Compounds > glycyrrhizic acid
Page last updated: 2024-08-21

glycyrrhizic acid and Disease Models, Animal

glycyrrhizic acid has been researched along with Disease Models, Animal in 117 studies

Research

Studies (117)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's5 (4.27)18.2507
2000's17 (14.53)29.6817
2010's67 (57.26)24.3611
2020's28 (23.93)2.80

Authors

AuthorsStudies
Fan, J; Kuang, Y; Li, B; Qiao, X; Ye, M1
Abrams, RPM; Bachani, M; Balasubramanian, A; Brimacombe, K; Dorjsuren, D; Eastman, RT; Hall, MD; Jadhav, A; Lee, MH; Li, W; Malik, N; Nath, A; Padmanabhan, R; Simeonov, A; Steiner, JP; Teramoto, T; Yasgar, A; Zakharov, AV1
Li, Q; Wu, X; Xin, M1
Bi, H; Chen, N; Chu, S; Cui, L; Gao, G; He, W; Li, X; Liu, F; Tian, Y; Wang, H; Wang, Z1
Alsamman, AM; Asseri, SM; El-Sherbiny, M; Elsherbini, AM; Elsherbiny, NM; Maysarah, NM; Sherif, IO1
Deng, J; Du, J; Gu, J; Jiang, B; Peng, G; Ran, X; Wen, D; Xia, F; Zhang, A1
Gao, D; Gao, X; Jiang, X; Jin, M; Liu, K; Paudel, YN; Ren, Q; Shang, X; Sheng, W; Zhang, P; Zhang, X1
Jiao, A; Liang, Y; Qin, J; Song, J; Yang, B1
Athari, SS; Chen, L; Mehrabi Nasab, E1
Ahn, SJ; Chokkakula, S; Jeong, JH; Jung, JM; Jung, JW; Kim, BK; Kim, EG; Lee, WH; Min, SC; Oh, S; Park, JH; Park, OB; Song, MS1
Jiang, Z; Lai, S; Lin, Z; Shi, L1
Chen, Q; Gong, Z; Jiao, F; Shi, C; Wang, Y1
Giardullo, P; Mancuso, M; Palone, F; Pasquali, E; Stronati, L; Vitali, R1
Gao, M; He, L; Li, X; Wei, H; Xiao, F; Yang, J; Ye, X1
Li, C; Li, X; Shen, P; Su, C; Tian, J; Wang, Z; Zhang, Y; Zhao, L; Zhu, L1
El Fayoumi, HM; Hasan, RA; Mahmoud, AAA; Mahmoud, MF; Zakaria, S1
An, HJ; Choi, SY; Geum, JH; Hong, JH; Kang, YM; Kim, HR; Kim, SH; Lee, YC; Yang, WK1
An, R; Chen, Y; Cui, B; Fan, YH; Li, XQ; Lu, J1
Gao, X; Guo, S; Liu, A; Shi, L; Wang, Q; Wen, A; Zhang, S; Zhang, T; Zhang, Y1
Bao, YZ; Lv, XL; Tang, Y; Wang, JR1
Cao, K; Chen, T; Fu, L; Sun, Q; Wang, J; Yang, H1
El Fayoumi, HM; Emara, NA; Mahmoud, AAA; Mahmoud, MF1
Han, K; Liu, F; Sun, Y; Xing, J; Yang, X1
An, Y; Cheng, L; Dai, H; Duan, Y; Li, P; Li, Y; Ma, Q; Ma, X; Wang, C; Wang, J; Wang, T; Zhang, M; Zhao, B1
Bian, Y; Li, J; Luo, Y; Wang, B; Wang, R; Zhang, Q1
Akkaoui, J; Duarte, C; Garcia, C; Ho, A; Movila, A; Yamada, C1
Hiramoto, K; Kawanishi, S; Ma, N; Murata, M; Ohnishi, S; Wang, G; Yoshikawa, N1
Chen, H; Gong, F; Li, J; Liu, W; Shi, J; Shu, X; Sun, Y; Tan, Z; Tu, C; Xiao, Y; Xu, Y; Zeng, F; Zheng, F1
Bryson, S; Castino, G; Del Río Hernández, A; Julian, L; McGarry, L; Mullin, M; Munro, J; Naylor, G; Olson, MF; Rath, N; Rice, A; Stevenson, D; Wickman, GR1
Cheng, X; Fan, M; Liu, S; Liu, Z; Lu, E; Pi, Z; Song, F; Zheng, Z1
Chen, H; Han, L; Ma, Y; Qiong, H; Xu, J; Yan, K; Zhang, N; Zhang, Z1
Chang, CC; Chuang, CL; Hou, MC; Hsu, SJ; Huang, HC; Huang, YH; Lee, FY; Pun, CK; Yen, CH1
Fan, C; Han, C; He, X; Jin, T; Li, C; Liu, S; Liu, X; Peng, S; Shan, L; Shan, Z; Teng, W; Wang, W; Wang, X; Xie, X; Zhang, H1
Hua, X; Jing, Z; Li, Y; Sun, F; Wan, L; Wang, X1
Jiang, Y; Liu, L; Steinle, JJ1
Chen, G; Dou, Y; Feng, D; Li, H; Liu, C; Shen, H; Sun, L; Sun, Q; Tian, X; Wang, Z; Zhou, F1
Ding, R; Dou, K; He, G; Li, X; Ma, B; Peng, W; Qu, S; Tao, K; Yang, H; Yang, Z; Yue, S; Zhang, H; Zhang, X; Zhang, Z1
Dong, X; Gong, H; Jiang, CL; Li, JS; Lian, YJ; Liu, LL; Peng, W; Su, WJ; Wang, B; Wang, YX; Zhang, T1
He, Y; Li, M; Lv, C; Ma, X; Song, J; Sun, L; Zhang, L1
Dong, RQ; Gao, HK; Hu, ZW; Li, M; Peng, D; Wu, RN; Wu, YQ; Yu, TY; Zhang, XW; Zhao, C; Zhou, JC1
Huo, X; Meng, X; Sun, X; Yang, S; Zhao, Y1
Bucala, R; Hunt, DE; Leng, L; Ma, F; Meyer-Siegler, KL; Vera, PL1
Kong, D; Liu, T; Tian, J; Wang, Z; Zhou, H1
Li, J; Shi, J; Sun, Y; Zheng, F1
Gao, F; Li, YJ; Wang, L; Yang, CM; Zhang, B1
Gong, L; Li, W; Liu, R; Mao, Y; Mei, X; Tang, L; Wang, B; Wang, Y; Wu, Y; Xu, H; Xu, X; Zeng, Z1
Jiang, S; Li, P; Tao, Y; Yin, J; Yu, R; Zhou, Q1
Avgustinovich, D; Dushkin, A; Goiman, E; Kovner, A; Lyakhov, N; Mordvinov, V; Orlovskaya, I; Sorokina, I; Tolstikova, T; Toporkova, L; Tsyganov, M; Vishnivetskaya, G1
Sun, T; Yao, L1
Deye, S; Jiangdong, N; Jun, H; Junjie, W; Mingming, Y; Muliang, D; Wenzhao, L; Xianzhe, H1
Elvy Suhana, MR; Fairus, A; Farihah, HS; Ima Nirwana, S; Santhana, R; Tan, MH1
Chakraborti, AS; Ray, D; Sil, R1
Hattori, T; Iizuka, S; Miura, A; Mogami, S; Nakazato, M; Tsubouchi, H; Yamada, C; Yanagi, S1
Choi, S; Kang, C; Lee, CY; Lee, JW; Shim, B; Shin, JW; Sohn, NW; Song, JH1
Abdolmohammadi, K; Fakhari, S; Jalili, A; Moghadam, AS; Nikkhoo, B; Panahi, Y; Peirmohammadi, H; Rahmani, MR1
Fu, Y; Guo, M; Liang, D; Wang, T; Wang, W; Wei, Z; Yang, Z; Zhang, N; Zhou, E1
Date, I; Haruma, J; Hui, Z; Liu, K; Liu, R; Mori, S; Nishibori, M; Nishimura, Y; Okuma, Y; Takahashi, HK; Teshigawara, K; Wake, H; Yamamoto, H; Yamamoto, Y1
Jin, Y; Kim, ID; Lee, JK; Luo, L1
Feng, T; Lin, Y; Weng, Z; Wu, Y; Zhang, J; Zhou, T1
Chang, CZ; Kwan, AL; Wu, SC1
Chang, HJ; Kang, WJ; Kim, DH; Lee, SE; Lee, YJ; Shin, JS; Yang, PS1
Cui, Z; Lin, Y; Shen, L; Tan, Q; Wang, S; Zheng, D1
Bhattacharjee, A; Choudhuri, SK; Majumdar, S; Majumdar, SB; Majumder, S; Roy, S1
Hu, X; Huang, J; Tang, Y; Wang, Q; Wu, Q; Zhang, J1
Cao, W; Chen, W; Dong, X; Gao, Y; Hua, W; Qi, J; Wang, J; Wu, H; Wu, T; Yang, Q; Zhao, X; Zhou, J1
Akman, T; Aras, AB; Cosar, M; Guven, M; Kalkan, Y; Okuyucu, A; Ozkan, A; Sehitoglu, I; Sen, HM; Silan, C1
Chen, Y; Li, PL; Li, X; Pitzer, AL; Wang, L; Zhang, Y1
Bi, XY; Gong, H; Jiang, CL; Liu, L; Liu, YZ; Shen, XL; Wang, YX; Wu, TY; Yang, YY; Zhang, W; Zhang, Y1
Li, YX; Ma, L; Niu, Y; Niu, YT; Shi, GJ; Sun, T; Wang, HL; Wu, J; Yu, JQ; Zheng, J1
Ha, JY; Jung, JC; Jung, YS; Kim, KM; Oh, S; Yu, JY1
Aloi, M; Cucchiara, S; Negroni, A; Oliva, S; Palone, F; Pierdomenico, M; Stronati, L; Vitali, R1
Hu, X; Huang, J; Lei, W; Tang, Y; Wang, Q; Wu, Q; Zhou, L1
Chen, X; Fang, X; Gao, J; Li, S; Luo, A; Tan, L; Wang, W; Zhang, J; Zhao, Y1
An, GL; Braun, FK; Lei, FR; Li, FE; Liu, ZQ; Meng, HM; Qi, L; Shen, YT; Sun, X; Tang, JL; Velasquez, LA; Wang, HH; Wu, C; Xu, F; Yang, L; Zhang, JG; Zhang, XD; Zhao, K; Zhu, BS; Zou, JX1
Chen, JX; Chen, XX; Li, YL; Ma, YJ; Ning, ZY; Qi, WB; Wang, GC; Zhou, HX1
Berg, D; Forrester, JV; Gasser, T; Hobert, MA; Maetzler, W; Martin, HL; Rattay, TW; Riedel, G; Santoro, M; Stathakos, P; Teismann, P; Tracey, KJ1
Li, S; Liu, J; Sun, CL; Wang, J; Wang, JF; Zhang, BL1
Guo, J; Yang, CX; Yang, JJ; Yao, Y1
Chakraborti, AS; Sil, R1
Feng, XY; Fu, J; Li, SY; Lin, SH; Liu, Q; Wang, CJ; Xu, F1
González-Reyes, S; Guevara-Guzmán, R; Jiménez-Osorio, AS; Pedraza-Chaverri, J; Santillán-Cigales, JJ1
Gu, L; Krams, S; Lee, J; Luo, Y; Wang, Y; Xiong, X; Zhang, H; Zhao, H; Zhu, S1
Waki, K; Yamada, A1
Asano, Y; Ichimura, Y; Miura, S; Nakamura, K; Saigusa, R; Sato, S; Takahashi, T; Taniguchi, T; Toyama, T; Trojanowska, M; Yamashita, T; Yoshizaki, A1
Barrett, RP; Ekanayaka, SA; Hazlett, LD; Kharotia, S; McClellan, SA1
Cao, N; Chen, T; Fu, LX; Guo, ZP; Qin, S; Yin, B1
Makarova, SI; Nikitin, YP; Ragino, YI; Safronova, OG; Salakhutdinov, NF; Stakhneva, EM; Tolstikov, GA; Vavilin, VA1
Cai, TT; Chen, T; Shen, Y; Sun, Y; Xu, Q; Zhou, XB1
Chen, L; Chen, YX; Davey, AK; Liu, XQ; Wang, JP; Yang, J1
Kong, XP; Liu, XY; Wan, HJ; Wang, HC; Wei, SL; Ye, HJ; Yi, XR; Yuan, YC1
Hisatsune, A; Isohama, Y; Katsuki, H; Miyata, T; Nishimoto, Y; Yokomizo, K1
Cao, Q; Cui, J; Yang, S; Zhu, Y1
Ding, H; Lee, RJ; Liu, M; Liu, Y; Wang, S; Xiang, J1
Hong, S; Jung, Y; Kim, DD; Kim, H; Kim, YM; Kong, H; Lee, Y; Yoon, JH1
Chen, DR; Dong, WQ; Fu, CY; Li, H; Li, Y; Li, Z; Tang, JP; Wang, P; Wei, W1
Chen, C; Chen, Y; Guan, D; Jin, J; Wang, X; Wang, Z; Xu, Y; Ye, D; Ye, L; Zhao, H; Zhu, X1
Fu, S; Han, J; Jin, S; Lu, Y; Lv, Q; Qi, J; Wu, W; Yuan, H1
Chen, J; Chen, S; Jiang, H; Xu, C; Xu, L; Yang, J; Zhang, J1
Akashi, T; Azuma, T; Inoue, J; Ishida, T; Kawauchi, S; Kondo, Y; Miki, I; Mizuno, S; Nishiumi, S; Tanahashi, T; Yamasaki, A; Yamazaki, A; Yoshida, M1
Abe, M; Akbar, F; Hasebe, A; Horiike, N; Onji, M1
Han, MJ; Kim, DH; Park, HY; Park, SH; Yoon, HK1
Meng, Q; Shen, C; Wu, YT; Yin, J; Yu, JP1
Handforth, A; Martin, FC1
Bhattacharya, I; Das, M; Dinda, AK; Gangal, SV; Ghosh, B; Mabalirajan, U; Ram, A1
Feng, YT; Ji, WS; Jiao, JX; Sun, LH; Wu, KX; Yuan, H1
Chen, LG; Huang, GC; Wang, CC; Wu, LS; Yang, LL1
Muriel, P; Rivera-Espinoza, Y1
Chi, BR; Song, LJ; Wang, ZX; Yang, GZ1
Iizuka, S; Imamura, S; Inoue, M; Makino, T; Mizukami, H; Ohtake, N; Tsuchiya, N; Watanabe, A1
Kimura, T; Kurosaki, Y; Nakayama, T; Okamoto, M; Wang, Z1
Basnet, P; Hase, K; Kadota, S; Matsushige, K; Namba, T1
Aikawa, T; Iga, T; Kotaki, H; Sawada, Y; Tanaka, N; Yamamura, Y1
Harada, K; Ishida, M; Ito, H; Katayama, S; Kawasaki, H; Okubo, M; Shiota, G; Tomie, Y1
Akaki, T; Kawahara, S; Ogasawara, K; Sato, K; Shimizu, T; Tomioka, H1
Okabe, S; Okamoto, T1
Fushiki, T; Kometani, T; Nakae, T; Nishimura, T; Okada, S; Takii, H1
Jeong, SY; Kobayashi, T; Okamoto, T1

