glycogen and Dermatitis--Exfoliative

Topics: Acid Phosphatase; Dermatitis, Exfoliative; Esterases; Glucuronidase; Glycogen; Humans; Lymphocytes; Microscopy, Electron; Mycosis Fungoides; Reticulocytes; Sezary Syndrome; Skin Neoplasms

A patient had Sézary syndrome and lymphocytic lymphoma. Cytoplasmic inclusions within the Sézary cells were demonstrated by histochemistry and electron microscopy to be composed of fetal-type glycogen. Results of tests for the presence of virus were negative. It is suggested that the Sézary cell represents a reversion of metabolic systems to more youthful types. Previously reported differences in diastase reactivity of the PAS-positive cytoplasmic inclusions are probably based on whether the glycogen is in fetal or mature configuration.

Topics: Chlorambucil; Cytoplasmic Granules; Dermatitis, Exfoliative; Glycogen; Humans; Lymphoma, Non-Hodgkin; Male; Middle Aged; Prednisone; Syndrome; Vincristine

This paper deals with the histological and ultrastructural findings in a case of the Sézary syndrome. The striking nuclear and cytoplasmic features of the Sézary cell are illustrated, and the similarities of this cell to the mycosis fungoides cell are once more stressed.

Topics: Cell Nucleus; Cytoplasm; Dermatitis, Exfoliative; Edema; Foot Dermatoses; Glycogen; Golgi Apparatus; Hand Dermatoses; Histocytochemistry; Humans; Keratosis; Lymphatic Diseases; Male; Microscopy, Electron; Middle Aged; Mitochondria; Mycosis Fungoides; Pruritus; Skin; Staining and Labeling

Topics: Alkaline Phosphatase; Anemia, Aplastic; Blood Cells; Bone Marrow; Bone Marrow Cells; Bone Marrow Diseases; Dermatitis, Exfoliative; Edema; Esterases; Foot Dermatoses; Glucuronidase; Glycogen; Hand Dermatoses; Histocytochemistry; Humans; Keratosis; Leukemia, Lymphoid; Lymphatic Diseases; Periodic Acid; Pruritus