glycogen and Cardiotoxicity

glycogen has been researched along with Cardiotoxicity* in 2 studies

Other Studies

2 other study(ies) available for glycogen and Cardiotoxicity

ArticleYear
Starch based hydrogel NPs loaded by anthocyanins might treat glycogen storage at cardiomyopathy in animal fibrotic model.
    International journal of biological macromolecules, 2021, Jul-31, Volume: 183

    Many reports have been published recently confirmed the limitation of cargo molecules delivered into the heart. This failure is mostly associated with lymphatic or vascular channels washing or to the immune system recognition. Delivery of anthocyanins by encapsulation may augment it retention in the heart at early time points as the capsules are too large to wash out by lymphatic or venous channels and the physical structure of the capsule may shield the anthocyanins from immunoglobulins and cellular components of the immune system. In the current study, the cardiac dysfunction was induced by using carbon tetrachloride and then animal were treated orally by using anthocyanins incorporated into hydrogel NPs twice time /week for 4 weeks. The results showed anthocyanin loaded hydrogel NPs has ability to re-maintain the glycogen content in the liver and heart tissues of fibrotic group (13 ± 1.4 and 5 ± 0.7 μmol glucose/g tissue). Additionally, MDA and hydroxyproline were significantly reduced. PAS stain showed depletion of glycogen granules from heart tissue. It is concluded that starch based hydrogel loaded by anthocyanins can improve histological cardiac functions after their injury .

    Topics: Animals; Anthocyanins; Carbon Tetrachloride; Cardiomyopathies; Cardiotoxicity; Disease Models, Animal; Drug Compounding; Fibrosis; Glycogen; Hydrogels; Liver; Mice; Myocytes, Cardiac; Nanoparticles; Starch

2021
Cardiomyopathy induced by T-2 toxin in rats.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2020, Volume: 137

    T-2 toxin, A trichothecenes mycotoxin, is immunotoxic to animals and humans. Although it is highly cardiotoxic, the pathogenesis of cardiomyopathy caused by T-2 toxin is not entirely clear. Hence, in our research, cardiomyopathy was induced by a single injection of T-2 mycotoxin (0.23 mg/kg s.c., 1 LD

    Topics: Animals; Cardiomyopathies; Cardiotoxicity; Glycogen; Male; Mast Cells; Myocardium; Myocytes, Cardiac; Rats, Wistar; T-2 Toxin

2020