Reviews

2 review(s) available for glycyrrhizic acid and Disease Models, Animal

ArticleYear
Glycyrrhizin, a Potential Drug for Autoimmune Encephalomyelitis by Inhibiting High-Mobility Group Box 1.
    DNA and cell biology, 2018, Volume: 37, Issue:12

    Topics: Animals; Autoimmune Diseases; Central Nervous System; Disease Models, Animal; Encephalomyelitis; Glycyrrhizic Acid; HMGB1 Protein; Humans; Signal Transduction

2018
Beneficial drugs for liver diseases.
    Journal of applied toxicology : JAT, 2008, Volume: 28, Issue:2

    Topics: Adrenal Cortex Hormones; Animals; Colchicine; Curcumin; Disease Models, Animal; Drug Combinations; Glycyrrhizic Acid; Humans; Interferons; Liver Diseases; Nitric Oxide; Plant Extracts; Resveratrol; S-Adenosylmethionine; Silymarin; Stilbenes; Thalidomide

2008

Trials

1 trial(s) available for glycyrrhizic acid and Disease Models, Animal

ArticleYear
The pharmacokinetics of glycyrrhizin and its restorative effect on hepatic function in patients with chronic hepatitis and in chronically carbon-tetrachloride-intoxicated rats.
    Biopharmaceutics & drug disposition, 1997, Volume: 18, Issue:8

    Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Area Under Curve; Aspartate Aminotransferases; Carbon Tetrachloride; Disease Models, Animal; Dose-Response Relationship, Drug; Glycyrrhizic Acid; Hepatitis, Chronic; Humans; Infusions, Intravenous; Injections, Intravenous; Liver; Male; Rats; Rats, Wistar

1997

Other Studies

114 other study(ies) available for glycyrrhizic acid and Disease Models, Animal

ArticleYear
Antitussive and expectorant activities of licorice and its major compounds.
    Bioorganic & medicinal chemistry, 2018, 01-01, Volume: 26, Issue:1

    Topics: Administration, Oral; Ammonia; Animals; Antitussive Agents; Cough; Disease Models, Animal; Dose-Response Relationship, Drug; Expectorants; Glyburide; Glycyrrhiza; Male; Methysergide; Mice; Mice, Inbred ICR; Molecular Structure; Phenolsulfonphthalein; Plant Extracts; Structure-Activity Relationship

2018
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
    Proceedings of the National Academy of Sciences of the United States of America, 2020, 12-08, Volume: 117, Issue:49

    Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Drug Evaluation, Preclinical; High-Throughput Screening Assays; Immunocompetence; Inhibitory Concentration 50; Methacycline; Mice, Inbred C57BL; Protease Inhibitors; Quantitative Structure-Activity Relationship; Small Molecule Libraries; Vero Cells; Zika Virus; Zika Virus Infection

2020
Strengthened rebamipide ocular nanoformulation to effectively treat corneal alkali burns in mice through the HMGB1 signaling pathway.
    Experimental eye research, 2021, Volume: 213

    Topics: Alanine; Animals; Antioxidants; Blotting, Western; Burns, Chemical; Chickens; Chorioallantoic Membrane; Disease Models, Animal; Drug Carriers; Enzyme-Linked Immunosorbent Assay; Epithelium, Corneal; Eye Burns; Glycyrrhizic Acid; HMGB1 Protein; Humans; Mice; Ophthalmic Solutions; Quinolones; Rabbits; Signal Transduction; Sodium Hydroxide; Wound Healing

2021
Up-regulation of Nrf2/P62/Keap1 involves in the anti-fibrotic effect of combination of monoammonium glycyrrhizinate and cysteine hydrochloride induced by CCl
    European journal of pharmacology, 2021, Dec-15, Volume: 913

    Topics: Animals; Antifibrotic Agents; Carbon Tetrachloride; Cysteine; Disease Models, Animal; Gene Knockdown Techniques; Gene Knockout Techniques; Glycyrrhizic Acid; Hep G2 Cells; Hepatocytes; Humans; Kelch-Like ECH-Associated Protein 1; Liver Cirrhosis; Male; NF-E2-Related Factor 2; Oxidative Stress; Rats; Sequestosome-1 Protein; Signal Transduction; Up-Regulation

2021
Glycyrrhizic acid ameliorates submandibular gland oxidative stress, autophagy and vascular dysfunction in rat model of type 1 diabetes.
    Scientific reports, 2022, 01-14, Volume: 12, Issue:1

    Topics: Animals; Autophagy; Diabetes Mellitus, Type 1; Disease Models, Animal; Glycyrrhizic Acid; Oxidative Stress; Phytotherapy; Rats; Submandibular Gland; Submandibular Gland Diseases

