glycogen and Vulvar-Neoplasms

Extraocular sebaceous carcinoma (SC) is a rare tumor usually found on the head and neck. A 78 year old Japanese female who had an asymptomatic vulvar tumor is reported here. The excised specimen showed SC with metastasis to the inguinal lymph nodes. This is the fourth reported case of SC arising from female genitalia, and the second case that apparently arose from the labia minora. Contrary to the previously reported cases, tumor cells in the present case had abundant glycogen. Thus, differential diagnosis of SC from metastatic renal cell carcinoma is difficult morphologically because both of them have glycogen and lipid. Intraepidermal invasion of tumor cells has been reported in SC, but a suspected lesion of this phenomenon in the present case was proved to be histiocytic infiltration by immunohistochemistry using anti-CD 68 antibody.

Topics: Adenocarcinoma, Sebaceous; Aged; Female; Glycogen; Humans; Lymphatic Metastasis; Microscopy, Electron; Vulvar Neoplasms

We report a case of Ewing sarcoma/peripheral primitive neuroectodermal tumor (ES/pPNET) arising in the vulva in a 17-year-old adolescent girl. Primary extraskeletal ES/pPNET is uncommon and only rarely affects the female genital tract. Characteristic histologic features of ES/pPNET were present in this case including a monomorphic population of small round blue cells with cytoplasmic glycogen confirmed by periodic acid-Schiff and were immunohistochemically positive for CD99 in a membranous and Fli-1 in a nuclear pattern. The presence of an EWS/Fli-1 fusion transcript was demonstrated by reverse transcription polymerase chain reaction and confirmed by direct sequencing. This report described another very rare case of ES/pPNET arising in the vulva and confirmed by molecular analysis.

Topics: Adolescent; Base Sequence; Biomarkers, Tumor; DNA, Neoplasm; Female; Glycogen; Humans; Molecular Sequence Data; Neoplasms, Multiple Primary; Neuroectodermal Tumors, Primitive, Peripheral; Oncogene Proteins, Fusion; Periodic Acid-Schiff Reaction; Proto-Oncogene Protein c-fli-1; RNA-Binding Protein EWS; Sarcoma, Ewing; Sequence Analysis, DNA; Transcription Factors; Vulvar Neoplasms

Topics: Adenoma, Sweat Gland; Biomarkers, Tumor; Carcinoembryonic Antigen; Female; Glycogen; Humans; Middle Aged; Mucin-1; Periodic Acid-Schiff Reaction; Sweat Gland Neoplasms; Vulvar Neoplasms

Histological, immunohistochemical, and ultrastructural studies were performed on two cases of histologically unusual extramammary Paget's disease. Histologically, the central area of the lesions showed a bowenoid pattern, and the peripheral area showed typical extramammary Paget's disease. The transition zone showed an intermediate pattern. All these areas were positive for CEA and EMA, and negative for S-100 protein. Ultrastructurally, in the intermediate pattern, the tumour cells had abundant cytoplasmic glycogen, and the widened intercellular spaces contained numerous glycogen particles, which were probably secreted by the tumour cells. It is well known that eccrine glands, but not apocrine glands, secrete glycogen particles. Therefore, the present findings suggest that some cases of extramammary Paget's disease are a proliferation of germinative cells with eccrine gland differentiation.

Topics: Aged; Bowen's Disease; Female; Glycogen; Humans; Male; Microscopy, Electron; Middle Aged; Paget Disease, Extramammary; Penile Neoplasms; Vulvar Neoplasms

One hundred eight patients were studied who had anogenital lesions showing microscopic features as seen in bowenoid papulosis (BP), a recently described condition occurring most commonly in young adults. Patients typically show multiple papules, small nodules, or plaques that clinically mimic verrucae or nevocellular nevi. Although the lesions show microscopic cytologic atypia, a distinction from Bowen's disease, erythroplasia of Queyrat, and other forms of carcinoma in situ can usually be made on the basis of histologic and clinical criteria. The disorder responds to conservative treatment, although recurrences are not uncommon. Evolution of the lesions to invasive carcinoma was not observed. Mounting evidence links the development of BP to infection with human papilloma virus, but other viruses, as well as hormonal and immunologic factors, may also play a role.

Topics: Adolescent; Adult; Age Factors; Antigens, Viral; Bowen's Disease; Carcinoma in Situ; Carcinoma, Squamous Cell; DNA, Viral; Erythroplasia; Female; Glycogen; Histocytochemistry; Humans; Hyaluronic Acid; Male; Microscopy, Electron; Middle Aged; Papillomaviridae; Penile Neoplasms; Pregnancy; Sex Factors; Skin Neoplasms; Vulvar Neoplasms

Topics: Adenoma, Sweat Gland; Adolescent; Cell Aggregation; Cell Nucleolus; Cell Nucleus; Cell Wall; Cytoplasm; Cytoplasmic Granules; Endoplasmic Reticulum; Epithelial Cells; Female; Glycogen; Golgi Apparatus; Humans; Keratins; Microscopy; Microscopy, Electron; Middle Aged; Mitochondria; Sweat Gland Neoplasms; Synaptic Vesicles; Vulvar Neoplasms

Topics: Epithelium; Female; Glycogen; Histocytochemistry; Humans; Leukoplakia; Vulva; Vulvar Lichen Sclerosus; Vulvar Neoplasms

Topics: Carcinoma, Squamous Cell; Epidermis; Female; Glycogen; Humans; Leukoplakia; Vulvar Neoplasms

Topics: Carcinoma; Carcinoma, Squamous Cell; Female; Glycogen; Humans; Vulvar Neoplasms