glycylproline and Pressure-Ulcer

glycylproline has been researched along with Pressure-Ulcer* in 1 studies

Other Studies

1 other study(ies) available for glycylproline and Pressure-Ulcer

Article	Year
Urine glycyl-L-proline increase and skin trophicity. Amino acids, 1999, Volume: 17, Issue:3 Glycyl-L-proline (gly-pro) is an end product of collagen metabolism that is further cleaved by prolidase (EC 3.4.13.9); the resulting proline molecules are recycled into collagen or other proteins. We postulated a relationship between defective gly-pro hydrolysis, increased collagen degradation and skin destruction. This relationship was tested using HPLC to measure the gly-pro in urine. 24 hour urine samples were collected from 27 old people (86 +/- 6 years old), of whom 15 were suffering from skin pressure sores of the sacrum or calcaneus. The urine from patients with pressure sores contained significantly more gly-pro than the urine from the control. A cut-off at 7 mumol/mmol creatinine gave the test a positive predictive value of 70%. Collagen breakdown was also increased as indicated by the increase of hydroxyproline (hyp) in the urine. But this breakdown seemed to stop at the gly-pro step. Topics: Aged; Aged, 80 and over; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Collagen; Dipeptides; Humans; Male; Pressure Ulcer; Skin	1999

Article

Year

Urine glycyl-L-proline increase and skin trophicity.

Amino acids, 1999, Volume: 17, Issue:3

Glycyl-L-proline (gly-pro) is an end product of collagen metabolism that is further cleaved by prolidase (EC 3.4.13.9); the resulting proline molecules are recycled into collagen or other proteins. We postulated a relationship between defective gly-pro hydrolysis, increased collagen degradation and skin destruction. This relationship was tested using HPLC to measure the gly-pro in urine. 24 hour urine samples were collected from 27 old people (86 +/- 6 years old), of whom 15 were suffering from skin pressure sores of the sacrum or calcaneus. The urine from patients with pressure sores contained significantly more gly-pro than the urine from the control. A cut-off at 7 mumol/mmol creatinine gave the test a positive predictive value of 70%. Collagen breakdown was also increased as indicated by the increase of hydroxyproline (hyp) in the urine. But this breakdown seemed to stop at the gly-pro step.

Topics: Aged; Aged, 80 and over; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Collagen; Dipeptides; Humans; Male; Pressure Ulcer; Skin

1999