glycogen and Skin-Neoplasms

Clear cell melanoma is a rare clear cell malignancy. Accurate diagnosis of clear cell melanoma requires integration of immunohistochemical and morphologic findings, with molecular studies to rule out clear cell sarcoma. The differential diagnosis includes melanoma, carcinoma, perivascular epithelioid cell tumor, and epidermotropic clear cell sarcoma. We use a case of a lesion on the helix of an 86-year-old man as an example. Histologic examination revealed an ulcerated clear cell malignant tumor. Tumor cell cytoplasm contained periodic acid-Schiff-positive, diastase-sensitive glycogen. Tumor cells showed positive labeling for S100, HMB-45, and Melan-A, and negative labeling for cytokeratins, p63, and smooth muscle actin. Molecular studies demonstrated BRAF V600E mutation, copy gains at the 6p25 (RREB1) and 11q13 (CCND1) loci, and absence of EWSR1-ATF1 fusion. These findings supported a diagnosis of clear cell melanoma. The rare pure clear cell morphology occurs due to accumulation of intracytoplasmic glycogen. We review the differential diagnosis of clear cell melanoma and describe the utility of immunohistochemical and molecular studies in confirming this diagnosis.

Topics: Aged, 80 and over; Amino Acid Substitution; Biomarkers, Tumor; Cyclin D1; Diagnosis, Differential; DNA-Binding Proteins; Ear Auricle; Gene Dosage; Glycogen; Humans; Male; Melanoma; Mutation; Perivascular Epithelioid Cell Neoplasms; Proto-Oncogene Proteins B-raf; Sarcoma, Clear Cell; Skin; Skin Neoplasms; Transcription Factors; Up-Regulation

Topics: Adult; Age Factors; Aged; Carcinoma, Squamous Cell; Female; Glycogen; Histocytochemistry; Humans; Leg; Male; Microscopy, Electron; Middle Aged; Skin; Skin Neoplasms

Topics: Acanthoma; Aged, 80 and over; Dermoscopy; Diagnosis, Differential; Glycogen; Humans; Male; Neoplasms, Multiple Primary; Skin Neoplasms

Clear cell acanthoma, firstly described by Degos as "an epidermal tumor with a particular aspect", although quite a rare lesion, raised an important interest because it may be easily confused with other dermatologic lesions, in the absence of a histopathological examination. Its clinical aspect is of a solitary nodule, with a red-brown varying color, with a size of 3 mm to 2 mm, sometimes covered with a thin scall. We present a case of a multiple rare cell acanthoma (seven nodular formations), having a rapid development (about two months) diagnosed in a 71-year-old patient within the lower 1/3 of the right shin.

Topics: Acanthoma; Aged; B-Lymphocytes; Dermis; Female; Glycogen; Humans; Immunohistochemistry; Inflammation; Keratinocytes; Keratins; Leg; Lymphocyte Count; Skin Neoplasms; T-Lymphocytes

