glycogen and Adenocarcinoma--Mucinous

Topics: Adenocarcinoma; Adenocarcinoma, Mucinous; Adenocarcinoma, Papillary; Adult; Aged; Female; Gastric Mucosa; Glycogen; Humans; Male; Middle Aged; Stomach Neoplasms; Triglycerides

Ten cases of glycogen-rich clear cell carcinoma of the breast are described. Only two previous case reports have been published. These neoplasms are composed of clear cells with abundant glycogen. Ultrastructurally, two cases showed large quantities of non-membrane-bound glycogen and numerous empty glycogen lakes. neoplastic cells formed tight junctions, immature desmosomes, and occasionally had short microvilli. In nine cases the glycogen-rich carcinoma grew in a solid pattern only, while one case had both solid and papillary patterns. One case was associated with a signet-ring cell carcinoma. Seven of nine patients who underwent axillary dissections had nodal metastases. Five patients died with residual disease, and one is currently alive with local skin recurrence. These data suggest that glycogen-rich clear cell carcinoma is associated with frequent lymph node metastases and mortality.

Topics: Adenocarcinoma; Adenocarcinoma, Mucinous; Adult; Aged; Breast Neoplasms; Female; Follow-Up Studies; Glycogen; Humans; Lymphatic Metastasis; Microscopy, Electron; Middle Aged

The inter-relationships of 32 pathologic and 7 clinical parameters encountered in the study of 1000 examples of invasive breast carcinoma have been presented. In some instances the biological significance of these associations is at present unclear. In others it is to be noted that there is no information provided as to the rank of their significance. Nevertheless, the associations that were encountered not only help further characterize the various forms of breast cancer but also provide information regarding the possible biological significance of some of their features. Although it is not our intention to minimize the possible significance of the inter-relationships of pathologic parameters, most emphasis in the summarizing statements which follow has been placed upon those correlations which may relate to prognosis. In this regard reference has been made to short-term treatment failure, vis a vis local recurrence and/or metastases, which may not necessarily accurately reflect patient survival, although generally such a relationship exists. Information in this regard as well as to the rank of the significance of these pathologic features shall be forthcoming when sufficient time has elapsed since the inception of this study to allow for such conclusions, i.e. survival or long-term treatment failure rates. Lastly, it becomes evident that the guidelines followed in the examination of these specimens appear to represent at least the minimum requirements necessary for a meaningful pathologic evaluation of breast carcinoma.

Topics: Adenocarcinoma, Mucinous; Adult; Blood Vessels; Breast Neoplasms; Calcium; Carcinoma; Carcinoma, Adenoid Cystic; Carcinoma, Intraductal, Noninfiltrating; Carcinoma, Papillary; Carcinosarcoma; Cell Nucleus; Connective Tissue; Elastic Tissue; Female; Glycogen; Histiocytes; Humans; Lymphatic Metastasis; Lymphocytes; Middle Aged; Mucins; Necrosis; Neoplasms, Multiple Primary; Paget's Disease, Mammary; Papilloma; Sweat Glands

Topics: Adenocarcinoma, Mucinous; Cecum; Cell Nucleolus; DNA, Neoplasm; Glycogen; Histocytochemistry; Hodgkin Disease; Humans; Lymphoma, Large B-Cell, Diffuse; Neoplasm Proteins; RNA, Neoplasm; Staining and Labeling

Topics: Adenocarcinoma, Mucinous; Amylases; Glycogen; Humans; Polysaccharides; Stomach Neoplasms

Topics: Adenocarcinoma; Adenocarcinoma, Mucinous; Adenocarcinoma, Papillary; Adenofibroma; Brenner Tumor; Carcinoma, Squamous Cell; Cystadenoma; Cystadenoma, Mucinous; Cystadenoma, Papillary; Cysts; Dysgerminoma; Female; Glycogen; Granulosa Cell Tumor; Histocytochemistry; Humans; Male; Mesonephroma; Mucins; Neuraminic Acids; Ovarian Neoplasms; Ovary; Pathology; Sertoli-Leydig Cell Tumor; Sex Cord-Gonadal Stromal Tumors; Thecoma