2022
Glycyrrhizin alleviates sepsis-induced acute respiratory distress syndrome via suppressing of HMGB1/TLR9 pathways and neutrophils extracellular traps formation.
    International immunopharmacology, 2022, Volume: 108

    Topics: Animals; Disease Models, Animal; Extracellular Traps; Glycyrrhizic Acid; HMGB1 Protein; Lung; Lung Injury; Mice; Myeloid Differentiation Factor 88; Neutrophils; Respiratory Distress Syndrome; Sepsis; Toll-Like Receptor 9

2022
Co-treatment with natural HMGB1 inhibitor Glycyrrhizin exerts neuroprotection and reverses Parkinson's disease like pathology in Zebrafish.
    Journal of ethnopharmacology, 2022, Jun-28, Volume: 292

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Disease Models, Animal; Glycyrrhizic Acid; HMGB1 Protein; Mice; Mice, Inbred C57BL; Molecular Docking Simulation; Neuroprotection; Neuroprotective Agents; Parkinson Disease; RNA, Messenger; Zebrafish

2022
In Silico Analysis Identifies the Anti-Liver Injury Targets of Diammonium Glycyrrhizinate: Validated in Perfluorooctanoic Acid-Lesioned Mouse Model.
    Chemistry & biodiversity, 2022, Volume: 19, Issue:8

    Topics: Animals; Caprylates; Caspase 3; Chemical and Drug Induced Liver Injury, Chronic; Cyclooxygenase 2; Disease Models, Animal; Fluorocarbons; Glycyrrhizic Acid; Mice; Molecular Docking Simulation

2022
Effect of Loaded Glycyrrhizic Acid on PLGA Nano-particle on Treatment of Allergic Asthma.
    Iranian journal of allergy, asthma, and immunology, 2022, Feb-06, Volume: 21, Issue:1

    Topics: Animals; Anti-Asthmatic Agents; Asthma; Disease Models, Animal; Glycyrrhizic Acid; Humans; Hypersensitivity; Inflammation

2022
Evaluation of the Antiviral Efficacy of Subcutaneous Nafamostat Formulated with Glycyrrhizic Acid against SARS-CoV-2 in a Murine Model.
    International journal of molecular sciences, 2023, May-31, Volume: 24, Issue:11

    Topics: Animals; Antiviral Agents; COVID-19; Disease Models, Animal; Glycyrrhizic Acid; Humans; Mice; Pandemics; Rats; Rats, Sprague-Dawley; SARS-CoV-2

2023
Glycyrrhizin treatment ameliorates post-traumatic stress disorder-like behaviours and restores circadian oscillation of intracranial serotonin.
    Clinical and experimental pharmacology & physiology, 2020, Volume: 47, Issue:1

    Topics: Amygdala; Animals; Anxiety; Circadian Clocks; Disease Models, Animal; Extinction, Psychological; Fear; Glycyrrhizic Acid; Hippocampus; Male; Memory; Prefrontal Cortex; Rats; Rats, Wistar; Serotonin; Stress Disorders, Post-Traumatic; Stress, Psychological

2020
Mechanism of glycyrrhizin on ferroptosis during acute liver failure by inhibiting oxidative stress.
    Molecular medicine reports, 2019, Volume: 20, Issue:5

    Topics: Animals; Biomarkers; Cell Survival; Cells, Cultured; Disease Models, Animal; Ferroptosis; Glycyrrhizic Acid; Heme Oxygenase-1; HMGB1 Protein; Humans; Liver Failure, Acute; Male; Mice; Oxidative Stress; Reactive Oxygen Species; Tumor Necrosis Factor-alpha

2019
Low Dose of Dipotassium Glycyrrhizate Counteracts Atherosclerosis Progression in Apoe-/- Female Mice.
    Journal of vascular research, 2019, Volume: 56, Issue:5

    Topics: Animals; Aorta, Thoracic; Aortic Diseases; Atherosclerosis; Disease Models, Animal; Disease Progression; Female; Glycyrrhizic Acid; HMGB1 Protein; Inflammation Mediators; Lipids; Mice, Knockout, ApoE; Plaque, Atherosclerotic; Sex Factors

2019
Diammonium Glycyrrhizinate Mitigates Liver Injury Via Inhibiting Proliferation Of NKT Cells And Promoting Proliferation Of Tregs.
    Drug design, development and therapy, 2019, Volume: 13

    Topics: Animals; Anti-Inflammatory Agents; Cell Proliferation; Chemical and Drug Induced Liver Injury; Concanavalin A; Disease Models, Animal; Dose-Response Relationship, Drug; Glycyrrhizic Acid; Hepatitis, Autoimmune; Male; Mice; Mice, Inbred C57BL; Molecular Structure; Natural Killer T-Cells; Structure-Activity Relationship; T-Lymphocytes, Regulatory

2019
Glycyrrhizic acid promotes neural repair by directly driving functional remyelination.
    Food & function, 2020, Jan-29, Volume: 11, Issue:1

    Topics: Animals; Cell Differentiation; Cells, Cultured; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Glycogen Synthase Kinase 3 beta; Glycyrrhizic Acid; Mice; Mice, Inbred C57BL; Neural Stem Cells; Oligodendroglia; Organ Culture Techniques; Remyelination; Signal Transduction

2020
The concurrent exposure to aluminium and fructose induces liver injury in rats: Protection by monoammonium glycyrrhizinate.
    Clinical and experimental pharmacology & physiology, 2020, Volume: 47, Issue:5

    Topics: Aluminum Chloride; Animals; Biomarkers; Blood Glucose; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Fructose; Glycyrrhizic Acid; Inflammation Mediators; Liver; Male; Oxidative Stress; Protective Agents; Proto-Oncogene Proteins c-bcl-2; Rats, Wistar; Signal Transduction; Silymarin; Toll-Like Receptor 4; Triglycerides

2020
Herbal Combinational Medication of
    Nutrients, 2020, Mar-27, Volume: 12, Issue:4

    Topics: Agastache; Animals; Chemokine CXCL2; Disease Models, Animal; Flavonoids; Glycosides; Glycyrrhiza; Glycyrrhizic Acid; Interleukin-17; Lung; Male; Mice; Mice, Inbred BALB C; Plant Extracts; Pneumonia; Polymerase Chain Reaction; Pulmonary Disease, Chronic Obstructive; Signal Transduction; STAT3 Transcription Factor

2020
[Differences in intestinal absorption of Gegen Qinlian Decoction between normal rats and rats with large intestinal damp-heat syndrome].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2020, Volume: 45, Issue:1

    Topics: Animals; Disease Models, Animal; Drugs, Chinese Herbal; Glycyrrhizic Acid; Intestinal Absorption; Medicine, Chinese Traditional; Rats

2020
Glycyrrhetinic acid attenuates disturbed vitamin a metabolism in non-alcoholic fatty liver disease through AKR1B10.
    European journal of pharmacology, 2020, Sep-15, Volume: 883

    Topics: Aldo-Keto Reductases; Animals; Diet, High-Fat; Disease Models, Animal; Enzyme Inhibitors; Glycyrrhetinic Acid; Glycyrrhizic Acid; Hep G2 Cells; Humans; Hydrolysis; Kinetics; Liver; Male; Mice, Inbred C57BL; Molecular Docking Simulation; Non-alcoholic Fatty Liver Disease; Vitamin A

2020
Glycyrrhizin improves bone metabolism in ovariectomized mice via inactivating NF-κB signaling.
    Climacteric : the journal of the International Menopause Society, 2021, Volume: 24, Issue:3

    Topics: Animals; Bone Density Conservation Agents; Bone Resorption; Disease Models, Animal; Female; Glycyrrhizic Acid; Humans; Mice; Mice, Inbred C57BL; Monocytes; NF-kappa B; Osteoclasts; Osteogenesis; Osteoporosis, Postmenopausal; Ovariectomy; RAW 264.7 Cells; Signal Transduction

2021
The Anti-inflammatory Effects of HMGB1 Blockades in a Mouse Model of Cutaneous Vasculitis.
    Frontiers in immunology, 2020, Volume: 11

    Topics: Animals; Anti-Inflammatory Agents; Biomarkers; Cytokines; Disease Models, Animal; Disease Susceptibility; Gene Expression; Glycyrrhizic Acid; HMGB1 Protein; Immunohistochemistry; Mice; Vasculitis, Leukocytoclastic, Cutaneous

2020
The renoprotective effect of glycyrrhizic acid in insulin-resistant rats exposed to aluminum involves the inhibition of TLR4/NF-κB signaling pathway.
    Naunyn-Schmiedeberg's archives of pharmacology, 2021, Volume: 394, Issue:5

    Topics: Aluminum Chloride; Animals; Disease Models, Animal; Fructose; Glycyrrhizic Acid; Inflammation; Insulin Resistance; Kidney Diseases; Male; NF-kappa B; Oxidative Stress; Rats; Rats, Wistar; Signal Transduction; Toll-Like Receptor 4

2021
Glycyrrhizin potentially suppresses the inflammatory response in preeclampsia rat model.
    Pregnancy hypertension, 2021, Volume: 23

    Topics: Animals; Blood Pressure; Disease Models, Animal; Female; Glycyrrhizic Acid; HMGB1 Protein; Humans; Pre-Eclampsia; Pregnancy; Proteinuria; Rats; Rats, Inbred Lew; Toll-Like Receptor 4

2021
Therapeutic effects and mechanisms study of Hanchuan Zupa Granule in a Guinea pig model of cough variant asthma.
    Journal of ethnopharmacology, 2021, Apr-06, Volume: 269

    Topics: Animals; Anti-Asthmatic Agents; Antitussive Agents; Asthma; Body Weight; Capsaicin; Cough; Cytokines; Disease Models, Animal; Drugs, Chinese Herbal; Flavonoids; GATA3 Transcription Factor; Glycyrrhizic Acid; Guinea Pigs; Lung; Medicine, Chinese Traditional; Ovalbumin; Respiratory Hypersensitivity; T-Box Domain Proteins; Th1 Cells; Th2 Cells; Toll-Like Receptor 4; Triterpenes