Clear-cell carcinoma of the skin was described by Kuo in 1980 as a cutaneous tumor composed of clear cells that lacked cytoplasmic glycogen or evidence of tricholemmal keratinization. Tricholemmal carcinoma (TC) is conventionally considered to be a neoplasm derived from adnexal keratinocytes with glycogenated clear cells and evidence of outer root sheath or tricholemmal differentiation. The existence of TC has been questioned as it has been argued that without clear immunohistochemical evidence of outer root sheath differentiation, TC cannot be distinguished from clear-cell carcinoma of the skin. Our laboratory has not routinely stained the cases that appear to be carcinomas with clear keratinocytes to determine if glycogen is present and has not made the diagnosis of TC. We sought to test whether the presence of glycogen, light microscopic features said to be typical of TC, or immunohistochemical findings would delineate a group of "true" TC among the cases that we have been recording as squamous cell carcinomas with clear cells (SCC-C). 40 cases of SCC-C were evaluated for 7 histologic and histochemical criteria (a lobular arrangement, peripheral palisading, tricholemmal keratinization, folliculocentricity, evidence of a preexisting tricholemmoma, the presence of intracytoplasmic glycogen, and a thickened basement membrane) said to characterize TC. Selected cases were then stained for immunohistochemical markers (CD34, CK17, and NGFR/p75) that have been used as evidence for tricholemmal differentiation in some studies. Of the 40 cases, 38 (95%) SCC-C showed intracytoplasmic glycogen (periodic Schiff positivity abolished by diastase) and 55% of cases showed foci of tricholemmal keratinization. Overall, the carcinomas showed a spectrum of the above aggregated criteria ranging from 0 to 5. None possessed all the criteria expected in an ideal TC. In addition, the majority of the selected SCC-C in this study were negative (85%) for antigens typically found in the outer root sheath epithelium of the hair follicle. The glycogen-free clear-cell carcinoma described by Kuo seems uncommon in our patient population. Rare cases of SCC-C met the majority of Headington's criteria for TC or showed immunohistochemical evidence of tricholemmal differentiation. Thus, we also conclude that well-differentiated TC is rare and its description in the literature may overstate the case that it is a well-characterized cutaneous neoplasm.

Topics: Aged; Aged, 80 and over; Carcinoma, Squamous Cell; Female; Glycogen; Humans; Immunohistochemistry; Inclusion Bodies; Male; Middle Aged; Neoplasms, Adnexal and Skin Appendage; Skin Neoplasms

Sebaceous carcinoma (SC) most commonly presents on the eyelid and is frequently misdiagnosed both clinically and pathologically. Only very rare cases of desmoplastic tricholemmoma (DTL) of the eyelid have been reported.. We present a case of DTL of the eyelid initially misdiagnosed as an invasive SC.. A 55-year-old man presented with a rapidly growing 5 mm erythematous lesion on his upper eyelid. Histologic examination showed a lobular, folliculocentric proliferation of palely eosinophilic to clear cells surrounded by peripheral basal cells with palisading. The central portion of the lesion appeared infiltrative with clear cells surrounded by a thickened basement embedded in a dense, collagenous stroma. However, the cells showed mostly uniform cytoplasmic clearing, lacking the multivacuolization or nuclear scalloping of sebocytes. In addition, a periodic acid Schiff stain was positive with diastase sensitivity, indicating cytoplasmic glycogen, not lipid. CD34 immunohistochemical staining was also positive, which has been reported in DTL but not in SC.. SC is often misdiagnosed as other entities, but misidentification of other neoplasms as SC is less common; however, this is an important diagnostic pitfall, as it may result in unnecessary and disfiguring surgical treatment and consequent medical-legal liability. Therefore, DTL should enter the differential diagnosis of clear-cell neoplasms on the eyelid.

Topics: Adenocarcinoma, Sebaceous; Antigens, CD34; Biomarkers, Tumor; Diagnosis, Differential; Eyelid Neoplasms; Glycogen; Hair Diseases; Hair Follicle; Humans; Male; Middle Aged; Skin Neoplasms

Clear cell acanthoma is a benign epidermal lesion with a variable clinical appearance and distinct histopathology features. Although, it is considered an entirely benign entity, few case reports describe unusual or atypical variants of clear cell acanthoma. We observed a case of a large clear cell acanthoma that also has features of a keratoacanthoma.

Topics: Acanthoma; Biomarkers, Tumor; Diagnosis, Differential; Glycogen; Humans; Keratinocytes; Keratoacanthoma; Male; Middle Aged; Periodic Acid-Schiff Reaction; Skin Neoplasms

The relationship between clear-cell syringoma and diabetes mellitus is well established. We present a case of clear-cell porocarcinoma in a diabetic patient. The lesion consisted of a 5-cm nodule on the lateral aspect of the left leg. Histopathologically, the neoplasm was composed of irregular aggregations of neoplastic cells with striking clear-cell appearance, showing features of ductal differentiation. The clear-cell appearance of neoplastic cells was due to glycogen accumulation within their cytoplasm. Immunohistochemistry and ultrastructural studies also supported the diagnosis of a neoplasm with sweat ductal differentiation. Enzyme histochemical reactions for phosphorylase immunoreactivity on fresh, unfixed sections of the neoplasm demonstrated that this immunoreactivity was remarkably decreased. Some adnexal neoplasms of the skin mostly composed of clear cells may be cutaneous markers of diabetes mellitus. Phosphorylase activity deficiency in diabetic patients may be responsible for glycogen accumulation in neoplastic cells resulting in clear-cell appearance of these neoplasms.

