glycogen and Gingivitis

We studied ultrastructural reorganization of the gingival mucosa in chronic gingivitis. It was found that chronic inflammation leads to significant intracellular reorganization of epitheliocytes in the basal and prickle cell layers of gingival epithelium and their pronounced structural and functional heterogeneity. The main ultrastructural alterations of epitheliocytes in the basal and prickle cell layers include pronounced vacuolization of the perinuclear zone (partial necrosis), formation of thick tonofilament bundles, focal lysis and sequestration of glycogen, and destruction and reduction of intracellular junctions in some cases accompanied by acantholytic alterations. Chronic inflammation in the gingival mucosa induced extensive remodeling of the lamina propria manifested in multiplication of the basement membrane and obturation of blood vessels with collagen fibrils.

Topics: Adult; Basement Membrane; Biopsy; Blood Vessels; Chronic Disease; Cytoplasm; Epithelial Cells; Gingiva; Gingivitis; Glycogen; Humans; Inflammation; Intercellular Junctions; Microscopy, Electron; Mucous Membrane; Necrosis

A biochemical study of an enzyme participating in the synthesis of glycogen is presented, with particular regard to the fluctuations in the amounts of this polysaccharide in human gingival epithelium, during inflammation. The increase in the activity of UDPglucose : glycogen glucosyltransferase can be related to the accumulation of glycogen. Some kinetic parameters of this enzyme are described.

Topics: Adult; Female; Gingiva; Gingivitis; Glucosephosphates; Glycogen; Glycogen Synthase; Humans; Hydrogen-Ion Concentration; Male; Middle Aged

Cytochemical studies of glycogen of oral mucosa cells have been made on the smears by freeze-drying and PAS staining. The specimens were obtained from different areas of oral cavity of 77 human subjects and an attempt was made to find some interrelation amoung glycogen deposition, keratinization and inflammation. The largest glycogen deposition was found in the mucosa cells from mouth floor and cheek, a little in those from gingiva and quite a small or no glycogen in those from mucosa of hard palate and tongue. In gingiva the cells showing much more keratinization were less in glycogen contents, and vice versa. In inflammation some increase in glycogen contents were found in the gingivitis and the highest glycogen content in the cases of denture irritation of the palate as far as the present observation is concerned.

Topics: Adolescent; Adult; Aged; Cheek; Denture, Complete; Female; Gingiva; Gingivitis; Glycogen; Humans; Inflammation; Keratins; Male; Middle Aged; Mouth Diseases; Mouth Floor; Mouth Mucosa; Palate; Stomatitis, Aphthous; Tongue

If the active permeability of the oral mucosa ensures the possibility of the direct application of various substances, its influence on the intensity of metabolic processes must be detectable in the histochemical way. The present animal experiments were intended for verifying thaction of a preparation (Herbadont) on the basis of vegetable active principles on changes in the contents of ribonucleic acid, glycogen and SH and COOH groups in the gingiva. It was shown that the removal of clinical inflammatory symptoms by this preparation is associated with a decrease in the contents of COOH and SH groups, ribonucleoproteids and glucogen which are increased in case of disease. Concomitantly, the intensity of the reaction on NH2 groups and the ascorbic acid content increase.

Topics: Gingiva; Gingivitis; Glycogen; Histocytochemistry; Humans; Periodontal Diseases; Plant Extracts; Plants; RNA; Sulfhydryl Compounds

Topics: Acid Phosphatase; Carbohydrates; Cell Membrane; Cytoplasmic Granules; Diabetes Complications; Epithelial Cells; Gingiva; Gingivitis; Glycogen; Histocytochemistry; Humans; Keratins; Lysosomes; Microscopy, Electron

Topics: Blood Glucose; Dentistry; Diabetes Mellitus; Gingiva; Gingivitis; Glycogen

Topics: Gingiva; Gingivitis; Glycogen; Humans