glycogen and Maxillary-Neoplasms

We describe two cases of primary intraosseous hyalinizing clear cell carcinomas of the jaws. One tumor arose in the mandible, the other in the maxilla. Both patients were adult women. Histologically, both tumors were characterized by a population of clear, glycogen-rich cells arranged in solid nests, trabeculae, and occasional single files, surrounded by a markedly hyalinized fibrous stroma. In close admixture with the clear cells, a second component of smaller cells having eosinophilic cytoplasms was also noted. Focal areas of squamous metaplasia were seen in one of the tumors. Neither nuclear pleomorphism nor mitotic activity were conspicuous features. Mucicarmine stains were negative in both tumors. Immunohistochemically, the tumor cells expressed cytokeratins and epithelial membrane antigen. Stains for S100 protein, smooth muscle specific actin, and carcinoembryonic antigen were all negative. Both patients are alive and well 14 and 17 months respectively after the diagnosis without evidence of metastasis or recurrence. The major importance of recognizing the existence of this rare form of salivary gland-type adenocarcinoma arising as a primary lesion in the mandible or the maxilla lies in avoiding misdiagnosing it as other primary or metastatic clear cell neoplasms, including various odontogenic clear cell tumors, other primary intraosseous salivary gland tumors, and metastatic clear cell adenocarcinomas from other organs, particularly the kidney.

Topics: Adenocarcinoma, Clear Cell; Aged; Diagnosis, Differential; Female; Glycogen; Humans; Hyalin; Mandibular Neoplasms; Maxillary Neoplasms; Middle Aged; Odontogenic Tumors; Salivary Gland Neoplasms

A rare case of clear cell variant of calcifying epithelial odontogenic tumor is presented with immunohistochemical and ultrastructural investigations. A 14-year-old Japanese girl was admitted with a complaint of swelling in the right posterior maxilla. Radiological examination showed a well-circumscribed radiolucent lesion located close to the impacted third molar. After only a partial tumor excision, the tumor recurred 13 years later. It appeared radiologically as an irregular radiodensity, and a subtotal maxillectomy was performed. Histological examination showed sheets and/or strands composed almost entirely of clear vacuolated epithelial cells in a stroma containing intercellular amyloid-like material and calcification. Histochemical and ultrastructural analysis detected cytoplasmic glycogen granules in the clear cells, and positive immunoreactivities for cytokeratins 8, 13 and 19; filaggrin and anti-ameloblastoma antibodies suggested an odontogenic epithelial origin.

Topics: Adolescent; Amyloid; Antibodies, Neoplasm; Calcinosis; Epithelial Cells; Female; Filaggrin Proteins; Glycogen; Humans; Immunohistochemistry; Intermediate Filament Proteins; Intermediate Filaments; Keratins; Maxillary Neoplasms; Microscopy, Electron; Odontogenic Tumors

Topics: Adolescent; Amyloid; Calcinosis; Calcium; Cell Division; Cell Nucleus; Cytoplasm; Cytoplasmic Granules; Desmosomes; Epithelium; Female; Glycogen; Humans; Intermediate Filaments; Keratins; Maxillary Neoplasms; Microscopy, Electron; Microvilli; Odontogenic Tumors

A gingival tumor that invaded the anterior maxilla was removed from a 14-year-old boy and studied by light and electron microscopy. The tumor was composed exclusively of myoepithelial cells and appeared to be malignant. By light microscopy, the tumor appeared to be a poorly differentiated epithelial neoplasm of undetermined origin; however, electron microscopical examination showed myoepithelial differentiation, indicative of a salivary gland origin. To our knowledge, the present case represents the only confirmed myoepithelioma that shows features indicative of malignant potential. Myoepitheliomas may be related to mixed tumors of salivary glands.

Topics: Adolescent; Biopsy; Cell Nucleus; Chromatin; Cobalt Radioisotopes; Diagnosis, Differential; Gingiva; Gingival Neoplasms; Glycogen; Humans; Male; Maxilla; Maxillary Neoplasms; Microscopy; Microscopy, Electron; Myoepithelioma; Radiography; Salivary Gland Neoplasms; Staining and Labeling

An extensive review of the English-language literature has produced only five undoubted cases of peripheral odontogenic fibroma. This article reports ten new cases. The age and sex of the patients and the distribution by site and histology of the lesions are compared with those of other cases of bifrous tumors and neoplasms of odontogenic origin. It is postulated that this lesion may be more closely related to the fibrous euplis than was previously realized. Both lesions show hyperplasia of the basal layer of the covering ipithelium into double strands resembling odontogenic epithelium. It is suggested that this hyperplasia may be related to induction of the covering epithelium by primitive ectomesenchymal remnants within the gingivae. Proliveration of odontogenic rests within the peripheral odontogenic frbroma may be related to the same stimulus.

Topics: Adolescent; Adult; Age Factors; Basement Membrane; Calcinosis; Cell Nucleus; Child; Collagen; Connective Tissue; Connective Tissue Cells; Cytoplasm; Epithelial Cells; Epithelium; Female; Gingival Neoplasms; Glycogen; Humans; Male; Mandible; Mandibular Neoplasms; Maxilla; Maxillary Neoplasms; Middle Aged; Odontogenic Tumors; Sex Factors; Staining and Labeling

Topics: Animals; Antibiotics, Antineoplastic; Biopsy; Bleomycin; Carcinoma, Squamous Cell; Culture Techniques; Desmosomes; Ear Neoplasms; Epiglottis; Glycogen; Humans; Keratins; Laryngeal Neoplasms; Maxillary Neoplasms; Mice; Microscopy, Electron; Mouth Neoplasms; Neoplasms, Experimental; Palatal Neoplasms; Tongue Neoplasms; Tonsillar Neoplasms