glycogen and Leukemia

Topics: Cell Division; DNA, Viral; Glycogen; Glycolysis; Humans; In Vitro Techniques; Leukemia; Leukocytes; Nucleic Acids; Retroviridae; RNA, Viral; Virus Cultivation

Topics: Blood Glucose; Carbohydrate Metabolism, Inborn Errors; Carbohydrates; Citric Acid Cycle; Clinical Enzyme Tests; DNA; Down Syndrome; Galactosemias; Glucosephosphate Dehydrogenase Deficiency; Glycogen; Glycogen Storage Disease; Glycolysis; Glycosaminoglycans; Humans; Leukemia; Leukocytes; Muramidase; Neutrophils; Pentosephosphates; Phagocytosis; Propionates; RNA

Topics: Acute Disease; Alkaline Phosphatase; Chronic Disease; Glycogen; Hematologic Diseases; Histocytochemistry; Humans; Leukemia; Leukocytes; Lipids; Methods; Peroxidases

Topics: Age Factors; Alkaline Phosphatase; Aminosalicylic Acids; Cell Differentiation; Child; Child, Preschool; Diagnosis, Differential; Esterases; Glycogen; Histocytochemistry; Humans; Leukemia; Leukemia, Erythroblastic, Acute; Leukemia, Lymphoid; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Peroxidases; Phospholipids

Topics: Acid Phosphatase; Alkaline Phosphatase; Bone Marrow Diseases; Bone Neoplasms; Esterases; Glucosyltransferases; Glycogen; Histocytochemistry; Leukemia; Lipid Metabolism; Myeloproliferative Disorders; Peroxidases; Succinate Dehydrogenase

Topics: Alpha-Globulins; Beta-Globulins; Blood Protein Electrophoresis; Blood Proteins; DNA; Electrophoresis; gamma-Globulins; Globulins; Glycogen; Haptoglobins; Hemoglobins; Humans; Leukemia; Lipoproteins; Macromolecular Substances; RNA; Serum Albumin

Topics: Alpha-Globulins; Beta-Globulins; Blood Protein Electrophoresis; Blood Proteins; Electrophoresis; gamma-Globulins; Globulins; Glycogen; Haptoglobins; Hemoglobins; Humans; Leukemia; Lipoproteins; Macromolecular Substances; RNA; Serum Albumin

In this report, we present a case of peripheral T-cell leukemia/lymphoma having mostly small- to medium-sized cells with abundant clear cytoplasmic vacuoles. The presentation at the time of diagnosis was one of leukemia/lymphoma. The phenotype of the leukemic cells of the peripheral blood was T1+, T11+, TQ1+, interleukin-2+, T3-, T4-, and T8-. The cells in the peripheral blood as well as those obtained from lymph node biopsy were strongly periodic acid-Schiff positive; the positivity was diastase sensitive. Electron microscopy confirmed the presence of glycogen in the cytoplasmic vacuoles. Serologic tests were negative for human T-cell lymphotropic virus type 1 antibody. The data presented in this article support the existence of a vacuolated variant of peripheral T-cell leukemia/lymphoma and further expand the morphological spectrum of T-cell lymphoproliferative disorders.

Topics: Aged; Aged, 80 and over; Flow Cytometry; Glycogen; Humans; Leukemia; Leukemia, T-Cell; Male; Microscopy, Electron; Periodic Acid-Schiff Reaction; T-Lymphocytes; Vacuoles

Receptor binding and biological effects of insulin and insulin-like growth factors I and II (IGF I/II) were assessed in three human malignant cell lines: a Burkitt-type ALL-cell line, a ANLL-cell line and a Hodgkin's disease-cell line. Insulin receptor binding could be demonstrated in Burkitt-type ALL cells and ANLL cells, whereas no insulin receptor binding was detectable in Hodgkin cells. IGF I and IGF II binding could be demonstrated in all leukemic cells. Insulin stimulated glycogen synthesis in the insulin receptor bearing cell lines. DNA synthesis was stimulated by insulin, IGF I and II. IGF I was more active in stimulating DNA synthesis than IGF II.