Topics: Acrospiroma; Aged; Biomarkers, Tumor; Cell Differentiation; Cell Nucleus; Cytoplasm; Cytoplasmic Granules; Diabetes Mellitus, Type 2; Eccrine Glands; Glycogen; Humans; Immunohistochemistry; Male; Microvilli; Mucin-1; Phosphorylases; Skin Neoplasms

A 33-year-old Japanese woman presented with a black papule on a pigmented lesion which had been on her right thigh since her early childhood. A hematoxylin-eosin-stained section revealed a sharply demarcated, acanthotic epidermis composed of enlarged clear cells, which stained positively for epithelial membrane antigen and negatively for carcinoembryonic antigen. With antikeratin antibodies, the tumor cells stained for AE1 and AE3, but did not stain for CAM5.2. They contained abundant glycogen. Histologically, we diagnosed the case as a clear cell acanthoma which developed in the pre-existing epidermal nevus. This is the second such case in the literature.

Topics: Adult; Female; Glycogen; Humans; Hyperplasia; Keratins; Mucin-1; Nevus, Pigmented; Skin Neoplasms

The differential diagnosis of cutaneous small round cell malignancies is a relatively uncommon but recurrent problem that usually requires adjuvant techniques including special histochemical stains, immunohistochemistry (IHC), electron microscopy (EM), and cytogenetics (CG) to arrive at a definite answer. This report describes a case of a primary cutaneous malignancy that, after workup, fulfilled the criteria of extraskeletal Ewing's family sarcoma, which was corroborated by IHC with an antibody to glycoprotein p30/32 mic2 that is highly expressed in these neoplasms. The lesions consisted of a large nodular proliferation of poorly differentiated monotonous small round cells confined to the dermis and subcutaneous tissue. The cells had high nuclear to cytoplasmic (N/C) ratios, scattered prominent nucleoli, and indistinct cytoplasm. A periodic acid-Schiff (PAS) stain with and without diastase demonstrated abundant cytoplasmic glycogen. The glycogen was confirmed with EM, which did not show neurosecretory granules, but extensive sectioning of the tissue blocks demonstrated with light microscopy a single focus with pseudorosette formation. IHC was positive for monoclonal antibody (MAb) O13 to glycoprotein p30/32 mic2 and negative for lymphoid (CD45), neural (S-100, NF, GFAP), neuroendocrine (NSE), and muscle (MSA, desmin) markers. To the best of our knowledge, this is one of few reported cases of primary cutaneous (extraskeletal/extraosseous) Ewing's sarcoma (EEWS) and the first to use IHC with MAb O13, which recognizes the cell surface glycoprotein p30/32 mic2. This case further illustrates the continuum between EEWS and primitive peripheral neuroepithelioma and supports the unifying concept that these two entities are merely subtle morphologic variants of the same malignant neoplasm, which is better designated a Ewing's family sarcoma.

Topics: 12E7 Antigen; Actins; Adolescent; Antibodies, Monoclonal; Antigens, CD; Biomarkers, Tumor; Cell Adhesion Molecules; Cell Differentiation; Cell Division; Cell Nucleolus; Cell Nucleus; Coloring Agents; Cytogenetics; Cytoplasm; Desmin; Diagnosis, Differential; Female; Glial Fibrillary Acidic Protein; Glycogen; Humans; Immunohistochemistry; Leukocyte Common Antigens; Microscopy, Electron; Neurofilament Proteins; Phosphopyruvate Hydratase; S100 Proteins; Sarcoma, Ewing; Skin; Skin Neoplasms

