glycogen and Nephrotic-Syndrome

Topics: Animals; Arteriosclerosis; Cholesterol; Fatty Acids, Nonesterified; Glycogen; Humans; Hyperlipidemias; Nephrotic Syndrome; Thyroxine; Triglycerides

Proteolytic enzymes exist in plasma ultrafiltrates, concentrated dialysates, and urine fractions of patients with posttraumatic acute renal failure (ARF), as well as in urine fractions of patients with nephrotic syndrome and in concentrated dialysates of patients or routine dialysis therapy (RDT). Differences in the digestion pattern of phosphorylase kinase suggest the existence on different proteases. Plasma trypsin-binding capacity is reduced in RDT patients and is markedly decreased in patients with posttraumatic ARF compared with healthy subjects. Protein catabolism of plasma fractions of patients with posttraumatic ARF is inhibited in vitro by alpha 2-macroglobulin. Urinary alpha 1-antitrypsin inactivates added kallikrein in urine fractions of patients with posttraumatic ARF or nephrotic syndrome. Proteases may also be involved in the disturbances of carbohydrate metabolism of uremic patients. The role of proteolytic degraded phosphorylase kinase, muscle contractile proteins, hormone receptors, or pancreas islets on the pathogenesis of altered carbohydrate metabolism in uremia is discussed.

Topics: Acute Kidney Injury; Adult; alpha 1-Antitrypsin; Animals; Aprotinin; Female; Glycogen; Humans; Hydrolysis; In Vitro Techniques; Kallikreins; Male; Muscle Proteins; Nephrotic Syndrome; Phosphorylase Kinase; Rats; Renal Dialysis; Time Factors; Trypsin

Topics: Acetyl Coenzyme A; Acetyl-CoA Carboxylase; Adipose Tissue; Amino Sugars; Animals; ATP Citrate (pro-S)-Lyase; Carbon Radioisotopes; Cholesterol; Deoxyadenosines; Epididymis; Fatty Acid Synthases; Fatty Acids; Fatty Acids, Nonesterified; Glycogen; Ligases; Liver; Malate Dehydrogenase; Male; Nephrotic Syndrome; Oxo-Acid-Lyases; Proteinuria; Rats; Time Factors; Triglycerides

Topics: Adult; Complement System Proteins; Creatinine; Fluorescent Antibody Technique; Glucose Tolerance Test; Glycogen; Glycosuria; Humans; Immunoglobulin G; Kidney Glomerulus; Kidney Tubules; Male; Microscopy, Electron; Nephrotic Syndrome; Proteinuria

Topics: Blood Glucose; Carbohydrate Metabolism; Fasting; Glucose; Glucose-6-Phosphatase; Glycogen; Kidney; Liver Glycogen; Muscles; Nephrotic Syndrome; Nucleosides; Pharmacology; Puromycin; Puromycin Aminonucleoside; Rabbits; Rats; Research

Topics: Adipose Tissue; Fasting; Fatty Acids; Glycerides; Glycogen; Hyperlipidemias; Lipid Metabolism; Lipoprotein Lipase; Lipoproteins; Metabolism; Nephrotic Syndrome; Rats; Research