Topics: Cell Line; DNA; Glycogen; Humans; Insulin; Leukemia; Receptor, Insulin; Receptors, Somatomedin; Somatomedins

Periodate-reactive glycoconjugates in human leukaemic cells were examined electron microscopically by the periodic acid-thiocarbohydrazide-silver proteinate (PA-TCH-SP) method. Granules in ALL cells were classified into 4 types based on PA-TCH-SP staining features. Abnormal granules containing glycogen were observed only in children with treatment-resistant ALL. Cytoplasmic granules in leukaemic cells of patients with AML and acute monocytic leukaemia exhibited moderate reactivity. The distribution pattern of glycogen in the cytoplasm of leukaemic cells was classified into 3 types, one lacking glycogen, one containing small glycogen particles scattered throughout cytoplasm, and one showing clusters of glycogen particles. Cells with glycogen clusters were observed in ALL cells and in erythroblasts from patients with erythroleukaemia. PA-TCH-SP reactivity was detected in the rough endoplasmic reticulum in acute promyelocytic leukaemia but not in ALL or other types of AML. Megakaryoblasts in megakaryocytic crisis of chronic myelogenous leukaemia exhibited characteristic PA-TCH-SP reactivity similar to that of normal megakaryocytes.

Topics: Bone Marrow; Cytoplasmic Granules; Glycogen; Humans; Indicators and Reagents; Leukemia; Leukemia, Erythroblastic, Acute; Leukemia, Lymphoid; Leukemia, Myeloid; Microscopy, Electron

Topics: Acute Disease; Alkaline Phosphatase; Electron Transport Complex IV; Glycogen; Humans; Isoenzymes; Leukemia; Lipids; Neutrophils; Peroxidase; Peroxidases

The eosinophils of a patient with eosinophilic leukaemia were studied with 13 different cytochemical methods using light and electron microscopy. Apart from the 'left shift' of the eosinophils in bone marrow and peripheral blood, the following morphological changes were noted: uncoordinated maturation of the nucleus and cytoplasm, changes in size of the specific granules, and hypogranulation to such an extent that some of the cells bore only very few granules. The cytochemical studies showed a strongly positive periodic acid Schiff reaction in the eosinophils, caused by a high content of glycogen, and a relatively strong positive acid-phosphatase reaction. These cells were also tested for aryl sulphatase and coenzyme Q. Electron microscopy confirmed the presence of a high-content glycogen and a strong acid phosphatase response in the cells. Peroxidase reaction, detected in electron microscopy as well, enabled us to trace the maturation of the eosinophil cell line.

Topics: Acid Phosphatase; Adult; Arylsulfatases; Cell Nucleus; Cytoplasm; Cytoplasmic Granules; Eosinophils; Glycogen; Humans; Leukemia; Male; Periodic Acid-Schiff Reaction; Peroxidases; Ubiquinone

Topics: Acute Disease; Adolescent; Adult; Child; Child, Preschool; Glycogen; Humans; Infant; Leukemia; Leukocyte Count; Lymphocytes; Middle Aged; Succinate Dehydrogenase

Different HT have been studied with the electron microscope and the findings compared to those in the literature. Five patients with thrombasthenia and three with Willebrand's diseases showed various disorders, usually anisocytosis and hypertrophic open canalicular system, in relation to regenerative states. Thirteen young children with 21-trisomy (2 with leukemia) and 13/15 trisomy (1 case) had enlarged platelets with abnormalities of membranes and vacuoles indicating some metabolic disorders and necrotic lesions. One child with Cooley's anemia showed a few granules and necrotic lesions. All these symptoms were related to regenerative or primitive megakaryocytopathias. The lesion of these latter cell appears in other HT: aberrations of membranes in giant platelets syndroms (J. Bernard and J. P. Soulier syndrome), disorders in membranes and/or granules in thrombopenic thrombopathias, the short platelet life span in May-Hegglin anomaly, storage pool disease in Hermansky-Pudlak syndrome. Finally the ultrastructural abnormalities of the platelets mainly help to distinguish several diseases of megakaryocytes.

