glyoxylic acid has been researched along with Disease Models, Animal in 24 studies
glyoxylic acid: RN given refers to parent cpd
glyoxylic acid : A 2-oxo monocarboxylic acid that is acetic acid bearing an oxo group at the alpha carbon atom.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Results confirm that hyperoxaluria induction alone is not sufficient to create calcium oxalate nephrolithiasis in mice." | 7.76 | Experimental induction of calcium oxalate nephrolithiasis in mice. ( Glenton, PA; Khan, SR, 2010) |
| "Calcium oxalate (CaOx) stones are the most common type of kidney stones and are associated with high recurrence, short chain fatty acids (SCFAs), and inflammation." | 4.02 | Short Chain Fatty Acids Prevent Glyoxylate-Induced Calcium Oxalate Stones by GPR43-Dependent Immunomodulatory Mechanism. ( Chen, X; Gong, L; Jian, Z; Jin, X; Li, H; Liu, Y; Ma, H; Ma, Y; Qi, S; Shu, X; Wang, K; Xiang, L; Zhu, S, 2021) |
| "Mouse models of nephrolithiasis were established via intraperitoneal injection of glyoxylate, and cell models of tubular epithelial cells and macrophages were established using calcium oxalate monohydrate (COM)." | 4.02 | Vitexin exerts protective effects against calcium oxalate crystal-induced kidney pyroptosis in vivo and in vitro. ( Ding, J; Ding, T; Guo, Z; Ji, B; Li, Y; Liu, Z; Wang, Y; Zhao, T, 2021) |
| " We develop and utilize a glyoxylate induced mouse model of kidney calcium oxalate crystal deposition for studying the pharmacological effects of fasudil, a Rho associated protein kinase (ROCK) specific inhibitor, on the kidney injury and fibrosis caused by calcium oxalate crystallization and deposition." | 3.81 | Fasudil prevents calcium oxalate crystal deposit and renal fibrogenesis in glyoxylate-induced nephrolithic mice. ( Chen, W; Ding, J; Guo, Z; Hu, H; Jia, M; Yin, J, 2015) |
| "In a murine model, the presence of calcium oxalate deposits increases pyelonephritis risk, likely due to preferential aggregation of bacteria on and around calcium oxalate crystals." | 3.81 | The Interaction between Enterobacteriaceae and Calcium Oxalate Deposits. ( Barr-Beare, E; Becknell, B; Hains, DS; Hilt, EE; Li, B; Saxena, V; Schober, M; Schwaderer, AL; Thomas-White, K; Wolfe, AJ, 2015) |
| "Results confirm that hyperoxaluria induction alone is not sufficient to create calcium oxalate nephrolithiasis in mice." | 3.76 | Experimental induction of calcium oxalate nephrolithiasis in mice. ( Glenton, PA; Khan, SR, 2010) |
| " Using genetically modified mice, we herein report GO as a safe and efficient target for substrate reduction therapy (SRT) in PH1." | 1.43 | Glycolate Oxidase Is a Safe and Efficient Target for Substrate Reduction Therapy in a Mouse Model of Primary Hyperoxaluria Type I. ( Luis-Lima, S; Martin-Higueras, C; Salido, E, 2016) |
| "These results suggest that the allodynia and hyperalgesia to mechanical stimuli in the SNI model is not sympathetically maintained." | 1.34 | Lumbar sympathectomy attenuates cold allodynia but not mechanical allodynia and hyperalgesia in rats with spared nerve injury. ( Borzan, J; Chen, L; Meyer, RA; Raja, SN; Ringkamp, M; Tall, JM; Tao, YX; Zhao, C, 2007) |