A single poroid neoplasm composed of three histologically distinct lesions (hidroacanthomas simplex, eccrine poroma, and dermal duct tumor) is reported. Comparative histologic, histochemical, and electron-microscopic studies revealed that each tumor subtype contained varying proportions of poroid cells, clear cells, and cuticular cells. The major component of all three neoplasms was poroid cells, which, under the electron microscope, were characterized by a few, small, poorly developed desmosomes, and were histochemically characterized by a positive succinic dehydrogenase reaction. The dermal duct tumor was cultured, and showed similar histochemical findings to the in vivo poroid cells. These results suggest that poroid cells play the most important role in the histogenesis of these three neoplasms.

Topics: Acrospiroma; Aged; Cytoplasm; Cytoplasmic Granules; Epidermis; Glycogen; Humans; Keratins; Male; Microscopy, Electron; Neoplasms, Glandular and Epithelial; Neoplasms, Multiple Primary; Skin Neoplasms; Sweat Gland Neoplasms; Tumor Cells, Cultured

We describe 13 cases of tricholemmal carcinoma, a rarely recognized cutaneous adnexal neoplasm. The patients were nine men and four women. In general, the tumors presented as slow-growing epidermal papules, indurated plaques, or nodules showing predilection for sun-exposed, hair-bearing skin. The lesions were most frequently misdiagnosed clinically as basal cell carcinoma. Histologically, they showed a variegation of growth patterns including solid, lobular, and trabecular; they were characterized by a proliferation of epithelial cells with features of outer root sheath differentiation, including abundant glycogen-rich, clear cytoplasm, foci of pilar-type keratinization, and peripheral palisading of cells with subnuclear vacuolization. Because of their variable growth pattern, overt cytologic atypia, abundant clear cytoplasm, occasional pagetoid intraepidermal spread, and brisk mitotic activity, these tumors may pose difficulties for diagnosis and be confused with other malignant skin tumors with clear cell changes. Despite the seemingly malignant cytological appearance of these lesions, clinical follow-up in 10 cases showed no recurrence or metastasis over a period of 2-8 years. Thus, conservative surgical excision with clear margins appears to be the treatment of choice for these neoplasms.

Topics: Adult; Aged; Aged, 80 and over; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Cytoplasm; Diagnosis, Differential; Epidermal Cyst; Epithelium; Female; Follow-Up Studies; Glycogen; Hair Diseases; Humans; Keratins; Male; Middle Aged; Mitosis; Neoplasms, Basal Cell; Skin Diseases; Skin Neoplasms; Vacuoles

A malignant epithelioid schwannoma occurred on the right second toe of a 30-year-old Japanese man. It was a firm, flesh-colored, benign-appearing nodule and measured 13 x 9 mm in diameter and 6 mm in height. To our knowledge, this is the first case of malignant epithelioid schwannoma occurring on the toe. Histopathology was characterized by a circumscribed nodule in the dermis that predominantly consisted of atypical large epithelioid cells with some spindle cells whose proliferation was similar to that of the Verocay bodies seen in ordinary schwannoma. Fontana-Masson staining demonstrated no melanin pigment in the tumor at the light microscopic level. The eosinophilic cytoplasm contained abundant glycogen and was positive for S-100 protein and HMB-45, as usually seen in melanomas. Electron microscopy revealed that there was an abundance of long-spacing collagen in the extracellular matrix, and the cells contained numerous dense-cored granules. But no definite melanosomes were observed in any stage. As far as we are aware, this is the first case of a malignant epithelioid schwannoma showing HMB-45 positivity.

Topics: Adult; Antigens, Neoplasm; Cytoplasm; Epidermis; Foot Diseases; Glycogen; Humans; Male; Neurilemmoma; Organelles; S100 Proteins; Skin Neoplasms; Toes; Vimentin

A long-standing tumor of scalp is reported characterized histologically by extensive proliferation of pilar epithelium made up exclusively of cells with small round nuclei and clear cytoplasms containing glycogen granules. The tumor epithelium showed no tendency for keratinization and no cytologic atypia. The growth, however, appeared aggressive and replaced the entire thickness of the dermis and extended into the subcutaneous fat tissue.

