glycogen has been researched along with Drug-Hypersensitivity* in 7 studies
7 other study(ies) available for glycogen and Drug-Hypersensitivity
| Article | Year |
|---|---|
Perfluorooctanoic acid exposure for 28 days affects glucose homeostasis and induces insulin hypersensitivity in mice.
Perfluoroalkyl acids (PFAAs) are widely used in many applications due to their unique physical and chemical characteristics. Because of the increasing prevalence of metabolic syndromes, including obesity, dyslipidemia and insulin resistance, concern has arisen about the roles of environmental pollutants in such diseases. Earlier epidemiologic studies showed a potential association between perfluorooctanoic acid (PFOA) and glucose metabolism, but how PFOA influences glucose homeostasis is still unknown. Here, we report on the modulation of the phosphatidylinositol 3-kinase-serine/threonine protein kinase (PI3K-AKT) signaling pathway in the livers of mice after 28 d of exposure to PFOA. Compared with normal mice, PFOA exposure significantly decreased the expression of the phosphatase and tensin homologue (PTEN) protein and affected the PI3K-AKT signaling pathway in the liver. Tolerance tests further indicated that PFOA exposure induced higher insulin sensitivity and glucose tolerance in mice. Biochemical analysis revealed that PFOA exposure reduced hepatic glycogen synthesis, which might be attributed to gluconeogenesis inhibition. The levels of several circulating proteins were altered after PFOA exposure, including proteins potentially related to diabetes and liver disease. Our results suggest that PFOA affected glucose metabolism and induced insulin hypersensitivity in mice. Topics: Animals; Caprylates; Drug Hypersensitivity; Fluorocarbons; Glucose; Glycogen; Homeostasis; Insulin; Liver; Male; Mice; Mice, Inbred BALB C; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Signal Transduction; Time Factors | 2015 |
Studies by electron microscopy of epidermis after topical application of mercuric chloride. Morphologic and histochemical findings in epidermal cells of human subjects who do not show allergic sensitivity or primary irritant reactions to mercuric chloride
Topics: Chlorides; Dermatologic Agents; Drug Hypersensitivity; Glycogen; Histocytochemistry; Humans; Irritants; Keratins; Langerhans Cells; Lysosomes; Melanocytes; Mercury; Microscopy, Electron; Skin | 1971 |
The effect of agents used in the treatment of bronchial asthma on carbohydrate metabolism and histamine sensitivity after beta-adrenergic blockade.
Topics: Adenine Nucleotides; Adrenal Cortex Hormones; Adrenalectomy; Alloxan; Aminophylline; Animals; Antigens; Asthma; Blood Glucose; Carbohydrate Metabolism; Diazoxide; Drug Hypersensitivity; Epinephrine; Glycogen; Gold; Histamine; Humans; Hydrocortisone; Hyperglycemia; Liver; Mice; Muscles; Obesity; Sympatholytics | 1970 |
Histamine hypersensitivity of mice induced by 5'-AMP.
Topics: Adenine Nucleotides; Animals; Cyclic AMP; Drug Hypersensitivity; Female; Glucosyltransferases; Glycogen; Histamine; Hyperglycemia; Mice; Muscles; Pharmacogenetics | 1968 |
Effects of diazoxide administration on plasma glucose, insulin, and lipids in Von Gierke's disease.
Topics: Antihypertensive Agents; Child; Diazoxide; Drug Eruptions; Drug Hypersensitivity; Glucose Tolerance Test; Glycerides; Glycogen; Glycogen Storage Disease Type I; Humans; Hyperglycemia; Hyperlipidemias; Hypoglycemia; Insulin; Lipids; Male; Triglycerides; Xanthomatosis | 1966 |
[The phenomenon of leukocyte agglomeration in the diagnosis of drug allergy in patients with pulmonary tuberculosis].
Topics: Adult; Antitubercular Agents; Drug Hypersensitivity; Female; Glycogen; Histocytochemistry; Humans; Leukocytes | 1965 |
[Reaction of blood neutrophils as an index of infectious and drug allergy].
Topics: Drug Hypersensitivity; Glycogen; Histamine; Humans; Hypersensitivity; Leukocytes; Neutrophils; Streptomycin; Tuberculin; Tuberculin Test | 1962 |