carcinogens; Consumer Product Safety; European Union; Food Safety; Glycine; Glyphosate; Herbicides;

2016
[Is there a threat to ban the herbicide glyphosate?].
    Kinderkrankenschwester : Organ der Sektion Kinderkrankenpflege, 2016, Volume: 35, Issue:6

    Topics: Consumer Product Safety; Food Contamination; Germany; Glycine; Glyphosate; Hazard Analysis and Criti

2016
On the International Agency for Research on Cancer classification of glyphosate as a probable human carcinogen.
    European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP), 2018, Volume: 27, Issue:1

    Topics: Animals; Carcinogenicity Tests; Carcinogens; Glycine; Glyphosate; Humans; International Agencies; Mo

2018
IARC use of oxidative stress as key mode of action characteristic for facilitating cancer classification: Glyphosate case example illustrating a lack of robustness in interpretative implementation.
    Regulatory toxicology and pharmacology : RTP, 2017, Volume: 86

    Topics: Animals; Carcinogens; Glycine; Glyphosate; Humans; International Agencies; Neoplasms; Oxidative Stre

2017
Cancer incidence among glyphosate-exposed pesticide applicators in the Agricultural Health Study.
    Environmental health perspectives, 2005, Volume: 113, Issue:1

    Topics: Adult; Aged; Agriculture; Cohort Studies; Female; Glycine; Glyphosate; Herbicides; Humans; Incidence

2005