glycogen and Subarachnoid-Hemorrhage

The contents of glycogen and ATP in the major cerebral arteries were examined in dogs undergoing subarachnoid haemorrhage (SAH). SAH was produced by a single injection of autologous arterial blood (1 ml/kg body weight) into the cisterna magna. Vertebral angiograms showed biphasic basilar arterial narrowings after the injection of blood: Early arterial narrowing occurred immediately after the injection and continued for a few hours. Late arterial narrowing occurred from Day 1 to Day 14 of post-SAH period, and recovered to the normal level on Day 21 of post-SAH period. The content of glycogen in the large pial arteries significantly decreased from Day 1 to Day 14 and returned to the control level on Day 21. The content of ATP in the large pial arteries also decreased from Day 1 to Day 7 and returned to the control level on Day 14. These results show that energy stores in the major cerebral arteries might be diminished during late arterial narrowing.

Topics: Adenosine Triphosphate; Animals; Basilar Artery; Cerebral Arteries; Disease Models, Animal; Dogs; Female; Glycogen; Male; Muscle, Smooth, Vascular; Radiography; Subarachnoid Hemorrhage; Time Factors

Topics: Acid-Base Equilibrium; Adenosine Triphosphate; Animals; Cerebral Cortex; Disease Models, Animal; Energy Metabolism; Glucose; Glycogen; Lactates; Oxygen Consumption; Pyruvates; Rats; Subarachnoid Hemorrhage

Topics: Action Potentials; Animals; Blood Flow Velocity; Blood Pressure; Cytoplasmic Granules; Dogs; Electrocardiography; Epinephrine; Female; Glycogen; Heart; Hemodynamics; Male; Microscopy, Electron; Mitochondria, Muscle; Myocardium; Norepinephrine; Sarcoplasmic Reticulum; Subarachnoid Hemorrhage

Topics: Adult; Aged; Blood Glucose; Cerebrospinal Fluid Proteins; Female; Glucose; Glycogen; Humans; Male; Middle Aged; Spinal Puncture; Subarachnoid Hemorrhage