Topics: Epithelium; Glycogen; Histocytochemistry; Humans; Male; Microscopy, Electron; Middle Aged; Scalp; Skin Neoplasms

Topics: Acid Phosphatase; Dermatitis, Exfoliative; Esterases; Glucuronidase; Glycogen; Humans; Lymphocytes; Microscopy, Electron; Mycosis Fungoides; Reticulocytes; Sezary Syndrome; Skin Neoplasms

One hundred eight patients were studied who had anogenital lesions showing microscopic features as seen in bowenoid papulosis (BP), a recently described condition occurring most commonly in young adults. Patients typically show multiple papules, small nodules, or plaques that clinically mimic verrucae or nevocellular nevi. Although the lesions show microscopic cytologic atypia, a distinction from Bowen's disease, erythroplasia of Queyrat, and other forms of carcinoma in situ can usually be made on the basis of histologic and clinical criteria. The disorder responds to conservative treatment, although recurrences are not uncommon. Evolution of the lesions to invasive carcinoma was not observed. Mounting evidence links the development of BP to infection with human papilloma virus, but other viruses, as well as hormonal and immunologic factors, may also play a role.

Topics: Adolescent; Adult; Age Factors; Antigens, Viral; Bowen's Disease; Carcinoma in Situ; Carcinoma, Squamous Cell; DNA, Viral; Erythroplasia; Female; Glycogen; Histocytochemistry; Humans; Hyaluronic Acid; Male; Microscopy, Electron; Middle Aged; Papillomaviridae; Penile Neoplasms; Pregnancy; Sex Factors; Skin Neoplasms; Vulvar Neoplasms

We report a new case of a clear-cell acanthoma with an unusual location (para-anal), which was studied by electronmicroscopic and immuno-histological methods, using monoclonal antibodies. The results of this study showed that: a) the inflammatory cellular infiltrate comprised a small number of T-suppressor/cytotoxic lymphocytes and a small number of Langerhans cells, b) Langerhans cells were present in the affected epidermis in reduced numbers (2.2 p. 100) when compared to normal epidermis (4-6 p. 100), c) there was a disorder of both keratinization and epidermal differentiation as was shown by the abnormal reactivity of the tumor to monoclonal antibodies KL1 and BL7, d) human papilloma viruses do not seem to be involved in the genesis of the tumour, e) tumoral cells did not show (secretory) eccrine differentiation, f) the pemphigus antigen was present in the intercellular space of the affected epidermis.

Topics: Anal Canal; Antibodies, Monoclonal; Fluorescent Antibody Technique; Glycogen; Humans; Male; Middle Aged; Papilloma; Skin; Skin Neoplasms

Hidroacanthoma simplex was first described in 1956, but because of its rarity there is still confusion regarding the nomenclature of this and similar entities. The histological features of fifteen cases are presented and the literature is reviewed.

Topics: Adult; Aged; Epidermis; Female; Glycogen; Humans; Male; Middle Aged; Skin Neoplasms; Sweat Gland Neoplasms

