glycogen and Aortic-Coarctation

Structural changes of renal arteries and glomeruli were studied in 25 dogs with hemodynamic model of coarctation of the aorta in different terms of experiment by of histochemical, histoenzymological and morphometric methods also using 10 control animals. Dystrophic processes were established to develop in media of renal arteries and myocytes within the first week of the disease induction. In later stages of the experiment a number of adaptive, compensatory and pathobiological changes associated with the decrease of renal basin blood supply appear in renal vessels. First lie in atrophia of the muscular coat circular layer in renal arteries and arterioles, second--in reorganization of part of them and third--in sclerosis and hyalinosis of arteriolar branches and glomeruli.

Topics: Animals; Aortic Coarctation; Arteries; Arterioles; Disease Models, Animal; Dogs; Glycogen; Histological Techniques; Kidney; Muscle, Smooth, Vascular; Periodic Acid-Schiff Reaction; Time Factors

Muscle biopsies from the deltoideus dx and vastus lat. dx muscles were taken in 17 children with coarctation of the aorta, aged 5.0 to 13.8 years, prior to surgery. Higher concentrations of glycogen, ATP and CP were found in the vastus lat. muscle compared to the deltoideus muscle. The same differences between these two muscles were also found in healthy controls. No differences were found between the patients with coarctation of the aorta and the control group. Nor were any differences found for the other variables studied; glucose, glucose-6-phosphate, lactate, muscle enzyme activities (SDH, LDH and phosphorylase), muscle fibre composition or fibre sizes. It seems reasonable to assume that the differences in muscle substrate levels found between the vasus lat. and the deltoideus muscles in the two groups were due to a higher degree of activity during daily life for the legs as compared to the arms. Patients with coarctation of the aorta do not seem to be influenced by the altered haemodynamic situation with regard to the studied variables.

Topics: Adenosine Triphosphate; Adolescent; Aortic Coarctation; Child; Child, Preschool; Creatine Kinase; Female; Glycogen; Humans; Male; Muscles

Muscle biopsies were taken from the quadriceps muscle during rest and exercise in 16 young men (ages 16-28 years) operated upon for coarctation of the aorta during childhood and 10 healthy men (ages 19-25 years). Resting values and depletion after exercise for ATP, CP and glycogen were similar in the two groups. Muscle-lactate concentrations were higher at all levels of exercise in the operated group, while blood-lactate concentrations did not differ. It is concluded that the operated patients have a disturbed blood-flow regulation and a somewhat impaired blood-flow to the working leg muscles.

Topics: Adenosine Triphosphate; Adolescent; Adult; Aortic Coarctation; Glycogen; Hemodynamics; Humans; Lactates; Male; Muscles; Oxygen Consumption; Phosphocreatine; Physical Exertion; Respiration

Muscle biopsies from the upper and the lower part of the body (m. deltoideus dx and m. vastus lat dx) were taken in young men, 17-28 years of age, who had been operated upon for coarctation of the aorta in childhood. Significant differences regarding SDH-activity and some muscle substrate levels were found, with higher values in the leg muscle. The same differences were found in ten healthy controls. It is concluded that arm and leg muscle differ in these respects but that the haemodynamic difference remaining after coarctectomy does not seem to influence this situation.

Topics: Adenosine Triphosphate; Adolescent; Adult; Aortic Coarctation; Arm; Glucose; Glycogen; Humans; L-Lactate Dehydrogenase; Lactates; Leg; Male; Muscles; Phosphocreatine; Succinate Dehydrogenase

Topics: Adaptation, Physiological; Altitude; Animals; Aortic Coarctation; Cerebral Cortex; Disease Models, Animal; Glycogen; Heart; Heart Failure; Hypoxia; Methods; Muscle Contraction; Myocardium; Phosphocreatine; Protein Biosynthesis; Rats; RNA

Topics: Adaptation, Physiological; Animals; Aortic Coarctation; Body Weight; Glycogen; Male; Myocardium; Oxygen Consumption; Physical Exertion; Rats

Topics: Adolescent; Aging; Aortic Coarctation; Basement Membrane; Blood Pressure; Child, Preschool; Collagen; Elastic Tissue; Endoplasmic Reticulum; Extracellular Space; Female; Glycogen; Histocytochemistry; Humans; Infant; Infant, Newborn; Male; Microscopy; Microscopy, Electron; Mitochondria; Muscle, Smooth; Ribosomes