glycyl-prolyl-glutamic-acid has been researched along with Inflammation* in 2 studies
2 other study(ies) available for glycyl-prolyl-glutamic-acid and Inflammation
| Article | Year |
|---|---|
Synthesis and biological evaluation of novel analogues of Gly-l-Pro-l-Glu (GPE) as neuroprotective agents.
This study investigated the anti-inflammatory effects of novel pseudotripeptides (GPE 1-3) as potential candidates to counteract neuroinflammation processes in Alzheimer's disease. GPE 1-3 pseudotripeptides are synthetic derivatives of Gly-l-Pro-l-Glu (GPE), the N-terminal tripeptide of IGF-1, obtained through the introduction of isosteres of the amidic bond (aminomethylene unit) to increase the metabolic stability of the native tripeptide. The results showed that all synthetic derivatives possessed higher half-lives (t Topics: Alzheimer Disease; Cytokines; Dose-Response Relationship, Drug; Humans; Inflammation; Molecular Structure; Neuroprotective Agents; Oligopeptides; Structure-Activity Relationship; THP-1 Cells | 2019 |
Improvement in inflammation is associated with the protective effect of Gly-Pro-Glu and cycloprolylglycine against Aβ-induced depletion of the hippocampal somatostatinergic system.
Glycine-proline-glutamate (GPE) is a cleaved tripeptide of IGF-I that can be processed to cycloprolylglycine (cPG) in the brain. IGF-I protects the hippocampal somatostatinergic system from β-amyloid (Aβ) insult and although neither IGF-I-derived peptides bind to IGF-I receptors, they exert protective actions in several neurological disorders. As their effects on the hippocampal somatostatinergic system remain unknown, the objective of this study was to evaluate if cPG and/or GPE prevent the deleterious effects of Aβ Topics: Amyloid beta-Peptides; Animals; Cell Death; Female; Hippocampus; Inflammation; Neurons; Neuroprotective Agents; Oligopeptides; Peptide Fragments; Peptides, Cyclic; Phosphorylation; Rats; Rats, Wistar; Receptors, Somatostatin; Signal Transduction; Somatostatin | 2019 |