A cell line of a benign tumor, trichilemmoma, was established in vitro and has been maintained in culture for 1.5 years with more than 30 passages. Plating efficiency was less than 0.1%, and population doubling time was 10 days. Saturation density was 10(5) cells/sq cm at the time of a monolayer with 98% cell viability. Ultrastructurally, tissue-cultured trichilemmoma cells showed desmosome-tonofilament complexes at cell-to-cell junctions. The tissue-cultured cells synthesized abundant glycogen (50 to 100 microgram/10(6) cells) e was 10 days. Saturation density was 10(5) cells/sq cm at the time of a monolayer with 98% cell viability. Ultrastructurally, tissue-cultured trichilemmoma cells showed desmosome-tonofilament complexes at cell-to-cell junctions. The tissue-cultured cells synthesized abundant glycogen (50 to 100 microgram/10(6) cells) e was 10 days. Saturation density was 10(5) cells/sq cm at the time of a monolayer with 98% cell viability. Ultrastructurally, tissue-cultured trichilemmoma cells showed desmosome-tonofilament complexes at cell-to-cell junctions. The tissue-cultured cells synthesized abundant glycogen (50 to 100 microgram/10(6) cells) as observed in vivo. Gas chromatographic analysis revealed that extracted glycogen was composed of glucose alone. Chromosome analyses with trypsin-Giemsa banding showed an abnormal karyotype with hypodiploid modal numbers of 44 and 45. There were four marker chromosomes observed in 100% of cells in 100 metaphase cells examined. Cells did not grow on fibroblast monolayers or in soft agar in vitro but did induce tumors in athymic nude mice (12 of 15) after the s.c. injection of tissue-cultured cells (2.5 x 10(6) to 4.5 x 10(7) cells/mouse). The histological characteristics of the tumors in nude mice were similar to those of the original tumor. This is the first time, to our knowledge, that a benign human tumor cell line has been established in vitro which can induce tumors in nude mice.

Topics: Aged; Amylases; Animals; Cell Line; Chromosomes; Female; Glycogen; Humans; Karyotyping; Mice; Mice, Nude; Microscopy, Electron; Neoplasm Transplantation; Neoplasms, Experimental; Skin Neoplasms; Staining and Labeling; Transplantation, Heterologous

A significant statistical difference was found between the incidence of intraepithelial elastic fibers in keratoacanthoma and squamous cell carcinoma arising in actinic keratosis (P < 0.001). There was no significant difference when keratoacanthoma was compared to adenoid squamous cell carcinoma (P = 0.13) and de novo squamous cell carcinoma (P = 0.73). However, in keratoacanthoma intraepithelial elastic fibers were found in areas of pseudoepitheliomatous hyperplasia and in the central keratin plug, as well as in areas of infiltrating, peripheral keratinocytes. In adenoid squamous cell carcinoma and de novo squamous cell carcinoma, the intraepithelial elastic fibers were found only in areas of atypical epithelial cells at the margin of the neoplasm. Intracytoplasmic glycogen was found to be statistically more abundant in keratoacanthoma than in squamous cell carcinoma arising in actinic keratosis (P < 0.001), adenoid squamous cell carcinoma (P < 0.001), and in de novo squamous cell carcinoma (P < 0.001)

Topics: Carcinoma, Squamous Cell; Cytoplasm; Diagnosis, Differential; Elastic Tissue; Glycogen; Humans; Keratoacanthoma; Skin Neoplasms

Topics: Adolescent; Adult; Carcinoma, Basal Cell; Child; Cytoplasmic Granules; Female; Glycogen; Humans; Skin Neoplasms

Two patients with clear-cell acanthoma with multiple lesions are reported; histologic and histochemical findings are similar to previous descriptions. The ultrastructural study confirms the overload of glycogen in keratinocytes, associated with an increase of mitochondria and nuclear deformations. The abundance of Langerhans' cells is emphasized. Extrusion of glycogen by keratinocytes and its phagocytosis by Langerhans' cells is suggested.

Topics: Aged; Female; Glycogen; Histocytochemistry; Humans; Langerhans Cells; Middle Aged; Papilloma; Skin Neoplasms; Steroids

The light and electron microscopic features of two mixed tumors of the skin of the salivary gland type demonstrate eccrine differentiation of the epithelial component. The tumors were made up of tuboalveolar spaces lined by an eccrine duct type of epithelium with luminal cells showing numerous microvilli. The mesenchymal elements were fibroblasts and chondrocytes embedded in a mucous and chondroid matrix. Groups of undifferentiated cells without eccrine differentiation but with ultrastructural features suggestive of epithelial origin were seen among the mesenchymal and epithelial elements of the tumor.