Topics: Blood Platelet Disorders; Blood Platelets; Cell Adhesion; Cell Membrane; Child; Chromosomes, Human, 13-15; Cytoplasmic Granules; Down Syndrome; Glycogen; Hemorrhagic Disorders; Humans; Leukemia; Lipid Metabolism; Megakaryocytes; Microscopy, Electron; Purpura, Thrombocytopenic; Thalassemia; Vacuoles; von Willebrand Diseases

Quantitative glycogen determinations can be made in single blood and bone marrow cells, using microspectrophotometry or microfluorometry after staining with variants of the periodic acid--Schiff (PAS) reaction. These PAS variant reactions generally do not indicate the presence of non-glycogen PAS-positive substances, known to be prevalent in various hematopoietic cells, possibly due to masking of reactive groups. The specificity of the reaction in blood cells was ascertained by alpha-amylase digestion, which removed more than 95% of the PAS-positive material. Calibration of the PAS reaction was undertaken with a microdroplet model of pure leukocyte glycogen. The glycogen amounts in the droplets were determined by microinterferometry, the droplets were stained with a variant PAS reaction, and the total extinction of the reaction product in the stained droplets was determined by microspectrophotometry. The extinction coefficient (k) was obtained from the equation k equals Etot divided by M where (Etot) is the total extinction as determined by microspectrophotometry and (M) the dry glycogen amount as determined by microinterferometry. The microinterferometric dry mass determinations were calibrated by X-ray absorption in order to obtain the absolute amounts of glycogen. For practical purposes a reference system was made of normal neutrophil leukocytes. The glycogen content in the reference neutrophils was first determined with the micromodel. These neutrophils, now with a known glycogen amount, were stained with the PAS reagents and measured microspectrophotometrically in parallel with cells containing an unknown glycogen amount. Alternatively, the staining was made with a fluorescent PAS reaction, and the glycogen content determined by microfluorometry. Both methods appeared suitable for determining the glycogen content of blood cells from patients with various diseases, though the microfluorometric method was preferable for measurements of small amounts of inhomogeneously distributed glycogen. The mean glycogen content of normal neutrophil leukocytes was found to be 13.6 times 10(-12) g. The content was increased in infectious diseases such as pneumonia and tonisillitis, as well as in polycythemia vera and myelofibrosis, while low amounts were found in untreated chronic myelocytic leukemia. In chronic myelocytic leukemia in remission, the glycogen content of mature neutrophils had completely normalized. Erythroblasts normally do not contain detectable amou

Topics: Autoradiography; Blood Cells; Bone Marrow; Bone Marrow Cells; Communicable Diseases; Diabetes Mellitus; Fluorometry; Glycogen; Glycogen Storage Disease; Histocytochemistry; Humans; Interferometry; Leukemia; Microradiography; Models, Biological; Myocardial Infarction; Neutrophils; Periodic Acid-Schiff Reaction; Polycythemia; Spectrophotometry; Thalassemia; X-Rays

Phosphorylase activity was detected in the cytoplasm of erythroid precursors of 6 of 7 patients with chronic erythremic myelosis (Di Guglielmo syndrome), in proerythroblasts and megaloblasts from 3 patients with pernicious anemia and in 2 patients with severe folate deficiency in neoplastic lymphocytes from 2 patients with acute lymphoblastic leukemia, and in 1 patient with leukemic lymphosarcoma. In all of these patients, most of the erythroid precursors and/or neoplastic lymphocytes contained increased amounts of glycogen when stained with the PAS reagent. Phosphorylase activity was not detected in erythroid precursors obtained from 6 presumed normal individuals or from 3 of 7 patients with a variety of other types of anemia in which the erythroid precursors were PAS-negative. Similarly, phosphorylase activity was absent in lymphocytes obtained from presumed normal individuals. Although the mechanisms responsible for the pathogenesis of PAS positivity are unclear, it is possible that the increased phosphorylase activity found in cells that are PAS-positive may reflect a disorder in the biosynthetic pathway of glycogen.

