glycogen and Keratoacanthoma

Clear cell acanthoma is a benign epidermal lesion with a variable clinical appearance and distinct histopathology features. Although, it is considered an entirely benign entity, few case reports describe unusual or atypical variants of clear cell acanthoma. We observed a case of a large clear cell acanthoma that also has features of a keratoacanthoma.

Topics: Acanthoma; Biomarkers, Tumor; Diagnosis, Differential; Glycogen; Humans; Keratinocytes; Keratoacanthoma; Male; Middle Aged; Periodic Acid-Schiff Reaction; Skin Neoplasms

Differentiation of keratoacanthoma from squamous cell carcinoma on the vermilion mucosa of the lower lip can sometimes be difficult. Two histopathologic features that are helpful in distinguishing between these two lesions when they occur on sun-exposed skin are the incidence of intraepithelial elastic fibers and the epithelial intracytoplasmic glycogen content. An analysis of thirty-one keratoacanthomas and twenty-eight squamous cell carcinomas from the vermillion mucosa of the lower lip indicates that while the incidence of intraepithelial elastic fibers and the tumor intracytoplasmic glycogen content are greater in keratoacanthomas, these features are not reliable for differentiating between the two lesions in this location.

Topics: Carcinoma, Squamous Cell; Cytoplasm; Diagnosis, Differential; Elastic Tissue; Glycogen; Humans; Keratoacanthoma; Lip Diseases; Lip Neoplasms

A significant statistical difference was found between the incidence of intraepithelial elastic fibers in keratoacanthoma and squamous cell carcinoma arising in actinic keratosis (P < 0.001). There was no significant difference when keratoacanthoma was compared to adenoid squamous cell carcinoma (P = 0.13) and de novo squamous cell carcinoma (P = 0.73). However, in keratoacanthoma intraepithelial elastic fibers were found in areas of pseudoepitheliomatous hyperplasia and in the central keratin plug, as well as in areas of infiltrating, peripheral keratinocytes. In adenoid squamous cell carcinoma and de novo squamous cell carcinoma, the intraepithelial elastic fibers were found only in areas of atypical epithelial cells at the margin of the neoplasm. Intracytoplasmic glycogen was found to be statistically more abundant in keratoacanthoma than in squamous cell carcinoma arising in actinic keratosis (P < 0.001), adenoid squamous cell carcinoma (P < 0.001), and in de novo squamous cell carcinoma (P < 0.001)

Topics: Carcinoma, Squamous Cell; Cytoplasm; Diagnosis, Differential; Elastic Tissue; Glycogen; Humans; Keratoacanthoma; Skin Neoplasms

Topics: Carcinoma, Squamous Cell; Desmosomes; Glycogen; Histocytochemistry; Humans; Isotope Labeling; Keratoacanthoma; Microscopy, Electron; Periodic Acid; RNA, Neoplasm; Skin Neoplasms

Topics: Animals; Benz(a)Anthracenes; Dactinomycin; Endoplasmic Reticulum; Glycogen; Golgi Apparatus; Inclusion Bodies; Keratoacanthoma; Macrophages; Male; Microscopy, Electron; Mucus; Neoplasms, Experimental; Rabbits; Ribosomes; Skin; Skin Neoplasms; Vitamin A

Topics: Basement Membrane; Carcinoma; Dermatology; Diagnosis, Differential; Esterases; Fluorescent Antibody Technique; Glycogen; Histocytochemistry; Humans; Keratins; Keratoacanthoma; Keratosis; Lupus Erythematosus, Discoid; Mast-Cell Sarcoma; Psoriasis; Skin; Skin Diseases; Skin Neoplasms; Sweat Glands; Urticaria

Topics: Glycogen; Histocytochemistry; Humans; Keratoacanthoma; Methods; Skin; Transferases

Topics: Animals; Cell Division; Connective Tissue; Edema; Glycogen; Glycosaminoglycans; Histocytochemistry; Humans; Keratoacanthoma; Parapsoriasis; Psoriasis; Skin; Sulfhydryl Compounds; Sulfides; Swine

Topics: Alkaline Phosphatase; Animals; Benz(a)Anthracenes; Coloring Agents; DNA, Neoplasm; Glycogen; Histocytochemistry; Keratoacanthoma; Neoplasms, Experimental; Papilloma; Rabbits; RNA, Neoplasm; Sulfhydryl Compounds