glycodeoxycholic-acid and Cholelithiasis

glycodeoxycholic-acid has been researched along with Cholelithiasis* in 2 studies

Other Studies

2 other study(ies) available for glycodeoxycholic-acid and Cholelithiasis

Article	Year
[Pre- and post-operative changes in serum levels of glycocholic acid and 3,5,3'-triiodothyronine and their clinical significance in patients with cholelithiasis]. Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University, 1997, Volume: 22, Issue:2 Pre- and post-operative changes of serum glycine-conjugated cholic acid (CG) and 3,5,3'-triiodothyronine (T3) levels were observed in twenty-two patients with cholelithiasis. The increase of the levels of serum CG varied with the patients; the highest levels were seen in patients with cirrhosis. After operation, the levels of serum CG and T3 were decreased significantly in patients without cirrhosis. There was positive correlation between serum CG and T3 (r = 0.4667, P < 0.01). It is indicated that the lowering of serum CG after operation may be related to the lowering of serum T3; the significant increase of serum CG level is useful to the diagnosis of liver cirrhosis, which is more sensitive than Type B ultrasonography or routine examination of liver function. Topics: Adult; Biomarkers; Cholelithiasis; Female; Glycodeoxycholic Acid; Humans; Liver Cirrhosis, Biliary; Male; Middle Aged; Postoperative Period; Triiodothyronine, Reverse	1997
Hyodeoxycholic acid: a new approach to gallstone prevention. American journal of surgery, 1985, Volume: 149, Issue:1 Hyodeoxycholic acid and its isomer, 6 beta-hyodeoxycholic acid, when added to a lithogenic diet prevented the formation of cholesterol gallstones and crystals in prairie dogs. This beneficial effect occurred in the presence of bile supersaturated with cholesterol. Hyodeoxycholic acid abolished the feedback inhibition of hepatic hydroxymethylglutaryl coenzyme A reductase activity, the rate-limiting enzyme of cholesterol synthesis, and prevented elevations in serum and liver cholesterol observed in animals fed a 0.4 percent cholesterol diet. The gallbladder bile of the animals fed hyodeoxycholic acid and 6 beta-hyodeoxycholic acid contained abundant liquid crystals. This suggests that these bile acids prevented the transition of cholesterol from its liquid crystalline phase to solid crystals and stones. Topics: Animals; Bile; Cholelithiasis; Cholesterol; Cholesterol, Dietary; Crystallization; Deoxycholic Acid; Diet; Disease Models, Animal; Female; Glycodeoxycholic Acid; Hydroxymethylglutaryl CoA Reductases; Liver; Male; Microsomes, Liver; Sciuridae	1985

Article

Year

[Pre- and post-operative changes in serum levels of glycocholic acid and 3,5,3'-triiodothyronine and their clinical significance in patients with cholelithiasis].

Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University, 1997, Volume: 22, Issue:2

Pre- and post-operative changes of serum glycine-conjugated cholic acid (CG) and 3,5,3'-triiodothyronine (T3) levels were observed in twenty-two patients with cholelithiasis. The increase of the levels of serum CG varied with the patients; the highest levels were seen in patients with cirrhosis. After operation, the levels of serum CG and T3 were decreased significantly in patients without cirrhosis. There was positive correlation between serum CG and T3 (r = 0.4667, P < 0.01). It is indicated that the lowering of serum CG after operation may be related to the lowering of serum T3; the significant increase of serum CG level is useful to the diagnosis of liver cirrhosis, which is more sensitive than Type B ultrasonography or routine examination of liver function.

Topics: Adult; Biomarkers; Cholelithiasis; Female; Glycodeoxycholic Acid; Humans; Liver Cirrhosis, Biliary; Male; Middle Aged; Postoperative Period; Triiodothyronine, Reverse

1997

Hyodeoxycholic acid: a new approach to gallstone prevention.

American journal of surgery, 1985, Volume: 149, Issue:1

Hyodeoxycholic acid and its isomer, 6 beta-hyodeoxycholic acid, when added to a lithogenic diet prevented the formation of cholesterol gallstones and crystals in prairie dogs. This beneficial effect occurred in the presence of bile supersaturated with cholesterol. Hyodeoxycholic acid abolished the feedback inhibition of hepatic hydroxymethylglutaryl coenzyme A reductase activity, the rate-limiting enzyme of cholesterol synthesis, and prevented elevations in serum and liver cholesterol observed in animals fed a 0.4 percent cholesterol diet. The gallbladder bile of the animals fed hyodeoxycholic acid and 6 beta-hyodeoxycholic acid contained abundant liquid crystals. This suggests that these bile acids prevented the transition of cholesterol from its liquid crystalline phase to solid crystals and stones.

Topics: Animals; Bile; Cholelithiasis; Cholesterol; Cholesterol, Dietary; Crystallization; Deoxycholic Acid; Diet; Disease Models, Animal; Female; Glycodeoxycholic Acid; Hydroxymethylglutaryl CoA Reductases; Liver; Male; Microsomes, Liver; Sciuridae

1985