glycogen and Gastroesophageal-Reflux

Glycogenic acanthosis is described as benign thickening of the esophageal squamous epithelium of unknown etiology. Although its etiology is unknown, it has been reported that glycogenic acanthosis may be related to gastroesophageal reflux and hiatal hernia. The aim of the present study was to review the patients who were diagnosed with glycogenic acanthosis on upper gastrointestinal endoscopy and to determine whether there is any association between glycogenic acanthosis and gastroesophageal reflux and hiatal hernia.. A total of 504 patients who underwent upper gastrointestinal endoscopy for evaluation of non-ulcer dyspepsia were reviewed retrospectively.. Glycogenic acanthosis was detected in 143 (28.3%) of those 504 patients. Of the 143 patients, 82 (57.3%) were male and 61 (42.7%) were female. Patients with glycogenic acanthosis were aged 20-83 years. Gastroesophageal reflux was detected in 50 (34.9%) cases with glycogenic acanthosis, while hiatal hernia was detected in 30 (20.9%) cases. Gastroesophageal reflux was detected in 102 (28.2%) control subjects, while hiatal hernia was detected in 50 (13.8%). Hiatal hernia was significantly higher in glycogenic acanthosis patients than in controls subjects (p<0.05). Glycogenic acanthosis patients had higher gastroesophageal reflux than seen in controls subjects, but the difference between groups was not statistically significant (p>0.05).. Our results suggest that glycogenic acanthosis is primarily an age-related disease. We demonstrated that glycogenic acanthosis may be associated with gastroesophageal reflux and hiatal hernia. Further studies are necessary to confirm these findings.

Topics: Adult; Age Factors; Aged; Aged, 80 and over; Case-Control Studies; Endoscopy, Gastrointestinal; Esophageal Diseases; Female; Gastroesophageal Reflux; Glycogen; Hernia, Hiatal; Humans; Hyperplasia; Male; Middle Aged; Retrospective Studies; Young Adult

Topics: Deglutition Disorders; Diagnosis, Differential; Esophageal Diseases; Gastroesophageal Reflux; Glycogen; Humans; Male; Middle Aged; Radiography

Hiatus hernia (HH) has major pathophysiological effects favoring gastroesophageal reflux and hence contributing to esophageal mucosa injury, especially in patients with severe gastroesophageal disease. However, prospective studies investigating the impact of HH on the esophageal mucosa in non-erosive reflux disease (NERD) are lacking. This study evaluated the association between the presence of (HH) and the histological findings in symptomatic patients with NERD.. Fifty consecutive patients with gastroesophageal reflux disease (GERD) were enrolled. After conventional endoscopy, Lugol solution was applied and biopsy specimens were obtained. Histological parameters including basal zone hyperplasia, papillary length and cellular infiltration were evaluated. The chi-square test with Yates' correlation was used for comparing discrete parameters between groups. However, Fisher's exact probability test was used where the expected frequencies were lower than 5. Wilcoxon's test for unpaired samples was preferred in cases of semi-quantitative parameters.. The presence of HH along with more severe findings (0.01

Topics: Adult; Biopsy; Endoscopy, Digestive System; Female; Gastroesophageal Reflux; Glycogen; Hernia, Hiatal; Humans; Male; Middle Aged; Prospective Studies; Single-Blind Method

A nodular appearance of the esophageal mucosa, observed in 3.5% of 2,328 consecutive upper endoscopic examinations, most commonly appeared as multiple, uniformly sized, oval or round elevations usually < 1 cm, involving otherwise normal esophageal mucosa. Endoscopic biopsies in 35 consecutive patients followed prospectively demonstrated the nodules to represent glycogenic acanthosis--a combination of cellular hyperplasia and increased cellular glycogen. When studied by 24-h ambulatory esophageal pH monitoring, 83% of these patients had pathologic gastroesophageal acid reflux; mean percentage of time with pH < 4.0 was 37.3%. Antireflux therapy improved symptoms in all patients but failed to eradicate the lesions of glycogenic acanthosis. Although its etiology and pathogenesis still remain elusive, glycogenic acanthosis may be related to gastroesophageal reflux.

Topics: Adult; Aged; Biopsy; California; Esophageal Diseases; Esophagoscopy; Esophagus; Gastric Acidity Determination; Gastroesophageal Reflux; Glycogen; Humans; Hydrogen-Ion Concentration; Middle Aged; Mucous Membrane; Prospective Studies

Topics: Esophageal Diseases; Esophagoscopy; Gastroesophageal Reflux; Glycogen; Hernia, Hiatal; Humans; Mucous Membrane

Topics: Aged; Alcoholism; Autopsy; Biopsy; Diagnosis, Differential; Endoscopy; Epithelium; Esophageal Diseases; Esophagitis; Esophagoscopy; Esophagus; Gastroesophageal Reflux; Glycogen; Humans; Hyperplasia; Intestinal Mucosa; Leukoplakia; Male; Middle Aged; Periodic Acid; Smoking; Staining and Labeling