glycyllysine and Hypertension

glycyllysine has been researched along with Hypertension* in 1 studies

Other Studies

1 other study(ies) available for glycyllysine and Hypertension

Article	Year
Angiotensin-I-converting enzyme inhibitory peptides: Chemical feature based pharmacophore generation. European journal of medicinal chemistry, 2011, Volume: 46, Issue:8 A validated 3D pharmacophore model was generated for a series of ACE inhibitory peptides, which consisted of five features (two hydrophobic functions, two hydrogen bond acceptors, and a negative ionizable function). The built model was able to correctly predict the activity of known ACE inhibitors. The model was then used as query to search 3D databases of peptides. Three novel peptides (I, II and III) were synthesized and biologically evaluated in vitro. It appears that the in vitro activity of peptides I, II and III was consistent with their molecular modeling results. Our results provided confidence for the utility of the pharmacophore model to retrieve novel ACE inhibitory peptides with desired biological activity by virtual screening. Topics: Algorithms; Angiotensin-Converting Enzyme Inhibitors; Blood Pressure; Databases, Factual; Humans; Hydrogen Bonding; Hypertension; Male; Models, Chemical; Models, Molecular; Peptides; Peptidyl-Dipeptidase A; Quantitative Structure-Activity Relationship; Software; Solutions; Testis	2011

Article

Year

Angiotensin-I-converting enzyme inhibitory peptides: Chemical feature based pharmacophore generation.

European journal of medicinal chemistry, 2011, Volume: 46, Issue:8

A validated 3D pharmacophore model was generated for a series of ACE inhibitory peptides, which consisted of five features (two hydrophobic functions, two hydrogen bond acceptors, and a negative ionizable function). The built model was able to correctly predict the activity of known ACE inhibitors. The model was then used as query to search 3D databases of peptides. Three novel peptides (I, II and III) were synthesized and biologically evaluated in vitro. It appears that the in vitro activity of peptides I, II and III was consistent with their molecular modeling results. Our results provided confidence for the utility of the pharmacophore model to retrieve novel ACE inhibitory peptides with desired biological activity by virtual screening.

Topics: Algorithms; Angiotensin-Converting Enzyme Inhibitors; Blood Pressure; Databases, Factual; Humans; Hydrogen Bonding; Hypertension; Male; Models, Chemical; Models, Molecular; Peptides; Peptidyl-Dipeptidase A; Quantitative Structure-Activity Relationship; Software; Solutions; Testis

2011