glycogen and Adenofibroma

Topics: Adenofibroma; Adenoma, Pleomorphic; Alkaline Phosphatase; Atrophy; Basement Membrane; Breast; Breast Diseases; Breast Neoplasms; Carcinoma; Carcinoma, Adenoid Cystic; Carcinosarcoma; Endocrine Glands; Epithelial Cells; Epithelium; Female; Glycogen; Humans; Hyperplasia; Lipids; Male; Middle Aged; Muscle, Smooth; Myoepithelioma; Myofibrils; Pigments, Biological; Salivary Gland Neoplasms; Sarcoma; Sweat Glands; Water

To confirm the eccrine acrosyringeal differentiation of eccrine syringofibroadenoma (ESFA) and to elucidate the histogenesis of its angiofibrotic stroma, a case of ESFA from a 45-year-old man was examined by light and electron microscopy. Histologically, the parenchyma featured anastomosing, slender epithelial cords containing small cuboidal cells and occasional duct-like structures. The stroma had increased numbers of mast cells, increased capillaries with swollen endothelial cells, and prominent fibrosis. Ultrastructurally, the following findings were characteristic of ESFA: a) abundant glycogen particles in epithelial cells, b) numerous intracytoplasmic and extracellular spaces lined with microvilli, c) intraepithelial duct formation, consisting of microvilli, vesicles, rod-shaped dense bodies, multivesicular dense bodies, and peripheral network of tonofilaments, and d) large numbers of mast cells, closely associated with fibroblasts, surrounding increased numbers of capillaries containing swollen endothelial cells. These ultrastructural features support the acrosyringeal differentiation of ESFA. We hypothesize that mast cell hyperplasia and degranulation may play an important role in the formation of the angiofibrotic stroma.

Topics: Adenofibroma; Adenoma, Sweat Gland; Cell Transformation, Neoplastic; Epithelium; Fibroblasts; Glycogen; Humans; Hyperplasia; Male; Mast Cells; Microscopy, Electron; Microvilli; Middle Aged; Sweat Gland Neoplasms

Topics: Adenocarcinoma; Adenofibroma; Adult; Aged; Breast Neoplasms; Carcinoma in Situ; Carcinoma, Intraductal, Noninfiltrating; Dihydrolipoamide Dehydrogenase; Female; Glucosephosphate Dehydrogenase; Glutamate Dehydrogenase; Glycogen; Glycosaminoglycans; Histocytochemistry; Humans; L-Lactate Dehydrogenase; Lymphatic Metastasis; Mammography; Middle Aged; RNA, Neoplasm; Succinate Dehydrogenase

Topics: Adenocarcinoma, Scirrhous; Adenofibroma; Breast Diseases; Breast Neoplasms; Carcinoma, Intraductal, Noninfiltrating; Cell Line; Cells, Cultured; Endoplasmic Reticulum; Female; Glycogen; Gynecomastia; Humans; In Vitro Techniques; Inclusion Bodies; Lung; Lymphatic Metastasis; Microscopy, Electron; Phyllodes Tumor; Pregnancy; Pregnancy Complications; Viruses

Topics: Adenofibroma; Breast Diseases; Breast Neoplasms; Cytodiagnosis; DNA; DNA, Neoplasm; Female; Glycogen; Glycosaminoglycans; Histocytochemistry; Humans; Hyperplasia; Lipid Metabolism; Microscopy, Fluorescence; RNA; RNA, Neoplasm

Topics: Adenocarcinoma; Adenofibroma; Breast; Breast Neoplasms; Carcinoma; Female; Glycogen; Humans

Topics: Adenofibroma; Breast Diseases; Breast Neoplasms; Carcinoma; Carcinoma, Intraductal, Noninfiltrating; Cysts; Diagnosis, Differential; Female; Glucosyltransferases; Glycogen; Histocytochemistry; Humans; Hyperplasia; Methods; Polysaccharides

Topics: Adenofibroma; Adult; Breast; Breast Neoplasms; Female; Glycogen; Histocytochemistry; Humans; Precancerous Conditions

Topics: Adenocarcinoma; Adenocarcinoma, Mucinous; Adenocarcinoma, Papillary; Adenofibroma; Brenner Tumor; Carcinoma, Squamous Cell; Cystadenoma; Cystadenoma, Mucinous; Cystadenoma, Papillary; Cysts; Dysgerminoma; Female; Glycogen; Granulosa Cell Tumor; Histocytochemistry; Humans; Male; Mesonephroma; Mucins; Neuraminic Acids; Ovarian Neoplasms; Ovary; Pathology; Sertoli-Leydig Cell Tumor; Sex Cord-Gonadal Stromal Tumors; Thecoma