2021
Protective effect of glycyrrhizin on osteoarthritis cartilage degeneration and inflammation response in a rat model.
    Journal of bioenergetics and biomembranes, 2021, Volume: 53, Issue:3

    Topics: Animals; Anti-Inflammatory Agents; Disease Models, Animal; Glycyrrhizic Acid; Inflammation; Male; Osteoarthritis; Rats; Rats, Wistar

2021
Glycyrrhizin mitigates inflammatory bone loss and promotes expression of senescence-protective sirtuins in an aging mouse model of periprosthetic osteolysis.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2021, Volume: 138

    Topics: Aging; Animals; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Gene Expression; Glycyrrhizic Acid; Male; Mice; Mice, Inbred C57BL; Osteolysis; Osteoporosis; Sirtuins; Skull

2021
Glycyrrhizin Attenuates Carcinogenesis by Inhibiting the Inflammatory Response in a Murine Model of Colorectal Cancer.
    International journal of molecular sciences, 2021, Mar-05, Volume: 22, Issue:5

    Topics: Animals; Azoxymethane; Carcinogenesis; Colon; Colorectal Neoplasms; Disease Models, Animal; Female; Glycyrrhizic Acid; HMGB1 Protein; Inflammation; Interleukin-6; Mice; Mice, Inbred ICR; NF-kappa B; Signal Transduction; Tumor Necrosis Factor-alpha

2021
HMGB1 Promotes the Release of Sonic Hedgehog From Astrocytes.
    Frontiers in immunology, 2021, Volume: 12

    Topics: Animals; Anti-Inflammatory Agents; Astrocytes; Cells, Cultured; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Glycyrrhizic Acid; Hedgehog Proteins; HMGB1 Protein; Mice, Inbred C57BL; Mice, Knockout; Multiple Sclerosis; Receptor for Advanced Glycation End Products; Recombinant Proteins; Signal Transduction

2021
Defective apoptotic cell contractility provokes sterile inflammation, leading to liver damage and tumour suppression.
    eLife, 2021, 04-19, Volume: 10

    Topics: Animals; Apoptosis; Carcinoma, Hepatocellular; Caspases; Cell Shape; Chemical and Drug Induced Liver Injury; Diethylnitrosamine; Disease Models, Animal; Enzyme Activation; Glycyrrhizic Acid; HEK293 Cells; HMGB1 Protein; Humans; Liver; Liver Neoplasms; Male; Mice, Inbred C57BL; Mice, Inbred ICR; Mice, Transgenic; Mutation; Myosin Light Chains; Neutrophil Infiltration; Phosphorylation; rho-Associated Kinases; Sulfonamides; Toll-Like Receptor 4

2021
A comprehensive strategy to clarify the pharmacodynamic constituents and mechanism of Wu-tou decoction based on the constituents migrating to blood and their in vivo process under pathological state.
    Journal of ethnopharmacology, 2021, Jul-15, Volume: 275

    Topics: Administration, Oral; Animals; Antirheumatic Agents; Arthritis, Experimental; Chromatography, High Pressure Liquid; Cyclooxygenase 2; Disease Models, Animal; Drugs, Chinese Herbal; Glycyrrhizic Acid; Inflammation; Lipopolysaccharides; Male; Mass Spectrometry; Medicine, Chinese Traditional; Metabolic Networks and Pathways; Mice; Rats, Sprague-Dawley; RAW 264.7 Cells; Tissue Distribution; Tumor Necrosis Factor-alpha

2021
Glycyrrhizin improves the pathogenesis of psoriasis partially through IL-17A and the SIRT1-STAT3 axis.
    BMC immunology, 2021, 05-27, Volume: 22, Issue:1

    Topics: Adult; Animals; Anti-Inflammatory Agents; Carbazoles; Disease Models, Animal; Female; Glycyrrhiza; Glycyrrhizic Acid; HaCaT Cells; Humans; Imiquimod; Interleukin-17; Mice; Psoriasis; RNA, Small Interfering; Sirtuin 1; Skin; STAT3 Transcription Factor

2021
Glycyrrhizin Attenuates Portal Hypertension and Collateral Shunting via Inhibition of Extrahepatic Angiogenesis in Cirrhotic Rats.
    International journal of molecular sciences, 2021, Jul-17, Volume: 22, Issue:14

    Topics: Animals; Anti-Inflammatory Agents; Collateral Circulation; Disease Models, Animal; Glycyrrhizic Acid; Hypertension, Portal; Liver Cirrhosis, Experimental; Male; Neovascularization, Pathologic; Rats; Rats, Sprague-Dawley; Signal Transduction; Splanchnic Circulation; Vascular Endothelial Growth Factor Receptor-2

2021
Glycyrrhizin, a Direct HMGB1 Antagonist, Ameliorates Inflammatory Infiltration in a Model of Autoimmune Thyroiditis via Inhibition of TLR2-HMGB1 Signaling.
    Thyroid : official journal of the American Thyroid Association, 2017, Volume: 27, Issue:5

    Topics: Animals; Anti-Inflammatory Agents; Cytokines; Disease Models, Animal; Glycyrrhizic Acid; HMGB1 Protein; Inflammation; Male; Mice; Myeloid Differentiation Factor 88; Signal Transduction; Sodium Iodide; T-Lymphocytes, Regulatory; Thyroid Gland; Thyroiditis, Autoimmune; Toll-Like Receptor 2

2017
Glycyrrhizic acid exerts anti-inflammatory effect to improve cerebral vasospasm secondary to subarachnoid hemorrhage in a rat model.
    Neurological research, 2017, Volume: 39, Issue:8

    Topics: Animals; Anti-Inflammatory Agents; Disease Models, Animal; Glycyrrhizic Acid; Male; Random Allocation; Rats; Rats, Sprague-Dawley; Subarachnoid Hemorrhage; Vasospasm, Intracranial

2017
Inhibition of HMGB1 protects the retina from ischemia-reperfusion, as well as reduces insulin resistance proteins.
    PloS one, 2017, Volume: 12, Issue:5

    Topics: Animals; Cells, Cultured; Disease Models, Animal; Drosophila Proteins; Drug Evaluation, Preclinical; GATA Transcription Factors; Glucose; Glycyrrhizic Acid; HMGB1 Protein; Humans; Insulin Resistance; Male; Mice, Inbred C57BL; Neuroprotection; Neuroprotective Agents; Proto-Oncogene Proteins c-akt; Reperfusion Injury; Retina; Retinal Diseases; Tumor Necrosis Factor-alpha

2017
HMGB1 promotes neurovascular remodeling via Rage in the late phase of subarachnoid hemorrhage.
    Brain research, 2017, Sep-01, Volume: 1670

    Topics: Animals; Benzamides; Brain; Brain Injuries; Cerebral Cortex; Disease Models, Animal; Doublecortin Protein; Glycyrrhizic Acid; HMGB1 Protein; Male; Neurons; Pyruvates; Rats; Rats, Sprague-Dawley; Receptor for Advanced Glycation End Products; Recombinant Proteins; Signal Transduction; Subarachnoid Hemorrhage; Vascular Remodeling

2017
The mTOR inhibition in concurrence with ERK1/2 activation is involved in excessive autophagy induced by glycyrrhizin in hepatocellular carcinoma.
    Cancer medicine, 2017, Volume: 6, Issue:8

    Topics: Animals; Autophagy; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Disease Models, Animal; Female; Glycyrrhizic Acid; Humans; Liver Neoplasms; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Proto-Oncogene Proteins c-akt; TOR Serine-Threonine Kinases; Xenograft Model Antitumor Assays

2017
Glycyrrhizic acid ameliorates the kynurenine pathway in association with its antidepressant effect.
    Behavioural brain research, 2018, 11-01, Volume: 353

    Topics: Animals; Antidepressive Agents; Depressive Disorder; Disease Models, Animal; Glycyrrhizic Acid; HMGB1 Protein; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Male; Mice, Inbred BALB C; Random Allocation; Stress, Psychological; Tissue Culture Techniques; Tryptophan

2018
Inhibiting High Mobility Group Box-1 Reduces Early Spinal Cord Edema and Attenuates Astrocyte Activation and Aquaporin-4 Expression after Spinal Cord Injury in Rats.
    Journal of neurotrauma, 2019, 02-01, Volume: 36, Issue:3

    Topics: Animals; Aquaporin 4; Astrocytes; Disease Models, Animal; Edema; Female; Glial Fibrillary Acidic Protein; Glycyrrhizic Acid; HMGB1 Protein; Laminectomy; NF-kappa B; Pyruvates; Rats; Rats, Sprague-Dawley; Spinal Cord; Spinal Cord Injuries

2019
Targeting HMGB1 ameliorates cardiac fibrosis through restoring TLR2-mediated autophagy suppression in myocardial fibroblasts.
    International journal of cardiology, 2018, Sep-15, Volume: 267

    Topics: Animals; Anti-Inflammatory Agents; Autophagy; Disease Models, Animal; Fibroblasts; Fibrosis; Glycyrrhizic Acid; Heart Diseases; HMGB1 Protein; Mice; Myocardium; Signal Transduction; Toll-Like Receptor 2

2018
Protective Effect of Glycyrrhizic Acid on Alcoholic Liver Injury in Rats by Modulating Lipid Metabolism.
    Molecules (Basel, Switzerland), 2018, 07-04, Volume: 23, Issue:7

    Topics: Acetyl-CoA Carboxylase; Alanine Transaminase; Animals; Disease Models, Animal; Gene Expression Regulation; Glycyrrhizic Acid; Lipid Metabolism; Liver Diseases, Alcoholic; Molecular Structure; Oxidative Stress; Rats; Rats, Sprague-Dawley; Sterol Regulatory Element Binding Protein 1; Superoxide Dismutase

2018
Protease activated-receptor 4 activation as a model of persistent bladder pain: Essential role of macrophage migration inhibitory factor and high mobility group box 1.
    International journal of urology : official journal of the Japanese Urological Association, 2018, Volume: 25, Issue:10

    Topics: Administration, Intravesical; Animals; Disease Models, Animal; Female; Glycyrrhizic Acid; HMGB1 Protein; Humans; Intramolecular Oxidoreductases; Macrophage Migration-Inhibitory Factors; Mice; Mice, Inbred C57BL; Pelvic Pain; Receptors, Thrombin; Urinary Bladder