Topics: Adenoma, Pleomorphic; Adult; Cell Nucleus; Cytoplasm; Cytoplasmic Granules; Endoplasmic Reticulum; Epithelial Cells; Epithelium; Female; Glycogen; Glycosaminoglycans; Humans; Intercellular Junctions; Male; Skin Neoplasms; Staining and Labeling

Topics: Glycogen; Humans; Papilloma; Skin Neoplasms

Topics: Adult; Age Factors; Aged; Callosities; DNA; Female; Glycogen; Glycosaminoglycans; Humans; Keratosis; Male; Middle Aged; Precancerous Conditions; RNA; Skin; Skin Neoplasms; Wound Healing

Topics: Adenoma, Sweat Gland; Aged; Carcinoma, Squamous Cell; Diagnosis, Differential; Female; Glycogen; Glycosaminoglycans; Histocytochemistry; Humans; Leg; Male; Microscopy, Electron; Middle Aged; Skin; Skin Neoplasms; Staining and Labeling; Sweat Gland Neoplasms

Topics: Adult; Aged; Basement Membrane; Biopsy; Carcinoma, Basal Cell; Diagnosis, Differential; Facial Neoplasms; Female; Glycogen; Hair; Humans; Male; Middle Aged; Papilloma; Sex Factors; Skin Neoplasms; Warts

Topics: Acid Phosphatase; Adenosine Triphosphatases; Aged; Biopsy; Carcinoma, Squamous Cell; Dendrites; Glycogen; Histocytochemistry; Humans; Ichthyosis; Langerhans Cells; Leukocytes; Lipids; Lysosomes; Male; Mast Cells; Microscopy, Electron; Middle Aged; Nucleotides; Phosphoric Monoester Hydrolases; Skin Neoplasms

Topics: Carcinoma, Squamous Cell; Desmosomes; Glycogen; Histocytochemistry; Humans; Isotope Labeling; Keratoacanthoma; Microscopy, Electron; Periodic Acid; RNA, Neoplasm; Skin Neoplasms

Topics: Adenoma, Sweat Gland; Adolescent; Aged; Collagen; Cytoplasmic Granules; Desmosomes; Ear, External; Epithelial Cells; Female; Glycogen; Humans; Inclusion Bodies; Infant; Keratins; Leukocytes; Lipids; Lysosomes; Macrophages; Male; Melanocytes; Microscopy, Electron; Mitochondria; Mucus; Neutrophils; Skin Neoplasms

Topics: Desmosomes; Endoplasmic Reticulum; Epithelial Cells; Female; Glycogen; Golgi Apparatus; Humans; Keratins; Lysosomes; Microscopy, Electron; Microtubules; Middle Aged; Mitochondria; Mitosis; Paget Disease, Extramammary; Ribosomes; Skin Neoplasms

Topics: Female; Glycogen; Histocytochemistry; Humans; Langerhans Cells; Lipase; Melanins; Microscopy; Microscopy, Electron; Nevus; Organoids; Phosphoric Monoester Hydrolases; Skin Neoplasms

Topics: Animals; Carcinoma 256, Walker; Chromium Isotopes; Glycogen; Leukocytes; Macrophages; Mycobacterium bovis; Peptones; Phagocytosis; Rats; Skin Neoplasms; Starch

Topics: Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Glycogen; Histological Techniques; Humans; Microscopy, Electron; Skin Neoplasms

Topics: Acid Phosphatase; Alkaline Phosphatase; Glycogen; Humans; Skin Neoplasms; Skin Tests

Topics: Animals; Benz(a)Anthracenes; Dactinomycin; Endoplasmic Reticulum; Glycogen; Golgi Apparatus; Inclusion Bodies; Keratoacanthoma; Macrophages; Male; Microscopy, Electron; Mucus; Neoplasms, Experimental; Rabbits; Ribosomes; Skin; Skin Neoplasms; Vitamin A

Topics: Acid Phosphatase; Glucuronidase; Glycogen; Glycosaminoglycans; Histocytochemistry; Humans; L-Lactate Dehydrogenase; Nucleic Acids; Precancerous Conditions; Skin; Skin Diseases; Skin Neoplasms; Succinate Dehydrogenase

