glycogen and Meningioma

Most meningiomas are benign and correspond to World Health Organization grade I, whereas chordoid meningioma is a rare subtype, which is regarded as grade II. This report presents 1 case of intraparenchymal chordoid meningioma. The intraparenchymal chordoid meningioma consisted predominantly of tissue that was histologically similar to chordoma, featuring cords or trabeculae of eosinophilic and often vacuolated cells in an abundant mucoid matrix background. Tumor cells were diffusing positive for epithelial membrane antigen and vimentin, and focusing positively for progesterone receptor, but showed lack of immunoreactivity with cytokeratin, S-100, and glial fibrillary acidic protein. Follow-up at 8 months showed no recurrence. Reports about chordoid meningioma are not uncommon, but reports on intraparenchymal lesion are rare. Besides, the result of magnetic resonance imaging in the present case suggested that intraparenchymal chordoid meningioma was a metastasis tumor. This report reminds of the importance of differential diagnosis in the case of intraparenchymal lesion.

Topics: Aged; Biomarkers, Tumor; Brain Neoplasms; Choroid Plexus; Diagnosis, Differential; Female; Glycogen; Humans; Magnetic Resonance Imaging; Meningeal Neoplasms; Meningioma; Mucin-1; Parietal Lobe; S100 Proteins; Treatment Outcome

Brain oedema is usually associated with intracranial meningiomas in about 50-66%. As underlying causes, different factors like localisation, vascular supply, angiogenic growth factors and histological subtypes are discussed, and its existence is probably multifactorial. We present 11 patients with the rare subtype of secretory meningiomas. Brain oedema was observed in 82%. These tumours are localised mainly at the frontal convexity and at the sphenoid ridge. All 11 patients were female so that hormonal factors also may play a role in the production of peritumoural oedema. The postoperative outcome was good and no recurrences were seen during follow-up.

Topics: Adult; Aged; Aged, 80 and over; Brain Edema; Carcinoembryonic Antigen; Female; Glycogen; Humans; Meningeal Neoplasms; Meningioma; Middle Aged; Mucin-1; Neoplasm Proteins; Periodic Acid-Schiff Reaction; Radiography; Receptors, Progesterone; Retrospective Studies

A case of meningioma with cytoplasm rich in glycogen granules is described as an atypical type of meningotheliomatous meningioma.

Topics: Cell Membrane; Cytoplasmic Granules; Desmosomes; Female; Glycogen; Humans; Meningeal Neoplasms; Meningioma; Middle Aged

Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Aerobiosis; Anaerobiosis; Animals; Brain; Brain Neoplasms; Creatine; Ependymoma; Glioma; Glucose; Glycogen; Glycolysis; Humans; Hypoxia; Ischemia; Lactates; Meningioma; Mice; Neoplasms, Experimental; Neurilemmoma; Oxygen Consumption; Periodic Acid; Phosphofructokinase-1; Phosphorus; RNA; Vestibulocochlear Nerve

Meningiomas are the most common extra-axial primary central nervous system tumors. There is no effective treatment or targeted therapy for meningioma except excision and radiotherapy. glycogen synthesis kinase 3β interaction protein (GSKIP) is an A-kinase anchor protein that has cytosolic scaffolding function and binds to a protein kinase A and glycogen synthesis kinase 3β to modulate different biological processes and malignant tumorigenesis through the Wnt pathway. The purpose of this study was to investigate the relationship between GSKIP expression and the clinico-pathological parameters in meningioma using immunohistochemical staining. We collected samples from 74 patients, from 2008 to 2012, in the Kaohsiung Medical University Hospital that had data on the staging and prognosis of the meningioma pathological section. Chi-square, Kaplan-Meier method, and cox regression were used to analyze the correlation between clinical parameters and immunohistochemistry staining for GSKIP. Following our immunohistochemical score, we found that higher expression of GSKIP was associated with high World Health Organization grading, recurrence, malignant transformation, and reduced overall survival time and recurrence-free survival time in meningioma. GSKIP may be a biomarker of poor prognosis and a target protein for therapy in meningioma.

