glycogen and Carcinoma--Mucoepidermoid

Mucoepidermoid carcinomas in the minor salivary glands usually originate in the palatine gland, and their occurrence in the retromolar region is rare. We report a rare case of mucoepidermoid carcinoma with clear cell components occurring in the retromolar region. The patient was a 63-year-old woman referred to our hospital with the chief complaint of a painless mass in the right retromolar region initially found during treatment at a local dental clinic. The 20×10-mm mass was well-defined, elastic, and flexible. The surface of the mucosa was healthy. The mass was clinically diagnosed as a gingival benign tumor in the right retromolar region. There were no significant findings in the patient's medical history. The tumor was resected under local anesthesia. Histopathology revealed that squamoid cells, undifferentiated intermediate cells, and clear cells were dominant, with mucus-producing cells in some areas. A mucoepidermoid carcinoma with clear cell components was diagnosed. There were no signs of recurrence or metastasis at 15 months postoperatively and the patient's progress has been satisfactory. Because the tumor was a painless, slow-growing mass, it was clinically diagnosed as a benign tumor of the gingiva, and resection was performed under local anesthesia without performing a biopsy. However, even if a mass in the retromolar region is clinically diagnosed as a benign tumor, the course of treatment should be decided after performing fine-needle aspiration cytology, taking into consideration the possibility of mucoepidermoid carcinoma.

Topics: Carcinoma, Mucoepidermoid; Diagnosis, Differential; Female; Follow-Up Studies; Gingival Neoplasms; Glycogen; Humans; Keratins; Middle Aged; Mucus

Topics: Adult; Carcinoma, Mucoepidermoid; Glycogen; Humans; Male; Palatal Neoplasms

Clear cells have been described in mucoepidermoid carcinoma of the salivary glands, but to our knowledge these cells have not been recognized as a distinctive component of sclerosing mucoepidermoid carcinoma with eosinophilia of the thyroid gland. We report four examples in which sclerosing mucoepidermoid carcinoma of the thyroid gland contained a minor component (10% to 30%) of clear cells. The four tumors occurred in women with Hashimoto's thyroiditis whose ages ranged from 38 to 52 years. All four patients presented with thyroid nodules, but two also had enlarged cervical lymph nodes. Although two tumors metastasized to multiple cervical lymph nodes and one recurred in the soft tissues of the neck, all four patients are disease-free 6 months to 6 years after surgical treatment. The locally aggressive behavior of the first three tumors was probably related to their size, rather than to the presence of clear cells. Microscopically, these tumors showed the classical features of sclerosing mucoepidermoid carcinoma with eosinophilia, as well as nests of clear cells that appeared to be glycogen-rich squamous cells. Although the four tumors were thyroglobulin negative, two were immunoreactive to thyroid transcription factor 1 (TTF-1), supporting the idea that they originated from squamous metaplasia of follicular epithelium rather than from solid cell nests of the ultimobranchial body.

Topics: Adult; Biomarkers, Tumor; Carcinoma, Mucoepidermoid; Disease-Free Survival; Female; Glycogen; Humans; Immunoenzyme Techniques; Lymph Nodes; Male; Middle Aged; Nuclear Proteins; Sclerosis; Thyroid Neoplasms; Thyroid Nuclear Factor 1; Thyroidectomy; Thyroiditis, Autoimmune; Transcription Factors