| "Hyperoxaluria was induced in two groups by the administration of 0." | 1.34 | Effect of sulphated polysaccharides on erythrocyte changes due to oxidative and nitrosative stress in experimental hyperoxaluria. ( Josephine, A; Preetha, SP; Varalakshmi, P; Veena, CK, 2007) |
| "Pyridoxamine treatment resulted in significantly lower (by approximately 50%) levels of urinary glycolate and oxalate excretion compared to untreated hyperoxaluric animals." | 1.33 | Pyridoxamine lowers kidney crystals in experimental hyperoxaluria: a potential therapy for primary hyperoxaluria. ( Belmont, JM; Chetyrkin, SV; Hudson, BG; Kim, D; Scheinman, JI; Voziyan, PA, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.17) | 18.7374 |
| 1990's | 2 (8.33) | 18.2507 |
| 2000's | 4 (16.67) | 29.6817 |
| 2010's | 13 (54.17) | 24.3611 |
| 2020's | 4 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Jin, X | 1 |
| Jian, Z | 1 |
| Chen, X | 1 |
| Ma, Y | 1 |
| Ma, H | 1 |
| Liu, Y | 1 |
| Gong, L | 1 |
| Xiang, L | 1 |
| Zhu, S | 1 |
| Shu, X | 1 |
| Qi, S | 1 |
| Li, H | 1 |
| Wang, K | 1 |
| Wang, B | 1 |
| Wei, J | 1 |
| Huangfu, Q | 1 |
| Gao, F | 1 |
| Qin, L | 1 |
| Zhong, J | 1 |
| Wen, J | 1 |
| Ye, Z | 3 |
| Yang, X | 2 |
| Liu, H | 2 |
| Ye, T | 1 |
| Duan, C | 1 |
| Lv, P | 1 |
| Wu, X | 1 |
| Liu, J | 1 |
| Jiang, K | 1 |
| Lu, H | 1 |
| Yang, H | 1 |
| Xia, D | 1 |
| Peng, E | 1 |
| Chen, Z | 1 |
| Tang, K | 1 |
| Ding, T | 1 |
| Zhao, T | 1 |
| Li, Y | 1 |
| Liu, Z | 2 |
| Ding, J | 2 |
| Ji, B | 1 |
| Wang, Y | 1 |
| Guo, Z | 3 |
| Yu, J | 1 |
| Kong, L | 1 |
| Zhang, A | 1 |
| Han, Y | 1 |
| Sun, H | 1 |
| Liu, L | 1 |
| Wang, X | 1 |
| Usami, M | 1 |
| Okada, A | 3 |
| Taguchi, K | 2 |
| Hamamoto, S | 3 |
| Kohri, K | 3 |
| Yasui, T | 3 |
| Zheng, R | 1 |
| Fang, X | 1 |
| He, L | 1 |
| Shao, Y | 1 |
| Guo, N | 1 |
| Wang, L | 2 |
| Liu, M | 1 |
| Li, D | 1 |
| Geng, H | 1 |
| Kukreja, A | 1 |
| Lasaro, M | 1 |
| Cobaugh, C | 1 |
| Forbes, C | 1 |
| Tang, JP | 1 |
| Gao, X | 1 |
| Martin-Higueras, C | 2 |
| Pey, AL | 1 |
| Salido, E | 3 |
| Sobolov, S | 1 |
| Subramanian, RR | 1 |
| Sugino, T | 1 |
| Unno, R | 1 |
| Ando, R | 1 |
| Mogami, T | 1 |
| Yamashita, H | 1 |
| Nikiforova, VJ | 1 |
| Giesbertz, P | 1 |
| Wiemer, J | 1 |
| Bethan, B | 1 |
| Looser, R | 1 |
| Liebenberg, V | 1 |
| Ruiz Noppinger, P | 1 |
| Daniel, H | 1 |
| Rein, D | 1 |
| Hu, H | 1 |
| Chen, W | 2 |
| Jia, M | 1 |
| Yin, J | 1 |
| Peng, Z | 1 |
| Gao, S | 1 |
| Sun, X | 1 |
| Barr-Beare, E | 1 |
| Saxena, V | 1 |
| Hilt, EE | 1 |
| Thomas-White, K | 1 |
| Schober, M | 1 |
| Li, B | 1 |
| Becknell, B | 1 |
| Hains, DS | 1 |
| Wolfe, AJ | 1 |
| Schwaderer, AL | 1 |
| Luis-Lima, S | 1 |
| Dutta, C | 1 |
| Avitahl-Curtis, N | 1 |
| Pursell, N | 1 |
| Larsson Cohen, M | 1 |
| Holmes, B | 1 |
| Diwanji, R | 1 |
| Zhou, W | 1 |
| Apponi, L | 1 |
| Koser, M | 1 |
| Ying, B | 1 |
| Chen, D | 1 |
| Shui, X | 1 |
| Saxena, U | 1 |
| Cyr, WA | 1 |
| Shah, A | 1 |
| Nazef, N | 1 |
| Wang, W | 1 |
| Abrams, M | 1 |
| Dudek, H | 1 |
