glycogen and Leukoplakia

Glycogenic acanthosis is a common benign lesion of the esophagus; however, reports of extra-esophageal manifestations are exceedingly rare. This case represents the first report of laryngeal glycogenic acanthosis found in a living patient, presenting as vocal fold leukoplakia. Glycogenic acanthosis may be considered among the differential diagnoses of conditions presenting as vocal fold leukoplakia. Laryngoscope, 132:1641-1643, 2022.

Topics: Esophageal Diseases; Glycogen; Humans; Laryngeal Diseases; Leukoplakia; Vocal Cords

We report a case of an incidental finding of glycogenic acanthosis of the larynx on autopsy in a 79-year-old man who died of myocardial infarction. The lesion was grossly recognized as a white plaque (leukoplakia) on the subglottic compartment of the left side of the larynx. Histological sections revealed thickened squamous mucosa positive for abundant glycogen on periodic acid-Schiff staining. No epithelial dysplasia was noted. The patient had a history of smoking. This case represents the first report of glycogenic acanthosis involving the larynx. This benign condition should be added to the vast differential diagnosis of leukoplakia in this anatomical location.

Topics: Aged; Diagnosis, Differential; Glycogen; Humans; Laryngeal Diseases; Laryngeal Mucosa; Leukoplakia; Male

The fine structural morphology of dyskeratotic and dysplastic keratinocytes in human oral epithelium was investigated by light microscopy as well as by transmission and scanning-electron microscopy. On the epithelial-connective tissue border, marked changes are seen in the form of polymorphous microinvasive cytoplasmic processes of basal keratinocytes, structural alterations of the basement membrane and rarefaction of the subepithelial connective tissue. Dyskeratotic keratinocytes with abnormal tonofilament configuration are phagocytized by dermal macrophages and are transported to the lamina propria. Ultrastructural signs of atypia are found in the nucleus, nucleolus, cytoplasmic organelles and mitotic apparatus. Furthermore, multiple alterations of the plasma membrane, decrease in numbers of junctional complexes and acantholytic widened intercellular spaces are observed. Intracytoplasmic lumina are formed by endocytotic invagination of desmosome-studed plasma membrane regions at the cell surface. Despite an inverse relationship between the degree of keratinization and the glycogen content of the epithelium at the subcellular level, large amounts of glycogen are found in some keratinocytes. The epithelial surface is formed by hyper-, para-, or orthokeratosis, or shows individual cell keratinization, alteration of the disintegration process and defective keratin synthesis. The ultrastructural analysis of dysplastic keratinocyte populations reveals some morphological criteria common with invasive squamous cell carcinoma, which may be important in the early diagnosis and prognosis of malignant transformation of epithelial dysplasia.

Topics: Cell Membrane; Cell Transformation, Neoplastic; Epithelial Cells; Epithelium; Glycogen; Humans; Intercellular Junctions; Keratins; Leukoplakia; Macrophages; Mouth Mucosa; Organoids; Phagocytosis

Topics: Biopsy; Glycogen; Humans; Keratins; Leukoplakia; Lichen Planus; Mouth Mucosa; Precancerous Conditions

Topics: Aged; Alcoholism; Autopsy; Biopsy; Diagnosis, Differential; Endoscopy; Epithelium; Esophageal Diseases; Esophagitis; Esophagoscopy; Esophagus; Gastroesophageal Reflux; Glycogen; Humans; Hyperplasia; Intestinal Mucosa; Leukoplakia; Male; Middle Aged; Periodic Acid; Smoking; Staining and Labeling

Topics: Adult; Aged; Biopsy; Cytoplasmic Granules; Epithelium; Female; Gingiva; Glycogen; Histocytochemistry; Humans; Keratins; Leukoplakia; Leukoplakia, Oral; Lichen Planus; Male; Microscopy, Electron; Middle Aged; Mouth Diseases; Mouth Mucosa; Mouth Neoplasms; Palate; Tongue

Topics: Cell Membrane; Cell Nucleus; Cheek; Cytoplasmic Granules; Epithelium; Glycogen; Histocytochemistry; Humans; Inflammation; Keratins; Keratosis; Leukoplakia; Leukoplakia, Oral; Lichen Planus; Microscopy, Electron; Mouth Mucosa; Mouth Neoplasms; Smoking

Topics: Aged; Autopsy; Carcinoma, Squamous Cell; Epithelium; Esophageal Diseases; Esophageal Neoplasms; Esophagus; Female; Glycogen; Humans; Hyperplasia; Hypertrophy; Leukoplakia; Male; Middle Aged; Precancerous Conditions

Topics: Epithelium; Female; Glycogen; Histocytochemistry; Humans; Leukoplakia; Vulva; Vulvar Lichen Sclerosus; Vulvar Neoplasms

Topics: Female; Glycogen; Histocytochemistry; Humans; Leukoplakia; Methods; Polyps; Uterine Cervical Diseases; Uterine Cervical Erosion; Uterine Cervical Neoplasms; Uterine Cervicitis

Topics: Adult; Aged; Glycogen; Histocytochemistry; Humans; Leukoplakia; Male; Middle Aged; Mouth

Topics: Adult; Aged; Female; Glycogen; Histocytochemistry; Humans; Inflammation; Keratins; Leukoplakia; Male; Middle Aged; Mouth Mucosa; Staining and Labeling; Vitamin A

Topics: Adult; Female; Gingival Hyperplasia; Glycogen; Humans; Keratins; Keratosis; Leukoplakia; Male; Middle Aged

Topics: Coloring Agents; Cystoscopy; Epithelium; Estrogens; Female; Glycogen; Humans; Leukoplakia; Metaplasia; Staining and Labeling; Urinary Bladder

Topics: Face; Gastrointestinal Tract; Glycogen; Humans; Leukoplakia; Mouth; Mouth Mucosa

Topics: Carcinoma, Squamous Cell; Epidermis; Female; Glycogen; Humans; Leukoplakia; Vulvar Neoplasms

Topics: Electrons; Glycogen; Leukoplakia; Microscopy, Electron; Mucous Membrane