glycogen and Adenocarcinoma--Bronchiolo-Alveolar

A clear cell type of bronchiolo-alveolar carcinoma removed from the lung of a 63-year-old man was studied by light and electron microscopy. The tumor was composed exclusively of Clara cells identified by the presence of secretory granules, an abundance of granular endoplasmic reticulum, a moderate number of mitochondria and prominent Golgi complexes. The tumor cells were tall columnar and had clear cytoplasm due to the presence of large pools of intracytoplasmic glycogen. This feature has not heretofore been described. Ultrastructural features distinguishing this tumor from benign clear cell tumors of the lung and clear cell carcinomas of the kidney are described.

Topics: Adenocarcinoma, Bronchiolo-Alveolar; Clinical Trials as Topic; Cytoplasmic Granules; Glycogen; Humans; Lung Neoplasms; Male; Middle Aged

Lung carcinoma of sheep (Jaagsiekte) is a bronchiolar-alveolar cell carcinoma. Differences in the ultrastructural patterns of early and advanced lesions of the disease are described. A-type and C-type viruses were observed in advanced tumors and were absent in early lesions. Numerous microtubules were characteristic in the epithelial tumor cells of the early lesions and were absent in the advanced tumor. In comparison to the early lesions, extensive cytosome production, surfactant secretion, and glycogen accumulation were observed in the advanced tumor. The immune response to the early tumor lesion was restricted to the peribronchiolar lymph aggregates, while in the advanced stages of the disease the systemic immune response was markedly increased.

Topics: Adenocarcinoma, Bronchiolo-Alveolar; Animals; Cytoplasmic Granules; Glycogen; Inflammation; Lung Neoplasms; Neoplasm Metastasis; Oncogenic Viruses; Retroviridae; Sheep; Sheep Diseases

Topics: Adenocarcinoma, Bronchiolo-Alveolar; Aged; Bronchial Neoplasms; Carcinoma, Squamous Cell; Cell Nucleus; Cytoplasmic Granules; DNA, Neoplasm; Endoplasmic Reticulum; Female; Glycogen; Histocytochemistry; Humans; Male; Microscopy, Electron; Middle Aged; Mitochondria; Ribosomes; Staining and Labeling