| Brown, BD | 1 |
| Lai, C | 1 |
| Rastogi, S | 1 |
| Agarwal, P | 1 |
| Krishnan, MY | 1 |
| Hirose, M | 1 |
| Tozawa, K | 1 |
| Shimizu, H | 1 |
| Kubota, Y | 1 |
| Itoh, Y | 1 |
| Khan, SR | 2 |
| Glenton, PA | 1 |
| Chetyrkin, SV | 1 |
| Kim, D | 1 |
| Belmont, JM | 1 |
| Scheinman, JI | 1 |
| Hudson, BG | 1 |
| Voziyan, PA | 1 |
| Zhao, C | 1 |
| Chen, L | 1 |
| Tao, YX | 1 |
| Tall, JM | 1 |
| Borzan, J | 1 |
| Ringkamp, M | 1 |
| Meyer, RA | 1 |
| Raja, SN | 1 |
| Veena, CK | 1 |
| Josephine, A | 1 |
| Preetha, SP | 1 |
| Varalakshmi, P | 1 |
| Sakharov, D | 1 |
| Voronezhskaya, E | 1 |
| Nezlin, L | 1 |
| Poonguzhali, PK | 1 |
| Chegu, H | 1 |
| Hackett, RL | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Treatment of Asymptomatic Renal Calculi in Recurrent UTIs: a Prospective Observational Cohort Study[NCT04495699] | 80 participants (Anticipated) | Observational [Patient Registry] | 2020-09-09 | Recruiting | |||
| A Phase 1 Study of DCR-PH1 in Patients With Primary Hyperoxaluria Type 1 (PH1)[NCT02795325] | Phase 1 | 41 participants (Actual) | Interventional | 2016-05-13 | Terminated | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for glyoxylic acid and Disease Models, Animal
| Article | Year |
|---|---|
Calcium oxalate urolithiasis in the rat: is it a model for human stone disease? A review of recent literature.
Topics: Animals; Calcium Oxalate; Diet; Disease Models, Animal; Ethylene Glycols; Female; Foreign Bodies; Gl | 1985 |
23 other studies available for glyoxylic acid and Disease Models, Animal
| Article | Year |
|---|---|
Short Chain Fatty Acids Prevent Glyoxylate-Induced Calcium Oxalate Stones by GPR43-Dependent Immunomodulatory Mechanism.
Topics: Animals; Antigens, Ly; Calcium Oxalate; CD24 Antigen; Cell Line; Coculture Techniques; CX3C Chemokin | 2021 |
Identification of Resolvin D1 and Protectin D1 as Potential Therapeutic Agents for Treating Kidney Stones.
Topics: Adult; Aged; Animals; Anti-Inflammatory Agents; Antioxidants; Calcium Oxalate; Case-Control Studies; | 2022 |
AhR activation attenuates calcium oxalate nephrocalcinosis by diminishing M1 macrophage polarization and promoting M2 macrophage polarization.
Topics: 3' Untranslated Regions; Animals; Basic Helix-Loop-Helix Transcription Factors; Calcium Oxalate; Car | 2020 |
Vitexin exerts protective effects against calcium oxalate crystal-induced kidney pyroptosis in vivo and in vitro.
Topics: Animals; Apigenin; Apoptosis; Calcium Oxalate; Cell Line; Disease Models, Animal; Glyoxylates; Human | 2021 |
High-Throughput Metabolomics for Discovering Potential Metabolite Biomarkers and Metabolic Mechanism from the APPswe/PS1dE9 Transgenic Model of Alzheimer's Disease.
Topics: Alzheimer Disease; Animals; Arginine; Biomarkers; Chromatography, High Pressure Liquid; Cognitive Dy | 2017 |
Genetic differences in C57BL/6 mouse substrains affect kidney crystal deposition.
Topics: Animals; Calcium Oxalate; Disease Models, Animal; Exons; Genetic Variation; Glyoxylates; Kidney; Kid | 2018 |
Generation of a Primary Hyperoxaluria Type 1 Disease Model Via CRISPR/Cas9 System in Rats.
