glycogen and Adenoma--Sweat-Gland

Topics: Adenoma, Sweat Gland; Biomarkers, Tumor; Carcinoembryonic Antigen; Female; Glycogen; Humans; Middle Aged; Mucin-1; Periodic Acid-Schiff Reaction; Sweat Gland Neoplasms; Vulvar Neoplasms

To confirm the eccrine acrosyringeal differentiation of eccrine syringofibroadenoma (ESFA) and to elucidate the histogenesis of its angiofibrotic stroma, a case of ESFA from a 45-year-old man was examined by light and electron microscopy. Histologically, the parenchyma featured anastomosing, slender epithelial cords containing small cuboidal cells and occasional duct-like structures. The stroma had increased numbers of mast cells, increased capillaries with swollen endothelial cells, and prominent fibrosis. Ultrastructurally, the following findings were characteristic of ESFA: a) abundant glycogen particles in epithelial cells, b) numerous intracytoplasmic and extracellular spaces lined with microvilli, c) intraepithelial duct formation, consisting of microvilli, vesicles, rod-shaped dense bodies, multivesicular dense bodies, and peripheral network of tonofilaments, and d) large numbers of mast cells, closely associated with fibroblasts, surrounding increased numbers of capillaries containing swollen endothelial cells. These ultrastructural features support the acrosyringeal differentiation of ESFA. We hypothesize that mast cell hyperplasia and degranulation may play an important role in the formation of the angiofibrotic stroma.

Topics: Adenofibroma; Adenoma, Sweat Gland; Cell Transformation, Neoplastic; Epithelium; Fibroblasts; Glycogen; Humans; Hyperplasia; Male; Mast Cells; Microscopy, Electron; Microvilli; Middle Aged; Sweat Gland Neoplasms

Topics: Adenoma, Sweat Gland; Adolescent; Cell Aggregation; Cell Nucleolus; Cell Nucleus; Cell Wall; Cytoplasm; Cytoplasmic Granules; Endoplasmic Reticulum; Epithelial Cells; Female; Glycogen; Golgi Apparatus; Humans; Keratins; Microscopy; Microscopy, Electron; Middle Aged; Mitochondria; Sweat Gland Neoplasms; Synaptic Vesicles; Vulvar Neoplasms

Topics: Adenoma, Sweat Gland; Aged; Carcinoma, Squamous Cell; Diagnosis, Differential; Female; Glycogen; Glycosaminoglycans; Histocytochemistry; Humans; Leg; Male; Microscopy, Electron; Middle Aged; Skin; Skin Neoplasms; Staining and Labeling; Sweat Gland Neoplasms

Topics: Adenoma, Sweat Gland; Adolescent; Aged; Collagen; Cytoplasmic Granules; Desmosomes; Ear, External; Epithelial Cells; Female; Glycogen; Humans; Inclusion Bodies; Infant; Keratins; Leukocytes; Lipids; Lysosomes; Macrophages; Male; Melanocytes; Microscopy, Electron; Mitochondria; Mucus; Neutrophils; Skin Neoplasms

Topics: Adenoma, Sweat Gland; Aged; Female; Glycogen; Histocytochemistry; Humans; Skin Neoplasms; Staining and Labeling; Sweat Gland Neoplasms

Topics: Adenoma, Sweat Gland; Adult; Aged; Child; Female; Glycogen; Glycosaminoglycans; Histocytochemistry; Humans; Male; Middle Aged; Sweat Gland Neoplasms

Topics: Adenoma, Sweat Gland; Adult; Aged; Diagnosis, Differential; Electron Transport Complex IV; Female; Glucosyltransferases; Glycogen; Histocytochemistry; Humans; Male; Middle Aged; Papilloma; Skin Neoplasms; Succinate Dehydrogenase; Tyrosine Decarboxylase

Topics: Adenoma, Sweat Gland; Adult; Aged; Cytoplasmic Granules; Dermatitis, Seborrheic; Female; Glycogen; Humans; Lipid Metabolism; Male; Melanins; Methods; Middle Aged; Neoplasms; Skin; Sweat Gland Neoplasms; Warts

Topics: Acrospiroma; Adenocarcinoma; Adenoma, Sweat Gland; Aminopeptidases; Clinical Enzyme Tests; Esterases; Glycogen; Humans; Indoles; Leucine; Pathology; Phosphotransferases; Sweat Gland Neoplasms; Sweat Glands