2018
Glycyrrhizin inactivates toll-like receptor (TLR) signaling pathway to reduce lipopolysaccharide-induced acute lung injury by inhibiting TLR2.
    Journal of cellular physiology, 2019, Volume: 234, Issue:4

    Topics: Acute Lung Injury; Animals; Cytokines; Disease Models, Animal; Gene Expression Regulation; Gene Regulatory Networks; Glycyrrhizic Acid; Humans; Inflammation Mediators; Lipopolysaccharides; Lung; Male; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Nude; NF-kappa B; Protein Interaction Maps; Signal Transduction; Toll-Like Receptor 2

2019
Glycyrrhizin, an HMGB1 inhibitor, exhibits neuroprotective effects in rats after lithium-pilocarpine-induced status epilepticus.
    The Journal of pharmacy and pharmacology, 2019, Volume: 71, Issue:3

    Topics: Animals; Apoptosis; Blood-Brain Barrier; Disease Models, Animal; Glycyrrhizic Acid; Hippocampus; HMGB1 Protein; Lithium; Male; Neurons; Neuroprotective Agents; Pilocarpine; Rats; Rats, Sprague-Dawley; Status Epilepticus

2019
Glycyrrhizin Attenuates
    Frontiers in immunology, 2018, Volume: 9

    Topics: Animals; Antigen Presentation; Cytokines; Cytotoxicity, Immunologic; Dendritic Cells; Disease Models, Animal; Female; Gastrointestinal Microbiome; Gene Expression Regulation, Bacterial; Glycyrrhizic Acid; Host-Pathogen Interactions; Inflammation Mediators; Intestinal Mucosa; Mice; Mitogen-Activated Protein Kinases; NF-kappa B; Salmonella Infections; Salmonella typhimurium; Signal Transduction; Virulence

2018
Inhibition of HMGB1 improves necrotizing enterocolitis by inhibiting NLRP3 via TLR4 and NF-κB signaling pathways.
    Journal of cellular physiology, 2019, Volume: 234, Issue:8

    Topics: Animals; Animals, Newborn; Anti-Inflammatory Agents; Cell Line; Disease Models, Animal; Enterocolitis, Necrotizing; Glycyrrhizic Acid; HMGB1 Protein; HT29 Cells; Humans; Mice; Mice, Inbred C57BL; NF-kappa B; NLR Family, Pyrin Domain-Containing 3 Protein; Rats; Rats, Sprague-Dawley; RNA, Messenger; Signal Transduction; Toll-Like Receptor 4; Up-Regulation

2019
Effects of supramolecular complexation of praziquantel with disodium glycyrrhizinate on the liver fluke Opisthorchis felineus: An in vitro and in vivo study.
    Acta tropica, 2019, Volume: 194

    Topics: Animals; Anthelmintics; Cricetinae; Disease Models, Animal; Glycyrrhizic Acid; Male; Mesocricetus; Opisthorchiasis; Opisthorchis; Praziquantel

2019
Glycyrrhizin administration ameliorates Streptococcus aureus-induced acute lung injury.
    International immunopharmacology, 2019, Volume: 70

    Topics: A549 Cells; Acute Lung Injury; Animals; Anti-Inflammatory Agents; Cytokines; Disease Models, Animal; Female; Glycyrrhizic Acid; Humans; Inflammation Mediators; Macrophages; Medicine, Chinese Traditional; Mice; Mice, Inbred C57BL; Neutrophil Infiltration; NF-kappa B; Pyroptosis; Signal Transduction; Streptococcal Infections; Streptococcus

2019
Dual regulatory roles of HMGB1 in inflammatory reaction of chondrocyte cells and mice.
    Cell cycle (Georgetown, Tex.), 2019, Volume: 18, Issue:18

    Topics: Animals; Apoptosis; Autophagy; Cells, Cultured; Chondrocytes; Cytosol; Disease Models, Animal; Glycyrrhizic Acid; HMGB1 Protein; Inflammation; Iodoacetic Acid; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Osteoarthritis; Time Factors; Transfection

2019
Piper sarmentosum is comparable to glycyrrhizic acid in reducing visceral fat deposition in adrenalectomised rats given dexamethasone.
    La Clinica terapeutica, 2013, Volume: 164, Issue:1

    Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; Adrenalectomy; Animals; Anti-Obesity Agents; Disease Models, Animal; Glycyrrhizic Acid; Intra-Abdominal Fat; Male; Obesity; Phytotherapy; Piper; Plant Extracts; Rats; Rats, Sprague-Dawley; Treatment Outcome

2013
Glycyrrhizin ameliorates insulin resistance, hyperglycemia, dyslipidemia and oxidative stress in fructose-induced metabolic syndrome-X in rat model.
    Indian journal of experimental biology, 2013, Volume: 51, Issue:2

    Topics: Animals; Biomarkers; Blood Glucose; Body Weight; Diet; Disease Models, Animal; DNA Damage; Dyslipidemias; Free Radical Scavengers; Fructose; Glucose Transporter Type 4; Glycyrrhizic Acid; Hemoglobins; Hyperglycemia; Insulin; Insulin Resistance; Lipids; Lymphocytes; Male; Metabolic Syndrome; Muscles; Oxidative Stress; PPAR gamma; Rats; Rats, Wistar; Tissue Extracts

2013
Rikkunshito ameliorates bleomycin-induced acute lung injury in a ghrelin-independent manner.
    American journal of physiology. Lung cellular and molecular physiology, 2014, Volume: 306, Issue:3

    Topics: Acute Lung Injury; Animals; Anti-Inflammatory Agents; Apoptosis; Bleomycin; Disease Models, Animal; Drugs, Chinese Herbal; Eating; Epithelial Cells; Ghrelin; Glycyrrhizic Acid; Hesperidin; Male; Mice; Mice, Inbred C57BL; Neutrophil Infiltration; NF-kappa B; Pulmonary Alveoli; Pulmonary Fibrosis; Signal Transduction

2014
Glycyrrhizin alleviates neuroinflammation and memory deficit induced by systemic lipopolysaccharide treatment in mice.
    Molecules (Basel, Switzerland), 2013, Dec-17, Volume: 18, Issue:12

    Topics: Animals; Brain; Cyclooxygenase 2; Cytokines; Disease Models, Animal; Encephalitis; Gene Expression Regulation; Glycyrrhizic Acid; Learning; Lipopolysaccharides; Male; Memory Disorders; Mice; Microglia; Nitric Oxide Synthase Type II

2013
Glycyrrhizin attenuates tissue injury and reduces neutrophil accumulation in experimental acute pancreatitis.
    International journal of clinical and experimental pathology, 2014, Volume: 7, Issue:1

    Topics: Animals; Anti-Inflammatory Agents; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Glycyrrhizic Acid; Male; Mice; Mice, Inbred C57BL; Neutrophil Infiltration; Pancreatitis

2014
Glycyrrhizin inhibits the inflammatory response in mouse mammary epithelial cells and a mouse mastitis model.
    The FEBS journal, 2014, Volume: 281, Issue:11

    Topics: Animals; Cell Survival; Disease Models, Animal; Epithelial Cells; Glycyrrhizic Acid; Interleukin-1beta; Interleukin-6; Mammary Glands, Animal; Mastitis; Mice; NF-kappa B; Peroxidase; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha

2014
Glycyrrhizin inhibits traumatic brain injury by reducing HMGB1-RAGE interaction.
    Neuropharmacology, 2014, Volume: 85

    Topics: Animals; Blood-Brain Barrier; Brain; Brain Edema; Brain Injuries; Capillary Permeability; Cognition; Disease Models, Animal; Dose-Response Relationship, Drug; Glycyrrhizic Acid; HMGB1 Protein; Male; Mice, Knockout; Motor Activity; Neuroprotective Agents; Random Allocation; Rats, Wistar; Receptor for Advanced Glycation End Products; Receptors, Immunologic

2014
Glycyrrhizin suppresses HMGB1 inductions in the hippocampus and subsequent accumulation in serum of a kainic acid-induced seizure mouse model.
    Cellular and molecular neurobiology, 2014, Volume: 34, Issue:7

    Topics: Animals; Astrocytes; CA1 Region, Hippocampal; CA3 Region, Hippocampal; Disease Models, Animal; Endothelial Cells; Glycyrrhizic Acid; Hippocampus; HMGB1 Protein; Kainic Acid; Male; Mice, Inbred BALB C; Neuroglia; Neurons; Protein Transport; Seizures

2014
Glycyrrhizin protects brain against ischemia-reperfusion injury in mice through HMGB1-TLR4-IL-17A signaling pathway.
    Brain research, 2014, Sep-25, Volume: 1582

    Topics: Animals; Apoptosis; Brain; Brain Ischemia; Disease Models, Animal; Glycyrrhizic Acid; HMGB1 Protein; Infarction, Middle Cerebral Artery; Interleukin-17; Male; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Knockout; Neurons; Neuroprotective Agents; Random Allocation; Reperfusion Injury; Signal Transduction; Toll-Like Receptor 4

2014
Glycyrrhizin attenuates Toll like receptor-2, -4 and experimental vasospasm in a rat model.
    Journal of immunology research, 2014, Volume: 2014

    Topics: Animals; Anti-Inflammatory Agents; Basilar Artery; Chemokine CCL2; Cytokines; Disease Models, Animal; Gene Expression; Glycyrrhizic Acid; Male; Rats; Subarachnoid Hemorrhage; Toll-Like Receptor 2; Toll-Like Receptor 3; Toll-Like Receptor 4; Vasospasm, Intracranial

2014
Glycyrrhizin, inhibitor of high mobility group box-1, attenuates monocrotaline-induced pulmonary hypertension and vascular remodeling in rats.
    Respiratory research, 2014, Nov-25, Volume: 15

    Topics: Animals; Antihypertensive Agents; Arterial Pressure; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelin-1; Glycyrrhizic Acid; HMGB1 Protein; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Muscle, Smooth, Vascular; Pneumonia; Pulmonary Artery; Rats, Sprague-Dawley; Time Factors; Vascular Remodeling; Ventricular Dysfunction, Right; Ventricular Function, Right