Topics: Anemia, Hemolytic; Anemia, Hemolytic, Autoimmune; Anemia, Pernicious; Bone Marrow; Bone Marrow Cells; Erythroblasts; Folic Acid Deficiency; Glycogen; Humans; Leukemia; Leukemia, Erythroblastic, Acute; Leukemia, Lymphoid; Phosphorylases; Spherocytosis, Hereditary; Staining and Labeling

From 63 children with acute leukaemia the bone-marrow smears were cytochemically examined before the beginning of therapy. The activity of peroxydase was examined according to Sato and Sekya, that of acid phosphatase according to Löffler and Berghoff, that of alpha-naphthyl-acetate-esterase according to Gomori; the evidence of glycogen was examined by means of the PAS-diastase response according to McManus. Among the 63 cases of leukaemia we found 6 cases of paramyeloblastic leukaemia, 2 cases of parapromyelocytic leukaemia, and 3 cases of myelomonocytic leukaemia. 52 cases of leukaemia could not be further differentiated in morphological respect. They represented an immature paraleukoblastic leukaemia. A division according to leading cytochemical criteria was made for them. The therapeutic possibility of influencing the various groups was checked by means of prolonged observations. Children affected with paraleukoblastic leukaemia of the phosphatase type had a significantly low rate of remission similar to the myeloid leukaemia. Paraleukoblastic leukaemia of the PAS type, esterase type and the undifferentiated type revealed no essential differences. The rate of remission, however, was highest in leukaemia of the PAS type amounting to 100%. In one part of patients the prolonged cytochemical observations in 8 children with recidives showed that the cytochemical type under chemotherapy was changed.

Topics: Acid Phosphatase; Acute Disease; Bone Marrow; Bone Marrow Cells; Child; Esterases; Glycogen; Histocytochemistry; Humans; Leukemia; Leukocytes; Peroxidases; Remission, Spontaneous

In exsudate cells separated from serous body cavities of 29 tumour patients and 30 patients with inflammatory and congestive effusion in cardiac failure or liver cirrhosis respectively the activities of acid and alkaline phosphatase were determined. In addition to sudanophilia the cell content of glycogen and that of ribonucleinic acid were evaluated. By means of cytochemical findings it could be found that an increase of unspecific esterase, acid phosphatase and ribonucleic acid in atypical cells points to a malignous ethiology of the exudate.

Topics: Acid Phosphatase; Alkaline Phosphatase; Ascitic Fluid; Esterases; Exudates and Transudates; Glycogen; Heart Failure; Histocytochemistry; Hodgkin Disease; Humans; Leukemia; Liver Cirrhosis; Lymphoma, Large B-Cell, Diffuse; Neoplasms; Peritonitis; Pleural Effusion; Pleurisy; RNA

In the bone marrow of two patients with acute leukemia 46% and 55% of atypical eosinophilic cells were found, respectively. Blood eosinophilia was absent. The N-AS-D-Cl-Esterase reaction of the granules was positive in the first case in 58%, and in the second case in 3% of the eosinophils, as well as the PAS-reaction in all cells of this series. The ultrastructure of the eosinophils reveals nuclear maturation up to hypersegmentation. The maturation of the granules, in part of abnormal size, is arrested at the primary stage. Typical secondary granules with cristalloid cores are lacking. Only in the first case a few, small, semicircular or circular profiles of lamellar substructure are seen in the granules. The cytoplasm of hypersegmentated eosinophils shows an abnormally high glycogen content. Besides the eosinophils, monocytic cells and their precursors proliferate in the bone marrow of the first patient. In the second patient myeloblasts, promyelocytes with Auer rods, and monocytic cells characterize further neoplastic cell population. The elements of the monocytic series can be identified by their ultrastructural features, such as irregular configuration of the nuclei, bundles of cytoplasmatic microfilaments, and numerous small electron-dense lysosomal granules. In both cases the Alpha-Naphthyl-Acetase-Esterase reaction is weakly positive. The findings presented are summarized under the terms "eosinophil-monocytic leukemia" and "eosinophil-myelomonocytic leukemia" (collective term).

Topics: Adult; Bone Marrow; Bone Marrow Cells; Eosinophils; Esterases; Glycogen; Humans; Leukemia; Leukemia, Monocytic, Acute; Leukemia, Myeloid, Acute; Male; Microscopy, Electron; Monocytes

In leukemic cows the percentage of leucocytes and lymphoid cells of the peripheral blood and marrow, with intensely stained violet glycogen granules in the plasma, which nevertheless exceptionally appear even in the leucocytes and lymphocytes of healthy cows, is significantly higher. Lymphocytes with a negative PAS reaction are found in both healthy and leukemic cows. PAS reaction can therefore be used as an auxiliary method for differentiating leukemic lymphocytes in a complex of further cytochemical reactions. In neutrophilous peripheral blood leucocytes of healthy and leucotic cattle the PAS reaction attained the values of ++ to +++. In the marrow of both groups an attenuated reaction was recorded in the myelocytes and promyelocytes (0 to +). Eosinophilous leucocytes and their developmental stages yielded negative PAS reaction. Monocytes showed a weak reaction in the periphery of healthy cattle whereas in the leucotic cattle the reaction was somewhat stronger, PAS reaction of the erythrocyte and thrombocyte bone marrow series was negative.