Topics: Cyclic AMP-Dependent Protein Kinases; Glycogen; Humans; Meningeal Neoplasms; Meningioma; Neoplasm Recurrence, Local; Prognosis

Clear cell meningioma is an uncommon variant of meningiomas that often occurs in young patients, shows a proclivity for spinal intradural extramedullary and cerebellopontine angle, and follows an aggressive clinical course. We render clinicopathologic features of ten cases of this rare tumor to further elucidate its behavior. Fifteen specimens of clear cell meningioma belonging to ten patients were obtained at a single institution from 2001 to 2009. Correlations of histologic parameters, immunohistochemical study, and clinical features were assessed. This series included eight men and two women with a mean age of 62.1 years at the first surgery. The mean post-operative follow-up period was 3.9 years. Four patients (40%) had single or multiple local tumor recurrences. The mean time to recurrence was 2.3 years. Seven tumors (46.7%) were combined with chordoid features. There was a wide range of MIB-1 labeling indices (4.4-33.5%, mean 15.8%), which were higher in recurrent tumors, tumors with chordoid features, and tumors with necrosis. There was no correlation between MIB-1 labeling indices and brain invasion. The study illustrates aggressive behavior of clear cell meningioma and frequently combined chordoid features in our cases.

Topics: Aged; Aged, 80 and over; Aggression; Female; Glycogen; Humans; Ki-67 Antigen; Longitudinal Studies; Male; Meningeal Neoplasms; Meningioma; Middle Aged; Mucin-1; Notochord; Retrospective Studies; S100 Proteins; Vimentin; Young Adult

Clear cell meningioma (CCM) is a rare variant of meningioma characterized by sheets of polygonal cells with clear cytoplasm, a feature attributable to its high glycogen content. Authors have described its propensity to recur and metastasize despite its benign pathological characteristics. Clinical response to radiation in these reports has varied. The authors present the case of a 7-year-old girl with a large petroclival CCM who underwent a staged subtotal resection and subsequent gamma knife surgery (GKS). Initially, the residual tumor decreased in size, but 6 years later, it had regrown (9 mm in size). A second GKS treatment was performed and the mass completely regressed without further complication. The findings in this case suggest that GKS is a safe and effective adjunct for residual and recurrent CCM after resection. The delayed recurrence also emphasizes the importance of undertaking close follow-up examination after treating this potentially aggressive variant of meningioma.

Topics: Cerebellopontine Angle; Child; Dominance, Cerebral; Female; Follow-Up Studies; Glycogen; Humans; Image Enhancement; Magnetic Resonance Imaging; Meningeal Neoplasms; Meningioma; Neoplasm Recurrence, Local; Neoplasm, Residual; Neurologic Examination; Reoperation; Stereotaxic Techniques; Temporal Lobe; Tomography, X-Ray Computed

A detailed immunohistochemical and electron microscopic study of a case of clear cell (glycogen-rich) meningioma is presented. The neoplasm recurred three times and the patient died of the disease. The specimens obtained at all three operations showed similar basic histologic patterns. The tumor was comprised mainly of a syncytial, sheet-like proliferation of polygonal cells with clear cytoplasm containing abundant glycogen. The immunohistochemical features included epithelial membrane antigen- and vimentin-positive cytoplasm. The ultrastructural examination revealed distinctive meningocytic cells which contained large amounts of glycogen granules. In addition, the presence of numerous blocky, collagen conglomerations were a conspicuous feature of this tumor. The collagen deposits exhibited intensive immunopositivity for types I, III, IV and VI collagen, and their fine structure suggested the production of the extracellular matrix substance from the contiguous meningothelial cells with well developed Golgi complexes and frequent vesicles near the cell membrane. Proliferating cell nuclear antigen cell kinetics study revealed high labeling index of this neoplasm. The findings for this clear cell (glycogen-rich) meningioma may be useful in the differential diagnosis and treatment of this distinctive subtype of meningioma.

Topics: Adult; Collagen; Diagnosis, Differential; Glycogen; Humans; Immunohistochemistry; Male; Meningeal Neoplasms; Meningioma; Neoplasm Recurrence, Local; Proliferating Cell Nuclear Antigen

This report is to demonstrate that specimen pretreated with tannic acid before osmification permits the ultrastructural identification of multilamellar phospholipids in 23 of the 30 meningiomas. The phospholipids very often had a fingerprint-like appearance, and were found within the cytoplasm of meningioma cells, among the plasma membranes and in the extracellular matrices. A preferential ultrastructural localization of multilamellar phospholipids to the glycogen-rich area within the cytoplasm was seen in 5 cases. They were intermingled with glycogen granules, or the latter were precipitated on the phospholipids. It is suggested that glycogen may serve as a source of energy for precursors of phospholipid synthesis in meningioma cells.