2014
Anti-inflammative effect of glycyrrhizin on rat thermal injury via inhibition of high-mobility group box 1 protein.
    Burns : journal of the International Society for Burn Injuries, 2015, Volume: 41, Issue:2

    Topics: Actins; Animals; Anti-Inflammatory Agents; Blotting, Western; Burns; Disease Models, Animal; Glycyrrhizic Acid; HMGB1 Protein; Inflammation; Injections, Intraperitoneal; Interleukin-1beta; Kidney; Liver; Lung; Male; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; RNA, Messenger; Tumor Necrosis Factor-alpha

2015
Co-administration of glycyrrhizic acid with the antileishmanial drug sodium antimony gluconate (SAG) cures SAG-resistant visceral leishmaniasis.
    International journal of antimicrobial agents, 2015, Volume: 45, Issue:3

    Topics: Animals; Antimony Sodium Gluconate; Antiprotozoal Agents; Biological Transport, Active; Disease Models, Animal; Drug Resistance; Drug Therapy, Combination; Enzyme Inhibitors; Glycyrrhizic Acid; Leishmania; Leishmaniasis, Visceral; Liver; Mice, Inbred BALB C; Parasite Load; Spleen; Treatment Outcome

2015
[Therapeutic effects of glycyrrhizic acid on asthma airway inflammation in mice and its mechanism].
    Zhonghua yi xue za zhi, 2014, Nov-18, Volume: 94, Issue:42

    Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Eosinophils; Female; Glycyrrhizic Acid; Inflammation; Interferon-gamma; Interleukin-10; Interleukin-4; Mice; Mice, Inbred BALB C; Ovalbumin

2014
PGE2 receptor agonist misoprostol protects brain against intracerebral hemorrhage in mice.
    Neurobiology of aging, 2015, Volume: 36, Issue:3

    Topics: Animals; Cerebral Hemorrhage; Disease Models, Animal; Fibroblast Growth Factor 1; Gene Expression; Glycyrrhizic Acid; Inflammation; Interleukin-1beta; Male; Matrix Metalloproteinase 2; Mice, Inbred C57BL; Misoprostol; Neuroprotective Agents; Receptors, Prostaglandin E; src-Family Kinases

2015
The Neuroprotective Effect of Glycyrrhizic Acid on an Experimental Model of Focal Cerebral Ischemia in Rats.
    Inflammation, 2015, Volume: 38, Issue:4

    Topics: Animals; Anti-Inflammatory Agents; Brain Ischemia; Disease Models, Animal; Glycyrrhizic Acid; Male; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Treatment Outcome

2015
Coronary endothelial dysfunction induced by nucleotide oligomerization domain-like receptor protein with pyrin domain containing 3 inflammasome activation during hypercholesterolemia: beyond inflammation.
    Antioxidants & redox signaling, 2015, May-01, Volume: 22, Issue:13

    Topics: Acetylcholine; Animals; Bradykinin; Carrier Proteins; Caspase 1; Cholesterol; Coronary Vessels; Cytoskeletal Proteins; Disease Models, Animal; Endothelial Cells; Glycyrrhizic Acid; HMGB1 Protein; Hypercholesterolemia; Inflammasomes; Inflammation; Male; Mice, Inbred C57BL; Nitric Oxide; NLR Family, Pyrin Domain-Containing 3 Protein; Nucleotides; Poloxamer; Pyrin; Pyroptosis; Reactive Oxygen Species; Receptors, Cell Surface; Serpins; Superoxides; Vasodilation; Viral Proteins

2015
High-mobility group box-1 was released actively and involved in LPS induced depressive-like behavior.
    Journal of psychiatric research, 2015, Volume: 64

    Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents; Cytokines; Depression; Disease Models, Animal; Glycyrrhizic Acid; Hindlimb Suspension; HMGB1 Protein; Humans; Lipopolysaccharides; Male; Mice; Mice, Inbred BALB C; Time Factors

2015
Observing Anti-inflammatory and Anti-nociceptive Activities of Glycyrrhizin Through Regulating COX-2 and Pro-inflammatory Cytokines Expressions in Mice.
    Inflammation, 2015, Volume: 38, Issue:6

    Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Capillary Permeability; Carrageenan; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Edema; Formaldehyde; Glycyrrhizic Acid; Indomethacin; Inflammation; Inflammation Mediators; Male; Mice, Inbred ICR; Motor Activity; Nitric Oxide Synthase Type II; Nociceptive Pain; Pain Threshold; Psychomotor Performance; Time Factors; Xylenes

2015
Anti-Inflammatory activities of licorice extract and its active compounds, glycyrrhizic acid, liquiritin and liquiritigenin, in BV2 cells and mice liver.
    Molecules (Basel, Switzerland), 2015, Jul-20, Volume: 20, Issue:7

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Cell Line; Disease Models, Animal; Flavanones; Glucosides; Glycyrrhiza; Glycyrrhizic Acid; Inflammation; Inflammation Mediators; Liver; Male; Mice; Mice, Inbred ICR; Nitric Oxide; Oxidative Stress; Plant Extracts; Tumor Necrosis Factor-alpha

2015
Dipotassium glycyrrhizate via HMGB1 or AMPK signaling suppresses oxidative stress during intestinal inflammation.
    Biochemical pharmacology, 2015, Oct-01, Volume: 97, Issue:3

    Topics: AMP-Activated Protein Kinases; Animals; Cell Line; Colitis; Cyclooxygenase 2; Disease Models, Animal; Female; Glycyrrhizic Acid; HMGB1 Protein; Intestinal Mucosa; Lipopolysaccharides; Macrophages; Mice, Inbred C57BL; Nitric Oxide Synthase Type II; Oxidative Stress; Signal Transduction

2015
Regulation of Th1/Th2 balance through OX40/OX40L signalling by glycyrrhizic acid in a murine model of asthma.
    Respirology (Carlton, Vic.), 2016, Volume: 21, Issue:1

    Topics: Animals; Anti-Inflammatory Agents; Asthma; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Glycyrrhizic Acid; Immunoglobulin E; Interleukin-13; Interleukin-4; Lung; Mice; Mice, Inbred BALB C; Ovalbumin; OX40 Ligand; p38 Mitogen-Activated Protein Kinases; Signal Transduction

2016
Glycyrrhizin attenuates isoflurane-induced cognitive deficits in neonatal rats via its anti-inflammatory activity.
    Neuroscience, 2016, Mar-01, Volume: 316

    Topics: Anesthetics; Animals; Animals, Newborn; Anti-Inflammatory Agents; Apoptosis; Cognition Disorders; Disease Models, Animal; Female; Gene Expression Regulation, Developmental; Glycyrrhizic Acid; Hippocampus; Isoflurane; Male; Maze Learning; Memory Disorders; Rats; Rats, Sprague-Dawley; Signal Transduction; Time Factors; Transcription Factor RelA

2016
HMGB1 Promotes Mitochondrial Dysfunction-Triggered Striatal Neurodegeneration via Autophagy and Apoptosis Activation.
    PloS one, 2015, Volume: 10, Issue:11

    Topics: Animals; Apoptosis; Autophagy; Caspase 3; Cell Proliferation; Cells, Cultured; Corpus Striatum; Disease Models, Animal; Glycyrrhizic Acid; Heat-Shock Proteins; HMGB1 Protein; Lentivirus; MAP Kinase Kinase 4; Mitochondria; Neurodegenerative Diseases; Neurons; Nitro Compounds; Oxidative Stress; Propionates; Rats; Rats, Sprague-Dawley; RNA, Small Interfering; Sequestosome-1 Protein; Signal Transduction

2015
[Antiviral effects of the combination of glycyrrhizin and ribavirin against influenza A H1N1 virus infection in vivo].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2015, Volume: 50, Issue:8

    Topics: Animals; Antiviral Agents; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Glycyrrhizic Acid; Inflammation; Influenza A Virus, H1N1 Subtype; Interleukin-1beta; Interleukin-6; Lung; Mice; Orthomyxoviridae Infections; Pneumonia, Viral; Ribavirin; Tumor Necrosis Factor-alpha

2015
In-vivo evidence that high mobility group box 1 exerts deleterious effects in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model and Parkinson's disease which can be attenuated by glycyrrhizin.
    Neurobiology of disease, 2016, Volume: 91

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Aged; Aged, 80 and over; Animals; Cell Death; Disease Models, Animal; Dopaminergic Neurons; Female; Glycyrrhizic Acid; HMGB1 Protein; Humans; Male; Mice, Inbred C57BL; Microglia; Middle Aged; Neuroprotective Agents; Parkinson Disease; Tumor Necrosis Factor-alpha

2016
High mobility group box1 protein is involved in acute inflammation induced by Clostridium difficile toxin A.
    Acta biochimica et biophysica Sinica, 2016, Volume: 48, Issue:6

    Topics: Animals; Anti-Inflammatory Agents; Bacterial Toxins; Cell Line; Disease Models, Animal; Enterocolitis, Pseudomembranous; Enterotoxins; Female; Glycyrrhizic Acid; HMGB1 Protein; Humans; Inflammation; Inflammation Mediators; Mice; RAW 264.7 Cells; Toll-Like Receptor 4

2016
Glycyrrhizic Acid Ameliorates Cognitive Impairment in a Rat Model of Vascular Dementia Associated with Oxidative Damage and Inhibition of Voltage-Gated Sodium Channels.
    CNS & neurological disorders drug targets, 2016, Volume: 15, Issue:8

    Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents; Brain Ischemia; Cognition Disorders; Dementia, Vascular; Disease Models, Animal; Electric Stimulation; Glycyrrhizic Acid; Hippocampus; In Vitro Techniques; Lipid Peroxidation; Long-Term Potentiation; Male; Malondialdehyde; Maze Learning; Oxidative Stress; Patch-Clamp Techniques; Rats; Rats, Wistar; Superoxide Dismutase; Voltage-Gated Sodium Channels