Topics: Animals; Bone Marrow; Bone Marrow Cells; Cattle; Cattle Diseases; Eosinophils; Glycogen; Leukemia; Leukocytes; Lymphocytes; Neutrophils

A decrease in glycogen content and glycogen-synthetase activity was observed in leukemic leucocytes compared to those of normal humans, but the decrease was lesser in chronic myeloid leukemic leucocytes than in those of acute leukemic patients. Incubation of crude leucocyte homogenates at 30 degrees C before assay of the enzyme activity, revealed a conversion of the glycogen-synthetase from the D to the I form. It took place if the enzyme source were enzyme extracts from acute myeloblastic, acute lymphoblastic, chronic lymphocytic, acute menoblastic and undifferenciate leucocytes. The conversion did not occur in crude homogenates from leucocytes of chronic myeloid leukemic patients. ATP-Mg caused a conversion of the glycogen-synthetase I form to the D form in acute myeloblastic, chronic lymphocytic and undifferenciate leukemic leucocytes. This conversion was not observed in chronic myelocytic leukemic leucocytes.

Topics: Glycogen; Glycogen Synthase; Humans; Leukemia; Leukocytes

Topics: Acute Disease; Adult; Age Factors; Aged; Aminosalicylic Acids; Asparaginase; Cytarabine; Cytodiagnosis; Cytoplasm; Daunorubicin; Diagnosis, Differential; Drug Therapy, Combination; Female; Glycogen; Histocytochemistry; Humans; Leukemia; Leukemia, Lymphoid; Male; Methotrexate; Middle Aged; Prognosis; Staining and Labeling; Vincristine

Topics: Adult; Aged; Blood Cell Count; Blood Glucose; Blood Platelets; Blood Proteins; Carbon Dioxide; Carbon Isotopes; Female; Glycogen; Humans; Lactates; Leukemia; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Male; Methods; Middle Aged; Purpura, Thrombocytopenic; Remission, Spontaneous; Thrombin; Thrombocytopenia

Topics: Aged; Eosinophilia; Erythrocytes; Female; Galactose; Genes; Glycogen; Humans; Karyotyping; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Leukocyte Count; Leukocytes; Lymphocytes; Male; Nucleotidyltransferases; Statistics as Topic; Trisomy; Uracil Nucleotides

Topics: Blood Platelets; Diabetes Mellitus; Glycogen; Glycogen Storage Disease; Histocytochemistry; Humans; Infant, Newborn; Infant, Newborn, Diseases; Infant, Premature, Diseases; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Liver Cirrhosis; Microscopy, Phase-Contrast; Myeloproliferative Disorders; Polycythemia; Primary Myelofibrosis; Purpura, Thrombocytopenic; Remission, Spontaneous; Uremia; von Willebrand Diseases

Topics: Acute Disease; Adolescent; Adult; Biopsy; Cytoplasm; Demyelinating Diseases; Female; Glycogen; Hodgkin Disease; Humans; Leukemia; Male; Microscopy; Microscopy, Electron; Middle Aged; Nerve Degeneration; Polyneuropathies; Schwann Cells; Sural Nerve; Vinblastine; Vinca Alkaloids; Vincristine

Topics: Adenosine Triphosphate; Blood Coagulation Disorders; Blood Platelets; Blood Proteins; Cell Separation; Centrifugation, Density Gradient; Chromium Isotopes; Glycogen; Leukemia; Lipids; Platelet Adhesiveness; RNA; Specific Gravity

Topics: Acute Disease; Adult; Autopsy; Blood Platelets; Bone Marrow; Bone Marrow Cells; Female; Glycogen; Histocytochemistry; Humans; Leukemia; Megakaryocytes; Microscopy, Electron; Platelet Adhesiveness; Staining and Labeling