Topics: Basement Membrane; Carcinoma; Dermatology; Diagnosis, Differential; Esterases; Fluorescent Antibody Technique; Glycogen; Histocytochemistry; Humans; Keratins; Keratoacanthoma; Keratosis; Lupus Erythematosus, Discoid; Mast-Cell Sarcoma; Psoriasis; Skin; Skin Diseases; Skin Neoplasms; Sweat Glands; Urticaria

Topics: Adenoma, Sweat Gland; Aged; Female; Glycogen; Histocytochemistry; Humans; Skin Neoplasms; Staining and Labeling; Sweat Gland Neoplasms

Topics: Alanine Transaminase; Animals; Benz(a)Anthracenes; Glucosephosphate Dehydrogenase; Glutamate Dehydrogenase; Glyceraldehyde-3-Phosphate Dehydrogenases; Glycogen; Hexokinase; Histocytochemistry; Isocitrate Dehydrogenase; L-Lactate Dehydrogenase; Malate Dehydrogenase; Phosphofructokinase-1; Phosphogluconate Dehydrogenase; Phosphotransferases; Precancerous Conditions; Primates; Pyruvate Kinase; Skin; Skin Neoplasms

Topics: Adenosine Triphosphatases; Animals; Carcinoma, Squamous Cell; Glycogen; Histocytochemistry; Male; Methylcholanthrene; Mice; Neoplasms, Experimental; Skin; Skin Neoplasms; Succinate Dehydrogenase

Topics: Glycogen; Histocytochemistry; Humans; Male; Mast Cells; Microscopy, Electron; Middle Aged; Neutrophils; Papilloma; Skin Neoplasms

Topics: Adolescent; Adult; Aged; Black or African American; Child; Connective Tissue; Diagnosis, Differential; Ethnology; Female; Glycogen; Glycosaminoglycans; Histocytochemistry; Humans; Leprosy; Lymphocytes; Male; Middle Aged; Sarcoidosis; Skin Neoplasms; Staining and Labeling; Tuberculosis, Cutaneous; White People

Topics: Carbohydrate Metabolism; Carcinoma, Basal Cell; Glycogen; Glycosaminoglycans; Humans; Skin; Skin Neoplasms

Topics: Adenoma, Sweat Gland; Adult; Aged; Diagnosis, Differential; Electron Transport Complex IV; Female; Glucosyltransferases; Glycogen; Histocytochemistry; Humans; Male; Middle Aged; Papilloma; Skin Neoplasms; Succinate Dehydrogenase; Tyrosine Decarboxylase

Topics: Acid Phosphatase; Alkaline Phosphatase; Cell Nucleus; Culture Techniques; DNA, Neoplasm; Glycogen; Histocytochemistry; Humans; Melanoma; RNA, Neoplasm; Skin Neoplasms; Succinate Dehydrogenase

Topics: Adult; Carcinoma, Squamous Cell; Glycogen; Glycosaminoglycans; Histocytochemistry; Humans; In Vitro Techniques; Middle Aged; Skin Neoplasms

Topics: Aminosalicylic Acids; Female; Glycogen; Histocytochemistry; Humans; Microscopy; Middle Aged; Skin Neoplasms; Sweat Glands

Topics: Breast Neoplasms; Female; Gastrointestinal Neoplasms; Glycogen; Humans; In Vitro Techniques; Male; Skin Neoplasms; Urogenital Neoplasms

Topics: Acanthoma; Glycogen; Humans; Skin Neoplasms

Topics: Autoradiography; Electrons; Geriatrics; Glycogen; Histocytochemistry; Microscopy, Electron; Pathology; Phosphotransferases; Poroma; Skin Neoplasms; Sweat Glands

Topics: Glycogen; Glycosaminoglycans; Radiation Injuries; Radiation Injuries, Experimental; Radiation, Ionizing; Skin Neoplasms

Topics: Carcinoma; Carcinoma, Basal Cell; Glycogen; Skin Neoplasms

Topics: Glycogen; Humans; Skin Neoplasms