glycyrrhizic acid has been researched along with Acute Liver Injury, Drug-Induced in 59 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (5.08) | 18.7374 |
| 1990's | 7 (11.86) | 18.2507 |
| 2000's | 16 (27.12) | 29.6817 |
| 2010's | 18 (30.51) | 24.3611 |
| 2020's | 15 (25.42) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, L; Chen, X; Wang, X; Wu, J; Wu, Y; Xu, C; Xu, H; Yang, L | 1 |
| Bian, H; Xia, M; Xu, Y; Yang, X | 1 |
| Chen, N; Chu, S; Cui, L; Gao, Y; He, H; Li, J; Mo, S; Sun, X; Wang, H; Zheng, J; Zhou, X | 1 |
| Aithal, GP; Bi, JF; Chang, BX; Huang, A; Ji, D; Liang, QS; Liangpunsakul, S; Liu, S; Ma, X; Mao, YM; Niu, M; Peng, XX; Saxena, R; Sun, Y; Teng, GJ; Tian, H; Wang, JB; Wang, Y; Xiao, XH; Xie, H; Xin, S; Zhao, J; Zhou, G; Zou, Z | 1 |
| Han, X; Jin, J; Li, H; Li, L; Li, X; Mao, Y; Raza, HK; Yao, L; Zhang, J | 1 |
| Huang, A; Ji, D; Wang, JB; Wang, Y; Zou, Z | 1 |
| Eickhoff, A; Teschke, R | 1 |
| Aithal, GP; Alvarez-Alvarez, I; Andrade, RJ; Arikan, C; Atallah, E; Lucena, MI; Medina-Caliz, I; Niu, H | 1 |
| Hua, H; Liu, X; Pan, Y; Ren, K; Ren, S; Wang, D; Wang, R; Zhang, X | 1 |
| Guo, F; Jiang, X; Li, W; Li, X; Li, Y; Yu, Z | 1 |
| Gao, S; Liu, X; Liu, Y; Sun, X; Tian, X | 1 |
| Hu, H; Ji, XY; Li, HZ; Liu, B; Liu, YQ; Lyu, C; Meng, X; Shi, NN; Shu, HY; Wang, YP; Yuan, RL | 1 |
| Gao, M; He, L; Li, X; Wei, H; Xiao, F; Yang, J; Ye, X | 1 |
| El Fayoumi, HM; Hasan, RA; Mahmoud, AAA; Mahmoud, MF; Zakaria, S | 1 |
| Bi, H; Cao, P; Chen, N; Chu, S; Guo, Q; He, W; Li, F; Li, X; Niu, Z; Sun, X; Zhang, Z | 1 |
| Li, JH; Li, RD; Ma, ZY; Shen, CH; Tao, YF; Wang, ZX; Zhang, QB | 1 |
| Cui, YL; Wang, GF; Wang, QS; Xu, D; Zhang, HY; Zhao, FQ | 1 |
| Bryson, S; Castino, G; Del Río Hernández, A; Julian, L; McGarry, L; Mullin, M; Munro, J; Naylor, G; Olson, MF; Rath, N; Rice, A; Stevenson, D; Wickman, GR | 1 |
| Chen, J; Chen, M; Gan, W; Nie, Y; Tan, Y; Tian, X; Ying, R; Zhang, C | 1 |
| Cao, YF; Fang, ZZ; Gonzalez, FJ; Krausz, KW; Meng, R; Tanaka, N; Wang, H | 1 |
| An, R; Guo, X; Tian, J; Wu, F; Yu, Z | 1 |
| Fang, M; Fei, X; Gong, F; Hua, S; Li, L; Qi, C; Zhang, Y | 1 |
| Dou, LP; Jing, Y; Tian, YM; Yao, S; Yao, ZL; Yu, L; Zhang, QF | 1 |
| Fakhredini, F; Khorsandi, L; Mansouri, E; Orazizadeh, M | 1 |
| Cao, QT; Dai, XN; Gao, YJ; Han, JC; Jiang, Y; Jiang, YS; Peng, YF; Sun, YM; Sun, Z; Yu, J | 1 |
| Mo, Y; Yan, Y; Zhang, D | 1 |
| Feng, ZQ; Guo, XL; Jin, J; Liang, B; Ma, YC | 1 |
