glycogen and Mesonephroma

Nine clear cell carcinomas (CCC) of the ovary with a prominent component of cells with abundant eosinophilic cytoplasm are reported. The majority of these tumors--which we have designated "oxyphilic clear cell carcinomas"--were misinterpreted by the referring pathologists as tumors of other types. Each specimen, however, had one or more features establishing it as a clear cell carcinoma, including tubules and cysts lined by cuboidal, hobnail, or flattened cells; nests and sheets of cells with abundant clear cytoplasm containing glycogen; and an adjacent adenofibromatous component. Two tumors were bilateral. The ages of the patients (average, 55 years), their clinical presentation, and the gross appearance of the neoplasms were similar to those of clear cell carcinomas in general. The diagnosis of clear cell carcinoma should always be considered in the differential diagnosis of an ovarian tumor with oxyphil cells, particularly if the patient is postmenopausal. Thorough sampling should be undertaken in such cases to identify other, more typical foci of clear cell carcinoma in order to avoid misdiagnosis.

Topics: Adenocarcinoma; Adult; Aged; Aminosalicylic Acid; Diagnosis, Differential; Female; Glycogen; Humans; Mesonephroma; Middle Aged; Ovarian Neoplasms; Staining and Labeling

Twelve cases of ovarian clear cell carcinoma were studied histologically. Four cases were examined electron microscopically and compared with other conditions. Five tumors were directly connected with ovarian endometriosis. They were histologically classified into a tubular type with hobnail cells and a solid type without tubular pattern or hobnail cells. Electron microscopic figures of the tumor cells are identical having large nuclei, abundant glycogen, lamellated RER, few lipid droplets, and sparse but well-developed microvilli. The basophilic dark cells frequently encountered in the tubular type are morphologically quite similar to clear cells excepting for sparsity of glycogen and lipid droplets. Alveolar arrangement of 6 to 10 tubular structures (honeycomb structure) resembling alveolate structure seen in late secretory endometrium was found in tumor cells of one case. Ultrastructural feature of clear cell carcinoma closely resemble those of Arias-Stella endometrium and clear cell carcinoma of endocervix suggesting their Muellerian origin.

Topics: Adenocarcinoma; Adult; Endometriosis; Endometrium; Female; Glycogen; Humans; Kidney Neoplasms; Mesonephroma; Microscopy, Electron; Middle Aged; Neoplasms, Multiple Primary; Ovarian Neoplasms; Uterine Cervical Neoplasms

Topics: Aged; Aminosalicylic Acids; Basement Membrane; Cell Membrane; Cell Nucleolus; Cell Nucleus; Cytoplasm; Cytoplasmic Granules; Female; Glycogen; Golgi Apparatus; Humans; Mesonephroma; Microscopy, Electron; Microtubules; Mitochondria; Mucins; Ovarian Neoplasms; Ribosomes; Staining and Labeling

Topics: Adenocarcinoma; Adenocarcinoma, Mucinous; Adenocarcinoma, Papillary; Adenofibroma; Brenner Tumor; Carcinoma, Squamous Cell; Cystadenoma; Cystadenoma, Mucinous; Cystadenoma, Papillary; Cysts; Dysgerminoma; Female; Glycogen; Granulosa Cell Tumor; Histocytochemistry; Humans; Male; Mesonephroma; Mucins; Neuraminic Acids; Ovarian Neoplasms; Ovary; Pathology; Sertoli-Leydig Cell Tumor; Sex Cord-Gonadal Stromal Tumors; Thecoma