glycogen and Neoplasms--Germ-Cell-and-Embryonal

A pulmonary blastoma is reported in a 19-year-old black female. The light and electron microscopic characterics are described; they are found to be similar to those of the fetal lung prior to the fourth gestational month. Although the ultrastructural features do not favor any particular theory of histogenesis of this unique tumor, evidence for the commonly held theory that the tumor arises from pluipotential pulmonary blastema seems tenuous. A brief review of the literature disclosed 38 other similar cases. There was a male predominance with an average age of detection at 39 years. Sputum cytology was rarely positive. Among tumors larger than 5 cm in diameter, survival was usually less than 2 years. Metastases were present in approximately half of the cases.

Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Epithelium; Female; Glycogen; Humans; Infant; Lung Neoplasms; Male; Middle Aged; Neoplasms, Germ Cell and Embryonal; Teratoma

Recent reports of Ewing's sarcoma (EW) and extraskeletal Ewing's sarcoma (EEW) support the hypothesis that these tumors are neuroectodermal in origin. Primitive neuroectodermal tumors (PNET) of bone (32 cases) and soft tissue (25 cases) including those previously categorized as EW in 27 cases and EEW in 15 cases were carefully studied histologically, immunocytochemically and morphometrically, focusing on tumor cell differentiation. This study attempts to subclassify these tumors on the basis of the size of tumor cells and nuclei, their variations (uniformity or diversity), arrangement of tumor cells (rosette or non-rosette), focal differentiation to larger ganglion-like cells, and staining intensity for neural markers. All tumors were histologically subclassified as small, medium or large cell types, three basic subtypes (rosette type, abortive rosette type, non-rosette type) and four complementary subtypes (fibrillary type, non-fibrillary type, angiomatoid type, ganglion cell type). Classic EW or EEW is consistent with small or medium, non-rosette, non-fibrillary type tumors, previously described large cell EW with large, non-rosette, fibrillary or non-fibrillary type tumors, and classic neuroectodermal tumor with small or medium, rosette, fibrillary type tumors, according to the present subclassification. Clinicopathologic correlations with the different subtypes are discussed. Long-term survival, more than 5 years, was seen in patients with small cell type, and those younger than 14 years of age.

Topics: Adolescent; Adult; Bone Neoplasms; Child; Child, Preschool; Female; Follow-Up Studies; Glycogen; Humans; Infant; Male; Neoplasms, Germ Cell and Embryonal; Neurofilament Proteins; Phosphopyruvate Hydratase; Sarcoma, Ewing; Soft Tissue Neoplasms; Survival Rate

Three cases of cloacogenous and 35 cases of squamous-cell carcinoma of the distal part of the rectum and anus were studied and compared histochemically to reveal considerable differences in mucopolysaccharides contained by the tumours. Squamous-cell carcinomas were characterized by the presence of glycogen which was not detected in cloacogenous carcinomas. In squamous-cell carcinomas, glycosamine glycanes were represented by sulfo- and sialo-mucin, while cloacogenous carcinomas largely contained a non-sulfated mucosubstance. The evidence obtained allows one to distinguish, among anal carcinomas of the rectum, a group of cloacogenous carcinomas that arose from the transitional epithelium of the serrate line and that differ from squamous-cell carcinomas in specific metabolic processes.

Topics: Anal Canal; Carcinoma, Squamous Cell; Diagnosis, Differential; Glycogen; Glycosaminoglycans; Humans; Neoplasms, Germ Cell and Embryonal; Rectal Neoplasms

Topics: Animals; Cytoplasm; Dog Diseases; Dogs; Endoplasmic Reticulum; Female; Glycogen; Golgi Apparatus; Mammary Glands, Animal; Microscopy, Electron; Neoplasms, Germ Cell and Embryonal

Topics: Aged; Cell Membrane; Cell Nucleolus; Cell Transformation, Neoplastic; Chromosomes; Epithelium; Female; Glycogen; Golgi Apparatus; Humans; Inclusion Bodies; Microscopy, Electron; Mitochondria; Mullerian Ducts; Neoplasms, Germ Cell and Embryonal; Uterine Neoplasms; Uterus

Topics: Carbohydrate Metabolism; Choriocarcinoma; Culture Techniques; Female; Glucose; Glycogen; Humans; Neoplasms, Germ Cell and Embryonal; Placenta; Pregnancy; Trophoblasts

Topics: Glycogen; Glycosaminoglycans; Histocytochemistry; Humans; Mucins; Neoplasms, Germ Cell and Embryonal; Neuraminic Acids; Parotid Neoplasms