Topics: Adult; Aged; Female; Glycogen; Histocytochemistry; Humans; Hydrolyzable Tannins; Male; Meningeal Neoplasms; Meningioma; Microscopy, Electron; Middle Aged; Phospholipids; Tumor Cells, Cultured

Two meningiomas were investigated that consisted largely of myxoid tissue. Staining with Alcian blue and incubation with staphylococcal, Streptomyces or testicular hyaluronidase revealed that the matrix of the myxoid tissue contained hyaluronic acid and chondroitin sulphate. Special fixation was used for ultrastructural preservation of the myxoid matrix, and its ultrastructural appearance was that of these glycosaminoglycans. The previous appellations of microcystic or vacuolated meningioma applied to this type of meningioma relate apparently to poor preservation of myxoid tissue.

Topics: Adult; Aged; Chondroitin Sulfates; Female; Glycogen; Humans; Hyaluronic Acid; Male; Meningeal Neoplasms; Meningioma; Microscopy, Electron

Biopsies from 15 human gliomas, five meningiomas, four Schwannomas, one medulloblastoma, and four normal brain areas were analyzed for 12 enzymes of energy metabolism and 12 related metabolites and cofactors. Samples, 0.01-0.25 microgram dry weight, were dissected from freeze-dried microtome sections to permit all the assays on a given specimen to be made, as far as possible, on nonnecrotic pure tumor tissue from the same region. Great diversity was found with regard to both enzyme activities and metabolite levels among individual tumors, but the following generalities can be made. Activities of hexokinase, phosphorylase, phosphofructokinase, glycerophosphate dehydrogenase, citrate synthase, and malate dehydrogenase levels were usually lower than in brain; glycogen synthase and glucose-6-phosphate dehydrogenase were usually higher; and the averages for pyruvate kinase, lactate dehydrogenase, 6-phosphogluconate dehydrogenase, and beta-hydroxyacyl coenzyme A dehydrogenase were not greatly different from brain. Levels of eight of the 12 enzymes were distinctly lower among the Schwannomas than in the other two groups. Average levels of glucose-6-phosphate, lactate, pyruvate, and uridine diphosphoglucose were more than twice those of brain; 6-phosphogluconate and citrate were about 70% higher than in brain; glucose, glycogen, glycerol-1-phosphate, and malate averages ranged from 104% to 127% of brain; and fructose-1,6-bisphosphate and glucose-1,6-bisphosphate levels were on the average 50% and 70% those of brain, respectively.

Topics: Adolescent; Adult; Aged; Brain; Brain Neoplasms; Child; Child, Preschool; Energy Metabolism; Female; Glioma; Glycogen; Glycolysis; Humans; Male; Medulloblastoma; Meningioma; Middle Aged; Mitochondria; Neurilemmoma; Oxidative Phosphorylation

Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Adolescent; Adult; Aged; Brain Neoplasms; Child; Creatine Kinase; Energy Metabolism; Female; Glioma; Glycogen; Humans; Lipids; Male; Meningioma; Middle Aged; Neurilemmoma; Phosphates; Phosphocreatine; Uridine Triphosphate

Topics: Animals; Axons; Biopsy; Brain Neoplasms; Cerebral Cortex; Cytoplasm; Dendrites; Glycogen; Histocytochemistry; Humans; Meningioma; Microscopy, Electron; Mitochondria; Neuroglia; Rabbits; Synapses; Synaptic Membranes; Synaptic Vesicles

Topics: Adenosine Triphosphatases; Central Nervous System Diseases; Glucosyltransferases; Glycogen; Hexosaminidases; Histocytochemistry; Humans; Hydrolases; L-Lactate Dehydrogenase; Lipids; Lysosomes; Mast Cells; Meningioma; Neoplasms; Oxidoreductases; Succinate Dehydrogenase

Topics: Animals; Brain Neoplasms; Cerebral Cortex; Glioblastoma; Glycogen; Humans; Meningioma; Microscopy, Electron; Neuroglia; Neurons; Rabbits

Topics: Glycogen; Histocytochemistry; Humans; Meningioma; Microscopy, Electron

Topics: Adult; Animals; Brain Chemistry; Female; Glioblastoma; Glycogen; Humans; Liver; Male; Meningioma; Mice; Microscopy, Electron; Middle Aged; Neoplasms, Experimental

Topics: Astrocytoma; Brain Neoplasms; Carbohydrate Metabolism; Cerebellar Neoplasms; Ependymoma; Glioma; Glycogen; Glycosaminoglycans; Histocytochemistry; Humans; Lipid Metabolism; Lipids; Medulloblastoma; Meningeal Neoplasms; Meningioma

Topics: Cell Nucleus; Cytoplasm; Glycogen; Golgi Apparatus; Meningeal Neoplasms; Meningioma; Mitochondria; RNA