2016
Oxidative Inactivation of Liver Mitochondria in High Fructose Diet-Induced Metabolic Syndrome in Rats: Effect of Glycyrrhizin Treatment.
    Phytotherapy research : PTR, 2016, Volume: 30, Issue:9

    Topics: Animals; Diet; Disease Models, Animal; Fructose; Glycyrrhizic Acid; Male; Metabolic Syndrome; Mitochondria, Liver; Oxidative Stress; Rats; Rats, Wistar

2016
HMGB1 regulates IL-33 expression in acute respiratory distress syndrome.
    International immunopharmacology, 2016, Volume: 38

    Topics: Animals; Disease Models, Animal; Glycyrrhizic Acid; HMGB1 Protein; Humans; Interleukin-33; Lipopolysaccharides; Lung; Male; Mice; Mice, Inbred C57BL; Respiratory Distress Syndrome; Th1 Cells; Up-Regulation

2016
Glycyrrhizin ameliorates oxidative stress and inflammation in hippocampus and olfactory bulb in lithium/pilocarpine-induced status epilepticus in rats.
    Epilepsy research, 2016, Volume: 126

    Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Disease Models, Animal; Fluorometry; Glycyrrhizic Acid; Hippocampus; Inflammation; Lithium Compounds; Male; Olfactory Bulb; Oxidative Stress; Pilocarpine; Rats, Wistar; Status Epilepticus; Stereoisomerism

2016
Glycyrrhizin protects against focal cerebral ischemia via inhibition of T cell activity and HMGB1-mediated mechanisms.
    Journal of neuroinflammation, 2016, 09-08, Volume: 13, Issue:1

    Topics: Animals; Anti-Inflammatory Agents; Brain; Brain Infarction; Brain Ischemia; Cell Proliferation; Concanavalin A; Cytokines; Disease Models, Animal; Gene Expression Regulation; Glycyrrhizic Acid; HMGB1 Protein; Mice; Mice, Inbred C57BL; Mice, SCID; Phosphopyruvate Hydratase; Rats; Rats, Nude; Rats, Sprague-Dawley; T-Lymphocytes

2016
Blockade of high mobility group box 1 augments antitumor T-cell response induced by peptide vaccination as a co-adjuvant.
    Cancer science, 2016, Volume: 107, Issue:12

    Topics: Adjuvants, Immunologic; Animals; Antigens; Cancer Vaccines; Cell Line, Tumor; Disease Models, Animal; Female; Gene Expression Regulation, Neoplastic; Glycyrrhizic Acid; HMGB1 Protein; Humans; Immunization; Lymphocyte Activation; Mice; Neoplasms; T-Lymphocyte Subsets; T-Lymphocytes; Vaccines, Subunit

2016
Glycyrrhizin Ameliorates Fibrosis, Vasculopathy, and Inflammation in Animal Models of Systemic Sclerosis.
    The Journal of investigative dermatology, 2017, Volume: 137, Issue:3

    Topics: Animals; Bleomycin; Disease Models, Animal; Fibroblasts; Fibrosis; Glycyrrhizic Acid; Humans; Inflammation; Mice; Mice, Inbred C57BL; Mice, Knockout; Phenotype; Scleroderma, Systemic; Skin; Th2 Cells; Transforming Growth Factor beta; Vascular Diseases

2017
Glycyrrhizin Reduces HMGB1 and Bacterial Load in Pseudomonas aeruginosa Keratitis.
    Investigative ophthalmology & visual science, 2016, Oct-01, Volume: 57, Issue:13

    Topics: Animals; Anti-Inflammatory Agents; Bacterial Load; Cornea; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Eye Infections, Bacterial; Female; Gene Expression Regulation; Glycyrrhizic Acid; HMGB1 Protein; Keratitis; Mice; Mice, Inbred C57BL; Pseudomonas aeruginosa; Pseudomonas Infections; Real-Time Polymerase Chain Reaction; RNA, Messenger

2016
Involvement of high mobility group box-1 in imiquimod-induced psoriasis-like mice model.
    The Journal of dermatology, 2017, Volume: 44, Issue:5

    Topics: Aminoquinolines; Animals; Anti-Inflammatory Agents; Cytokines; Disease Models, Animal; Drug Evaluation, Preclinical; Glycyrrhizic Acid; HMGB1 Protein; Imiquimod; Phytotherapy; Plant Extracts; Psoriasis

2017
Study of cholesterol-lowering effect and safety of simvaglisin on rabbit model of hypercholesterolemia.
    Bulletin of experimental biology and medicine, 2008, Volume: 145, Issue:3

    Topics: Animals; Anticholesteremic Agents; Cholesterol; Creatine Kinase; Disease Models, Animal; Glycyrrhizic Acid; Hypercholesterolemia; Male; Rabbits; Simvastatin

2008
Si-Ni-San, a traditional Chinese prescription, and its active ingredient glycyrrhizin ameliorate experimental colitis through regulating cytokine balance.
    International immunopharmacology, 2009, Volume: 9, Issue:12

    Topics: Animals; Body Weight; Colitis; Colon; Crohn Disease; Cytokines; Diarrhea; Disease Models, Animal; Drugs, Chinese Herbal; Female; Glycyrrhizic Acid; Humans; Medicine, Chinese Traditional; Mice; Mice, Inbred C57BL; Peroxidase; Trinitrobenzenesulfonic Acid

2009
Effects of diammonium glycyrrhizinate on the pharmacokinetics of aconitine in rats and the potential mechanism.
    Xenobiotica; the fate of foreign compounds in biological systems, 2009, Volume: 39, Issue:12

    Topics: Aconitine; Administration, Oral; Animals; Biological Transport; Cyclosporine; Disease Models, Animal; Enzyme Inhibitors; Glycyrrhizic Acid; Intestinal Absorption; Male; Membrane Transport Proteins; Nitrophenols; Rats; Rats, Sprague-Dawley; Time Factors; Verapamil

2009
[Therapeutic effects of compound glycyrrhizin liposome on fibrosis of the rats with nonalcoholic steatohepatitis].
    Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology, 2009, Volume: 17, Issue:11

    Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents; Aspartate Aminotransferases; Dietary Fats; Disease Models, Animal; Drugs, Chinese Herbal; Fatty Liver; Glycyrrhizic Acid; Injections; Liposomes; Liver; Liver Cirrhosis; Male; Phenanthrolines; Random Allocation; Rats; Rats, Sprague-Dawley; Salvia miltiorrhiza; Treatment Outcome

2009
Glycyrrhizin attenuates mucus production by inhibition of MUC5AC mRNA expression in vivo and in vitro.
    Journal of pharmacological sciences, 2010, Volume: 113, Issue:1

    Topics: Animals; Cell Line; Disease Models, Animal; Dose-Response Relationship, Drug; Gene Expression Regulation; Glycyrrhizic Acid; Goblet Cells; Hyperplasia; Interleukin-4; Lipopolysaccharides; Lung Diseases, Obstructive; Male; Mice; Mice, Inbred ICR; Mucin 5AC; Mucus; Promoter Regions, Genetic; Transforming Growth Factor alpha

2010
[Preparation and pharmacodynamic evaluation of diammonium glycyrrhizinate-loaded chitosan nanoparticles].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2010, Volume: 35, Issue:16

    Topics: Animals; Chitosan; Colitis, Ulcerative; Dextran Sulfate; Disease Models, Animal; Female; Glycyrrhizic Acid; Male; Mice; Nanoparticles

2010
Protective effects of glycyrrhizic acid by rectal treatment on a TNBS-induced rat colitis model.
    The Journal of pharmacy and pharmacology, 2011, Volume: 63, Issue:3

    Topics: Administration, Oral; Administration, Rectal; Animals; Anti-Inflammatory Agents; Colitis; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Female; Glycyrrhizic Acid; Interleukin-10; Interleukin-6; Macrophages; Mice; Mice, Inbred BALB C; Rats; Rats, Wistar; Spleen; Trinitrobenzenesulfonic Acid

2011
Susceptibility of glucocorticoids to colonic metabolism and pharmacologic intervention in the metabolism: implication for therapeutic activity of colon-specific glucocorticoid 21-sulfate sodium at the target site.
    The Journal of pharmacy and pharmacology, 2012, Volume: 64, Issue:1

    Topics: Animals; Carbenoxolone; Chromatography, High Pressure Liquid; Colon; Disease Models, Animal; Drug Delivery Systems; Glucocorticoids; Glycyrrhizic Acid; Intestinal Absorption; Male; Rats; Rats, Sprague-Dawley

2012
The use of albendazole and diammonium glycyrrhizinate in the treatment of eosinophilic meningitis in mice infected with Angiostrongylus cantonensis.
    Journal of helminthology, 2013, Volume: 87, Issue:1

    Topics: Albendazole; Angiostrongylus cantonensis; Animals; Anthelmintics; Body Weight; Dexamethasone; Disease Models, Animal; Eosinophilia; Female; Glycyrrhizic Acid; Humans; Immunoglobulin E; Leukocyte Count; Meningitis; Mice; Mice, Inbred BALB C; Strongylida Infections; Survival Analysis; T-Lymphocytes, Regulatory; Treatment Outcome

2013
Diammonium glycyrrhizinate upregulates PGC-1α and protects against Aβ1-42-induced neurotoxicity.
    PloS one, 2012, Volume: 7, Issue:4

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Apoptosis; Caspase 3; Caspase 9; Cells, Cultured; Disease Models, Animal; Glycyrrhizic Acid; Membrane Potential, Mitochondrial; Mice; Mitochondria; Neurons; Neuroprotective Agents; Peptide Fragments; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Reactive Oxygen Species; RNA Interference; RNA, Small Interfering; Trans-Activators; Transcription Factors; Up-Regulation

2012
Improvement of oral bioavailability of glycyrrhizin by sodium deoxycholate/phospholipid-mixed nanomicelles.
    Journal of drug targeting, 2012, Volume: 20, Issue:7

    Topics: Administration, Oral; Alanine Transaminase; Animals; Anti-Inflammatory Agents; Aspartate Aminotransferases; Biological Availability; Biphenyl Compounds; Carbon Tetrachloride; Deoxycholic Acid; Disease Models, Animal; Drug Stability; Glycyrrhizic Acid; Liver; Male; Micelles; Nanoconjugates; Particle Size; Phospholipids; Rats; Rats, Wistar; Surface Properties