| Fakhredini, F; Khorsandi, L; Mansori, E; Orazizadeh, M | 1 |
| Brocker, CN; Chai, Y; Che, Y; Cheng, X; Gonzalez, FJ; Hao, H; Krausz, KW; Li, F; Wang, G; Wang, H; Wu, Y; Xie, C; Yagai, T; Yan, T; Zhang, J; Zhao, M | 1 |
| Qin, H; Song, Y; Wu, X; Zhang, G; Zhao, J; Zhou, L; Zhou, Y | 1 |
| Horikiri, T; Kaneko, Y; Kinoshita, A; Kurita, Y; Kuwano, K; Odashima, K; Saito, Z; Seki, A; Seki, Y; Takeda, H; Yoshii, Y | 1 |
| Abe, K; Ikeda, T; Inoue, H; Kida, Y; Kuroda, N; Morito, M; Sato, T; Wake, K | 1 |
| Abe, K; Hatta, A; Inoue, H; Sato, T; Takata, M; Tsuruoka, N; Wake, K | 1 |
| Fujii, H; Hara, M; Kono, H; Ogiku, M; Tsuchiya, M | 1 |
| Gao, Y; Li, H; Liang, QD; Ma, ZC; Tan, HL; Wang, YG; Xiao, CR; Zhang, BL; Zhou, JM | 1 |
| Akhundzhanova, LL; Aripov, OA; Khalimbetov, GS | 1 |
| Goto, H; Kakemizu, N; Miyazawa, N; Odagiri, S; Ogura, T; Sato, M; Takahashi, H; U, CH; Watanuki, Y; Yamakawa, Y; Yoshiike, Y | 1 |
| Hirakawa, T; Kinjo, J; Nagao, T; Nohara, T; Okabe, H; Okawa, M; Tsuchihashi, R | 1 |
| KURISU, A; KUROYANAGI, T; SAITO, M; SUGIYAMA, H | 1 |
| Meng, Q; Shen, C; Wu, YT; Yin, J; Yu, JP | 1 |
| Meng, Q; Shen, C; Zhang, G; Zhang, H | 1 |
| Abe, K; Ikeda, T; Inoue, H; Matsushita, T; Sato, T; Wake, K; Yoshida, T | 1 |
| Kang, SS; Kim, JA; Kim, YS; Lee, CH; Lee, SH; Lee, SM; Park, SW | 1 |
| Meng, F; Qiao, H; Sun, X; Tang, B | 1 |
| Abe, K; Ikeda, T; Inoue, H; Sato, T; Wake, K | 1 |
| Cheng, X; Li, D; Meng, Q; Shen, C | 1 |
| Hattori, M; Hikino, H; Kiso, Y; Namba, T; Sakamoto, T; Tohkin, M | 1 |
| Kimura, T; Kurosaki, Y; Nakayama, T; Okamoto, M; Wang, Z | 1 |
| Basnet, P; Hase, K; Kadota, S; Namba, T; Takahashi, T | 1 |
| Basnet, P; Hase, K; Kadota, S; Matsushige, K; Namba, T | 1 |
| Cheng, TY; Lin, G; Nnane, IP | 1 |
| Imai, K; Ishizu, T; Kaku, TI; Kato, Y; Liu, KX; Santa, T; Sugiyama, Y; Yagi, A | 1 |
| Okabe, S; Okamoto, T | 1 |
| Jeong, SY; Kobayashi, T; Okamoto, T | 1 |
| Iwahashi, N; Nose, M; Ogihara, Y; Oguri, K; Terawaki, K | 1 |
| Li, BR; Lu, J; Ru, RP; Wu, XM; Zhang, BG | 1 |
| Chiba, S; Suga, M; Sugaya, T; Sugiyama, T; Yabana, T; Yachi, A | 1 |
| Hayashi, Y; Ishiguro, I; Kuroda, K; Nagamura, Y; Nishida, K; Saito, S; Sasaki, Y | 1 |
| Shibayama, Y | 1 |
3 review(s) available for glycyrrhizic acid and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
Metabolic dysfunction associated fatty liver disease and coronavirus disease 2019: clinical relationship and current management.