Topics: Animals; Bone Marrow; Cattle; Cattle Diseases; DNA; Glycogen; Histocytochemistry; Leukemia; Leukocytes; Lipid Metabolism; Lymph Nodes; Peroxidases

Topics: Adult; Arteriosclerosis; Diabetes Mellitus; Glycogen; Histocytochemistry; Humans; Leukemia; Microscopy, Electron; Middle Aged; Nephritis; Neurons; Retina; Retinitis

Topics: Acute Disease; Aged; Aminosalicylic Acids; Antineoplastic Agents; Cytodiagnosis; Glycogen; Histocytochemistry; Humans; Leukemia; Leukocyte Count; Leukocytes; Male; Peroxidases; Staining and Labeling

Topics: Acid Phosphatase; Culture Techniques; Esterases; Glycogen; Hodgkin Disease; Humans; Lectins; Leukemia; Leukemia, Lymphoid; Lymphocyte Activation; Lymphocytes; Lymphoma; Lymphoma, Non-Hodgkin; Succinate Dehydrogenase

Topics: Alkaline Phosphatase; Animals; Azo Compounds; Disease Models, Animal; Glycogen; Histocytochemistry; Humans; Indicators and Reagents; Leukemia; Leukemoid Reaction; Leukocyte Count; Leukocytes; Leukocytosis; Lipids; Rabbits; Staphylococcal Infections

Topics: Adenosine Triphosphate; Carbon Isotopes; Glucose; Glycine; Glycogen; Glycolysis; Humans; Leukemia; Leukocytes; Phosphoglucomutase; Phosphorus Isotopes; Polycythemia

Topics: Animals; Bone Marrow; Bone Marrow Cells; Cattle; Cattle Diseases; Glycogen; Leukemia; Lymphocytes

Topics: Acute Disease; Adolescent; Adult; Bone Marrow; Bone Marrow Cells; Deoxyuridine; Female; Glucosephosphate Dehydrogenase; Glucosyltransferases; Glycogen; Glycolysis; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Leukocytes; Male; Middle Aged; NADP; Nucleosides; Oxygen Consumption; Phosphogluconate Dehydrogenase; Phosphotransferases; Polycythemia; Uridine

Topics: Acute Disease; Bone Marrow; Bone Marrow Cells; Glucosyltransferases; Glycogen; Humans; Leukemia; Leukemia, Myeloid; Leukocytes; Nucleotidyltransferases; Oxidoreductases; Oxygen Consumption; Phosphoglucomutase

Topics: Adult; Aged; Esterases; Exudates and Transudates; Female; Glycogen; Histocytochemistry; Humans; Inflammation; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Leukocytes; Lipids; Male; Middle Aged; NADP; Phagocytosis; Phosphoric Monoester Hydrolases; Skin Window Technique; Succinate Dehydrogenase

Topics: Asthma; Cell Nucleus; Colitis, Ulcerative; Eosinophils; Eye Injuries; Glycogen; Hepatitis; Humans; Leukemia; Leukocytes; Lung Diseases; Schistosomiasis; Skin Window Technique

Topics: Animals; Chromatography; Epinephrine; Glucagon; Glycogen; In Vitro Techniques; Leukemia; Leukocytes; Liver; Muscles; Nucleotides; Phosphoric Monoester Hydrolases; Phosphotransferases; Rats; Salts; Sarcoma, Experimental

Topics: Adolescent; Aminosalicylic Acids; Blood Cells; Bone Marrow Cells; Child; Female; Glycogen; Humans; Leukemia; Lymphocytes; Lymphocytosis; Lymphoma, Non-Hodgkin; Male; Statistics as Topic

Topics: Chemical Phenomena; Chemistry; Glycogen; Humans; Leukemia; Leukemia, Lymphoid; Lymphocytes; Lymphoma; Lymphoma, Non-Hodgkin; Microscopy; Microscopy, Phase-Contrast

Topics: Blood Glucose; Glucose-6-Phosphatase; Glycogen; Glycogen Phosphorylase; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Leukocytes; Lymphocytes; Metabolism

Topics: Carbohydrate Metabolism; Fibrinogen; Glycogen; Glycogenolysis; Leukemia; Leukemia, Myeloid; Leukocytes; Povidone; Research; Tissue Culture Techniques