2012
Inhibition of neointimal hyperplasia in the rat carotid artery injury model by a HMGB1 inhibitor.
    Atherosclerosis, 2012, Volume: 224, Issue:2

    Topics: Angiotensin II; Animals; Anti-Inflammatory Agents; Antioxidants; Cardiovascular Agents; Carotid Arteries; Carotid Artery Injuries; Cell Differentiation; Cell Movement; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Glycyrrhizic Acid; HMGB1 Protein; Hyperplasia; Inflammation Mediators; Male; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Neointima; NF-kappa B; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Phenotype; Rats; Rats, Sprague-Dawley; Receptors, Notch; Signal Transduction; Time Factors

2012
Linoleoyl ethanolamide reduces lipopolysaccharide-induced inflammation in macrophages and ameliorates 2,4-dinitrofluorobenzene-induced contact dermatitis in mice.
    European journal of pharmacology, 2013, Jan-15, Volume: 699, Issue:1-3

    Topics: Animals; Anti-Inflammatory Agents; Cell Line; Cytokines; Dermatitis, Contact; Dinitrofluorobenzene; Disease Models, Animal; Female; Glycyrrhizic Acid; Inflammation; Inflammation Mediators; Linoleic Acids; Lipopolysaccharides; Macrophages; Mice; Mice, Inbred BALB C; NF-kappa B; Polyunsaturated Alkamides; Signal Transduction

2013
Glycyrrhizin enhances interleukin-10 production by liver dendritic cells in mice with hepatitis.
    Journal of gastroenterology, 2003, Volume: 38, Issue:10

    Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Concanavalin A; Dendritic Cells; Disease Models, Animal; Dose-Response Relationship, Drug; Genes, MHC Class II; Glycyrrhizic Acid; Hepatitis; Injections, Intraperitoneal; Interleukin-10; Interleukin-12; Liver; Male; Mice; Mice, Inbred C57BL; Phenotype; Sodium Chloride; T-Lymphocytes, Helper-Inducer; Time Factors

2003
Anti-allergic activity of 18beta-glycyrrhetinic acid-3-O-beta-D-glucuronide.
    Archives of pharmacal research, 2004, Volume: 27, Issue:1

    Topics: Administration, Oral; Animals; Anti-Allergic Agents; beta-N-Acetylhexosaminidases; Cell Line; Dermatitis, Contact; Dexamethasone; Disease Models, Animal; Drug Evaluation, Preclinical; Glucuronides; Glycyrrhetinic Acid; Glycyrrhizic Acid; Humans; Injections, Intraperitoneal; Intestines; Male; Mice; Mice, Inbred ICR; Nitrites; Oxazolone; Passive Cutaneous Anaphylaxis; Streptococcus

2004
Azathioprine hepatotoxicity and the protective effect of liquorice and glycyrrhizic acid.
    Phytotherapy research : PTR, 2006, Volume: 20, Issue:8

    Topics: Acetylcysteine; Animals; Azathioprine; Cell Survival; Cells, Cultured; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Glutathione; Glycyrrhiza; Glycyrrhizic Acid; Hepatocytes; Humans; Immunosuppressive Agents; Male; Plant Extracts; Plant Roots; Rats; Rats, Sprague-Dawley; Species Specificity

2006
Carbenoxolone and mefloquine suppress tremor in the harmaline mouse model of essential tremor.
    Movement disorders : official journal of the Movement Disorder Society, 2006, Volume: 21, Issue:10

    Topics: 1-Octanol; Animals; Carbenoxolone; Central Nervous System Stimulants; Cerebellum; Chloroquine; Connexins; Disease Models, Animal; Dose-Response Relationship, Drug; Essential Tremor; Female; Gap Junction delta-2 Protein; Gap Junctions; Glycyrrhizic Acid; Harmaline; Heptanol; Injections, Subcutaneous; Mefloquine; Mice; Mice, Inbred ICR; Olivary Nucleus

2006
Glycyrrhizin alleviates experimental allergic asthma in mice.
    International immunopharmacology, 2006, Volume: 6, Issue:9

    Topics: Allergens; Animals; Anti-Asthmatic Agents; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Disease Models, Animal; Glycyrrhizic Acid; Hydrocortisone; Immunoglobulin E; Male; Mice; Mice, Inbred BALB C; Ovalbumin

2006
Anti-inflammatory effect of Diammonium Glycyrrhizinate in a rat model of ulcerative colitis.
    World journal of gastroenterology, 2006, Jul-28, Volume: 12, Issue:28

    Topics: Acetic Acid; Animals; Anti-Inflammatory Agents; Colitis, Ulcerative; Disease Models, Animal; Female; Gene Expression Regulation; Glycyrrhizic Acid; Intercellular Adhesion Molecule-1; Intestinal Mucosa; NF-kappa B; Peroxidase; Rats; Rats, Sprague-Dawley; Severity of Illness Index; Tumor Necrosis Factor-alpha

2006
Immuno-enhancement effects of Huang Qi Liu Yi Tang in a murine model of cyclophosphamide-induced leucopenia.
    Journal of ethnopharmacology, 2007, Jan-19, Volume: 109, Issue:2

    Topics: Animals; Astragalus Plant; Astragalus propinquus; Cell Proliferation; Cells, Cultured; Chromatography, High Pressure Liquid; Cyclophosphamide; Disease Models, Animal; Dose-Response Relationship, Immunologic; Drugs, Chinese Herbal; Female; Glycyrrhizic Acid; Immunologic Factors; Interleukin-2; Isoflavones; Killer Cells, Natural; Leukopenia; Mice; Mice, Inbred BALB C; Spleen; Taiwan

2007
[Regulatory effect of diammonium glycyrrhizinate on Th1/Th2 deviation in bronchial asthma: experiment with rats].
    Zhonghua yi xue za zhi, 2007, Oct-30, Volume: 87, Issue:40

    Topics: Animals; Asthma; Disease Models, Animal; Glycyrrhizic Acid; Immunoglobulin E; Interferon-gamma; Interleukin-4; Lung; Male; Random Allocation; Rats; Rats, Wistar; Th1 Cells; Th2 Cells

2007
Down-regulation of a hepatic transporter multidrug resistance-associated protein 2 is involved in alteration of pharmacokinetics of glycyrrhizin and its metabolites in a rat model of chronic liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Administration, Oral; Animals; ATP-Binding Cassette Transporters; Chronic Disease; Disease Models, Animal; Down-Regulation; Glycyrrhizic Acid; Immunohistochemistry; Infusions, Intravenous; Liver; Male; Rats; Rats, Wistar

2008
Pharmacokinetics of glycyrrhizin in rats with D-galactosamine-induced hepatic disease.
    Biological & pharmaceutical bulletin, 1996, Volume: 19, Issue:6

    Topics: Administration, Oral; Animals; Antiviral Agents; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Galactosamine; Gastric Emptying; Glycyrrhetinic Acid; Glycyrrhizic Acid; Injections, Intravenous; Intestinal Absorption; Liver Diseases; Male; Rats; Rats, Wistar

1996
Potent antihepatotoxic activity of dicaffeoyl quinic acids from propolis.
    Biological & pharmaceutical bulletin, 1996, Volume: 19, Issue:4

    Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Cells, Cultured; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Glycyrrhetinic Acid; Glycyrrhizic Acid; L-Lactate Dehydrogenase; Liver; Liver Diseases; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Structure; Propolis; Quinic Acid; Rats

1996
Inhibition of hepatocellular carcinoma by glycyrrhizin in diethylnitrosamine-treated mice.
    Carcinogenesis, 1999, Volume: 20, Issue:1

    Topics: Adenoma; Animals; Anticarcinogenic Agents; Body Weight; Diethylnitrosamine; Disease Models, Animal; Drug Screening Assays, Antitumor; Glycyrrhizic Acid; Hepatitis, Chronic; Hepatitis, Viral, Human; Liver; Liver Function Tests; Liver Neoplasms, Experimental; Lung Neoplasms; Male; Mice; Mice, Inbred BALB C; Organ Size

1999
[Therapeutic effects of benzoxazinorifamycin KRM-1648 administered alone or in combination with glycyrrhizin against Mycobacterium avium complex infection in mice].
    Kekkaku : [Tuberculosis], 1999, Volume: 74, Issue:8

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibiotics, Antitubercular; Disease Models, Animal; Drug Interactions; Drug Therapy, Combination; Female; Glycyrrhizic Acid; Macrophages, Peritoneal; Mice; Mice, Inbred BALB C; Mycobacterium avium Complex; Rifamycins; Tuberculosis

1999
Development of anorexia in concanavalin A-induced hepatitis in mice.
    International journal of molecular medicine, 2001, Volume: 7, Issue:2

    Topics: Alanine Transaminase; Animals; Anorexia; Body Weight; Brain; Chemical and Drug Induced Liver Injury; Concanavalin A; Disease Models, Animal; Eating; Female; Glycyrrhizic Acid; Hepatitis, Animal; Interleukin-1; Liver; Mice; Mice, Inbred BALB C; RNA, Messenger; Tumor Necrosis Factor-alpha

2001
Antidiabetic effect of glycyrrhizin in genetically diabetic KK-Ay mice.
    Biological & pharmaceutical bulletin, 2001, Volume: 24, Issue:5

    Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Type 2; Disease Models, Animal; Glycyrrhizic Acid; Hypoglycemic Agents; Male; Mice

2001
NC-1500 prevents concanavalin A-induced mice hepatitis without affecting cytokine gene expression.
    International journal of molecular medicine, 2001, Volume: 8, Issue:2

    Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspartate Aminotransferases; Calcium Channel Blockers; Chemical and Drug Induced Liver Injury; Concanavalin A; Dihydropyridines; Disease Models, Animal; Female; Gene Expression; Glycyrrhizic Acid; Mice; Mice, Inbred BALB C; Naphthyridines; RNA, Messenger; Tumor Necrosis Factor-alpha

2001