Topics: Age Factors; Angiotensin-Converting Enzyme 2; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; COVID-19; COVID-19 Drug Treatment; Cytokines; Dipeptides; Gene Expression Regulation; Glucose; Glycyrrhizic Acid; Humans; Hypoxia; Liver; Lung; Non-alcoholic Fatty Liver Disease; Receptors, Virus; SARS-CoV-2; Severity of Illness Index | 2021 |
Therapeutic Management of Idiosyncratic Drug-Induced Liver Injury and Acetaminophen Hepatotoxicity in the Paediatric Population: A Systematic Review.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adrenal Cortex Hormones; Adult; Carnitine; Chemical and Drug Induced Liver Injury; Child; Drug-Related Side Effects and Adverse Reactions; Glutathione; Glycyrrhizic Acid; Humans; Infant, Newborn; Liver; Liver Failure, Acute; Retrospective Studies; S-Adenosylmethionine; Ursodeoxycholic Acid | 2022 |
[Toxicity-reducing effect of compatibility of Tripterygium and licorice in animals: systematic review].
Topics: Animals; Chemical and Drug Induced Liver Injury; Drugs, Chinese Herbal; Glycyrrhiza; Glycyrrhizic Acid; Tripterygium | 2019 |
3 trial(s) available for glycyrrhizic acid and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
Corticosteroid plus glycyrrhizin therapy for chronic drug- or herb-induced liver injury achieves biochemical and histological improvements: a randomised open-label trial.
Topics: Adrenal Cortex Hormones; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Injury, Chronic; Female; Glycyrrhizic Acid; Hepatitis, Autoimmune; Humans; Male | 2022 |
[Protective effect of ademetionine 1, 4-butanedisulfonate on liver injury caused by chemotherapeutic agents].
Topics: Adult; Antineoplastic Agents; Chemical and Drug Induced Liver Injury; Female; Glycyrrhizic Acid; Humans; Leukemia; Male; Middle Aged; S-Adenosylmethionine; Young Adult | 2013 |
[Magnesium isoglycyrrhizinate prevention of chemotherapy-induced liver damage during initial treatment of patients with gastrointestinal tumors].
Topics: Alanine Transaminase; Alkaline Phosphatase; Antineoplastic Combined Chemotherapy Protocols; Aspartate Aminotransferases; Bilirubin; Capecitabine; Chemical and Drug Induced Liver Injury; Deoxycytidine; Fluorouracil; Gastrointestinal Neoplasms; Glycyrrhizic Acid; Humans; Leucovorin; Organoplatinum Compounds; Oxaliplatin; Oxaloacetates; Prospective Studies; Saponins; Triterpenes | 2015 |
53 other study(ies) available for glycyrrhizic acid and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
Magnesium isoglycyrrhizinate prevents cadmium-induced activation of JNK and apoptotic hepatocyte death by reversing ROS-inactivated PP2A.
Topics: Animals; Apoptosis; Cadmium; Cell Line; Cell Survival; Chemical and Drug Induced Liver Injury; Drugs, Chinese Herbal; Environmental Pollutants; Glycyrrhizic Acid; Hepatocytes; Humans; JNK Mitogen-Activated Protein Kinases; Liver; MAP Kinase Signaling System; Mice; Oxidative Stress; Protein Phosphatase 2; Reactive Oxygen Species; Saponins; Signal Transduction; Triterpenes | 2021 |
Combination of monoammonium glycyrrhizinate and cysteine hydrochloride protects mice against acetaminophen-induced liver injury via Keap1/Nrf2/ARE pathway.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Injury, Chronic; Cysteine; Glutathione; Glycyrrhizic Acid; Kelch-Like ECH-Associated Protein 1; Liver; Mice; NF-E2-Related Factor 2; Oxidative Stress; Signal Transduction | 2022 |
An analysis of the efficacy and safety of compound glycyrrhizin injections in the treatment of drug-induced liver injury using a nationwide database.
Topics: Alanine Transaminase; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Glycyrrhizic Acid; Humans; Liver | 2022 |
Editorial: chronic DILI and HILI-corticosteroid plus glycyrrhizin as standard therapy? Authors' reply.
Topics: Adrenal Cortex Hormones; Chemical and Drug Induced Liver Injury; Drugs, Chinese Herbal; Glycyrrhizic Acid; Humans | 2022 |
Editorial: chronic DILI and HILI - corticosteroid plus glycyrrhizin as standard therapy?
Topics: Adrenal Cortex Hormones; Chemical and Drug Induced Liver Injury; Glycyrrhizic Acid; Humans | 2022 |
The inhibitory effect of licorice on the hepatotoxicity induced by the metabolic activation of Euodiae Fructus.