Topics: Animals; CRISPR-Cas Systems; Disease Models, Animal; Glyoxylates; Hyperoxaluria, Primary; Mitochondr | 2018 |
Systemic Alanine Glyoxylate Aminotransferase mRNA Improves Glyoxylate Metabolism in a Mouse Model of Primary Hyperoxaluria Type 1.
Topics: Animals; Disease Models, Animal; Genetic Vectors; Glyoxylates; Humans; Hyperoxaluria, Primary; Liver | 2019 |
Brown adipocytes and β
Topics: Adipocytes, Brown; Adipogenesis; Adipose Tissue, Brown; Adrenergic beta-3 Receptor Agonists; Animals | 2019 |
Glyoxylate, a new marker metabolite of type 2 diabetes.
Topics: Animals; Biomarkers; Diabetes Mellitus, Type 2; Disease Models, Animal; Fasting; Genotype; Glyoxylat | 2014 |
Fasudil prevents calcium oxalate crystal deposit and renal fibrogenesis in glyoxylate-induced nephrolithic mice.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Animals; Apoptosis; Cadherins; Calcium Oxalat | 2015 |
Inhalation of hydrogen gas ameliorates glyoxylate-induced calcium oxalate deposition and renal oxidative stress in mice.
Topics: Administration, Inhalation; Animals; Apoptosis; Disease Models, Animal; Glyoxylates; Hydrogen; Immun | 2015 |
The Interaction between Enterobacteriaceae and Calcium Oxalate Deposits.
Topics: Adolescent; Animals; Calcium Oxalate; Child; Disease Models, Animal; DNA, Bacterial; Enterobacteriac | 2015 |
Glycolate Oxidase Is a Safe and Efficient Target for Substrate Reduction Therapy in a Mouse Model of Primary Hyperoxaluria Type I.
Topics: Alcohol Oxidoreductases; Animals; Cells, Cultured; Disease Models, Animal; Gene Knockout Techniques; | 2016 |
Inhibition of Glycolate Oxidase With Dicer-substrate siRNA Reduces Calcium Oxalate Deposition in a Mouse Model of Primary Hyperoxaluria Type 1.
Topics: Alcohol Oxidoreductases; Animals; Calcium Oxalate; DEAD-box RNA Helicases; Disease Models, Animal; G | 2016 |
Use of an adipocyte model to study the transcriptional adaptation of Mycobacterium tuberculosis to store and degrade host fat.
Topics: Adaptation, Physiological; Adipocytes; Animals; Bacterial Proteins; Disease Models, Animal; DNA-Bind | 2016 |
Glyoxylate induces renal tubular cell injury and microstructural changes in experimental mouse.
Topics: Animals; Calcium Oxalate; Crystallization; Disease Models, Animal; Epithelial Cells; Glyoxylates; Im | 2008 |
Experimental induction of calcium oxalate nephrolithiasis in mice.
Topics: Animals; Calcium Oxalate; Disease Models, Animal; Ethylene Glycol; Female; Glyoxylates; Hydroxyproli | 2010 |
Pyridoxamine lowers kidney crystals in experimental hyperoxaluria: a potential therapy for primary hyperoxaluria.
Topics: Animals; Calcium Oxalate; Crystallization; Disease Models, Animal; Glyoxylates; Humans; Hyperoxaluri | 2005 |
Lumbar sympathectomy attenuates cold allodynia but not mechanical allodynia and hyperalgesia in rats with spared nerve injury.
Topics: Animals; Blood Vessels; Cold Temperature; Disease Models, Animal; Glyoxylates; Hyperalgesia; Male; N | 2007 |
Effect of sulphated polysaccharides on erythrocyte changes due to oxidative and nitrosative stress in experimental hyperoxaluria.
Topics: Animals; Biomarkers; Carbon Radioisotopes; Disease Models, Animal; Erythrocytes; Ethylene Glycol; Fu | 2007 |
Chronic haloperidol: neural correlates of motor disorders in an invertebrate model.
Topics: Animals; Catecholamines; Disease Models, Animal; Dopamine; Fluorescence; Glyoxylates; Haloperidol; H | 1994 |
The influence of banana stem extract on urinary risk factors for stones in normal and hyperoxaluric rats.
Topics: Animals; Calcium; Disease Models, Animal; Fruit; Glycolates; Glyoxylates; Hyperoxaluria; Male; Phosp | 1994 |