glycogen and Carcinoma--Basal-Cell

We describe 13 cases of tricholemmal carcinoma, a rarely recognized cutaneous adnexal neoplasm. The patients were nine men and four women. In general, the tumors presented as slow-growing epidermal papules, indurated plaques, or nodules showing predilection for sun-exposed, hair-bearing skin. The lesions were most frequently misdiagnosed clinically as basal cell carcinoma. Histologically, they showed a variegation of growth patterns including solid, lobular, and trabecular; they were characterized by a proliferation of epithelial cells with features of outer root sheath differentiation, including abundant glycogen-rich, clear cytoplasm, foci of pilar-type keratinization, and peripheral palisading of cells with subnuclear vacuolization. Because of their variable growth pattern, overt cytologic atypia, abundant clear cytoplasm, occasional pagetoid intraepidermal spread, and brisk mitotic activity, these tumors may pose difficulties for diagnosis and be confused with other malignant skin tumors with clear cell changes. Despite the seemingly malignant cytological appearance of these lesions, clinical follow-up in 10 cases showed no recurrence or metastasis over a period of 2-8 years. Thus, conservative surgical excision with clear margins appears to be the treatment of choice for these neoplasms.

Topics: Adult; Aged; Aged, 80 and over; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Cytoplasm; Diagnosis, Differential; Epidermal Cyst; Epithelium; Female; Follow-Up Studies; Glycogen; Hair Diseases; Humans; Keratins; Male; Middle Aged; Mitosis; Neoplasms, Basal Cell; Skin Diseases; Skin Neoplasms; Vacuoles

We report the light and electron microscopic study of 7 examples of an unusual clear cell variant of basal cell epithelioma (BCE). The clear cells show cytoplasmic vacuoles that contain glycogen but do not stain with mucicarmine or fat stains. By electron microscopy the cytoplasmic vacuoles consist of empty spaces not surrounded by membranes. The clear cell pattern may occupy all or part of a given tumor. Typical nodular BCE was found in all 7 cases, but not in every section. Some nodules were composed of mixed solid and clear cell types. Differentiation of this uncommon variant from other clear cell tumors is important.

Topics: Aged; Aged, 80 and over; Carcinoma, Basal Cell; Female; Glycogen; Head and Neck Neoplasms; Humans; Lysosomes; Male; Microscopy, Electron; Middle Aged; Vacuoles

A case of glycogen-rich adenocarcinoma of the parotid gland of a 23 years old man was investigated ultrastructually. The cytoplasm of the tumour cells was abundantly filled with glycogen-rich particles. Among these particles well developed cytoplasmic organelles were observed, too. In addition, another tumour all type could be found, i.e. a tumour cell of basal cell origin with tonofibris in the cytoplasm, attached to the glycogen-rich tumour cell type by desmosomes.

Topics: Adenocarcinoma; Adult; Carcinoma, Basal Cell; Glycogen; Humans; Male; Parotid Neoplasms

Topics: Adolescent; Adult; Carcinoma, Basal Cell; Child; Cytoplasmic Granules; Female; Glycogen; Humans; Skin Neoplasms

A lesion presenting a typical histopathological picture of sebaceous epithelioma comprised three kinds of cells; immature, transitional, and mature cells corresponding to the components of the normal sebaceous gland. Melanocytes and melanosomes were absent. These findings clearly distinguished the tumor from basal cell epithelioma, and it was concluded that sebaceous epithelioma represents a primary neoplasm of the sebaceous gland. New observations on lipid droplet formation are made with regard to the glycogen-containing cytolysome - tentatively designated a Liposome - and membrane structures around the lipid droplet found in mature cells.

Topics: Aged; Carcinoma, Basal Cell; Cell Membrane; Female; Glycogen; Humans; Lipids; Melanocytes; Microscopy, Electron; Organoids; Sebaceous Gland Neoplasms

Topics: Aged; Atrophy; Biopsy; Carcinoma, Basal Cell; Ectropion; Entropion; Eyelid Neoplasms; Female; Glycogen; Humans; Lipids; Male; Middle Aged; Mitochondria, Muscle; Oculomotor Muscles; Pigments, Biological

Topics: Adult; Aged; Basement Membrane; Biopsy; Carcinoma, Basal Cell; Diagnosis, Differential; Facial Neoplasms; Female; Glycogen; Hair; Humans; Male; Middle Aged; Papilloma; Sex Factors; Skin Neoplasms; Warts

Topics: Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Glycogen; Histological Techniques; Humans; Microscopy, Electron; Skin Neoplasms

Topics: Adenocarcinoma; Basement Membrane; Carcinoma; Carcinoma, Basal Cell; Cell Membrane; Cell Nucleus; Cilia; Connective Tissue; Cytoplasm; Cytoplasmic Granules; Epithelial Cells; Fibroblasts; Glycogen; Golgi Apparatus; Humans; Inclusion Bodies; Intercellular Junctions; Kidney; Kidney Neoplasms; Leiomyosarcoma; Microscopy, Electron; Mitochondria; Mitosis; Muscle, Smooth; Neuroblastoma; Wilms Tumor

Topics: Carbohydrate Metabolism; Carcinoma, Basal Cell; Glycogen; Glycosaminoglycans; Humans; Skin; Skin Neoplasms

Topics: Carcinoma; Carcinoma, Basal Cell; Glycogen; Skin Neoplasms

Topics: Carcinoma; Carcinoma, Basal Cell; Cervix Uteri; Diagnosis, Differential; Female; Glycogen; Humans; Neoplasms; Uncertainty; Uterine Cervical Neoplasms