Topics: Activation, Metabolic; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Fruit; Glutathione; Glycyrrhiza; Glycyrrhizic Acid; Male; Mice; Mice, Inbred C57BL | 2024 |
Compound ammonium glycyrrhizin protects hepatocytes from injury induced by lipopolysaccharide/florfenicol through oxidative stress and a MAPK pathway.
Topics: Ammonium Compounds; Animals; Apoptosis; Chemical and Drug Induced Liver Injury; Chickens; Glycyrrhizic Acid; Hepatocytes; Lipopolysaccharides; Liver; Male; Mitochondria; Mitogen-Activated Protein Kinase Kinases; Oxidative Stress; Protective Agents; Thiamphenicol | 2019 |
Glycyrrhizic acid ammonium salt alleviates Concanavalin A-induced immunological liver injury in mice through the regulation of the balance of immune cells and the inhibition of hepatocyte apoptosis.
Topics: Ammonium Compounds; Animals; Apoptosis; Chemical and Drug Induced Liver Injury; Concanavalin A; Cytokines; Down-Regulation; Glycyrrhizic Acid; Hepatocytes; Liver; Male; Mice; Mice, Inbred BALB C; T-Lymphocyte Subsets; Up-Regulation | 2019 |
Diammonium Glycyrrhizinate Mitigates Liver Injury Via Inhibiting Proliferation Of NKT Cells And Promoting Proliferation Of Tregs.
Topics: Animals; Anti-Inflammatory Agents; Cell Proliferation; Chemical and Drug Induced Liver Injury; Concanavalin A; Disease Models, Animal; Dose-Response Relationship, Drug; Glycyrrhizic Acid; Hepatitis, Autoimmune; Male; Mice; Mice, Inbred C57BL; Molecular Structure; Natural Killer T-Cells; Structure-Activity Relationship; T-Lymphocytes, Regulatory | 2019 |
The concurrent exposure to aluminium and fructose induces liver injury in rats: Protection by monoammonium glycyrrhizinate.
Topics: Aluminum Chloride; Animals; Biomarkers; Blood Glucose; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Fructose; Glycyrrhizic Acid; Inflammation Mediators; Liver; Male; Oxidative Stress; Protective Agents; Proto-Oncogene Proteins c-bcl-2; Rats, Wistar; Signal Transduction; Silymarin; Toll-Like Receptor 4; Triglycerides | 2020 |
Combination of monoammonium glycyrrhizinate and cysteine hydrochloride ameliorated lipopolysaccharide/galactosamine-induced acute liver injury through Nrf2/ARE pathway.
Topics: Animals; Antioxidant Response Elements; Cells, Cultured; Chemical and Drug Induced Liver Injury; Cysteine; Cytokines; Drug Combinations; Galactosamine; Glutathione; Glycyrrhizic Acid; Heme Oxygenase-1; Hepatocytes; Lipopolysaccharides; Liver; Male; Malondialdehyde; Mice, Inbred C57BL; Mice, Knockout; NF-E2-Related Factor 2; Peroxidase; Signal Transduction; Superoxide Dismutase | 2020 |
Glycyrrhizin improves inflammation and apoptosis via suppressing HMGB1 and PI3K/mTOR pathway in lipopolysaccharide-induced acute liver injury.
Topics: Administration, Oral; Animals; Apoptosis; Cells, Cultured; Chemical and Drug Induced Liver Injury; Glycyrrhizic Acid; HMGB1 Protein; Humans; Inflammation; Injections, Intraperitoneal; Lipopolysaccharides; Liver; Macrophages; Male; Mice; Mice, Inbred C57BL; Phosphatidylinositol 3-Kinases; TOR Serine-Threonine Kinases | 2020 |
Glycyrrhizin mediated liver-targeted alginate nanogels delivers quercetin to relieve acute liver failure.
Topics: Alanine Transaminase; Alginates; Animals; Antioxidants; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; China; Glycyrrhizic Acid; Inflammation; Liver; Liver Failure, Acute; Male; Mice; Nanogels; Nitric Oxide Synthase Type II; Oxidative Stress; Quercetin; Tumor Necrosis Factor-alpha | 2021 |
Defective apoptotic cell contractility provokes sterile inflammation, leading to liver damage and tumour suppression.
