glycogen and Palatal-Neoplasms

Topics: Adult; Carcinoma, Mucoepidermoid; Glycogen; Humans; Male; Palatal Neoplasms

Glycogen-rich clear cell carcinoma arising from minor salivary glands of the uvula in a 35-year-old woman is reported. This tumor was composed of nests and cords of clear cells containing cytoplasmic glycogen but no mucin. The epithelial nature of this lesion was obvious because of positive immunoreactivity for cytokeratin and epithelial membrane antigen, and the presence of immature lumina and intercellular spaces lined by many microvilli, associated with desmosomal junctions and basal lamina, as revealed by ultrastructural study. However, no myoepithelial cells could be detected. From these findings, it may be concluded that this tumor corresponds to glycogen-rich clear cell carcinoma (a variant of clear cell tumor), revealing glandular differentiation.

Topics: Adenocarcinoma; Adult; Female; Glycogen; Histocytochemistry; Humans; Immunohistochemistry; Microscopy, Electron; Palatal Neoplasms; Salivary Gland Neoplasms; Salivary Glands, Minor; Uvula

A case of a glycogen-rich adenocarcinoma arising in the minor salivary glands of the hard palate is described. The clinical, light microscopic, histochemical, and ultrastructural findings supporting this diagnosis are presented.

Topics: Adenocarcinoma; Glycogen; Humans; Male; Middle Aged; Palatal Neoplasms; Salivary Gland Neoplasms; Salivary Glands; Salivary Glands, Minor

Tissues from four local recurrences of a palatal tumor and regional lymph node metastases were studied by light microscopy while ultrastructural observations were made on the most recent tumor. The tumor was composed of solid sheets, clumps, and small nests of polyhedral epithelial cells with well-defined cell boundaries, clear cytoplasm, and cellular pleomorphism. Histochemical stains indicated the presence of abundant intracellular glycogen deposits in all tumor specimens examined. Ultrastructural observations revealed solid sheets of epithelial cells which lacked both surrounding basement lamina and ductal arrangements. The cytoplasm of the tumor cells was filled with beta glycogen deposits and contained scattered bundles of tonofilaments and scant organelles. The transition between the glycogen-rich tumor cells and surface epithelium showed intervening cells which contained diffusely dispersed ribosomes and small amounts of glycogen. The tumor probably originated from surface epithelium.

Topics: Adenocarcinoma; Aged; Cell Nucleus; Epithelial Cells; Epithelium; Female; Glycogen; Humans; Lymphatic Metastasis; Neoplasm Recurrence, Local; Palatal Neoplasms; Palate

Topics: Animals; Antibiotics, Antineoplastic; Biopsy; Bleomycin; Carcinoma, Squamous Cell; Culture Techniques; Desmosomes; Ear Neoplasms; Epiglottis; Glycogen; Humans; Keratins; Laryngeal Neoplasms; Maxillary Neoplasms; Mice; Microscopy, Electron; Mouth Neoplasms; Neoplasms, Experimental; Palatal Neoplasms; Tongue Neoplasms; Tonsillar Neoplasms