Topics: Aminosalicylic Acid; Aminosalicylic Acids; Antibodies; Biochemical Phenomena; Biochemistry; Cell Biology; Culture Media; Glycogen; Growth; Leukemia; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Lymphoid; Leukocyte Count; Lymphocytes; Lymphoma; Lymphoma, Non-Hodgkin; Phytohemagglutinins

Topics: Autoradiography; Chemical Phenomena; Chemistry; Coloring Agents; DNA; DNA, Neoplasm; Glycogen; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Lymphocytes; Oxidoreductases; Plant Lectins; Staining and Labeling; Thymidine; Tissue Culture Techniques

Topics: Blood Glucose; Carbohydrate Metabolism; Enzymes; Glycogen; Humans; Leukemia; Leukocytes; Polycythemia

Topics: Carbohydrate Metabolism; Glucose; Glycogen; Humans; Leukemia; Leukocytes; Uracil Nucleotides; Uridine Diphosphate Glucose

Topics: Diagnosis, Differential; Glycogen; Humans; Infectious Mononucleosis; Leukemia; Leukemia, Lymphoid; Lymphocytes; Lymphocytosis

Topics: Classification; Glycogen; Histocytochemistry; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Leukocytes; Lymphocytes; Succinate Dehydrogenase

Topics: Alkaline Phosphatase; Anemia; Anemia, Macrocytic; Anemia, Myelophthisic; Anemia, Pernicious; Clinical Enzyme Tests; Coloring Agents; Glycogen; Hematologic Diseases; Hematology; Histocytochemistry; Leukemia; Periodic Acid; Polycythemia Vera; Staining and Labeling

Topics: Agranulocytosis; Glycogen; Histocytochemistry; Humans; Leukemia; Leukocytes; Lipids; Oxidoreductases; Peroxidases

Topics: Alkaline Phosphatase; Blood Chemical Analysis; Bone Marrow Examination; Clinical Enzyme Tests; DNA; Electron Transport Complex IV; Glycogen; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Leukocytes; Lipids; Oxidoreductases; Peroxidases; RNA

Topics: Clinical Enzyme Tests; Glucosyltransferases; Glycogen; Humans; Leukemia; Leukemia, Myeloid; Leukocytes; Uridine Diphosphate Glucose

Topics: Coloring Agents; Glycogen; Leukemia; Leukocytes; Periodic Acid-Schiff Reaction; Spectrophotometry; Staining and Labeling

Topics: Alkaline Phosphatase; Blood Cells; Endocarditis; Endocarditis, Bacterial; Female; Glycogen; Hepatitis; Hepatitis A; Histocytochemistry; Humans; Infant, Newborn; Infectious Mononucleosis; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Lymphoma; Polycythemia Vera; Pregnancy; Pregnancy Complications; Pregnancy Complications, Infectious; Primary Myelofibrosis; Sepsis

Topics: Coloring Agents; Fats; Glycogen; Histocytochemistry; Humans; Leukemia; Leukocytes; Staining and Labeling; Sulfhydryl Compounds

Topics: Antimitotic Agents; Antineoplastic Agents; Bone Marrow; Glycogen; Humans; Leukemia; Leukocytes

Topics: Cell Nucleus; Glycogen; Humans; Leukemia; Leukemia, Lymphoid; Lymphocytes

Topics: Glycogen; Humans; Leukemia; Leukemia, Lymphoid; Lymphocytes; Lymphocytosis; Lymphoma; Lymphoma, Non-Hodgkin

Topics: Diploidy; Glycogen; Humans; Leukemia; Leukemia, Lymphoid

Topics: Glycogen; Humans; Leukemia; Leukemia, Lymphoid; Lymphatic Vessels; Lymphocytes

Topics: Glycogen; Humans; Leukemia; Leukemia, Lymphoid; Lymphatic Vessels; X-Rays

Topics: Chronic Disease; Glycogen; Glycogenolysis; Humans; Leukemia; Leukocytes; X-Rays

Topics: Glycogen; Humans; Kidney; Leukemia

Topics: Glycogen; Humans; Leukemia; Leukocyte Count; Leukocytes; Polycythemia

Topics: Anemia; Animals; Ducks; Glycogen; Humans; Leukemia; Leukocytes; Polycythemia