Topics: Animals; Apoptosis; Carcinoma, Hepatocellular; Caspases; Cell Shape; Chemical and Drug Induced Liver Injury; Diethylnitrosamine; Disease Models, Animal; Enzyme Activation; Glycyrrhizic Acid; HEK293 Cells; HMGB1 Protein; Humans; Liver; Liver Neoplasms; Male; Mice, Inbred C57BL; Mice, Inbred ICR; Mice, Transgenic; Mutation; Myosin Light Chains; Neutrophil Infiltration; Phosphorylation; rho-Associated Kinases; Sulfonamides; Toll-Like Receptor 4 | 2021 |
Clinical efficacy and security of glycyrrhizic acid preparation in the treatment of anti-SARS-CoV-2 drug-induced liver injury: a protocol of systematic review and meta-analysis.
Topics: Chemical and Drug Induced Liver Injury; China; COVID-19; Glycyrrhizic Acid; Humans; Meta-Analysis as Topic; Research Design; Retrospective Studies; SARS-CoV-2; Systematic Reviews as Topic; Treatment Outcome | 2021 |
Glycyrrhizin and glycyrrhetinic acid inhibits alpha-naphthyl isothiocyanate-induced liver injury and bile acid cycle disruption.
Topics: 1-Naphthylisothiocyanate; Animals; Bile Acids and Salts; Chemical and Drug Induced Liver Injury; Chromatography, Liquid; Gene Expression Regulation; Glycyrrhetinic Acid; Glycyrrhizic Acid; Least-Squares Analysis; Liver; Male; Mass Spectrometry; Metabolomics; Mice | 2017 |
Protective effects of compound ammonium glycyrrhizin, L‑arginine, silymarin and glucurolactone against liver damage induced by ochratoxin A in primary chicken hepatocytes.
Topics: Alanine Transaminase; Animals; Apoptosis; Arginine; Aspartate Aminotransferases; Caspase 3; Cells, Cultured; Chemical and Drug Induced Liver Injury; Chickens; Glucuronates; Glutathione; Glycyrrhizic Acid; Hepatocytes; Ochratoxins; Oxidative Stress; Protective Agents; Proto-Oncogene Proteins c-bcl-2; Silymarin; Superoxide Dismutase | 2018 |
Glycyrrhizin alleviates Con A-induced hepatitis by differentially regulating the production of IL-17 and IL-25.
Topics: Animals; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Concanavalin A; Glycyrrhizic Acid; Hepatitis; Interleukin-17; Interleukins; Male; Mice; Mice, Inbred C57BL | 2019 |
Effect of glycyrrhizic acid on titanium dioxide nanoparticles-induced hepatotoxicity in rats.
Topics: Animals; Chemical and Drug Induced Liver Injury; Glycyrrhizic Acid; Liver; Male; Microscopy, Atomic Force; Nanoparticles; Rats; Rats, Wistar; Titanium | 2014 |
Targeted metabolomic study indicating glycyrrhizin’s protection against acetaminophen-induced liver damage through reversing fatty acid metabolism.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Carnitine; Chemical and Drug Induced Liver Injury; Chromatography, Liquid; Glycyrrhizic Acid; Lipid Metabolism; Male; Mass Spectrometry; Metabolome; Mice; Mice, Inbred C57BL | 2014 |
Glycyrrhizic acid inhibits apoptosis and fibrosis in carbon-tetrachloride-induced rat liver injury.
Topics: Actins; Animals; Apoptosis; bcl-2-Associated X Protein; Carbon Tetrachloride; Caspase 3; Chemical and Drug Induced Liver Injury; Collagen Type I; Collagen Type III; Connective Tissue Growth Factor; Cytoprotection; Glycyrrhizic Acid; Hepatic Stellate Cells; Liver; Liver Cirrhosis, Experimental; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Protective Agents; Rats, Sprague-Dawley; RNA, Messenger | 2015 |
Glycyrrhizic acid attenuated lipid peroxidation induced by titanium dioxide nanoparticles in rat liver.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Antioxidants; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Glutathione; Glutathione Peroxidase; Glycyrrhizic Acid; Lipid Peroxidation; Liver; Male; Malondialdehyde; Metal Nanoparticles; Oxidative Stress; Rats; Superoxide Dismutase; Titanium | 2015 |
Glycyrrhizin Protects against Acetaminophen-Induced Acute Liver Injury via Alleviating Tumor Necrosis Factor α-Mediated Apoptosis.
Topics: Acetaminophen; Activation, Metabolic; Animals; Apoptosis; Cell Line; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1; Glycyrrhizic Acid; Hepatocytes; Humans; Liver; Male; Mice; Mice, Inbred C57BL; Mitochondria, Liver; Protective Agents; Receptor-Interacting Protein Serine-Threonine Kinases; Tumor Necrosis Factor-alpha | 2016 |
Monoammonium glycyrrhizinate protects rifampicin- and isoniazid-induced hepatotoxicity via regulating the expression of transporter Mrp2, Ntcp, and Oatp1a4 in liver.
Topics: Administration, Oral; Animals; Antitubercular Agents; ATP-Binding Cassette Transporters; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Drug Synergism; Gene Expression Regulation; Glycyrrhizic Acid; Isoniazid; Male; Organic Anion Transporters; Organic Anion Transporters, Sodium-Dependent; Rats, Wistar; Rifampin; Symporters | 2016 |
Effectiveness of hepatoprotective drugs for anti-tuberculosis drug-induced hepatotoxicity: a retrospective analysis.
Topics: Adult; Aged; Alanine Transaminase; Antitubercular Agents; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Cysteine; Drug Combinations; Female; Glycine; Glycyrrhetinic Acid; Glycyrrhizic Acid; Humans; Liver; Male; Middle Aged; Retrospective Studies; Risk Factors; Tuberculosis; Ursodeoxycholic Acid; Young Adult | 2016 |
The inhibition of apoptosis by glycyrrhizin in hepatic injury induced by injection of lipopolysaccharide / D-galactosamine in mice.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Caspases; Chemical and Drug Induced Liver Injury; Galactosamine; Glycyrrhizic Acid; Hepatocytes; Immunohistochemistry; Injections; Lipopolysaccharides; Male; Mice; Mice, Inbred BALB C; Time Factors | 2008 |
Hepatic protection by glycyrrhizin and inhibition of iNOS expression in concanavalin A-induced liver injury in mice.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Concanavalin A; Glycyrrhizic Acid; Humans; Liver; Male; Mice; Mice, Inbred BALB C; Nitric Oxide Synthase Type II; T-Lymphocytes | 2009 |
Glycyrrhizin prevents liver injury by inhibition of high-mobility group box 1 production by Kupffer cells after ischemia-reperfusion in rats.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury; Clodronic Acid; Drug Carriers; Glycyrrhizic Acid; HMGB1 Protein; Immunohistochemistry; Kupffer Cells; Liposomes; Male; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2011 |
Pregnane X receptor mediated-transcription regulation of CYP3A by glycyrrhizin: a possible mechanism for its hepatoprotective property against lithocholic acid-induced injury.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cholestasis; Cholesterol 7-alpha-Hydroxylase; Cytochrome P-450 CYP3A; Cytoprotection; Dose-Response Relationship, Drug; Enzyme Induction; Gene Expression Regulation; Glycyrrhizic Acid; Hep G2 Cells; Humans; Lithocholic Acid; Liver; Male; Mice; Pregnane X Receptor; Promoter Regions, Genetic; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Time Factors; Transcription, Genetic | 2012 |
[Membrane-stabilizing effect of phospholipid liposomes in toxic hepatitis].
Topics: Animals; Cell Membrane; Chemical and Drug Induced Liver Injury; Glycyrrhizic Acid; Gossypium; Lipid Peroxidation; Liposomes; Liver; Male; Phosphatidylcholines; Rats; Unithiol | 2002 |
[Effect of glycyrrhizin on anti-tuberculosis drug-induced hepatitis].
Topics: Adult; Aged; Antitubercular Agents; Chemical and Drug Induced Liver Injury; Glycyrrhizic Acid; Humans; Middle Aged; Treatment Outcome | 2003 |
Hepatoprotective constituents in plants. 14. Effects of soyasapogenol B, sophoradiol, and their glucuronides on the cytotoxicity of tert-butyl hydroperoxide to HepG2 cells.
Topics: Carbohydrate Sequence; Cell Line; Cell Survival; Chemical and Drug Induced Liver Injury; Glucuronides; Glycyrrhizic Acid; Humans; Liver; Molecular Sequence Data; Oleanolic Acid; Saponins; tert-Butylhydroperoxide | 2003 |
[Studies on experimental allergic hepatitis. 2. Effect of prednisolone and glycyrrhizin on experimental allergic hepatitis].
Topics: Antioxidants; Chemical and Drug Induced Liver Injury; Glycyrrhiza; Glycyrrhizic Acid; Hepatitis; Hepatitis A; Humans; Prednisolone | 1962 |
Azathioprine hepatotoxicity and the protective effect of liquorice and glycyrrhizic acid.
Topics: Acetylcysteine; Animals; Azathioprine; Cell Survival; Cells, Cultured; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Glutathione; Glycyrrhiza; Glycyrrhizic Acid; Hepatocytes; Humans; Immunosuppressive Agents; Male; Plant Extracts; Plant Roots; Rats; Rats, Sprague-Dawley; Species Specificity | 2006 |
Isoniazid-induced hepatotoxicity in rat hepatocytes of gel entrapment culture.
Topics: Acetylcysteine; Animals; Antidotes; Antitubercular Agents; Cell Survival; Cells, Cultured; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1; Ditiocarb; Female; Glutathione; Glycyrrhiza; Glycyrrhizic Acid; Hepatocytes; Isoniazid; Plant Extracts; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Serum Albumin | 2006 |
Inhibitory effect of glycyrrhizin on lipopolysaccharide and d-galactosamine-induced mouse liver injury.
Topics: Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Cytokines; Galactosamine; Glycyrrhizic Acid; Lipopolysaccharides; Liver Diseases; Male; Mice; Mice, Inbred BALB C; Protective Agents | 2007 |
Protective mechanism of glycyrrhizin on acute liver injury induced by carbon tetrachloride in mice.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Blotting, Western; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Cyclooxygenase 2; Glutathione; Glycyrrhizic Acid; Heme Oxygenase-1; Lipid Peroxidation; Liver; Male; Mice; Mice, Inbred ICR; Nitric Oxide Synthase Type II; Oxidative Stress; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Necrosis Factor-alpha | 2007 |
Glycyrrhizin attenuates endotoxin- induced acute liver injury after partial hepatectomy in rats.
Topics: Acute Disease; Alanine Transaminase; Animals; Anti-Inflammatory Agents; Apoptosis; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Glycyrrhizic Acid; Hepatectomy; Immunohistochemistry; L-Lactate Dehydrogenase; Lipopolysaccharides; Liver Diseases; Male; Proliferating Cell Nuclear Antigen; Rats; Rats, Wistar; Severity of Illness Index; Tumor Necrosis Factor-alpha | 2007 |
Glycyrrhizin prevents of lipopolysaccharide/D-galactosamine-induced liver injury through down-regulation of matrix metalloproteinase-9 in mice.
Topics: Acute Disease; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Down-Regulation; Galactosamine; Glycyrrhizic Acid; Immunohistochemistry; Injections, Intraperitoneal; Injections, Intravenous; Lipopolysaccharides; Liver; Liver Diseases; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice; Mice, Inbred BALB C; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Up-Regulation | 2008 |
Investigation of rifampicin-induced hepatotoxicity in rat hepatocytes maintained in gel entrapment culture.
Topics: Acetylcysteine; Albumins; Animals; Antitubercular Agents; Cell Culture Techniques; Cell Survival; Cells, Cultured; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Drug Antagonism; Enzyme Inhibitors; Glutathione; Glycyrrhizic Acid; Hepatocytes; Lipid Metabolism; Male; Malondialdehyde; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Rifampin; Tetrazolium Salts; Thiazoles | 2009 |
Mechanism of antihepatotoxic activity of glycyrrhizin. I: Effect on free radical generation and lipid peroxidation.
Topics: Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Free Radicals; Glycyrrhetinic Acid; Glycyrrhizic Acid; Lipid Peroxides; Male; Rats; Rats, Inbred Strains | 1984 |
Pharmacokinetics of glycyrrhizin in rats with D-galactosamine-induced hepatic disease.
Topics: Administration, Oral; Animals; Antiviral Agents; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Galactosamine; Gastric Emptying; Glycyrrhetinic Acid; Glycyrrhizic Acid; Injections, Intravenous; Intestinal Absorption; Liver Diseases; Male; Rats; Rats, Wistar | 1996 |
Protective effect of celosian, an acidic polysaccharide, on chemically and immunologically induced liver injuries.
Topics: Animals; Bilirubin; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Enzymes; Galactosamine; Glycyrrhetinic Acid; Glycyrrhizic Acid; Lipid Peroxidation; Lipid Peroxides; Lipopolysaccharides; Liver; Liver Diseases; Male; Mice; Mice, Inbred BALB C; Necrosis; Plant Extracts; Polysaccharides; Rats; Rats, Sprague-Dawley; Seeds; Tumor Necrosis Factor-alpha | 1996 |
Potent antihepatotoxic activity of dicaffeoyl quinic acids from propolis.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Cells, Cultured; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Glycyrrhetinic Acid; Glycyrrhizic Acid; L-Lactate Dehydrogenase; Liver; Liver Diseases; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Structure; Propolis; Quinic Acid; Rats | 1996 |
The effects of pretreatment with glycyrrhizin and glycyrrhetinic acid on the retrorsine-induced hepatotoxicity in rats.
Topics: Administration, Topical; Alanine Transaminase; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents, Phytogenic; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Drug Administration Schedule; Glutathione; Glycyrrhetinic Acid; Glycyrrhizic Acid; Liver; Liver Diseases; Male; Pyrrolizidine Alkaloids; Rats; Rats, Sprague-Dawley; Time Factors | 1999 |
Hydroxyprolylserine derivatives JBP923 and JBP485 exhibit the antihepatitis activities after gastrointestinal absorption in rats.
Topics: 1-Naphthylisothiocyanate; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carbon Radioisotopes; Cells, Cultured; Chemical and Drug Induced Liver Injury; Cytosol; Dipeptides; Gastric Mucosa; Glycyrrhizic Acid; Intestinal Absorption; Intestinal Mucosa; Intestines; Liver; Male; Microvilli; Peptides, Cyclic; Rabbits; Rats; Rats, Wistar | 2000 |
Development of anorexia in concanavalin A-induced hepatitis in mice.
Topics: Alanine Transaminase; Animals; Anorexia; Body Weight; Brain; Chemical and Drug Induced Liver Injury; Concanavalin A; Disease Models, Animal; Eating; Female; Glycyrrhizic Acid; Hepatitis, Animal; Interleukin-1; Liver; Mice; Mice, Inbred BALB C; RNA, Messenger; Tumor Necrosis Factor-alpha | 2001 |
NC-1500 prevents concanavalin A-induced mice hepatitis without affecting cytokine gene expression.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspartate Aminotransferases; Calcium Channel Blockers; Chemical and Drug Induced Liver Injury; Concanavalin A; Dihydropyridines; Disease Models, Animal; Female; Gene Expression; Glycyrrhizic Acid; Mice; Mice, Inbred BALB C; Naphthyridines; RNA, Messenger; Tumor Necrosis Factor-alpha | 2001 |
Comparative study of the high molecular mass fraction and low molecular mass fraction of Sho-saiko-to in a murine immunologically induced liver injury model.
Topics: Animals; BCG Vaccine; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Flavonoids; Glycyrrhizic Acid; Lipopolysaccharides; Male; Mice; Mice, Inbred ICR; Molecular Weight; Nitric Oxide; Shock, Septic | 2002 |
[Therapeutic effects of epimeric glycyrrhizic acids on hepatic injury in rats].
Topics: Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Galactosamine; Glycyrrhetinic Acid; Glycyrrhizic Acid; Liver Failure; Male; Putrescine; Rats; Rats, Wistar; Stereoisomerism; Structure-Activity Relationship | 1992 |
[A case of drug-induced allergic hepatitis by glycyrrhizin].
Topics: Aged; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Glycyrrhetinic Acid; Glycyrrhizic Acid; Humans; Lymphocyte Activation; Lymphocyte Subsets; Male | 1992 |
Preparation of glycyrrhetic acid glycosides having various beta(1----2)-linked disaccharides and their cytoprotective effects on carbon tetrachloride-induced hepatic injury.
Topics: Animals; Carbohydrate Sequence; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Disaccharides; Glycosides; Glycyrrhetinic Acid; Glycyrrhizic Acid; Liver Diseases; Molecular Sequence Data; Rats; Rats, Inbred Strains; Saponins | 1991 |
Prevention of hepatotoxic responses to chemicals by glycyrrhizin in rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Endotoxins; Formates; Formic Acid Esters; Glycyrrhetinic Acid; Glycyrrhizic Acid; Rats; Rats, Inbred Strains | 1989 |